公开(公告)号：US20050276759A1

公开(公告)日：2005-12-15

申请号：US11134701

申请日：2005-05-20

Applicant: Bruce Roser ,  Jaap Kampinga ,  Camilo Colaco ,  Julian Blair

Inventor： Bruce Roser ,  Jaap Kampinga ,  Camilo Colaco ,  Julian Blair

IPC: A61K9/14 ,  A61K9/16 ,  A61K38/17 ,  A61L9/04

CPC classification number: A61K9/1623 ,  A61K9/0021 ,  A61K9/145 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/389 ,  Y02A50/463 ,  Y02A50/465 ,  Y02A50/469 ,  Y02A50/471 ,  Y02A50/475

Abstract: The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.

公开(公告)号：US20120225067A1

公开(公告)日：2012-09-06

申请号：US13470227

申请日：2012-05-11

Applicant: CAMILO COLACO

Inventor： CAMILO COLACO

IPC: A61K39/395 ,  A61P37/04 ,  A61P25/28 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  C07K16/46 ,  A61P31/00

CPC classification number: C07K14/005 ,  A61K39/00 ,  A61K2039/53 ,  C07K2319/30 ,  C12N2710/14143 ,  C12N2740/16122 ,  C12N2760/16122

Abstract: The present invention provides a fusion protein comprising an Fc receptor binding polypeptide and an antigenic polypeptide. The fusion protein may further comprise a linker sequence or hinge portion which joins the Fc receptor binding polypeptide and the antigenic polypeptide. The Fc receptor binding polypeptide typically comprises the CH2 constant domain of a human IgG immunoglobulin. The antigenic polypeptide can be any polypeptide which induces an immune response. Administration of the fusion protein to a subject results in a cytotoxic T lymphocyte response being induced against the antigenic polypeptide provided within the fusion protein. The invention further extends to methods for the treatment of a disease condition in a subject using the fusion proteins of the invention.

Abstract translation: 本发明提供了包含Fc受体结合多肽和抗原多肽的融合蛋白。 融合蛋白还可以包含连接Fc受体结合多肽和抗原多肽的接头序列或铰链部分。 Fc受体结合多肽通常包含人IgG免疫球蛋白的CH2恒定结构域。 抗原多肽可以是诱导免疫应答的任何多肽。 向受试者施用融合蛋白导致针对融​​合蛋白内提供的抗原性多肽诱导的细胞毒性T淋巴细胞应答。 本发明进一步延伸到使用本发明的融合蛋白治疗受试者疾病状况的方法。

公开(公告)号：US20120135029A1

公开(公告)日：2012-05-31

申请号：US13378808

申请日：2010-06-21

Applicant: Camilo Colaco ,  Colin Richard Bignell

Inventor： Camilo Colaco ,  Colin Richard Bignell

IPC: A61K39/385 ,  C09K3/00 ,  A61P37/04 ,  C07K1/18

CPC classification number: C07K1/18 ,  A61K39/0011 ,  A61K39/04 ,  A61K39/092 ,  A61K39/095 ,  A61K39/12 ,  A61K39/145 ,  A61K39/29 ,  A61K39/385 ,  A61K39/39 ,  A61K2039/55516 ,  A61K2039/605 ,  C07K14/195 ,  C12N2710/14043 ,  C12N2760/16134 ,  C12N2770/24234 ,  Y02A50/394 ,  Y02A50/397 ,  Y02A50/403 ,  Y02A50/464 ,  Y02A50/466 ,  Y02A50/478

Abstract: The present invention provides an improved method for the purification of a mixture of complexes comprising a stress protein complexed to a peptide or peptide fragment from a source mixture, typically a cell lysate. The method of the invention provides for protein complexes to be purified using ion exchange chromatography based methods, wherein a modified buffer solution is used which results in the purified stress protein complexes being more immunogenic than protein complexes obtained using conventional methodology. The purified complexes can be used to produce improved vaccine preparations which elicit enhanced immune responses in the subjects to whom the vaccine compositions are administered.

