公开(公告)号：US4118468A

公开(公告)日：1978-10-03

申请号：US741397

申请日：1976-11-12

Applicant: Helmut Strecker ,  Reinhard Kasmarker ,  Gerhard Kloss

Inventor： Helmut Strecker ,  Reinhard Kasmarker ,  Gerhard Kloss

IPC: A61K31/28 ,  A61K51/00 ,  A61K51/04 ,  G01N33/60 ,  G21H5/02 ,  A61K29/00 ,  A61K43/00

CPC classification number: A61K51/0478 ,  A61K2123/00

Abstract: A diagnostic agent for the visualization of the kidneys is disclosed as well as a process for its manufacture. The new agent consists of pyrrolidinomethyl-tetracycline in a buffer solution, a tin(II) salt and technetium-99m in physiological sodium chloride solution.

Abstract translation: 公开了用于肾脏可视化的诊断剂以及其制造方法。 新的试剂由缓冲溶液中的吡咯烷基甲基四环素，生理氯化钠溶液中的锡（II）盐和锝-99m组成。

公开(公告)号：US07792248B2

公开(公告)日：2010-09-07

申请号：US11571109

申请日：2005-06-28

Applicant: Helmut Strecker ,  Gabriel Zienert ,  Armin Schmiegel

Inventor： Helmut Strecker ,  Gabriel Zienert ,  Armin Schmiegel

IPC: G01N23/04

CPC classification number: G01V5/0016

Abstract: The invention relates to a method of examining an item of luggage 1, in which an X-ray fluoroscopic image of the whole item of luggage 1 is produced first, then planiform suspect regions 4, 5, 6 in the X-ray fluoroscopic image are determined and the scanning time during the following production of an X-ray diffraction image depends on whether the X-ray beam is located specifically in a planiform suspect region 4, 5, 6, wherein the scanning time heads towards zero outside a planiform suspect region 4, 5, 6 and lasts long enough inside a planiform suspect region 4, 5, 6 to obtain an informative X-ray diffraction image.

Abstract translation: 本发明涉及一种检查行李1的方法，其中首先制造整个行李1的X射线透视图像，然后X射线透视图像中的平面状可疑区域5,6,6 并且在随后的X射线衍射图像生成期间的扫描时间取决于X射线束是否特别地位于平面状可疑区域5,6中，其中扫描时间在平面状可疑区域外朝向零 在平面状的嫌疑区域4,5,6中持续足够长的时间，以获得信息丰富的X射线衍射图像。

公开(公告)号：US20090016487A1

公开(公告)日：2009-01-15

申请号：US11571109

申请日：2005-06-28

Applicant: Helmut Strecker ,  Gabriel Zienert ,  Armin Schmiegel

Inventor： Helmut Strecker ,  Gabriel Zienert ,  Armin Schmiegel

IPC: G01N23/201 ,  G01N23/04

CPC classification number: G01V5/0016

Abstract: The invention relates to a method of examining an item of luggage 1, in which an X-ray fluoroscopic image of the whole item of luggage 1 is produced first, then planiform suspect regions 4, 5, 6 in the X-ray fluoroscopic image are determined and the scanning time during the following production of an X-ray diffraction image depends on whether the X-ray beam is located specifically in a planiform suspect region 4, 5, 6, wherein the scanning time heads towards zero outside a planiform suspect region 4, 5, 6 and lasts long enough inside a planiform suspect region 4, 5, 6 to obtain an informative X-ray diffraction image

Abstract translation: 本发明涉及一种检查行李1的方法，其中首先制造整个行李1的X射线透视图像，然后X射线透视图像中的平面状可疑区域5,6,6 并且在随后的X射线衍射图像生成期间的扫描时间取决于X射线束是否特别地位于平面状可疑区域5,6中，其中扫描时间在平面状可疑区域外朝向零 4,5,6，并在平面状嫌疑区域4,5,6中持续足够长的时间，以获得信息丰富的X射线衍射图像

