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公开(公告)号:US10392379B2
公开(公告)日:2019-08-27
申请号:US15760343
申请日:2016-09-15
发明人: William Turner , Lee Daniel Arnold , Hans Maag , Mark Bures
IPC分类号: C07D243/38 , C07D267/20 , C07D281/16 , C07D401/12 , C07D403/12 , C07D417/12 , C07D417/14 , C07D453/02 , C07D471/04 , A61K45/06 , A61P31/20 , C07D413/12
摘要: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
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公开(公告)号:US20180258084A1
公开(公告)日:2018-09-13
申请号:US15760284
申请日:2016-09-15
发明人: William Turner , Lee Daniel Arnold , Hans Maag , Leping Li , Mark Bures , Simon Haydar , Samson Francis
IPC分类号: C07D417/12 , C07D417/14 , C07D453/02 , C07D471/04
CPC分类号: C07D417/12 , A61K45/06 , A61P31/20 , C07D243/38 , C07D267/20 , C07D281/16 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/14 , C07D453/02 , C07D471/04
摘要: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
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公开(公告)号:US10947224B2
公开(公告)日:2021-03-16
申请号:US15965655
申请日:2018-04-27
IPC分类号: A61P31/12 , C07D417/12 , C07D403/12 , C07D223/20 , C07D401/12 , C07D413/12 , C07D243/38 , C07D281/14 , A61K31/55 , A61K31/5513 , A61K31/553 , A61K31/554 , A61K45/06 , C07D281/16
摘要: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
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公开(公告)号:US20230019129A1
公开(公告)日:2023-01-19
申请号:US17154721
申请日:2021-01-21
IPC分类号: C07D417/12 , C07D403/12 , C07D223/20 , C07D401/12 , C07D413/12 , C07D243/38 , C07D281/14 , A61P31/12 , A61K31/55 , A61K31/5513 , A61K31/553 , A61K31/554 , A61K45/06 , C07D281/16
摘要: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
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公开(公告)号:US10377748B2
公开(公告)日:2019-08-13
申请号:US15760284
申请日:2016-09-15
发明人: William Turner , Lee Daniel Arnold , Hans Maag , Leping Li , Mark Bures , Simon Haydar , Samson Francis
IPC分类号: C07D417/12 , A61P31/20 , C07D403/12 , A61K45/06 , C07D401/12 , C07D413/12 , C07D417/14 , C07D453/02 , C07D471/04 , C07D243/38 , C07D267/20 , C07D281/16
摘要: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
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公开(公告)号:US20170266197A1
公开(公告)日:2017-09-21
申请号:US15310070
申请日:2015-05-11
IPC分类号: A61K31/5377 , A61K31/506 , G01N33/50 , A61K31/445 , G01N33/576 , A61K45/06 , A61K31/18
CPC分类号: A61K31/5377 , A61K31/18 , A61K31/445 , A61K31/506 , A61K31/713 , A61K45/06 , G01N33/5023 , G01N33/5032 , G01N33/5762 , G01N2500/04
摘要: Described herein are methods for identifying compounds useful for the treatment of infection by hepatitis B virus (HBV) and for identifying compounds useful for the same.
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公开(公告)号:US10183936B2
公开(公告)日:2019-01-22
申请号:US15125911
申请日:2015-03-13
IPC分类号: C07D417/12 , C07D403/12 , C07D223/20 , C07D401/12 , C07D413/12 , C07D243/38 , C07D281/14 , A61K31/55 , A61K31/5513 , A61K31/553 , A61K31/554 , A61K45/06 , C07D281/16
摘要: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
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公开(公告)号:US20180273521A1
公开(公告)日:2018-09-27
申请号:US15965655
申请日:2018-04-27
IPC分类号: C07D417/12 , C07D281/14 , A61K45/06 , C07D281/16 , A61K31/554 , C07D401/12 , A61K31/5513 , A61K31/553 , C07D413/12 , C07D223/20 , C07D403/12 , A61K31/55 , C07D243/38
摘要: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
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公开(公告)号:US20180273520A1
公开(公告)日:2018-09-27
申请号:US15760343
申请日:2016-09-15
发明人: William Turner , Lee Daniel Arnold , Hans Maag , Mark Bures
IPC分类号: C07D417/12 , C07D417/14 , A61P31/20
CPC分类号: C07D417/12 , A61K45/06 , A61P31/20 , C07D243/38 , C07D267/20 , C07D281/16 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/14 , C07D453/02 , C07D471/04
摘要: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
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公开(公告)号:US10273228B2
公开(公告)日:2019-04-30
申请号:US15566633
申请日:2016-04-15
IPC分类号: C07D403/14 , C07D401/04 , C07D403/12 , C07D401/12 , C07D403/04 , C07D239/42 , C07D239/48 , C07D409/12 , C07D417/04 , C07D417/12 , C07D401/14 , C07D417/14 , C07D213/74 , C07D239/47 , C07D413/04 , A61K31/496 , A61K31/506 , A61P31/20
摘要: Novel assembly effector compounds having a therapeutic effect against hepatitis B viral (HBV) infection are disclosed. Assembly effector molecules described herein can lead to defective viral assembly and also may affect other viral activities associated with chronic HBV infection. Also disclosed is a process to synthesize disclosed compounds, method of treatment of HBV by administration of disclosed compounds, and use of these compounds in the manufacture of medicaments against HBV.
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