Abstract translation: 本发明提供了一种用于纯化复合物的混合物的改进方法，其包括与源混合物（通常为细胞裂解物）与肽或肽片段复合的应激蛋白。 本发明的方法提供使用基于离子交换层析的方法纯化的蛋白质复合物，其中使用修饰的缓冲溶液，其导致纯化的应激蛋白复合物比使用常规方法获得的蛋白质复合物更具免疫原性。 纯化的复合物可用于产生改进的疫苗制剂，其在施用疫苗组合物的受试者中引起增强的免疫应答。

公开(公告)号：US20080193546A1

公开(公告)日：2008-08-14

申请号：US11932592

申请日：2007-10-31

Applicant: Bruce J. ROSER ,  Jaap KAMPINGA ,  Camilo COLACO ,  Julian BLAIR

Inventor： Bruce J. ROSER ,  Jaap KAMPINGA ,  Camilo COLACO ,  Julian BLAIR

IPC: A61K9/16 ,  A61K38/16 ,  A61K38/43 ,  A61K38/19 ,  A61K38/20 ,  A61K38/21 ,  A61K38/18 ,  A61K38/22 ,  A61K38/28 ,  A61K39/395 ,  A61K39/38

CPC classification number: A61K9/1623 ,  A61K9/0021 ,  A61K9/145 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/389 ,  Y02A50/463 ,  Y02A50/465 ,  Y02A50/469 ,  Y02A50/471 ,  Y02A50/475

Abstract: The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.

Abstract translation: 本发明包括用于将生物活性材料弹性施用于皮下和皮内组织的固体剂量递送载体，所述递送载体的尺寸和形状用于穿透表皮。 递送载体还包含负载有生物活性材料并能够原位释放生物活性物质的稳定多元醇玻璃。 本发明还包括制备和使用本发明的固体剂量递送载体的方法。

公开(公告)号：US20050163750A1

公开(公告)日：2005-07-28

申请号：US11084223

申请日：2005-03-18

Applicant: Bruce Roser ,  Camilo Colaco ,  Jaap Kampinga ,  Christopher Smith

Inventor： Bruce Roser ,  Camilo Colaco ,  Jaap Kampinga ,  Christopher Smith

IPC: A61K9/00 ,  A61K35/18 ,  A61K47/26 ,  C07K1/00 ,  C07K14/61 ,  A61K38/20 ,  A61K38/22 ,  A61K38/21 ,  A61K31/7012 ,  A61K48/00 ,  A61K38/28 ,  A61K31/56

CPC classification number: C07K14/61 ,  A61K9/0019 ,  A61K35/18 ,  A61K47/26 ,  C07K1/00 ,  Y02A50/465

Abstract: The present invention encompasses methods to prevent aggregation of a wide variety of substances during freezing/thawing and/or dehydrating/rehydrating. The substances thus obtained and compositions comprising the substances are also encompassed by the invention.

公开(公告)号：US06893657B2

公开(公告)日：2005-05-17

申请号：US10376136

申请日：2003-02-27

Applicant: Bruce J. Roser ,  Jaap Kampinga ,  Camilo Colaco ,  Julian Blair

Inventor： Bruce J. Roser ,  Jaap Kampinga ,  Camilo Colaco ,  Julian Blair

IPC: A61K9/14 ,  A61K9/16 ,  A61K9/48 ,  A61K9/20 ,  A61F2/02 ,  A61F6/06

CPC classification number: A61K9/1623 ,  A61K9/0021 ,  A61K9/145 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/389 ,  Y02A50/463 ,  Y02A50/465 ,  Y02A50/469 ,  Y02A50/471 ,  Y02A50/475

Abstract: The present invention encompasses a solid dose delivery vehicle for ballistic administration of a bioactive material to subcutaneous and intradermal tissue, the delivery vehicle being sized and shaped for penetrating the epidermis. The delivery vehicle further comprises a stabilizing polyol glass loaded with the bioactive material and capable of releasing the bioactive material in situ. The present invention further includes methods of making and using the solid dose delivery vehicle of the invention.

公开(公告)号：US06890512B2

公开(公告)日：2005-05-10

申请号：US09836625

申请日：2001-04-16

Applicant: Bruce J. Roser ,  Camilo Colaco ,  Jaap Kampinga ,  Christopher Smith

Inventor： Bruce J. Roser ,  Camilo Colaco ,  Jaap Kampinga ,  Christopher Smith

IPC: A61K9/00 ,  A61K35/18 ,  A61K47/26 ,  C07K1/00 ,  C07K14/61 ,  A61K51/00

CPC classification number: C07K14/61 ,  A61K9/0019 ,  A61K35/18 ,  A61K47/26 ,  C07K1/00 ,  Y02A50/465

Abstract: The present invention encompasses methods to prevent aggregation of a wide variety of substances during freezing/thawing and/or dehydrating/rehydrating. The substances thus obtained and compositions comprising the substances are also encompassed by the invention.

