公开(公告)号：US10196607B2

公开(公告)日：2019-02-05

申请号：US15110826

申请日：2015-01-12

Applicant: Laboratoires Expanscience

Inventor： Stephanie Bredif ,  Caroline Baudouin ,  Philippe Msika ,  Marisa Meloni

IPC: C12N9/04 ,  C07K14/52 ,  C07K14/78 ,  C12N5/071 ,  G01N33/50 ,  C07K14/495

Abstract: A skin model comprises keratinocytes capable of overexpressing filaggrin. A method for evaluating the in vitro activity of a formulation or of at least one active agent on the healing of nipple skin and/or on the reduction of nipple skin inflammation, by bringing said active agent or said formulation into contact with a skin model comprising keratinocytes overexpressing filaggrin and also comprising a lesion, and measuring the level of production of at least one biological marker chosen from lactate dehydrogenase (LDH), TNFα, filaggrin, TGFβ1 and β1 integrin.

公开(公告)号：US20170157019A1

公开(公告)日：2017-06-08

申请号：US15323347

申请日：2015-07-03

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Caroline BAUDOUIN ,  Sophie LECLERE- BIENFAIT ,  Philippe MSIKA ,  Stéphanie BREDIF

IPC: A61K8/64 ,  A61Q19/06

CPC classification number: A61K8/645 ,  A61K8/97 ,  A61K2800/74 ,  A61Q19/06 ,  A61Q19/08

Abstract: The present invention relates to the use of a lupin peptide extract to prevent loss of skin firmness or to increase the firmness of skin. Advantageously, the lupin peptide extract can prevent the appearance of cellulite and/or reduce skin cellulite.

公开(公告)号：US20160245795A1

公开(公告)日：2016-08-25

申请号：US15023882

申请日：2014-09-24

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Caroline Baudouin ,  Stephanie Bredif ,  Philippe MSIKA

IPC: G01N33/50 ,  G01N33/68

CPC classification number: G01N33/5023 ,  G01N33/5044 ,  G01N33/6881 ,  G01N2333/4721 ,  G01N2333/5421 ,  G01N2333/545 ,  G01N2333/96486

Abstract: The invention relates to in vitro methods for testing formulations or active ingredients for preventing the harmful effects of UV on children's skin, in particular children aged three or less. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the harmful effects of UV on the skin of children aged three or less, using a skin model specifically capable of reproducing the characteristics of the skin of children of this age.

Abstract translation: 本发明涉及用于测试制剂或活性成分以防止紫外线对儿童皮肤，特别是三岁以下儿童的有害影响的体外方法。 本发明人已经开发了使用特别能够再现这种年龄的儿童的皮肤特征的皮肤模型来评价制剂在体外预防紫外线对三岁以下儿童皮肤的有害影响的体外功效的方法。

公开(公告)号：US20160074312A1

公开(公告)日：2016-03-17

申请号：US14652449

申请日：2013-12-18

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Philippe Msika ,  Sophie Leclere-Bienfait ,  Sebastien Debrock ,  Stephanie Bredif ,  Sebastien Garnier

IPC: A61K8/97 ,  A61K8/60 ,  A61Q19/02 ,  A61Q19/08 ,  A61Q5/12 ,  A61Q19/00 ,  A61K36/185 ,  A61K45/06 ,  A61Q5/02 ,  A61K8/64 ,  A61Q17/04

CPC classification number: A61K8/97 ,  A61K8/60 ,  A61K8/645 ,  A61K36/185 ,  A61K45/06 ,  A61K2236/15 ,  A61K2236/19 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q7/00 ,  A61Q17/00 ,  A61Q17/04 ,  A61Q19/005 ,  A61Q19/007 ,  A61Q19/02 ,  A61Q19/06 ,  A61Q19/08

Abstract: The invention relates to a composition comprising an extract of passionflower seeds, and preferentially Passiflora edulis seeds. The composition is advantageously cosmetic, pharmaceutical, dermatological or nutraceutical. The subject matter of the invention is also a process for extracting an extract of passionflower seeds and preferentially Passiflora edulis seeds, and also the extract which can be obtained by means of said process. The invention also relates to such a composition or such an extract for use in the prevention or treatment of disorders or pathological conditions of the skin, of the mucous membranes or of the skin appendages, for use in the prevention or treatment of vascular disorders, for use for combating oxidative stress, or else for use in the prevention or treatment of adipose tissue modifications. Finally, the invention relates to a cosmetic care process for the skin, the skin appendages or the mucous membranes, with a view to improving, the condition thereof or the appearance thereof, consisting in administering such a composition or such an extract.

