公开(公告)号：US20060234581A1

公开(公告)日：2006-10-19

申请号：US11402004

申请日：2006-04-12

申请人： Junichi Saito ,  Akinori Hanatani ,  Hitoshi Akemi

发明人： Junichi Saito ,  Akinori Hanatani ,  Hitoshi Akemi

IPC分类号： B32B5/02 ,  B32B27/04

CPC分类号： A61K9/7061 ,  Y10T442/20 ,  Y10T442/2738 ,  Y10T442/2754

摘要： The present invention provides an adhesive preparation superior in adhesion property, which does not peel off or fall off easily and which can be adhered for a long time. An adhesive preparation 10 has a support 1 made of a cloth, and a pressure sensitive adhesive layer 3 formed on one surface of the support 1, which contains a pressure sensitive adhesive and a drug. The ratio (CW/AW) of a mass (CW) per unit area of the support 1 and a mass (AW) per unit area of the pressure sensitive adhesive layer 3 is 1.0-5.0, an adhesive layer-free surface of the support 1 has a static friction coefficient of 0.25-0.75, and a 20% modulus (AM) in one direction of the adhesive preparation 10 and a 20% modulus (EM) in the direction perpendicular to that direction are each 0.5-1.5 N/cm, and the ratio thereof (AM/EM) is 0.5-2.0.

公开(公告)号：US09707189B2

公开(公告)日：2017-07-18

申请号：US13611165

申请日：2012-09-12

申请人： Arimichi Okazaki ,  Tsuyoshi Mukobata ,  Sachiko Sakamoto ,  Akinori Hanatani

发明人： Arimichi Okazaki ,  Tsuyoshi Mukobata ,  Sachiko Sakamoto ,  Akinori Hanatani

IPC分类号： A61K47/18 ,  A61K9/70 ,  A61K31/41 ,  A61K31/422

CPC分类号： A61K9/7061 ,  A61K31/41 ,  A61K31/422

摘要： The problem of the present invention is to provide a composition for enhancing transdermal absorption of a drug, which shows a sufficiently high enhancing effect on transdermal absorption of an acidic drug.A composition for enhancing transdermal absorption of an acidic drug, comprising a polyvalent alcohol having 3-8 carbon atoms, a higher alcohol having 12-20 carbon atoms and an organic amine having 2-9 carbon atoms.

公开(公告)号：US20130064868A1

公开(公告)日：2013-03-14

申请号：US13611154

申请日：2012-09-12

申请人： Arimichi OKAZAKI ,  Tsuyoshi MUKOBATA ,  Sachiko SAKAMOTO ,  Akinori HANATANI

发明人： Arimichi OKAZAKI ,  Tsuyoshi MUKOBATA ,  Sachiko SAKAMOTO ,  Akinori HANATANI

IPC分类号： A61K47/10 ,  A61K9/00 ,  A61K47/18

CPC分类号： A61K9/7038 ,  A61K9/0014 ,  A61K9/7084 ,  A61K31/405 ,  A61K31/41 ,  A61K31/422 ,  A61K31/565

摘要： The problem of the present invention is to provide a composition for enhancing transdermal absorption of a drug, which shows a sufficiently high enhancing effect on transdermal absorption of a drug, particularly, a composition for enhancing transdermal absorption of a drug, which shows a sufficiently high enhancing effect on transdermal absorption of an acidic drug.A composition for enhancing transdermal absorption of a drug, comprising an unsaturated higher alcohol having 12-20 carbon atoms and a polyvalent alcohol having 3-8 carbon atoms. A composition for enhancing transdermal absorption of a drug, comprising an unsaturated higher alcohol having 12-20 carbon atoms, a polyvalent alcohol having 3-8 carbon atoms and an organic amine having 2-9 carbon atoms.