Abstract translation: 本发明包括在冷冻/解冻和/或脱水/再水合期间防止多种物质聚集的方法。 由此获得的物质和包含该物质的组合物也包括在本发明中。

公开(公告)号：US06468782B1

公开(公告)日：2002-10-22

申请号：US08985343

申请日：1997-12-04

Applicant: Alan G. Tunnacliffe ,  David T. Welsh ,  Bruce J. Roser ,  Kamaljit S. Dhaliwal ,  Camilo Colaco

Inventor： Alan G. Tunnacliffe ,  David T. Welsh ,  Bruce J. Roser ,  Kamaljit S. Dhaliwal ,  Camilo Colaco

IPC: C12N104

CPC classification number: A61K39/02 ,  A61K35/741 ,  A61K35/742 ,  C12N1/04

Abstract: This invention provides methods of drying and stabilizing prokaryotic cells, and the compositions obtained thereby. The cells are first cultured or incubated under conditions sufficient to induce intracellular trehalose, suspended in a stabilizing solution and dried to form a solid glass. The resulting product is storage-stable at room temperature, showing little viability loss on storage.

Abstract translation: 本发明提供干燥和稳定原核细胞的方法以及由此获得的组合物。 细胞首先在足以诱导细胞内海藻糖的条件下培养或孵育，悬浮于稳定溶液中并干燥以形成固体玻璃。 所得产品在室温下储存稳定，储存时生物活性损失小。

公开(公告)号：US5955448A

公开(公告)日：1999-09-21

申请号：US293157

申请日：1994-08-19

Applicant: Camilo Colaco ,  Bruce J. Roser ,  Shevanti Sen

Inventor： Camilo Colaco ,  Bruce J. Roser ,  Shevanti Sen

IPC: F26B1/00 ,  A01N1/02 ,  A23L3/42 ,  A61K9/14 ,  A61K9/19 ,  A61K31/00 ,  A61K31/155 ,  A61K38/26 ,  A61K38/46 ,  A61K47/22 ,  A61K47/26 ,  C07K1/00 ,  C12N1/00 ,  C12N5/00 ,  C12N7/00 ,  A01N43/04 ,  A01N43/50 ,  A61K31/415 ,  A61K31/715

CPC classification number: A61K31/00 ,  A61K31/155 ,  A61K31/70 ,  A61K47/22 ,  A61K47/26 ,  A61K9/19 ,  A61K38/00 ,  Y10T436/108331

Abstract: The present invention encompasses methods of increasing stability of biological substances during drying and the dried compositions derived therefrom. The compositions have improved storage stability.

Abstract translation: 本发明包括增加干燥过程中生物物质的稳定性的方法和由其衍生的干燥组合物。 组合物具有改善的储存稳定性。

公开(公告)号：US5891873A

公开(公告)日：1999-04-06

申请号：US727597

申请日：1997-01-16

Applicant: Camilo Colaco ,  Bruce Joseph Roser

Inventor： Camilo Colaco ,  Bruce Joseph Roser

IPC: A61K45/00 ,  A61K31/00 ,  A61K31/047 ,  A61K31/155 ,  A61K31/47 ,  A61K31/665 ,  A61K31/70 ,  A61P25/28 ,  A61P43/00 ,  A61K31/535

CPC classification number: A61K31/155 ,  A61K31/00 ,  A61K31/7048

Abstract: Inhibitors of the Maillard reaction are useful in the treatment or prophylaxis of amyloidosis-based disease, particularly Alzheimer's disease. Particular examples include aminoguanidine and amphotericin B.

Abstract translation: PCT No.PCT / GB95 / 00843 Sec。 371日期1997年1月16日 102（e）日期1997年1月16日PCT提交1995年4月13日PCT公布。 WO95 / 28151 PCT出版物 日期1995年10月26日美拉德反应的抑制剂可用于治疗或预防基于淀粉样变性疾病，特别是阿尔茨海默氏病。 具体实例包括氨基胍和两性霉素B.