Abstract translation: 本发明涉及包含西番莲花提取物，优选西番莲花种子的组合物。 该组合物有利地是化妆品，药​​物，皮肤病学或营养品。 本发明的主题也是提取西番莲子提取物和优选西番莲种子的方法，以及可以通过所述方法获得的提取物。 本发明还涉及用于预防或治疗皮肤，粘膜或皮肤附件的疾病或病理状况的用于预防或治疗血管疾病的组合物或这种提取物，用于 用于抵抗氧化应激，或用于预防或治疗脂肪组织修饰。 最后，本发明涉及一种美容护理方法，用于皮肤，皮肤附属物或粘膜，以改善其状况或其外观，包括施用这样的组合物或这种提取物。

公开(公告)号：US20150374605A1

公开(公告)日：2015-12-31

申请号：US14766602

申请日：2014-02-11

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Philippe Msika ,  Caroline Baudouin

IPC: A61K8/60 ,  A61Q19/08 ,  A61K8/97

CPC classification number: A61K8/60 ,  A61K8/97 ,  A61K31/22 ,  A61K31/23 ,  A61K31/232 ,  A61K31/7012 ,  A61K31/7024 ,  A61K36/54 ,  A61K45/06 ,  A61Q5/02 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/005 ,  A61Q19/08 ,  A61Q19/10 ,  C07C69/02 ,  C07C69/52 ,  C07C69/533 ,  C07C69/587 ,  A61K2300/00

Abstract: The invention concerns a use of C7 sugars and derivatives of formula (I), called avocado perseose, which have, inter alia, a protective activity to epidermal skin cells. These C7 sugars and derivatives are capable of maintaining the expression of markers of adult stem cells, in particular basal stem cells. Avocado perseose can also be used for preventing the deleterious effects of environmental damage. Avocado perseose has a beneficial effect on the conservation of the potential of epidermal stem cells and thus helps maintain skin homeostasis.

Abstract translation: 本发明涉及C7糖和式（I）的衍生物，其被称为鳄梨坚果，其特别地对表皮皮肤细胞具有保护性活性。 这些C7糖和衍生物能够维持成体干细胞，特别是基础干细胞的标志物的表达。 鳄梨坚果也可用于防止环境破坏的有害影响。 鳄梨坚果对保护表皮干细胞的潜力有益，从而有助于维持皮肤稳态。

公开(公告)号：US20150153328A1

公开(公告)日：2015-06-04

申请号：US14418645

申请日：2013-08-02

Applicant: LABORATOIRES EXPANSCIENCE

Inventor： Philippe Msika ,  Nadège Lachmann ,  Joachim Fluhr

IPC: G01N33/50

Abstract: The present invention relates to a method for determining the isotropy of the skin surface of a subject, and hence the degree of maturation of the said skin surface, by examining various parameters reflecting the cell organization. Methods for identifying active agents, raw materials and formulation are also provided.

Abstract translation: 本发明涉及通过检查反映细胞组织的各种参数来确定受试者的皮肤表面的各向同性，从而确定所述皮肤表面的成熟度的方法。 还提供了确定活性剂，原料和制剂的方法。

公开(公告)号：US20140348967A1

公开(公告)日：2014-11-27

申请号：US14371057

申请日：2013-01-14

Applicant: LABORATORIES EXPANSCIENCE

Inventor： Philippe Msika ,  Jacques Legrand ,  Sebastien Garnier

IPC: C11B1/06 ,  A61K36/54

CPC classification number: C11B1/06 ,  A23D9/007 ,  A23D9/02 ,  A23L2/52 ,  A23L19/07 ,  A23L33/105 ,  A23L33/11 ,  A23L33/115 ,  A61K8/922 ,  A61K36/54 ,  A61Q19/06 ,  A61Q19/08 ,  C11B1/08

Abstract: The present invention relates to the use of avocado seeds in order to obtain avocado oil enriched in alkyl polyols and/or acetylated derivatives thereof, said avocado seeds accounting for 10 to 50% by weight relative to the total weight of avocado used. The invention also relates to a method for obtaining avocado oil enriched in alkyl polyols or acetylated derivatives thereof from at least avocado seeds, said avocado seeds accounting for 10 to 50% by weight relative to the total weight of avocado used. The invention also relates to avocado oil enriched in alkyl polyols and/or acetylated derivatives thereof, obtainable by the present method. The invention also relates to the use of avocado oil in order to prepare an avocado oil concentrate enriched in alkyl polyols and/or acetylated derivatives thereof, or to prepare an avocado unsaponifiable enriched in alkyl polyols. Lastly, the invention relates to an avocado unsaponifiable enriched in alkyl polyols or an avocado oil concentrate enriched in alkyl polyols and/or acetylated derivatives thereof, obtainable from said avocado oil, for use as a drug, advantageously in the prevention and/or treatment of conjunctive tissue disorders such as arthrosis, articular pathologies such as rheumatism, or periodontal diseases such as gingivitis or periodontitis.

