Abstract:
Conjugates of antibodies and cytotoxic methotrexate drugs make use of liners between the drug and antibody which are simple organic groups, wherein the link to the antibody is an acyl group and the link to the drug is an alkylidene hydrazide.
Abstract:
A series of antibody-vinca drug conjugates comprise antibodies which target antigens associated with undesirable cells, so that the cells are controlled or killed by the cytotoxic vinca drug. The drug is linked to the antibody through an organic group comprising a carbonyl at the antibody end, and an alkylidene hydrazide at the vinca end.
Abstract:
Molded article having improved thermal resistance and strength formed from a homogeneous mixture comprising from about 5 to 75 percent by weight polybenzimidazole and from about 95 to 25 percent by weight of a polyaryleneketone. These articles are obtained by injection molding techniques.
Abstract:
An integrally formed multi-component structure is disclosed, the multi-component structure comprising a plurality of components, at least one of which is a three-dimensional bonded fiber fluid transmissive component comprised of a plurality of polymeric fibers bonded to each other at spaced apart contact points, the fibers collectively defining tortuous fluid flow paths, and wherein each component has an interface with at least one other component.
Abstract:
A work vehicle includes a frame, a cab structure connected to the frame and a seat connected to the frame. A substantially rigid restraining device of unitary construction is pivotably connected behind the seat to any one of the frame, the cab structure, or the frame and the cab structure. The pivotable connection between the restraining device and the frame and/or the cab structure is adjustable.
Abstract:
An arcuate die board formed as a multi-layered paperboard structure. The die board is initially produced as a full cylindrical paperboard tube, which is subsequently cut lengthwise to form two or more part-cylindrical portions each of which is used to fabricate a die board. The die board is then cut to form the slots in its outer surface for mounting die tools. The multi-layered paperboard tube can be spirally wound, convolutely wound, or formed by a linear draw process. The part-cylindrical wall is formed predominantly, substantially entirely, or entirely of paperboard plies adhesively laminated together.
Abstract:
Methods for the preparation of chemical intermediates in the synthesis of HIV-protease inhibitors related to and including nelfinavir mesylate are disclosed. The method of this invention comprises converting tetrohydran derivatives into oxazolines to provide key reaction intermediates for the preparation of nelfinavir. Also disclosed is a method for the preparation of a chiral amino alcohol from an epoxy-tetrahydrofuran.