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公开(公告)号：US5989867A
公开(公告)日：1999-11-23
申请号：US934959
申请日：1997-09-22
CPC分类号： C07K14/5428 , A61K39/00
摘要： Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译： 提供了编码哺乳动物细胞因子的纯化基因，与其相关的试剂，包括纯化蛋白质，特异性抗体和编码该分子的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
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公开(公告)号：US20050009106A1
公开(公告)日：2005-01-13
申请号：US10916256
申请日：2004-08-10
IPC分类号： A61K38/00 , A61K39/00 , C07K14/54 , C07K14/715 , C07H21/04 , C07K16/24 , C12P21/02 , G01N33/53
CPC分类号： C07K16/244 , A61K38/00 , A61K39/00 , C07K14/5428 , C07K14/7155
摘要： Purified genes encoding a cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译： 提供了编码来自哺乳动物的细胞因子的纯化基因，与其相关的试剂，包括纯化的蛋白质，特异性抗体和编码该分子的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
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公开(公告)号：US06797813B2
公开(公告)日：2004-09-28
申请号：US10083720
申请日：2002-02-28
IPC分类号： C07K1624
CPC分类号： C07K16/244 , A61K38/00 , A61K39/00 , C07K14/5428 , C07K14/7155
摘要： Purified genes encoding a cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using these reagents and diagnostic kits are also provided.
摘要翻译： 提供了编码来自哺乳动物的细胞因子的纯化基因，与其相关的试剂，包括纯化的蛋白质，特异性抗体和编码该分子的核酸。 还提供了使用这些试剂和诊断试剂盒的方法。
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14.发明授权Human herpesvirus type 6 protein p100, the corresponding DNA sequences, their preparation and use 失效人类疱疹病毒6型蛋白p100，相应的DNA序列，其制备和应用公开(公告)号：US06174685B1
公开(公告)日：2001-01-16
申请号：US08467528
申请日：1995-06-06
IPC分类号： G01N3353
CPC分类号： C07K14/005 , A61K38/00 , C12N2710/16522 , Y10S435/822 , Y10S435/849 , Y10S435/942
摘要： The invention relates to the human herpesvirus type 6 protein p100 and parts thereof having its specific immunological properties. It further relates to antibodies directed to them and to the corresponding DNA sequences. They can be used in pharmaceutical or diagnostic compositions, optionally together with other HHV-6 proteins or the corresponding DNA sequences.
摘要翻译： 本发明涉及人疱疹病毒6型蛋白质p100及其具有其特异性免疫学特性的部分。 它还涉及针对它们的抗体和相应的DNA序列。 它们可以用于药物或诊断组合物，任选地与其他HHV-6蛋白质或相应的DNA序列一起使用。
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公开(公告)号：US5849522A
公开(公告)日：1998-12-15
申请号：US467143
申请日：1995-06-06
申请人： Bernhard Fleckenstein , Walter Schaffner , Frank Weber , Karoline Dorsch-Hasler , Gerhard Jahn , Michael Boshart
发明人： Bernhard Fleckenstein , Walter Schaffner , Frank Weber , Karoline Dorsch-Hasler , Gerhard Jahn , Michael Boshart
CPC分类号： C12N15/85 , C12N2800/60
摘要： An enhancer has been located in the upstream region of the major immediate early gene of human cytomegalovirus and has been isolated, which enhancer is more active than that from SV40 and has a wide host cell spectrum. Hence, it is suitable for eukaryotic expression systems wherein it can be incorporated upstream or downstream of the structural gene or of the regulation region.
摘要翻译： 增强子已经位于人巨细胞病毒的主要即时早期基因的上游区域，并且已被分离，其增强剂比来自SV40的活性更强，并且具有广泛的宿主细胞谱。 因此，它适合于其可以结合到结构基因或调节区的上游或下游的真核表达系统。
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16.发明授权Human herpesvirus type 6 protein p100, the corresponding DNA sequences, their preparation and use 失效人类疱疹病毒6型蛋白p100，相应的DNA序列，其制备和应用
公开(公告)号：US5827519A
公开(公告)日：1998-10-27
申请号：US467527
申请日：1995-06-06
IPC分类号： A61K39/395 , A61K38/00 , A61K39/245 , A61K39/42 , A61P31/12 , A61P31/22 , C07K14/02 , C07K14/03 , C07K16/08 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/38 , C12N15/70 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/85 , G01N33/53 , G01N33/571 , G01N33/577 , C12Q1/70 , G01N33/569
CPC分类号： C07K14/005 , A61K38/00 , C12N2710/16522 , Y10S435/822 , Y10S435/849 , Y10S435/942
摘要： The invention relates to the human herpesvirus type 6 protein p100 and parts thereof having its specific immunological properties. It further relates to antibodies directed to them and to the corresponding DNA sequences. They can be used in pharmaceutical or diagnostic compositions, optionally together with other HHV-6 proteins or the corresponding DNA sequences.
