中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

20 records (took 0.022 seconds)

    Blood Biomarker for Early Blood Brain Barrier Disruption in Ischemic Stroke
    11.
    发明申请
    Blood Biomarker for Early Blood Brain Barrier Disruption in Ischemic Stroke 有权
    血液生物标志物用于缺血性脑卒中早期血脑屏障中断

    公开(公告)号：US20140314737A1

    公开(公告)日：2014-10-23

    申请号：US14325126

    申请日：2014-07-07

    Applicant: Ke Jian Liu ,  Wenlan Liu ,  Graham Timmins ,  Rong Pan

    Inventor： Ke Jian Liu ,  Wenlan Liu ,  Graham Timmins ,  Rong Pan

    IPC: G01N33/68

    CPC classification number: G01N33/6893 ,  G01N2333/4703 ,  G01N2800/2871 ,  G01N2800/52

    Abstract: Methods and apparatus for determining blood brain barrier (BBB) damage and treating patients who may have suffered from BBB damage due to an ischemic event are provided. The methods and apparatus involve detecting the presence of cleaved occludin fragments in a sample of blood. According to some embodiments, the method further provides determining the degree of BBB damage based on the concentration of occludin fragments in the sample. In further embodiments the present disclosure provides kits for detecting the presence of occludin fragments in a blood sample.

    Abstract translation: 提供了用于确定血脑屏障（BBB）损伤并治疗可能由于缺血事件而遭受BBB损伤的患者的方法和装置。 所述方法和装置涉及检测血液样品中裂解的闭合蛋白片段的存在。 根据一些实施方案，该方法进一步提供基于样品中闭合蛋白片段的浓度确定BBB损伤的程度。 在进一步的实施方案中，本公开提供用于检测血液样品中闭合蛋白片段的存在的试剂盒。

    Non-invasive rapid diagnostic test for M. tuberculosis infection
    12.
    发明授权
    Non-invasive rapid diagnostic test for M. tuberculosis infection 有权
    结核分枝杆菌感染的非侵入性快速诊断试验

    公开(公告)号：US07897400B2

    公开(公告)日：2011-03-01

    申请号：US11955773

    申请日：2007-12-13

    Applicant: Graham Timmins ,  Vojo P. Deretic

    Inventor： Graham Timmins ,  Vojo P. Deretic

    IPC: G01N33/00 ,  A61K31/44

    CPC classification number: A61B5/0002 ,  A61B5/082 ,  A61B5/411 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  A61K49/0004 ,  G01N33/5695

    Abstract: This invention relates to a test for detecting a Mycobacterium tuberculosis (tuberculosis or TB) infection in a patient or subject, specifically a diagnostic test, including a breath test, whereby patients are provided a small dose of an isotopically labeled TB drug, Isoniazid (INH) orally or directly to the lungs of the patient or subject. If TB is present, a TB enzyme mycobacterial peroxidase KatG oxidizes the INH; and KatG specific metabolites, in particular, isotopically labeled nitric oxide (NO), nitrites, nitrates, carbon monoxide (CO) or carbon dioxide converted from carbon monoxide of INH cleavage are measured. Other embodiments relate to a diagnostic breath test for detecting TB utilizing isotopically labeled urea (preferably, carbon-13 labeled urea), alone or in combination with isotopically labeled isoniazid (preferably, nitrogen-15 labeled isoniazid), wherein M. tuberculosis organism, if present in the patient or subject's lungs (or other tissues), will metabolize the isotopically labeled urea to isotopically labeled carbon dioxide (CO2) such that a determination of the residence of M. tuberculosis, including residence of an isoniazid resistant strain of M. tuberculosis, may be made.

    Abstract translation: 本发明涉及一种用于检测患者或受试者中结核分枝杆菌（结核病或结核病）感染的试验，特别是包括呼吸试验的诊断试验，其中向患者提供小剂量的同位素标记的结核病药物异烟肼（INH ）口服或直接给予患者或受试者的肺。 如果TB存在，TB酶分枝杆菌过氧化物酶KatG氧化INH; 并测定KatG特异性代谢物，特别是同位素标记的一氧化氮（NO），亚硝酸盐，硝酸盐，一氧化碳（CO）或由INH切割的一氧化碳转化的二氧化碳。 其他实施方案涉及用于使用同位素标记的尿素（优选碳-13标记的尿素）单独或与同位素标记的异烟肼（优选氮-15标记的异烟肼）组合来检测结核病的诊断性呼吸试验，其中结核分枝杆菌生物体如果 存在于患者或受试者的肺部（或其他组织）中，将同位素标记的尿素代谢为同位素标记的二氧化碳（CO 2），从而确定结核分枝杆菌的住所，包括结核分枝杆菌的异烟肼抗性菌株的停留 ，可以做。

