公开(公告)号：US08348997B2

公开(公告)日：2013-01-08

申请号：US12391372

申请日：2009-02-24

Applicant: Dustin Thompson ,  D. H. Perkins

Inventor： Dustin Thompson ,  D. H. Perkins

IPC: A61F2/24 ,  A61F2/06

CPC classification number: A61F2/2436 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2475 ,  A61F2/88 ,  A61F2230/0091

Abstract: Artificial valves for use as a venous valve or a heart valve are disclosed. The valve includes a frame including a platform and a valve material coupled to the frame. The valve material is a plurality of filaments or a flap. The valve material is coupled to the frame such that in response to a force in a first direction, e.g. blood flow, the valve material extends in the direct of the force to allow blood to flow past the valve material. In absence of the force in the first direction, the valve material rests against the platform to block blood flow in a direction opposite the first direction.

Abstract translation: 公开了用作静脉瓣或心脏瓣膜的人造瓣膜。 该阀包括一个框架，该框架包括一个平台和一个与该框架连接的阀门材料。 阀门材料是多根长丝或翼片。 阀材料联接到框架，使得响应于在第一方向上的力，例如， 血液流动，阀门材料直接延伸，使血液流过阀门材料。 在没有第一方向的力的情况下，阀材料靠在平台上以阻止与第一方向相反的方向的血流。

公开(公告)号：US20100217385A1

公开(公告)日：2010-08-26

申请号：US12391372

申请日：2009-02-24

Applicant: Dustin Thompson ,  D.H. Perkins

Inventor： Dustin Thompson ,  D.H. Perkins

IPC: A61F2/24

CPC classification number: A61F2/2436 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2475 ,  A61F2/88 ,  A61F2230/0091

Abstract: Artificial valves for use as a venous valve or a heart valve are disclosed. The valve includes a frame including a platform and a valve material coupled to the frame. The valve material is a plurality of filaments or a flap. The valve material is coupled to the frame such that in response to a force in a first direction, e.g. blood flow, the valve material extends in the direct of the force to allow blood to flow past the valve material. In absence of the force in the first direction, the valve material rests against the platform to block blood flow in a direction opposite the first direction.

Abstract translation: 公开了用作静脉瓣或心脏瓣膜的人造瓣膜。 该阀包括一个框架，该框架包括一个平台和一个与该框架连接的阀门材料。 阀门材料是多根长丝或翼片。 阀材料联接到框架，使得响应于在第一方向上的力，例如， 血液流动，阀门材料直接延伸，使血液流过阀门材料。 在没有第一方向的力的情况下，阀材料靠在平台上以阻止与第一方向相反的方向的血流。

公开(公告)号：US20090264826A1

公开(公告)日：2009-10-22

申请号：US12106689

申请日：2008-04-21

Applicant: Dustin Thompson

Inventor： Dustin Thompson

IPC: A61M25/09

CPC classification number: A61B17/3207 ,  A61B2017/00252 ,  A61B2017/00455 ,  A61B2017/22044 ,  A61B2017/22094 ,  A61B2017/22095 ,  A61B2090/3784 ,  A61M2025/0008 ,  A61M2025/0092 ,  A61M2025/0095 ,  A61M2025/0197

Abstract: A catheter system comprising a) an elongate flexible catheter; b) a lumen that extends from a proximal insertion port to a side outlet opening; c) a penetrating guidewire insertable into the proximal insertion port and thereafter advanceable through the lumen and out of the side outlet opening; and d) an orientation element useable to provide an indication of the trajectory on which the penetrating guidewire will advance from the catheter body. Also disclosed are methods for using such catheter to direct the penetrating guidewire out of the side opening and into the true lumen of a blood vessel when bypassing an obstruction in the blood vessel such as a chronic total occlusion (CTO) of an artery.

