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公开(公告)号:US20180078375A1
公开(公告)日:2018-03-22
申请号:US15608679
申请日:2017-05-30
Applicant: AlloSource
Inventor: Carolyn Barrett , Yaling Shi
CPC classification number: A61F2/30756 , A61F2002/30113 , A61F2002/30153 , A61F2002/30154 , A61F2002/30759 , A61F2002/30784 , A61F2002/3097 , A61F2240/002 , A61F2310/00359 , A61F2310/00371 , A61L27/3608 , A61L27/3612
Abstract: Compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles and a biocompatible carrier are provided. Methods of manufacturing cartilage compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles are also provided.
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公开(公告)号:US09829302B2
公开(公告)日:2017-11-28
申请号:US14940549
申请日:2015-11-13
Applicant: ALLOSOURCE
Inventor: Tyler A. Reinke
CPC classification number: G01B5/08 , A61B5/107 , A61B5/4523 , A61B19/46 , A61B90/06 , A61B2019/461 , A61B2090/061
Abstract: There is disclosed a system and method for measuring the diameter or thickness of a tendon. In an embodiment, the device includes an adjustable tube having a variably sized cross-sectional diameter in a direction perpendicular to an axis extending between the first end and the second end, the adjustable tube being positionable from an open configuration in which the variably sized cross-sectional diameter is larger than a diameter of a tendon so as to allow loading of the tendon, to a closed configuration in which the variably sized cross-sectional diameter approximates the diameter of the tendon so as to allow measurement of the tendon. The device includes a measurement gradient in operable configuration with the adjustable tube so as to allow measurement of the tendon in the closed configuration. Other embodiments are also disclosed.
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公开(公告)号:US09814803B2
公开(公告)日:2017-11-14
申请号:US14880563
申请日:2015-10-12
Applicant: AlloSource
Inventor: Yaling Shi
CPC classification number: A61L27/3834 , A01N1/021 , A61K35/12 , A61K35/38 , A61L27/3608 , A61L27/3847 , A61L27/3895 , A61L27/54 , A61L2300/406 , A61L2430/02 , C12N5/0662 , C12N5/0667 , C12N2509/00 , C12N2533/18 , C12N2533/90
Abstract: There is disclosed a method of combining mesenchymal stem cells (MSCs) with a bone substrate. In an embodiment, the method includes obtaining tissue having MSCs together with unwanted cells. The tissue is digested to form a cell suspension having MSCs and unwanted cells. The cell suspension is added to the substrate. The substrate is cultured to allow the MSCs to adhere. The substrate is rinsed to remove unwanted cells. In various embodiments, the tissue is adipose tissue, muscle tissue, or bone marrow tissue. In an embodiment, there is disclosed an allograft product including a combination of MSCs with a bone substrate in which the combination is manufactured by culturing MSCs disposed on the substrate for a period of time to allow the MSCs to adhere to the substrate, and then rinsing the substrate to remove unwanted cells from the substrate. Other embodiments are also disclosed.
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公开(公告)号:US09603710B2
公开(公告)日:2017-03-28
申请号:US14858386
申请日:2015-09-18
Applicant: AlloSource
Inventor: Yaling Shi , Carolyn Barrett
CPC classification number: A61F2/30756 , A61F2/28 , A61F2/3094 , A61F2002/30759 , A61F2002/30762 , A61F2002/30764 , A61F2002/30784 , A61F2002/30827 , A61F2002/3096 , A61F2002/3097 , A61L27/3612 , A61L27/3804 , A61L27/56 , A61L2430/24
Abstract: Osteochondral graft composition that include a cartilage component and a bone component, and which include one or more perforations in the bone component and/or the cartilage component, are provided. Methods of manufacturing and using such osteochondral graft compositions are also provided.
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公开(公告)号:US20160144454A1
公开(公告)日:2016-05-26
申请号:US14941275
申请日:2015-11-13
Applicant: ALLOSOURCE
Inventor: Meghan Gabriel , Raymond Klein
CPC classification number: B23K26/127 , A61B18/20 , B23K26/38 , G02B5/208
Abstract: There is disclosed a system and method for laser cutting of human allograft tissue. One embodiment includes a laser canister having a housing fabricated with a sterilizable material. The housing defines an interior portion, an exterior portion, and a selectively operable opening into the interior portion. The selectively operable opening includes a hermetic seal to maintain a sterile environment from the exterior portion when the selectively operable opening is closed. The canister includes an infrared (IR) transmissive optical window disposed in the housing and configured to allow a laser beam to penetrate therethrough to the interior portion. The canister also includes an insert within the interior portion configured to support human allograft tissue in a sterile environment, the insert being removable from the housing to move the human allograft tissue into another sterile environment after the housing has been exposed to a non-sterile environment. Other embodiments are also disclosed.
