公开(公告)号：US11596783B2

公开(公告)日：2023-03-07

申请号：US16975455

申请日：2019-03-06

Applicant: Indiana University Research and Technology Corporation

Inventor： Mark D. Rodefeld

IPC: A61M60/405 ,  A61M60/148 ,  A61M60/205 ,  A61M60/82 ,  A61M60/824 ,  A61M60/35 ,  A61M60/882 ,  A61M60/806 ,  A61M60/232

Abstract: Methods and devices for a self-contained device including a hydraulic motor and a hydraulic pump. Preferably, the motor is incorporated either within the interior of the pump, on the exterior of the pump, or a combination of the two. The pump increases the kinetic energy of the fluid by centrifugal means, and in some embodiments is a viscous impeller pump. Applications include building flow systems, industrial processes, and biological circulatory systems.

公开(公告)号：US20230044112A1

公开(公告)日：2023-02-09

申请号：US17140800

申请日：2021-01-04

Applicant: Assembly Biosciences, Inc. ,  INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： William W. Turner, JR. ,  Lee D. Arnold ,  Hans Maag ,  Leping Li ,  Mark G. Bures ,  Simon Nicolas Haydar ,  Samson Francis

IPC: C07D417/12 ,  C07D403/12 ,  A61K45/06 ,  C07D401/12 ,  C07D413/12 ,  C07D417/14 ,  C07D453/02 ,  C07D471/04 ,  A61P31/20 ,  C07D243/38 ,  C07D267/20 ,  C07D281/16

Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：US20230019129A1

公开(公告)日：2023-01-19

申请号：US17154721

申请日：2021-01-21

Applicant: Indiana University Research and Technology Corporation ,  Assembly Biosciences, Inc.

Inventor： William W. Turner, JR. ,  Lee Daniel Arnold ,  Hans Maag ,  Adam Zlotnick

IPC: C07D417/12 ,  C07D403/12 ,  C07D223/20 ,  C07D401/12 ,  C07D413/12 ,  C07D243/38 ,  C07D281/14 ,  A61P31/12 ,  A61K31/55 ,  A61K31/5513 ,  A61K31/553 ,  A61K31/554 ,  A61K45/06 ,  C07D281/16

Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：US11534362B2

公开(公告)日：2022-12-27

申请号：US15757468

申请日：2016-09-16

Applicant: Indiana University Research and Technology Corporation

Inventor： Mary T. Loghmani ,  Sohel Anwar ,  Ahmed Alotaibi ,  Keith L. March ,  Stanley Chien

IPC: A61H7/00 ,  G16H20/30 ,  G16H10/60

Abstract: A manually-operated quantification soft tissue mobilization (QSTM) device includes a pressure applicator and a sensor member. The pressure applicator is configured to enable a user to dynamically apply a stroking mechanical force as the pressure applicator is moved over an area treatment areas of a patient's soft tissue. The sensor member including an accelerometer and a gyrometer is configured to determine various parameters of the dynamically applied stroking mechanical force in three dimensions as the pressure applicator is moved over the treatment areas of the patient's soft tissue. These parameters include a force magnitude in three dimensions, an angle in multiple axes, a stroke position, a stroke frequency, a sensed vibration magnitude at dominant spectral frequencies, and/or a rate of the stroking mechanical force dynamically applied to the soft tissue.

公开(公告)号：US20220184016A1

公开(公告)日：2022-06-16

申请号：US17688081

申请日：2022-03-07

Applicant: Indiana University Research and Technology Corporation

Inventor： Mark R. Kelley

IPC: A61K31/201 ,  A61K31/203 ,  A61K31/454 ,  A61K31/198 ,  A61K31/7068 ,  A61K33/243 ,  A61K31/122 ,  A61K31/13 ,  A61K31/195 ,  A61K31/282 ,  A61K45/06 ,  A61K39/395

Abstract: Disclosed are novel methods for the therapeutic treatment of cancer and angiogenesis. The enzyme Ape1/Ref-1, via its redox function, enhances the DNA binding activity of transcription factors that are associated with the progression of cancer. The present invention describes the use of agents to selectively inhibit the redox function of Ape1/Ref-1 and thereby reduce tumor cell growth, survival, migration and metastasis. In addition, Ape1/Ref-1 inhibitory activity is shown to augment the therapeutic effects of other therapeutics and protect normal cells against toxicity. Further, Ape1/Ref-1 inhibition is shown to decrease angiogenesis, for use in the treatment of cancer as well other pathologic conditions of which altered angiogenesis is a component.