公开(公告)号：US06103486A

公开(公告)日：2000-08-15

申请号：US75832

申请日：1993-06-14

Applicant: Guido Simons ,  Helmut Strecker, deceased ,  Peter Molz ,  Gerd Schnorr ,  Heinz Jurgen Skrzipczyk ,  Hans Wissmann

Inventor： Guido Simons ,  Helmut Strecker, deceased ,  Peter Molz ,  Gerd Schnorr ,  Heinz Jurgen Skrzipczyk ,  Hans Wissmann

IPC: G01N33/53 ,  G01N33/00 ,  G01N33/536 ,  G01N33/543 ,  G01N33/78

CPC classification number: G01N33/536 ,  G01N33/0055 ,  G01N33/78

Abstract: A method for determining the concentration of the free fraction of an active compound, present in a biological fluid, in the presence of natural binders, the free and bound fractions of the active compound being in mutual equilibrium, bya) contacting a sample of the fluid with an unlabeled antibody,b) separating the sample from the unlabeled antibody,c) incubating the unlabeled antibody with a labeled substance (tracer) for cross-reaction with the antibody andd) measuring the amount of the tracer which is or is not bound to the antibody and calculating from this the concentration of the free fraction of the active compound,wherein the quantity of the unlabeled antibody and/or its affinity for the active compound are so small that they do not substantially effect the equilibrium between the free and bound fractions of the active compound, and the affinity of the tracer for the antibody is substantially higher or substantially lower than that of the active compound itself, and a test kit suitable for this method.

Abstract translation: 在天然粘合剂存在下，确定存在于生物流体中的活性化合物的游离级分浓度的方法，所述活性化合物的游离和结合级分是相互平衡的，所述方法是通过以下步骤： 具有未标记抗体的液体，b）从未标记的抗体中分离样品，c）将未标记的抗体与标记物质（示踪剂）孵育以与抗体交叉反应，以及d）测量示踪剂的量或不是 与抗体结合，从此计算活性化合物的游离级分的浓度，其中未标记的抗体的量和/或其对活性化合物的亲和力如此之小，使得它们基本上不影响游离和 活性化合物的结合部分，示踪剂对抗体的亲和力显着高于或显着低于活性化合物本身的亲和力， t kit适用于此方法。

公开(公告)号：US4820860A

公开(公告)日：1989-04-11

申请号：US87805

申请日：1987-08-21

Applicant: Hans Wissmann ,  Guido Simons ,  Helmut Strecker, deceased

Inventor： Hans Wissmann ,  Guido Simons ,  Helmut Strecker, deceased

IPC: C08G65/08 ,  C07C67/00 ,  C07C239/00 ,  C07C271/22 ,  C08G65/02 ,  C08G65/28 ,  C08G65/32 ,  C08G65/333 ,  C08G65/48 ,  G01N33/53 ,  G01N33/78 ,  C07C101/32

CPC classification number: C08G65/33396 ,  G01N33/78

Abstract: The invention relates to novel thyronine derivatives of the formula ##STR1## in which n is 10-400, R denotes H, alkyl or N-carbonylthyronine, R.sup.1 and R.sup.2 are identical or different and denote hydrogen or iodine, and R.sup.3 denotes H or alkyl, a process for the preparation of the compounds, and their use when carrying out immunoassays.

Abstract translation: 本发明涉及其中n为10-400，R表示H，烷基或N-羰基甲状腺氨酸的式（I）＆lt; IMAGE＆gt;的新颖的甲状腺素衍生物，R 1和R 2相同或不同，表示氢或碘， 并且R3表示H或烷基，制备化合物的方法及其在进行免疫测定时的用途。

公开(公告)号：US4504587A

公开(公告)日：1985-03-12

申请号：US474457

申请日：1983-03-11

Applicant: Rupert Timpl ,  Dietrich Brocks ,  Horst Neubauer ,  Helmut Strecker

Inventor： Rupert Timpl ,  Dietrich Brocks ,  Horst Neubauer ,  Helmut Strecker

IPC: G01N33/53 ,  A61K38/17 ,  A61K39/00 ,  A61K39/395 ,  G01N33/537 ,  G01N33/68 ,  G01N33/52 ,  G01N33/54 ,  G01N33/56

CPC classification number: G01N33/537 ,  G01N33/6887 ,  Y10S436/80 ,  Y10S436/804 ,  Y10S436/811 ,  Y10S436/819 ,  Y10S436/824

Abstract: The antigens procollagen peptide (type (III) and procollagen peptide col 1 (type III) can be determined together immunologically by either(a) reacting a specified amount in each case of labeled procollagen peptide (type III) or procollagen peptide col 1 (type III) and a highly specific antiserum containing antibodies having affinity for both the antigens mentioned together with a sample having an unknown content of procollagen peptide (type III) and/or procollagen peptide col 1 (type III), separating off the antigen-antibody complex formed and measuring the amount of labeling in the complex and/or in the supernatant, or(b) bringing a specified amount of the highly specific antiserum to reaction with a sample having an unknown content of procollagen peptide (type III) and/or procollagen peptide col 1 (type III), fixing the unreacted amount of the antibody to procollagen peptide (type III) or procollagen peptide col 1 (type III) bound to a support, and bringing to reaction with a labeled second antibody, and then determining the amount of bound or excess second antibody by measuring the labeling. An anti-procollagen peptide col 1 (type III) serum is preferred as the highly specific serum, and this is obtained by using procollagen peptide col 1 (type III) for immunizing experimental animals and obtaining their serum.

Abstract translation: 抗原原胶原肽（类型（III）和前胶原肽肽1（III型））可以通过以下方式一起免疫测定：（a）在标记的前胶原肽（III型）或前胶原肽肽1（类型 III）和具有抗体的高度特异性抗血清，所述抗体与所述抗原一起提供与具有未知含量的原胶原肽（III型）和/或前胶原肽第1号（III型）的样品的亲和力，分离出抗原 - 抗体复合物 形成和测量复合物和/或上清液中的标记量，或（b）使特定量的高度特异性抗血清与具有未知含量的前胶原肽（III型）和/或前胶原的样品反应 肽柱1（III型），将未反应量的抗体固定到与载体结合的前胶原肽（III型）或前胶原肽肽1（III型）上，并与标记物反应 然后通过测量标记来确定结合或过量的第二抗体的量。 优选抗原胶原肽col 1（III型）血清作为高度特异性血清，并且通过使用前胶原肽肽1（III型）免疫实验动物并获得其血清而获得。

公开(公告)号：US4480332A

公开(公告)日：1984-10-30

申请号：US374124

申请日：1982-05-03

Applicant: Helmut Strecker

Inventor： Helmut Strecker

IPC: G01N23/203 ,  A61B6/02 ,  G01N23/02

CPC classification number: G01N23/02

Abstract: The invention relates to an apparatus for imaging a layer of a body to be examined. The body is irradiated by primary radiation, in response to which the layer emits scattered radiation. The apparatus comprises a diaphragm plate which is disposed outside the primary radiation beam. The diaphragm is rotatable about an axis perpendicular to its major surface, and it has at least one aperture which is disposed off of the axis of rotation. A detector or a superposition device is provided for measuring or superimposing the scattered radiation which passes through the diaphragm plate at different aperture settings. The primary radiation is stopped down to form a flat fan-shaped beam. The diaphragm plate is oriented parallel to the fan-shaped beam. Each aperture corresponds to an associated detector, which follows the rotation of the diaphragm plate. The input face of each detector extends parallel to the diaphragm plate. The detector is arranged so as to be rotatable about a detector axis which is perpendicular to an input face and which extends through its center. The detector rotates in a direction opposite to the direction of rotation of the diaphragm plate and with the same angular velocity as this plate.