    Non-Invasive Rapid Diagnostic Test For M.Tuberculosis Infection
    13.
    发明申请
    Non-Invasive Rapid Diagnostic Test For M.Tuberculosis Infection 有权
    结核分枝杆菌感染的非侵入性快速诊断试验

    公开(公告)号：US20090191639A1

    公开(公告)日：2009-07-30

    申请号：US11955773

    申请日：2007-12-13

    Applicant: Graham TIMMINS ,  Vojo P. DERETIC

    Inventor： Graham TIMMINS ,  Vojo P. DERETIC

    IPC: G01N33/00 ,  A61K31/44

    CPC classification number: A61B5/0002 ,  A61B5/082 ,  A61B5/411 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  A61K49/0004 ,  G01N33/5695

    Abstract: This invention relates to a test for detecting a Mycobacterium tuberculosis (tuberculosis or TB) infection in a patient or subject, specifically a diagnostic test, including a breath test, whereby patients are provided a small dose of an isotopically labeled TB drug, Isoniazid (INH) orally or directly to the lungs of the patient or subject. If TB is present, a TB enzyme mycobacterial peroxidase KatG oxidizes the INH; and KatG specific metabolites, in particular, isotopically labeled nitric oxide (NO), nitrites, nitrates, carbon monoxide (CO) or carbon dioxide converted from carbon monoxide of INH cleavage are measured. Other embodiments relate to a diagnostic breath test for detecting TB utilizing isotopically labeled urea (preferably, carbon-13 labeled urea), alone or in combination with isotopically labeled isoniazid (preferably, nitrogen-15 labeled isoniazid), wherein M. tuberculosis organism, if present in the patient or subject's lungs (or other tissues), will metabolize the isotopically labeled urea to isotopically labeled carbon dioxide (CO2) such that a determination of the residence of M. tuberculosis, including residence of an isoniazid resistant strain of M. tuberculosis, may be made.

    Abstract translation: 本发明涉及一种用于检测患者或受试者中结核分枝杆菌（结核病或结核病）感染的试验，特别是包括呼吸试验的诊断试验，其中向患者提供小剂量的同位素标记的结核病药物异烟肼（INH ）口服或直接给予患者或受试者的肺。 如果TB存在，TB酶分枝杆菌过氧化物酶KatG氧化INH; 并测定KatG特异性代谢物，特别是同位素标记的一氧化氮（NO），亚硝酸盐，硝酸盐，一氧化碳（CO）或由INH切割的一氧化碳转化的二氧化碳。 其他实施方案涉及用于使用同位素标记的尿素（优选碳-13标记的尿素）单独或与同位素标记的异烟肼（优选氮-15标记的异烟肼）组合来检测结核病的诊断性呼吸试验，其中结核分枝杆菌生物体如果 存在于患者或受试者的肺部（或其他组织）中，将同位素标记的尿素代谢为同位素标记的二氧化碳（CO 2），从而确定结核分枝杆菌的住所，包括结核分枝杆菌的异烟肼抗性菌株的停留 ，可以做。

    Analysis of P. aeruginosa infection in patients
    14.
    发明申请
    Analysis of P. aeruginosa infection in patients 有权
    分析铜绿假单胞菌感染患者

    公开(公告)号：US20080305050A1

    公开(公告)日：2008-12-11

    申请号：US12150199

    申请日：2008-04-25

    Applicant: Graham Timmins ,  Vojo P. Deretic

    Inventor： Graham Timmins ,  Vojo P. Deretic

    IPC: A61K8/40 ,  G01N33/554 ,  A61K31/17 ,  A61K31/195 ,  A61K33/00

    CPC classification number: C12Q1/04 ,  A61K51/04 ,  A61K51/0406 ,  A61K51/1206 ,  G01N33/497 ,  G01N2333/21

    Abstract: The present invention relates to methods for detecting P aeruginosa infection and bacterial burden in the lungs of patients who are at risk for P. aeruginosa infections, especially including patients with Cystic Fibrosis (CF). The present method provides numerous tests (breath, blood, urine) which are readily administered to a patient that will sensitively and specifically detect the presence and extent of lung infection P. aeruginosa (both mucoid and non-mucoid), and allow monitoring of bacterial load as a parameter in monitoring treatment.