摘要翻译： 本发明的问题是提供一种用于增强药物经皮吸收的组合物，其对药物的经皮吸收具有足够高的增强效果，特别是用于增强药物经皮吸收的组合物，其显示出足够高的 增强对酸性药物经皮吸收的作用。 一种用于增强药物透皮吸收的组合物，其包含具有12-20个碳原子的不饱和高级醇和具有3-8个碳原子的多元醇。 一种用于增强药物透皮吸收的组合物，其包含具有12-20个碳原子的不饱和高级醇，具有3-8个碳原子的多元醇和具有2-9个碳原子的有机胺。

公开(公告)号：US20120027840A1

公开(公告)日：2012-02-02

申请号：US13190767

申请日：2011-07-26

申请人： Akinori HANATANI ,  Sachiko SAKAMOTO ,  Arimichi OKAZAKI ,  Hitoshi AKEMI

发明人： Akinori HANATANI ,  Sachiko SAKAMOTO ,  Arimichi OKAZAKI ,  Hitoshi AKEMI

IPC分类号： A61K9/70 ,  B32B7/12

CPC分类号： A61L15/58 ,  Y10T428/28

摘要： The present invention provides an adhesive patch including a backing and a pressure-sensitive adhesive layer formed on at least one surface of the backing, in which (a) a surface of the pressure-sensitive adhesive layer has a logarithmic decrement, as determined by the rigid-pendulum free-damped oscillation method, in the range of 0.03 to 0.35, and (b) the pressure-sensitive adhesive layer has a maximum shear displacement in the range of 18 μm to 1,000 μm. The present invention further provides a patch preparation containing a drug. The adhesive patch and the patch preparation according to the present invention are reduced in skin irritation during wear.

摘要翻译： 本发明提供了一种粘合贴片，其包括背衬和形成在背衬的至少一个表面上的压敏粘合剂层，其中（a）压敏粘合剂层的表面具有对数递减，如 刚性摆摆动阻尼振荡法，在0.03〜0.35的范围内，（b）压敏粘合剂层的最大剪切位移在18μm〜1000μm的范围内。 本发明还提供含有药物的贴片制剂。 根据本发明的粘合贴剂和贴剂制剂在穿着期间减少皮肤刺激。

公开(公告)号：US08096417B2

公开(公告)日：2012-01-17

申请号：US12314563

申请日：2008-12-12

申请人： Yoshihiro Iwao ,  Akinori Hanatani ,  Junichi Sekiya ,  Hitoshi Akemi

发明人： Yoshihiro Iwao ,  Akinori Hanatani ,  Junichi Sekiya ,  Hitoshi Akemi

IPC分类号： A61B19/02 ,  B65D73/00 ,  B65D65/26

CPC分类号： A61F15/001 ,  A61L15/24 ,  C08L33/20

摘要： The main object of the present invention is to provide a patch package structure capable of stably retaining the physiologically active ingredient in a patch during preservation of the patch. This object can be achieved by employing the following constitution.To be specific, the present invention is a patch package structure including a patch 1 and a packaging member 51 holding the patch, wherein the patch 1 includes a support 2 and an adhesive layer 3 formed on at least one surface of the support 2, the packaging member 51 includes a first package 11, the first package 11 including an acrylonitrile resin layer 12, a moisture-absorbing layer 13 formed on the acrylonitrile resin layer 12, and a moisture impermeable layer 14 formed on the moisture-absorbing layer 13, and the acrylonitrile resin layer 12 is provided on the proximal side of the patch 1.