摘要翻译： 本发明涉及人疱疹病毒6型蛋白质p100及其具有其特异性免疫学特性的部分。 它还涉及针对它们的抗体和相应的DNA序列。 它们可以用于药物或诊断组合物，任选地与其他HHV-6蛋白质或相应的DNA序列一起使用。
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17.发明授权Use of lymphocytes transformed with herpesvirus saimiri in a process for replicating viruses of the HIV type which cause immune deficiency 失效使用疱疹病毒simiri转化的淋巴细胞在复制HIV型病毒的过程中引起免疫缺陷
公开(公告)号：US5656475A
公开(公告)日：1997-08-12
申请号：US208299
申请日：1994-03-10
申请人： Sigrid Nick , Helmut Fickenscher , Brigitte Biesinger-Zwosta , Gerhard Jahn , Bernhard Fleckenstein
发明人： Sigrid Nick , Helmut Fickenscher , Brigitte Biesinger-Zwosta , Gerhard Jahn , Bernhard Fleckenstein
CPC分类号： C12N7/00 , C12N2710/16611
摘要： A process is disclosed for replicating viruses of the HIV type which cause immune deficiency, in which process lymphocytes are employed which have been transformed with herpesvirus saimiri.
摘要翻译： 公开了一种用于复制引起免疫缺陷的HIV型病毒的方法，其中使用已经用疱疹病毒saimiri转化的淋巴细胞。
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公开(公告)号：US07968696B1
公开(公告)日：2011-06-28
申请号：US09230048
申请日：1996-07-19
申请人： Bernhard Fleckenstein , Jens-Christian Albrecht , Frank Neipel , Alvin Friedman-Kien , Yao-Qi Huang
发明人： Bernhard Fleckenstein , Jens-Christian Albrecht , Frank Neipel , Alvin Friedman-Kien , Yao-Qi Huang
CPC分类号： C07K14/005 , A61K38/00 , C07K14/5412 , C07K16/085 , C12N2710/16422 , C12N2710/16622 , G01N33/6869
摘要： The present invention relates to viral interleukin-6 (v-IL-6), which can be obtained by recombinant expression of the DNA of human herpesvirus type 8 (HHV-8), and which may be used in diagnosis and treatment of human diseases such as kaposi sarcoma, Castleman's disease, multiple myeloma, kidney cell carcinoma, mesangial proliferative glomerulonephritis or B cell lymphoma.
摘要翻译： 本发明涉及通过重组表达人疱疹病毒8型（HHV-8）的DNA获得的病毒白细胞介素-6（v-IL-6），其可用于人类疾病的诊断和治疗 如卡波西肉瘤，卡斯尔曼氏病，多发性骨髓瘤，肾细胞癌，肾小球膜增生性肾小球性肾炎或B细胞淋巴瘤。
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19.发明申请Human semaphorin L (H-SemaL) and corresponding semaphorins in other species 失效人类信号素L（H-SemaL）和其他物种中的相应semaphorins公开(公告)号：US20060029998A1
公开(公告)日：2006-02-09
申请号：US10933746
申请日：2004-09-03
CPC分类号： C07K14/4703 , A61K48/00 , C07K2319/02
摘要： The invention relates to novel semaphorins which are distinguished by a particular domain structure and derivatives thereof, nucleic acids (DNA, RNA, cDNA) which code for these semaphorins, and derivatives thereof, and the use thereof. The present invention relates to semaphorins which have a novel, as yet undisclosed and unexpected domain structure and which possess a biochemical function in the immune system (immunomodulating semaphorins). The novel semaphorins are referred to as type L semaphorins (SemaL). They comprise an N-terminal signal peptide, a characteristic Sema domain and, in the C-terminal region of the protein, an immunoglobulin-like domain and a hydrophobic domain which represents a potential transmembrane domain.
摘要翻译： 本发明涉及通过特定结构域结构及其衍生物，编码这些信号素的核酸（DNA，RNA，cDNA）及其衍生物及其用途来区分的新的信号素。 本发明涉及具有新颖尚未公开和意想不到的结构域结构并且在免疫系统（免疫调节信号素）中具有生物化学功能的信号素。 新的信号素被称为L型信号素（SemaL）。 它们包括N-末端信号肽，特征Sema结构域，并且在蛋白质的C-末端区域中，代表潜在跨膜结构域的免疫球蛋白样结构域和疏水结构域。
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20.发明授权Human herpesvirus type 6 protein p100, the corresponding DNA seqences, their preparation and use 失效人类疱疹病毒6型蛋白p100，相应的DNA序列，其制备和应用
公开(公告)号：US5814475A
公开(公告)日：1998-09-29
申请号：US266311
申请日：1994-06-27
IPC分类号： A61K39/395 , A61K38/00 , A61K39/245 , A61K39/42 , A61P31/12 , A61P31/22 , C07K14/02 , C07K14/03 , C07K16/08 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/38 , C12N15/70 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/85 , G01N33/53 , G01N33/571 , G01N33/577 , C07H21/04 , C12P21/00
CPC分类号： C07K14/005 , A61K38/00 , C12N2710/16522 , Y10S435/822 , Y10S435/849 , Y10S435/942
摘要： The invention relates to the human herpesvirus type 6 protein p100 and parts thereof having its specific immunological properties. It further relates to antibodies directed to them and to the corresponding DNA sequences. They can be used in pharmaceutical or diagnostic compositions, optionally together with other HHV-6 proteins or the corresponding DNA sequences.
摘要翻译： 本发明涉及人疱疹病毒6型蛋白质p100及其具有其特异性免疫学特性的部分。 它还涉及针对它们的抗体和相应的DNA序列。 它们可以用于药物或诊断组合物，任选地与其他HHV-6蛋白质或相应的DNA序列一起使用。
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