    Abstract translation: 本发明涉及用于检测铜绿假单胞菌感染风险的患者肺部铜绿假单胞菌感染和细菌负担的方法，特别是包括囊性纤维化（CF）患者。 本方法提供了许多试验（呼吸，血液，尿液），其易于对患者施用，其将敏感且特异性地检测肺部感染铜绿假单胞菌（粘液样和非粘液样）的存在和程度，并允许监测细菌 负载作为监测治疗的参数。

    System and methods of melanoma prevention
    18.
    发明申请
    System and methods of melanoma prevention 审中-公开
    黑色素瘤预防的系统和方法

    公开(公告)号：US20080070982A1

    公开(公告)日：2008-03-20

    申请号：US11901056

    申请日：2007-09-14

    Applicant: Graham Timmins ,  Leslie Lund

    Inventor： Graham Timmins ,  Leslie Lund

    IPC: A61K31/351 ,  A61P17/16 ,  A61Q17/04

    CPC classification number: A61K31/351 ,  A61K8/37 ,  A61K8/46 ,  A61K8/498 ,  A61K2800/782 ,  A61K2800/92 ,  A61Q17/04

    Abstract: Inhibiting the enzymic action of tyrosinase in the melanocyte prior to, during, or after ultraviolet (UV) radiation exposure, including over-exposure causing erythema, or sunburn, prevents the production of melanin and thereby melanoma. Melanoma can be prevented by using a tyrosinase inhibitor agent that inhibits the enzymic action of tyrosinase to prevent damage and/or death of melanocytes. The inhibitor agent can be applied to the skin or ingested.

    Abstract translation: 在紫外线（UV）辐射暴露（包括过度暴露引起红斑或晒伤）之前，期间或之后，在黑素细胞中抑制酪氨酸酶的酶作用可以防止黑色素和黑色素瘤的产生。 可以通过使用抑制酪氨酸酶的酶作用以防止黑素细胞的损伤和/或死亡的酪氨酸酶抑制剂来防止黑素瘤。 抑制剂可以施用于皮肤或摄取。

    System and methods for measuring a skin protection factor
    19.
    发明申请
    System and methods for measuring a skin protection factor 有权

    公开(公告)号：US20080056995A1

    公开(公告)日：2008-03-06

    申请号：US11827034

    申请日：2007-07-10

    Applicant: Graham Timmins

    Inventor： Graham Timmins

    IPC: A61K49/00 ,  C12M1/34 ,  C12Q1/02

    CPC classification number: A61K49/0008 ,  A61B5/0059 ,  A61B5/444 ,  A61B5/445 ,  G01R33/60

    Abstract: The present invention is a system and methods of establishing a Melanocyte Protection Factor (MPF), which indicates the level of protection against DNA damage to a target cell, such as the level of protection a particular sunscreen offers against UVA rays when compared to the unprotected case, i.e., no sunscreen. The present invention determines and records levels of stable melanin radicals (SMR) in a target cell. Light is applied to the target cell forming light-induced melanin radicals (LIR). The levels of SMR and intensity of LIR are measured to determine the amount of incident light reaching the target cell. Since LIR is proportional to the square root of light intensity reaching the target cell, the ratio of light reaching the target cell is defined as the MPF: MPF = UV ⁢   ⁢ reaching ⁢   ⁢ melanocyte without ⁢   ⁢ sunscreen UV ⁢   ⁢ reaching ⁢   ⁢ melanocyte with ⁢   ⁢ sunscreen = [ SMR + screen LIR + UV + screen ] 2 [ SMR control LIR ⁢ + UV ⁢   ⁢ control ] 2

    Dectecting melanoma by electron paramagnetic resonance
    20.
    发明申请
    Dectecting melanoma by electron paramagnetic resonance 审中-公开
    通过电子顺磁共振检测黑素瘤

    公开(公告)号：US20050288573A1

    公开(公告)日：2005-12-29

    申请号：US11142631

    申请日：2005-06-01

    Applicant: Graham Timmins

    Inventor： Graham Timmins

    IPC: A61B5/05 ,  A61B5/055 ,  A61B5/103

    CPC classification number: A61B5/415 ,  A61B5/055 ,  A61B5/418 ,  A61B5/441 ,  G01R33/60

    Abstract: Embodiments of methods and apparatus use electron paramagnetic resonance spectroscopy to provide a signal from melanin to image a melanoma. Embodiments of methods and apparatus use electron paramagnetic resonance spectroscopy to provide a signal from melanin to detect metastatic melanoma in a sentinel lymph node. Embodiments of methods and apparatus use electron paramagnetic resonance spectroscopy to provide a signal from melanin to measure light penetration in melanocytes in skin.

    Abstract translation: 方法和装置的实施方案使用电子顺磁共振光谱法来提供来自黑色素的信号以成像黑素瘤。 方法和装置的实施例使用电子顺磁共振光谱法来提供来自黑色素的信号以检测前哨淋巴结中的转移性黑素瘤。 方法和装置的实施方案使用电子顺磁共振光谱法来提供来自黑色素的信号以测量皮肤中黑素细胞中的光穿透。

Patent Agency Ranking