Abstract translation: 一种导管系统，包括：a）细长柔性导管; b）从近端插入口延伸到侧出口的内腔; c）穿透导丝，其可插入到所述近端插入口中，然后可以通过所述内腔并从所述侧出口开出; 以及d）可用于提供所述穿透导丝将从导管主体前进的轨迹的指示的定向元件。 还公开了当绕过血管阻塞物（例如动脉的慢性完全闭塞（CTO））时，使用这种导管将穿透导线引导出侧开口并进入血管的真腔的方法。

公开(公告)号：US09283305B2

公开(公告)日：2016-03-15

申请号：US12500359

申请日：2009-07-09

Applicant: Matthew J. Birdsall ,  Christopher Storment ,  D. H. Perkins ,  Dustin Thompson

Inventor： Matthew J. Birdsall ,  Christopher Storment ,  D. H. Perkins ,  Dustin Thompson

IPC: A61L27/54 ,  A61L31/02 ,  A61L31/16

CPC classification number: A61M25/0015 ,  A61B2017/00526 ,  A61L31/022 ,  A61L31/16 ,  A61M25/0012 ,  A61N1/0587

Abstract: A method of a forming a hollow, drug-eluting medical device includes providing composite member having an outer member and a core member disposed within a lumen of the outer member. The composite member is shaped into a pattern. Openings are formed through the outer member of the composite member. The composite member is processed to remove the core member from the lumen of the outer member without harming the outer member, leaving a hollow tubular member already formed into the desired pattern. The lumen of the outer member is filled with a therapeutic substance.

Abstract translation: 形成中空药物洗脱医疗装置的方法包括提供具有外部构件和设置在外部构件的内腔内的芯构件的复合构件。 复合构件成形为图案。 通过复合构件的外部构件形成开口。 处理复合构件以从外部构件的内腔移除芯构件而不损害外部构件，留下已经形成为期望图案的中空管状构件。 外部构件的内腔填充有治疗物质。

公开(公告)号：US08377115B2

公开(公告)日：2013-02-19

申请号：US12618881

申请日：2009-11-16

Applicant: Dustin Thompson

Inventor： Dustin Thompson

IPC: A61F2/06 ,  A61F2/24

CPC classification number: A61F2/2475 ,  A61F2/2427 ,  A61F2/2469 ,  A61F2230/0091

Abstract: A valve prosthesis for percutaneous placement within a vein is disclosed that includes a valve scaffold and a backflow barrier. The valve scaffold is of a shape memory or resilient material and the backflow barrier is a flap of flexible material attached to the valve scaffold. The valve prosthesis is operable to alternate between open and closed configurations in response to changes in retrograde blood flow pressure. In the open configuration, the valve scaffold has a frustoconical coil shape of consecutive windings with open spaces therebetween and the backflow barrier allows antegrade blood flow through the open spaces. In the closed configuration, the consecutive windings of the valve scaffold are collapsed such that the valve scaffold has a substantially flat profile and the backflow barrier covers the opens spaces of the flattened valve scaffold to prevent retrograde blood flow from leaking there through.

Abstract translation: 公开了一种用于在静脉内经皮放置的瓣膜假体，其包括阀支架和回流屏障。 瓣膜支架是形状记忆或弹性材料，并且回流屏障是连接到瓣膜支架的柔性材料的瓣。 瓣膜假体可操作以响应于逆行血流压力的变化在开放和闭合构型之间交替。 在开放构型中，瓣膜支架具有截头圆锥形的连续绕组，其间具有开放空间，并且回流屏障允许顺畅的血液流过开放空间。 在闭合构型中，瓣膜支架的连续绕组被折叠，使得瓣膜支架具有基本上平坦的轮廓，并且回流阻挡件覆盖扁平瓣膜支架的开放空间，以防止逆行血液从其中泄漏出来。

公开(公告)号：US07959612B2

公开(公告)日：2011-06-14

申请号：US12106839

申请日：2008-04-21

Applicant: Dustin Thompson ,  Patrick Macaulay

Inventor： Dustin Thompson ,  Patrick Macaulay

IPC: A61M5/00 ,  A61M5/315 ,  B67D7/70 ,  B65D88/54 ,  G01F11/00

CPC classification number: A61M5/19 ,  A61B17/00491 ,  A61B2017/00495 ,  A61B2017/00685 ,  A61B2017/2925 ,  A61M5/16827 ,  A61M5/31511

Abstract: Devices and methods for simultaneous injection or delivery of two or more substances from separate syringes. The syringes are loaded into a device that has a handle and a screw driven mechanism for simultaneously depressing the plungers of the syringes. The user grasps the handle and positions the device. Thereafter, the screw mechanism is used to simultaneously advance the plungers of the syringes thereby simultaneously expelling the substances from the syringes.