Abstract translation: 本发明涉及鳄梨种子的使用以获得富含烷基多元醇和/或其乙酰化衍生物的鳄梨油，所述鳄梨种子占所用鳄梨总重量的10至50重量％。 本发明还涉及从至少鳄梨种子获得富含烷基多元醇或其乙酰化衍生物的鳄梨油的方法，所述鳄梨种子占所用鳄梨总重量的10至50重量％。 本发明还涉及通过本方法获得的富含烷基多元醇和/或其乙酰化衍生物的鳄梨油。 本发明还涉及鳄梨油的用途，以制备富含烷基多元醇和/或其乙酰化衍生物的鳄梨油浓缩物，或制备不可皂化的富含烷基多元醇的鳄梨油。 最后，本发明涉及一种不可皂化的富含鳄梨油的富含烷基多元醇的牛油果油或富含其烷基多元醇和/或其乙酰化衍生物的鳄梨油浓缩物，其可从所述鳄梨油获得，有利地用于预防和/或治疗 结膜组织疾病如关节病，关节病变如风湿病，或牙周病如牙龈炎或牙周炎。

公开(公告)号：US3574850A

公开(公告)日：1971-04-13

申请号：US3574850D

申请日：1969-10-07

Applicant: EXPANSCIENCE

Inventor： GUILLON CLAUDE R

IPC: A61K31/195 ,  A61K31/35 ,  A61K27/00

CPC classification number: A61K31/195 ,  A61K31/35 ,  A61K31/14 ,  A61K31/19 ,  A61K2300/00

Abstract: AN ANTISEPTIC COMPOSITION COMPRISING AN AQUEOUS SOLUTION OF DODECYLOXYPROPYLAMINE-B-BUTYRIC ACID, DODECYLAMINOPROPYLAMINO-B-BUTYRIC ACID AND AN ALKYL DIMETHYL BENZYL CHLORIDE, SAID ALKYL HAVING FROM 8 TO 18 CARBON ATOMS, IN A WEIGHT RATIO OF 1 TO 1 TO 0.5, IN A PHARMACOLOGICAL SOLVENT MEDIUM. THE ANTISEPTIC COMPOSITION OF THE INVENTION HAS AN ANTIFUNGICIDAL, BACTERICIDAL AND BACTERIOSTATIC ACTIVITY.

公开(公告)号：US11892447B2

公开(公告)日：2024-02-06

申请号：US16062488

申请日：2016-12-16

Applicant: Laboratoires Expanscience

Inventor： Stephanie Bredif ,  Caroline Baudouin

IPC: G01N33/50 ,  G01N33/68 ,  C12N5/071 ,  C12Q1/6883

CPC classification number: G01N33/5088 ,  C12N5/0698 ,  C12Q1/6883 ,  G01N33/6881 ,  C12Q2600/148 ,  C12Q2600/158

Abstract: The invention relates to biomarkers in children's skin, in particular in the skin of infants, the expression of which changes when the skin is dry. Such markers are particularly advantageous in that they allow the skin's response to dehydration to be monitored. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the effects of dehydration on children's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.

公开(公告)号：US11604184B2

公开(公告)日：2023-03-14

申请号：US16311378

申请日：2017-06-23

Applicant: Laboratoires Expanscience

Inventor： Caroline Baudouin ,  Stephanie Bredif

IPC: C12Q1/68 ,  G01N33/50 ,  C12Q1/6883 ,  C12N5/00 ,  C12N5/071

Abstract: The invention relates to biomarkers in children's skin, in particular in the skin of infants, the expression of which changes when the skin is affected by atopic dermatitis. Such markers are particularly advantageous in that they allow the skin's response to atopic dermatitis to be monitored. The inventors have developed methods for evaluating the in vitro efficacy of formulations in preventing the effects of atopic dermatitis on a child's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.