Abstract translation: 公开了用于激光切割人类同种异体移植组织的系统和方法。 一个实施例包括具有由可灭菌材料制成的壳体的激光罐。 壳体限定内部部分,外部部分以及到内部部分中的可选择操作的开口。 当可选择性地操作的开口关闭时,选择性操作的开口包括气密密封件以保持来自外部部分的无菌环境。 所述罐包括布置在所述壳体中并被配置为允许激光束穿过其中的红外(IR)透射光学窗口到所述内部部分。 所述罐还包括在所述内部部分内的插入物,其构造成在无菌环境中支撑人类同种异体移植组织,所述插入物可从所述壳体移除,以在所述壳体暴露于非无菌环境之后将所述人类同种异体移植组织移动到另一无菌环境中 。 还公开了其他实施例。
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公开(公告)号:US09267870B2
公开(公告)日:2016-02-23
申请号:US13746929
申请日:2013-01-22
Applicant: Allosource
Inventor: Raymond J. Klein
CPC classification number: G01N3/08 , G01F19/00 , G01F19/007
Abstract: There is disclosed a constant force compression tool for measuring a compressible material. In an embodiment, the tool includes a handle having a passageway receiving a plunger. The tool includes a biasing member in communication with the plunger and the handle. The tool includes a retaining element in communication with the plunger and the handle. There is disclosed a system for measuring a compressible material with a measurement tube and a constant force compression tool. There is disclosed a method of measuring a compressible material. In an embodiment, the method includes selecting a measurement tube. The method includes placing a compressible material into the measurement tube. The method includes pressing a plunger against the compressible material. The method includes monitoring an indicator to determine a full volume of compressible material between the end of the plunger and the conical tube. Other embodiments are also disclosed.
Abstract translation: 公开了一种用于测量可压缩材料的恒力压缩工具。 在一个实施例中,该工具包括具有接收柱塞的通道的把手。 该工具包括与柱塞和手柄连通的偏置构件。 该工具包括与柱塞和手柄连通的保持元件。 公开了一种用测量管和恒力压缩工具测量可压缩材料的系统。 公开了一种测量可压缩材料的方法。 在一个实施例中,该方法包括选择测量管。 该方法包括将可压缩材料放入测量管中。 该方法包括将柱塞压靠在可压缩材料上。 该方法包括监测指示器以确定柱塞端部和锥形管之间的可压缩材料的全部体积。 还公开了其他实施例。
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17.
公开(公告)号:US20140271570A1
公开(公告)日:2014-09-18
申请号:US14210111
申请日:2014-03-13
Applicant: AlloSource
Inventor: Yaling Shi , Carolyn Barrett
IPC: A61F2/30
CPC classification number: A61F2/30756 , A61F2/28 , A61F2/3094 , A61F2002/30759 , A61F2002/30762 , A61F2002/30764 , A61F2002/30784 , A61F2002/30827 , A61F2002/3096 , A61F2002/3097 , A61L27/3612 , A61L27/3804 , A61L27/56 , A61L2430/24
Abstract: Osteochondral graft composition comprising a cartilage component and a bone component, and further comprising one or more perforations in the bone component and/or the cartilage component, are provided. Methods of manufacturing and using osteochondral graft compositions comprising one or more perforations in the bone component and/or the cartilage component are also provided.
Abstract translation: 提供了包含软骨组分和骨组分的骨软骨移植组合物,并且还包括骨组分和/或软骨组分中的一个或多个穿孔。 还提供了在骨组分和/或软骨组分中制备和使用包含一个或多个穿孔的骨软骨移植组合物的方法。
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公开(公告)号:US20140243993A1
公开(公告)日:2014-08-28
申请号:US14187093
申请日:2014-02-21
Applicant: AlloSource
Inventor: Carolyn Barrett , Yaling Shi
CPC classification number: A61F2/30756 , A61F2002/30113 , A61F2002/30153 , A61F2002/30154 , A61F2002/30759 , A61F2002/30784 , A61F2002/3097 , A61F2240/002 , A61F2310/00359 , A61F2310/00371 , A61L27/3608 , A61L27/3612
Abstract: Compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles and a biocompatible carrier are provided. Methods of manufacturing cartilage compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles are also provided.
Abstract translation: 提供包含软骨片的组合物,其包含多个相互连接的软骨片和生物相容性载体。 还提供了制造软骨组合物的方法,所述软骨组合物包括包含多个相互连接的软骨片的软骨片。
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公开(公告)号:US20140134212A1
公开(公告)日:2014-05-15
申请号:US14081913
申请日:2013-11-15
Applicant: AlloSource
Inventor: Yaling Shi , Carolyn Barrett , Peter Stevens
IPC: A61K35/12
CPC classification number: A61K35/32 , A61L24/0005 , A61L2430/06
Abstract: Compositions comprising a plurality of cartilage particles from a human adult cadaveric donor, wherein the cartilage particles comprise viable chondrocytes, and a biocompatible carrier are provided. Methods of manufacturing cartilage compositions comprising a plurality of cartilage particles from a human adult cadaveric donor are also provided.
Abstract translation: 包含来自人成人尸体供体的多个软骨颗粒的组合物,其中所述软骨颗粒包含活的软骨细胞,以及生物相容性载体。 还提供了制造包含来自人类成年尸体供体的多种软骨颗粒的软骨组合物的方法。
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公开(公告)号:US20130273597A1
公开(公告)日:2013-10-17
申请号:US13900577
申请日:2013-05-23
Applicant: Allosource
Inventor: Jan Zajdowicz , Todd Huft
IPC: C12Q1/04
CPC classification number: C12Q1/04 , A01N1/0263
Abstract: There is disclosed a method of procuring allograft tissue. In an embodiment, the method includes inserting an allograft through an opening into a procurement extraction container, sealing the opening, adding extraction fluid through a second opening, agitating the fluid, collecting the fluid for detection of contamination, and sealing the second opening. There is disclosed a procurement extraction container. In one embodiment, the container includes a wall defining an interior to receive the allograft, an opening into the interior, sized to receive the allograft, a closure device for the opening, the closure device providing a hermetic seal, a second opening providing a second passageway into the interior, the second opening having a connector interface and a second closure device providing a hermetic seal so as to provide, with the first closure and the at least one wall, a sterile barrier. Other embodiments are also disclosed.
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