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128 条记录 (耗时 0.071 秒)

    GENETIC POLYMORPHISMS ASSOCIATED WITH AUTOINFLAMMATORY DISEASES, METHODS OF DETECTION AND USES THEREOF
    14.
    发明申请
    GENETIC POLYMORPHISMS ASSOCIATED WITH AUTOINFLAMMATORY DISEASES, METHODS OF DETECTION AND USES THEREOF 审中-公开
    与自身免疫性疾病相关的遗传多态性，检测方法及其用途

    公开(公告)号：US20160222450A1

    公开(公告)日：2016-08-04

    申请号：US14960707

    申请日：2015-12-07

    申请人： CELERA CORPORATION

    发明人： Steven SCHRODI ,  Yonghong LI

    IPC分类号： C12Q1/68 ,  C07K16/24

    CPC分类号： C12Q1/6883 ,  C07K16/244 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

    摘要： The present invention provides compositions and methods based on genetic polymorphisms that are associated with autoinflammatory diseases such as psoriasis. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection.

    摘要翻译： 本发明提供了与自身炎症性疾病如牛皮癣相关的遗传多态性的组合物和方法。 例如，本发明涉及含有多态性的核酸分子，由这些核酸分子编码的变体蛋白，用于检测多态型核酸分子和变体蛋白的试剂，以及使用核酸分子和蛋白质的方法以及方法 使用试剂进行检测。

    MULTI-GENE SIGNATURES FOR PREDICTING RESPONSE TO CHEMOTHERAPY OR RISK OF METASTASIS FOR BREAST CANCER
    16.
    发明申请
    MULTI-GENE SIGNATURES FOR PREDICTING RESPONSE TO CHEMOTHERAPY OR RISK OF METASTASIS FOR BREAST CANCER 审中-公开
    用于预防针对乳腺癌的化疗反应或METASASIS的风险的多基因信号

    公开(公告)号：US20140315844A1

    公开(公告)日：2014-10-23

    申请号：US14091790

    申请日：2013-11-27

    申请人： Celera Corporation

    发明人： Shirley KWOK ,  Alice WANG

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  C12Q2600/16 ,  G16B20/00

    摘要： Exemplary embodiments of the invention provide methods and compositions relating to a multi-gene signature, and subsets thereof, for predicting whether an individual with breast cancer will respond to chemotherapy based on expression of the genes in the multi-gene signature, as well as for prognosing risk of breast cancer metastasis.

    摘要翻译： 本发明的示例性实施方案提供了与多基因特征及其子集相关的方法和组合，用于预测基于多基因签名中基因表达的乳腺癌患者是否对化学疗法作出反应，以及 预后乳腺癌转移的风险。

    GENETIC POLYMORPHISMS ASSOCIATED WITH STROKE, METHODS OF DETECTION AND USES THEREOF
    19.
    发明申请
    GENETIC POLYMORPHISMS ASSOCIATED WITH STROKE, METHODS OF DETECTION AND USES THEREOF 审中-公开
    与STROKE相关的遗传多态性，检测方法及其用途

    公开(公告)号：US20130303558A1

    公开(公告)日：2013-11-14

    申请号：US13655905

    申请日：2012-10-19

    申请人： CELERA CORPORATION

    发明人： May LUKE ,  James J. DEVLIN

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  A61K31/22 ,  A61K31/35 ,  A61K31/40 ,  A61K31/404 ,  A61K31/435 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/172

    摘要： The present invention provides compositions and methods based on genetic polymorphisms that are associated with vascular diseases such as stroke. In particular, the present invention relates to genetic polymorphisms that have utility for such uses as predicting disease risk or predicting an individual's response to a treatment such as statins, including groups of polymorphisms that may be used as a signature marker set for such uses, as well as nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.

    摘要翻译： 本发明提供了与诸如中风等血管疾病相关的遗传多态性的组合物和方法。 特别地，本发明涉及对预测疾病风险或预测个体对治疗的反应（例如他汀类药物）的用途的遗传多态性，所述治疗包括可以用作为此类用途设定的签名标记的多形性组，如 以及含有多态性的核酸分子，由该核酸分子编码的变体蛋白，用于检测多态性核酸分子和蛋白质的试剂，以及使用该核酸和蛋白质的方法以及使用试剂进行检测的方法。