Abstract translation: 从单独的注射器同时注射或递送两种或多种物质的装置和方法。 将注射器装载到具有手柄和螺杆驱动机构的装置中，以同时按压注射器的柱塞。 用户抓住手柄并对设备进行定位。 此后，螺杆机构用于同时推进注射器的柱塞，从而同时从注射器排出物质。

公开(公告)号：US20110106136A1

公开(公告)日：2011-05-05

申请号：US12608217

申请日：2009-10-29

Applicant: Dustin Thompson ,  D.H. Perkins

Inventor： Dustin Thompson ,  D.H. Perkins

IPC: A61F2/01

CPC classification number: A61F2/01 ,  A61F2002/016 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/0091 ,  A61F2250/0068

Abstract: Retrievable inferior vena cava filters are disclosed. Such filters provide for easy removal of the filter and provide drug delivery for dissolution of captured emboli. Methods of using such systems for the prevention, capture, dissolution and removal of emboli are described.

Abstract translation: 公开了可检索的下腔静脉滤器。 这种过滤器提供容易地去除过滤器并提供用于溶出捕获的栓子的药物递送。 描述了使用这种系统来预防，捕获，溶解和去除栓子的方法。

公开(公告)号：US20100022940A1

公开(公告)日：2010-01-28

申请号：US12179802

申请日：2008-07-25

Applicant: Dustin Thompson

Inventor： Dustin Thompson

IPC: A61F2/06 ,  A61F2/00 ,  A61K35/00

CPC classification number: A61F2/07 ,  A61B17/11 ,  A61B2017/00862 ,  A61B2017/1107 ,  A61B2017/1139 ,  A61F2/2493 ,  A61F2/89 ,  A61F2230/005 ,  A61F2230/0071

Abstract: Catheters, implantable shunt devices and methods usable to establish passageways between blood vessels and/or other anatomical structures within the body of a human or animal subject.

Abstract translation: 导管，可植入分流装置和可用于在人或动物受试者的体内建立血管和/或其他解剖结构之间的通道的方法。

公开(公告)号：US20090264831A1

公开(公告)日：2009-10-22

申请号：US12106839

申请日：2008-04-21

Applicant: Dustin Thompson ,  Patrick Macaulay

Inventor： Dustin Thompson ,  Patrick Macaulay

IPC: A61M5/19

CPC classification number: A61M5/19 ,  A61B17/00491 ,  A61B2017/00495 ,  A61B2017/00685 ,  A61B2017/2925 ,  A61M5/16827 ,  A61M5/31511

Abstract: Devices and methods for simultaneous injection or delivery of two or more substances from separate syringes. The syringes are loaded into a device that has a handle and a screw driven mechanism for simultaneously depressing the plungers of the syringes. The user grasps the handle and positions the device. Thereafter, the screw mechanism is used to simultaneously advance the plungers of the syringes thereby simultaneously expelling the substances from the syringes.

Abstract translation: 从单独的注射器同时注射或递送两种或多种物质的装置和方法。 将注射器装载到具有手柄和螺杆驱动机构的装置中，以同时按压注射器的柱塞。 用户抓住手柄并对设备进行定位。 此后，螺杆机构用于同时推进注射器的柱塞，从而同时从注射器排出物质。

公开(公告)号：US20090248142A1

公开(公告)日：2009-10-01

申请号：US12054553

申请日：2008-03-25

Applicant: D.H. Perkins ,  Rany Huynh ,  Nasser Rafiee ,  Dustin Thompson

Inventor： D.H. Perkins ,  Rany Huynh ,  Nasser Rafiee ,  Dustin Thompson

IPC: A61F2/04

CPC classification number: A61F2/2475 ,  A61B17/12013 ,  A61F2/2445 ,  A61F2/95

Abstract: Methods and systems for improving the competency of a venous valve wherein one or more compressor(s) (e.g., space occupying material(s) or implantable device(s)) is/are delivered to one or more location(s) adjacent to a venous valve to compress the venous valve in a manner that causes one or both leaflets of the valve to move toward the other, thereby improving closure or coaptation of the valve leaflets. The compressor(s) may be delivered by an open surgical approach, by a direct percutaneous approach or by a transluminal catheter-based approach.

Abstract translation: 用于提高静脉瓣的能力的方法和系统，其中一个或多个压缩机（例如，空间占用材料或可植入装置）被输送到邻近的一个或多个位置 静脉瓣以使阀的一个或两个小叶向另一个移动的方式压缩静脉瓣，从而改善瓣膜小叶的闭合或接合。 压缩机可以通过开放式手术方式，通过直接经皮方式或基于导管的方法来递送。