摘要翻译： 本发明的主要目的是提供一种贴片包装结构，其能够在贴片保存期间将贴片的生理活性成分稳定地保持。 该目的可以通过采用以下结构来实现。 具体而言，本发明是一种贴片包装结构，其包括贴片1和保持贴片的包装部件51，其中贴片1包括形成在支撑体2的至少一个表面上的支撑体2和粘合剂层3， 包装部件51包括第一包装11，包含丙烯腈树脂层12的第一包装11，形成在丙烯腈树脂层12上的吸湿层13和形成在吸湿层13上的不透水层14，以及 丙烯腈树脂层12设置在贴剂1的近侧。

公开(公告)号：US20110212140A1

公开(公告)日：2011-09-01

申请号：US13106144

申请日：2011-05-12

申请人： Akinori Hanatani ,  Hitoshi Akemi

发明人： Akinori Hanatani ,  Hitoshi Akemi

IPC分类号： A61K9/00 ,  A61K31/4164 ,  A61P31/10

CPC分类号： A61K8/0208 ,  A61K8/02 ,  A61K8/891 ,  A61Q3/00 ,  C08L83/00 ,  C08L2666/02 ,  C09J183/04

摘要： The present invention aims at providing a pressure-sensitive adhesive composition applicable to nail, which shows superior adhesive performance (adhesive force, cohesion etc.), and superior drug releasability and drug stability, and an adhesive agent for nail, which uses this composition. The composition of the present invention contains a condensation polymer of a silicone resin and a silicone rubber. The composition of the present invention preferably contains not less than two kinds of condensation polymers having different resin/rubber ratios. The adhesive agent of the present invention has a support and an adhesive layer formed on one surface of the support, which contains the above-mentioned composition.

摘要翻译： 本发明的目的在于提供一种适用于指甲的压敏粘合剂组合物，其具有优异的粘合性能（粘合力，内聚力等）和优异的药物释放性和药物稳定性，以及使用该组合物的指甲粘合剂。 本发明的组合物含有有机硅树脂和硅橡胶的缩聚物。 本发明的组合物优选含有不少于两种具有不同树脂/橡胶比的缩聚物。 本发明的粘合剂具有形成在载体的一个表面上的载体和粘合剂层，其含有上述组合物。

公开(公告)号：US20090166236A1

公开(公告)日：2009-07-02

申请号：US12314563

申请日：2008-12-12

申请人： Yoshihiro Iwao ,  Akinori Hanatani ,  Junichi Sekiya ,  Hitoshi Akemi

发明人： Yoshihiro Iwao ,  Akinori Hanatani ,  Junichi Sekiya ,  Hitoshi Akemi

IPC分类号： A61B19/02 ,  B65D85/00

CPC分类号： A61F15/001 ,  A61L15/24 ,  C08L33/20

摘要： The main object of the present invention is to provide a patch package structure capable of stably retaining the physiologically active ingredient in a patch during preservation of the patch. This object can be achieved by employing the following constitution.To be specific, the present invention is a patch package structure including a patch 1 and a packaging member 51 holding the patch, wherein the patch 1 includes a support 2 and an adhesive layer 3 formed on at least one surface of the support 2, the packaging member 51 includes a first package 11, the first package 11 including an acrylonitrile resin layer 12, a moisture-absorbing layer 13 formed on the acrylonitrile resin layer 12, and a moisture impermeable layer 14 formed on the moisture-absorbing layer 13, and the acrylonitrile resin layer 12 is provided on the proximal side of the patch 1.

摘要翻译： 本发明的主要目的是提供一种贴片包装结构，其能够在贴片保存期间将贴片的生理活性成分稳定地保持。 该目的可以通过采用以下结构来实现。 具体而言，本发明是一种贴片包装结构，其包括贴片1和保持贴片的包装部件51，其中贴片1包括形成在支撑体2的至少一个表面上的支撑体2和粘合剂层3， 包装部件51包括第一包装11，包含丙烯腈树脂层12的第一包装11，形成在丙烯腈树脂层12上的吸湿层13和形成在吸湿层13上的不透水层14，以及 丙烯腈树脂层12设置在贴剂1的近侧。

