Method of producing l-lysine by fermentation
    11.
    发明授权
    Method of producing l-lysine by fermentation 失效
    通过发酵生产L-赖氨酸的方法

    公开(公告)号:US3871960A

    公开(公告)日:1975-03-18

    申请号:US40055273

    申请日:1973-09-25

    申请人: AJINOMOTO KK

    IPC分类号: C12P13/08 C12D1/00

    CPC分类号: C12P13/08 Y10S435/843

    摘要: Strains of the genus Corynebacterium which combine resistance to feedback inhibition by S-(2-aminoethyl)-L-cysteine with methionine sensitivity and additionally may require proline or arginine, produce a large amount of L-lysine by fermentation of otherwise conventional culture media.

    摘要翻译: 通过S-(2-氨基乙基)-L-半胱氨酸与甲硫氨酸敏感性的结合抗反馈抑制作用的棒状杆菌属菌株,另外可能需要脯氨酸或精氨酸,通过其他常规培养基的发酵产生大量的L-赖氨酸。

    Isocyanate-modified polymers of aspartic and glutamic acid and method of preparing the same
    12.
    发明授权
    Isocyanate-modified polymers of aspartic and glutamic acid and method of preparing the same 失效
    天冬氨酸和谷氨酸的异氰酸酯改性聚合物及其制备方法

    公开(公告)号:US3867352A

    公开(公告)日:1975-02-18

    申请号:US31671172

    申请日:1972-12-20

    申请人: AJINOMOTO KK

    摘要: Polymers whose backbone includes aspartic or glutamic acid units, peptide-linked by their amino and Alpha -carboxyl groups, improve greatly in wet strength when contacted in a liquid medium with organic isocyanates until a sufficient number of the omega -carboxyl groups in the side chains of the polymer is converted to groups of the formula - CO - NH - C * by reaction with NCO groups of the isocyanate. Compounds having two or more NCO groups may cause cross linking. The high permeability of the glutamic or aspartic acid polymers to moisture, oxygen, carbon dioxide, and solutes in aqueous solutions is not significantly impaired, and may be enhanced by conversion of the omega -carboxyl groups, while wet strength is sharply increased, thereby improving utily of the polymers as dialysis membranes and in like applications.

    摘要翻译: 其主链包括天冬氨酸或谷氨酸单元,通过其氨基和α-羧基肽连接的聚合物在与有机异氰酸酯在液体介质中接触直至足够数量的侧链中的ω-羧基之间大大改善湿强度 的聚合物通过与异氰酸酯的NCO基团反应转化成式-CO-NH-C 3BOND的基团。 具有两个或更多个NCO基团的化合物可引起交联。 谷氨酸或天冬氨酸聚合物对水溶液中的水分,氧气,二氧化碳和溶质的高渗透性没有显着损害,并且可以通过ω-羧基的转化来增强,同时湿强度急剧增加,从而改善 作为透析膜和类似应用的聚合物。

    Method of producing pyrimidine nucleoside derivatives
    14.
    发明授权
    Method of producing pyrimidine nucleoside derivatives 失效
    制备吡咯烷酮核苷衍生物的方法

    公开(公告)号:US3856777A

    公开(公告)日:1974-12-24

    申请号:US31393672

    申请日:1972-12-11

    申请人: AJINOMOTO KK

    IPC分类号: C07H19/09 C07H19/06 C07D51/52

    CPC分类号: C07H19/06

    摘要: Uridine, cytidine, and derivatives thereof arrived at by substitution in positions 4, 5 and 5'' are converted to the corresponding 2,2''-anhydro compounds by reaction with cyclic lower alkylene and alkenylene esters of carbonic acid. The anhydro compounds are hydrolyzed to arabinofuranosylpyrimidine derivatives in a basically known manner. The latter as well as the anhydro compounds are known physiologically active agents and/or intermediates in the synthesis of such agents.

    摘要翻译: 通过与环状低级亚烷基和碳酸亚烯基酯反应,将4,5,6'位置上的尿苷,胞苷及其衍生物转化为相应的2,2'-脱水化合物。 以基本已知的方式将脱水化合物水解成阿拉伯呋喃糖基嘧啶衍生物。 后者以及脱水化合物是合成这种试剂的已知的生理活性剂和/或中间体。

    Method of producing l-proline by fermentation
    17.
    发明授权
    Method of producing l-proline by fermentation 失效
    通过发酵生产L-精氨酸的方法

    公开(公告)号:US3819483A

    公开(公告)日:1974-06-25

    申请号:US32666173

    申请日:1973-01-26

    申请人: AJINOMOTO KK

    IPC分类号: C12P13/24 C12D1/00

    摘要: Proline-producing, artificially induced mutants of Brevibacterium and Corynebacterium produce more proline than the respective parent strains if the growth of the mutants is less inhibited by sulfa drugs than that of the parent strains.

    摘要翻译: 如果突变体的生长受到磺胺药物的抑制比母本菌株少,则脯氨酸生产人工诱导的短杆菌和棒状杆菌的突变体比各自亲本菌株产生更多的脯氨酸。