Abstract translation: 本发明涉及一种用于对要检查的身体的层进行成像的装置。 身体被初级辐射照射，响应于该层发射散射辐射。 该装置包括设置在一次辐射束外部的隔膜板。 隔膜可绕垂直于其主表面的轴线旋转，并且其具有远离旋转轴线设置的至少一个孔。 提供了一种检测器或叠加装置，用于测量或叠加在不同孔径设置下穿过隔膜板的散射辐射。 主辐射被停止以形成平坦的扇形光束。 隔膜板平行于扇形梁定向。 每个孔对应于跟随膜板旋转的相关联的检测器。 每个检测器的输入面平行于隔膜板延伸。 检测器布置成可围绕垂直于输入面并且延伸穿过其中心的检测器轴线旋转。 检测器沿与膜板的旋转方向相反的方向以与该板相同的角速度旋转。

公开(公告)号：US4291012A

公开(公告)日：1981-09-22

申请号：US908

申请日：1979-01-04

Applicant: Helmut Strecker ,  Michael Molter ,  Gerhard Kloss ,  Eberhard Schickel

Inventor： Helmut Strecker ,  Michael Molter ,  Gerhard Kloss ,  Eberhard Schickel

IPC: A61K51/00 ,  A61K51/04 ,  A61K49/00 ,  A61K43/00 ,  G01T1/00

CPC classification number: A61K51/025 ,  A61K51/04 ,  A61K2123/00

Abstract: A process is disclosed for the preparation of a diagnositc agent for scanning the RES, in particular the liver, by mixing the sodium salt of 1-phenyl-2,3-dimethyl-pyrazolone-4-methylamino-methylsulfonic acid or 1-phenyl-2,3-dimethyl-pyrazolone in aqueous solution with tin(II) salt, adjusting the solution to a pH between 4 and 9, optionally lyophilizing the mixture and adding .sup.99m Tc-pertechnetate in physiological saline solution.

Abstract translation: 公开了通过将1-苯基-2,3-二甲基 - 吡唑啉酮-4-甲基氨基 - 甲基磺酸或1-苯基-2,3-二氢吡喃酮的钠盐混合来制备用于扫描RES，特别是肝脏的诊断剂的方法， （II）盐的水溶液中，将溶液调节至4至9的pH，任选地将混合物冷冻干燥并在生理盐水溶液中加入99mTc-高锝酸盐。

公开(公告)号：US4188539A

公开(公告)日：1980-02-12

申请号：US888756

申请日：1978-03-21

Applicant: Helmut Strecker

Inventor： Helmut Strecker

IPC: G21G4/08 ,  A61N5/10 ,  G21G1/04 ,  G21H5/02 ,  H01J27/00

CPC classification number: G21G1/04

Abstract: Nuclide generators for preparing sterile and pyrogen-free radioactive solutions consist of a generator column which is provided with radiation shielding and connected to a container for eluting agent and has a connection to a container for eluate. The generator and the container for eluting agent are located in vessels with centering devices, wherein the generator column with its radiation shielding is located in a fixed position relative to the vessel between two centering devices and connected via a cannula to the container for eluting agent which is held in a recess of one centering device in a fixed position relative to the generator column. The other centering device has also a recess for guiding and holding the eluate container which is connected to the generator column via a cannula.

Abstract translation: 用于制备无菌和无热原的放射性溶液的核素发生器由发生器柱组成，发生器柱具有辐射屏蔽并连接到用于洗脱剂的容器并具有与容器的连接用于洗脱。 发生器和用于洗脱剂的容器位于具有定心装置的容器中，其中具有其辐射屏蔽的发生器柱相对于两个定心装置之间的容器位于固定位置，并通过套管连接到用于洗脱剂的容器， 被保持在相对于发电机柱的固定位置的一个定心装置的凹部中。 另一个定心装置还具有用于引导和保持通过套管连接到发生器柱的洗脱容器的凹槽。