公开(公告)号：US20060171908A1

公开(公告)日：2006-08-03

申请号：US11345520

申请日：2006-02-02

申请人： Akinori Hanatani ,  Hitoshi Akemi

发明人： Akinori Hanatani ,  Hitoshi Akemi

IPC分类号： A61K8/81

CPC分类号： A61K8/0208 ,  A61K8/02 ,  A61K8/891 ,  A61Q3/00 ,  C08L83/00 ,  C08L2666/02 ,  C09J183/04

摘要： The present invention aims at providing a pressure-sensitive adhesive composition applicable to nail, which shows superior adhesive performance (adhesive force, cohesion etc.), and superior drug releasability and drug stability, and an adhesive agent for nail, which uses this composition. The composition of the present invention contains a condensation polymer of a silicone resin and a silicone rubber. The composition of the present invention preferably contains not less than two kinds of condensation polymers having different resin/rubber ratios. The adhesive agent of the present invention has a support and an adhesive layer formed on one surface of the support, which contains the above-mentioned composition.

公开(公告)号：US20060165764A1

公开(公告)日：2006-07-27

申请号：US11334386

申请日：2006-01-19

申请人： Akinori Hanatani ,  Masaaki Ito ,  Junichi Saito

发明人： Akinori Hanatani ,  Masaaki Ito ,  Junichi Saito

IPC分类号： A61L15/16

CPC分类号： A61K9/7007 ,  A61K9/7053 ,  A61K9/7061 ,  A61K31/00 ,  C08K5/101 ,  C09J7/383 ,  C09J2205/102

摘要： The present invention provides a tape preparation including a support and an adhesive layer directly or indirectly formed on at least one surface of the support, wherein the adhesive layer contains a rubber adhesive containing at least one kind of rubber polymer and capsaicin as an active ingredient. Since the adhesive layer shows extremely fine adhesive property and superior capsaicin releaseability, a rapid pharmacological effect can be afforded with a small capsaicin content.

摘要翻译： 本发明提供了一种胶带制剂，其包括直接或间接形成在载体的至少一个表面上的载体和粘合剂层，其中粘合剂层含有含有至少一种橡胶聚合物和辣椒素作为活性成分的橡胶粘合剂。 由于粘合剂层显示出非常好的粘附性和优异的辣椒素释放性，所以可以获得较小的辣椒素含量的快速药理作用。

公开(公告)号：US20110243998A1

公开(公告)日：2011-10-06

申请号：US13074911

申请日：2011-03-29

申请人： Sachiko SAKAMOTO ,  Akinori Hanatani ,  Arimichi Okazaki ,  Hitoshi Akemi ,  Yoshihiro Iwao ,  Kensuke Matsuoka

发明人： Sachiko SAKAMOTO ,  Akinori Hanatani ,  Arimichi Okazaki ,  Hitoshi Akemi ,  Yoshihiro Iwao ,  Kensuke Matsuoka

IPC分类号： A61K9/00 ,  A61K31/445 ,  A61K31/4174 ,  A61K31/34 ,  A61K31/192 ,  A61K31/195 ,  A61K31/4152 ,  A61K31/46

CPC分类号： A61K9/7061 ,  A61K9/7053

摘要： The invention provides a patch preparation containing (a) a support and (b) an adhesive layer containing a drug on the surface of the support, wherein a crystal of the drug is formed in the adhesive layer immediately after application of a physical stimulation to the adhesive layer, while a crystal of the drug is formed during preservation after the physical stimulation. The patch preparation which does not require an increase in the area and thickness of an adhesive layer, achieves a sufficiently high skin permeation amount of the drug, shows good adhesiveness to skin, and permits a long-term adhesion to skin. The invention also provides a method of producing the patch preparation.

摘要翻译： 本发明提供了一种补片制剂，其包含（a）支持物和（b）在载体表面上含有药物的粘合剂层，其中在施加物理刺激之后立即在粘合剂层中形成药物的晶体 而在物理刺激后的保存期间形成药物的晶体。 不需要增加粘合剂层的面积和厚度的贴片制剂能够获得足够高的皮肤渗透量的药物，对皮肤具有良好的粘附性，并且可以长期粘附到皮肤上。 本发明还提供一种制备贴剂的方法。