公开(公告)号：US11324398B2

公开(公告)日：2022-05-10

申请号：US16522183

申请日：2019-07-25

Applicant: Indiana University Research and Technology Corporation

Inventor： Donald Thomas Miller ,  Zhuolin Liu ,  Kazuhiro Suzuki ,  Furu Zhang

IPC: A61B3/00 ,  A61B3/10 ,  A61B3/12 ,  A61B3/13 ,  A61B3/14

Abstract: A method is provided for observing structure and function of individual cells in a living human eye, comprising: using an adaptive optics optical coherence tomography (AO-OCT) system to image a volume of a retinal patch including numerous cells of different types, as for example, ganglion cells; using 3D subcellular image registration to correct for eye motion, including digitally dissecting the imaged volume; and using organelle motility inside the cell to increase cell contrast and to measure cell temporal dynamics.

公开(公告)号：US11293931B2

公开(公告)日：2022-04-05

申请号：US16576160

申请日：2019-09-19

Applicant: Indiana University Research and Technology Corporation

Inventor： Avinash Shivaputrappa Patil

IPC: G01N33/74 ,  G01N33/68

Abstract: Disclosed are methods for identifying a pregnant female who is susceptible to spontaneous preterm delivery. In particular, disclosed are methods for identifying a pregnant female who is susceptible to spontaneous preterm delivery based on ratios of steroids in samples obtained from the pregnant female. Further, the methods can include treating the pregnant female identified susceptible to spontaneous preterm delivery.

公开(公告)号：US11291466B2

公开(公告)日：2022-04-05

申请号：US15745955

申请日：2016-08-10

Applicant: Indiana University Research and Technology Corporation

Inventor： Luke G. Gutwein ,  Rajiv Sood ,  Barry Davignon

IPC: A61B17/285 ,  A61B17/3201 ,  A61B17/00 ,  A61B17/32

Abstract: A scar subcision devices comprising a first elongated element comprising a pivotal connection to a second elongated element, the first elongated element having a blunt distal end, the second elongated element having a proximal-facing cutting edge at a distal end thereof, the device having a first state wherein the cutting edge is retracted to a location within an outer perimeter of the first elongated element, and a second state wherein the cutting edge is exposed outside of the outer perimeter of the first elongated element and the device transitioning between the first state and the second state by the first elongated element and the second elongated element rotating relative to each other about the pivotal connection are disclosed. Methods are also disclosed.

公开(公告)号：US11252965B2

公开(公告)日：2022-02-22

申请号：US16316847

申请日：2017-07-13

Applicant: Indiana University Research and Technology Corporation ,  University of Notre Dame du Lac

Inventor： Molly Duman Scheel ,  David W. Severson ,  Kathleen Eggleson ,  Na Wei

IPC: C12N15/113 ,  C12N15/81 ,  A01N57/16 ,  A01K67/033 ,  A01N25/00 ,  A01N25/02 ,  A01N25/10 ,  A01N63/60

Abstract: The present invention provides a novel class of insecticides for control of disease vector insects, particularly mosquitoes. These insecticides prevent maturation or development of larvae into adult insects using interfering RNA (iRNA). The present invention further includes compositions comprising iRNA and methods of controlling, reducing, or treating an insect infestation with the iRNA or compositions described herein.

公开(公告)号：US20210363150A1

公开(公告)日：2021-11-25

申请号：US16965283

申请日：2019-05-22

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： Amar H. Flood ,  Yun Liu ,  Wei Zhao

IPC: C07D487/22 ,  C09D5/08 ,  B01D11/04 ,  C02F1/26 ,  B01D15/08

Abstract: The present disclosure concerns synthesis, anion binding features, liquid-liquid extraction of salts, and anti-corrosion character of aryl-triazole bicyclic macrocycles of Formula (I) and related compounds: