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公开(公告)号：US06803128B2
公开(公告)日：2004-10-12
申请号：US10394066
申请日：2003-03-24
Applicant: Il Han Lee
Inventor： Il Han Lee
IPC: H05B3326
CPC classification number: H01L51/5092 , H01L51/0059 , H01L51/0081 , H01L51/5221 , H01L2251/558 , Y10S428/917 , Y10T428/24967 , Y10T428/31678
Abstract: An organic electroluminescent (EL) device and a method of manufacturing the same utilize a cathode, an anode, and organic layers formed between the cathode and the anode, wherein the cathode includes a first cathode containing aluminum, and a second cathode disposed under the first cathode, formed in the vicinity of an organic layer and containing a metal having a work function of 3.5 to 5.0 eV, and metallic carboxylate represented by: RCOOM Formula 1 wherein M is an alkali metal or alkaline-earth metal, and R is a C1-C10 alkyl or C6-C20 aryl.
Abstract translation: 有机电致发光（EL）器件及其制造方法利用形成在阴极和阳极之间的阴极，阳极和有机层，其中阴极包括含有铝的第一阴极和设置在第一阴极上的第二阴极 阴极，在有机层附近形成，并含有功函数为3.5〜5.0eV的金属和金属羧酸盐，其中M为碱金属或碱土金属，R为C1-C10烷基 或C 6 -C 20芳基。
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公开(公告)号：US20090033601A1
公开(公告)日：2009-02-05
申请号：US12081689
申请日：2008-04-18
Applicant: Hyo-jin Lee , Il-han Lee , Jin-Hyun Choi
Inventor： Hyo-jin Lee , Il-han Lee , Jin-Hyun Choi
IPC: G09G3/30
CPC classification number: G09G3/3233 , G09G2300/0842 , G09G2300/0861 , G09G2320/0257 , G09G2320/043 , G09G2320/0626 , G09G2360/16
Abstract: An organic light emitting display and its driving method includes: a pixel unit divided into a first display region and a second display region; a light emitting control driver outputting in parallel a plurality of light emitting control signals through a plurality of light emitting control lines; a switch unit including a plurality of switches each respectively coupled to one of the plurality of light emitting control lines to switch the transfers of the light emitting control signals to each have a turn-on period and a turn-off period within a period of one frame; and a luminance controller controlling the switching time of the switch unit using image signals and setting the number of switchings of the plurality of light emitting control lines coupled to the first display region differently from that of the plurality of light emitting control lines coupled to the second display region.
Abstract translation: 一种有机发光显示器及其驱动方法，包括：划分为第一显示区域和第二显示区域的像素单元; 发光控制驱动器，通过多个发光控制线并行地输出多个发光控制信号; 开关单元，包括多个开关，每个开关分别耦合到所述多个发光控制线中的一个，以将所述发光控制信号的转换切换为各自的发光控制信号，所述发光控制信号在一个周期内具有导通周期和关断周期 帧; 以及亮度控制器，其使用图像信号来控制开关单元的切换时间，并且设置耦合到第一显示区域的多个发光控制线的切换次数与耦合到第二显示区域的多个发光控制线的切换时间不同 显示区域。
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13.发明申请VECTOR FOR TREATMENT VACCINE FOR STABLE AND CONSTITUTIVE HIGH-EXPRESSION CERVICAL CANCER AND RECOMBINANT LACTOBACILLUS TRANSFORMED BY THE SAME 有权用于稳定和构成型高表达癌细胞的转基因疫苗和由其转化的重组乳酸杆菌公开(公告)号：US20110318384A1
公开(公告)日：2011-12-29
申请号：US13143700
申请日：2010-01-08
Applicant: Moon-Hee Sung , Haryoung Poo , Il Han Lee
Inventor： Moon-Hee Sung , Haryoung Poo , Il Han Lee
CPC classification number: C12N15/746 , A61K39/12 , A61K2039/523 , A61K2039/542 , C12N2710/20034 , C12N2710/20045 , C12N2810/55
Abstract: A surface expression vector for preparing HPV vaccines, in which the surface expression vector contains a gene encoding a repE mutant protein having an amino acid sequence of SEQ ID NO: 1, a promoter, a poly-gamma-glutamate synthetase complex gene, and a gene which is linked with the poly-gamma-glutamate synthetase complex gene and encodes a tumor induction-associated antigen protein of human papillomavirus.An expression vector constitutively expressing a high level of the human papillomavirus (HPV) antigen protein is provided. Also, a recombinant lactic acid bacteria, transformed with the expression vector and expressing the HPV antigen protein on the surface thereof, and a composition comprising the recombinant lactic acid bacteria are provided. The recombinant lactic acid bacteria and the composition are very effective as a vaccine for the treatment of cervical cancer, because they can be applied orally or directly to the vagina.
Abstract translation: 用于制备HPV疫苗的表面表达载体，其中所述表面表达载体含有编码具有SEQ ID NO：1的氨基酸序列的repE突变蛋白的基因，启动子，聚-γ-谷氨酸合成酶复合物基因和 基因，其与多聚-γ-谷氨酸合成酶复合物基因连接并编码人乳头瘤病毒的肿瘤诱导相关抗原蛋白。 提供了组成型表达高水平人乳头瘤病毒（HPV）抗原蛋白的表达载体。 此外，提供了用表达载体转化并在其表面上表达HPV抗原蛋白的重组乳酸菌和包含重组乳酸菌的组合物。 重组乳酸菌和组合物作为用于治疗子宫颈癌的疫苗非常有效，因为它们可以口服或直接施用于阴道。
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14.发明申请COMPOSITION FOR PREVENTING VIRUS INFECTION COMPRISING POLY-GAMMA-GLUTAMIC ACID 审中-公开用于预防包含多糖 - 谷氨酸的病毒感染的组合物公开(公告)号：US20100256050A1
公开(公告)日：2010-10-07
申请号：US12678027
申请日：2007-09-13
Applicant: Moon-Hee Sung , Chul Joong Kim , Haryoung Poo , Young-Ki Choi , Il Han Lee , Dai-Won Yoo
Inventor： Moon-Hee Sung , Chul Joong Kim , Haryoung Poo , Young-Ki Choi , Il Han Lee , Dai-Won Yoo
CPC classification number: A61K31/785 , A61K38/164
Abstract: The present invention relates to a pharmaceutical composition for inhibiting or preventing viral infection, which comprises an effective dose of poly-gamma-glutamic acid (γ-PGA), and more particularly, to a pharmaceutical composition, a functional food, and a feedstuff additive capable of inhibiting viral infection and preventing viral diseases, which comprise poly-gamma-glutamic acid having an infection-inhibiting effect against viruses, such as an influenza virus, inducing respiratory infection or systemic infection, as an effective ingredient.The composition containing poly-gamma-glutamic acid as an effective ingredient according to the present invention, is effective for use as an animal feedstuff additive or a pharmaceutical agent for preventing influenza virus infection and various viral diseases as well as a pharmaceutical composition and a functional food to promote human health.
Abstract translation: 本发明涉及用于抑制或预防病毒感染的药物组合物，其包含有效剂量的聚-γ-谷氨酸（γ-PGA），更具体地，涉及药物组合物，功能性食品和饲料添加剂 能够抑制病毒感染和预防病毒性疾病，其包含对病毒（例如流感病毒）诱导呼吸道感染或全身感染具有感染抑制作用的聚-γ-谷氨酸作为有效成分。 含有根据本发明的有效成分的聚-γ-谷氨酸的组合物可用作动物饲料添加剂或用于预防流感病毒感染和各种病毒性疾病的药剂以及药物组合物和功能性 食物促进人体健康。
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公开(公告)号：US20090244054A1
公开(公告)日：2009-10-01
申请号：US12416798
申请日：2009-04-01
Applicant: Hyo-Jin Lee , Il-Han Lee , Yun-Tae Kim
Inventor： Hyo-Jin Lee , Il-Han Lee , Yun-Tae Kim
IPC: G06F3/038
CPC classification number: G09G3/3233 , G09G2330/02 , G09G2330/026
Abstract: A display device and a method of driving the display device are provided. The display device includes a scan driver for transmitting scan signals to a plurality of scan lines, a data driver for transmitting data signals to a plurality of data lines, and a signal controller for controlling the transmissions of the scan driver and the data driver. The scan driver and the data driver are configured to begin operating in response to a reset signal. The signal controller is configured to detect the reset signal, to determine whether the detected reset signal is a normal reset signal or an abnormal reset signal applied after an on time at which power is supplied to the scan driver and the data driver, and to apply a normal reset signal when the detected reset signal is determined to be an abnormal reset signal.
Abstract translation: 提供了显示装置和驱动显示装置的方法。 显示装置包括用于将扫描信号发送到多条扫描线的扫描驱动器，用于将数据信号发送到多条数据线的数据驱动器，以及用于控制扫描驱动器和数据驱动器的传输的信号控制器。 扫描驱动器和数据驱动器被配置为响应于复位信号开始操作。 信号控制器被配置为检测复位信号，以确定检测到的复位信号是正常复位信号还是在向扫描驱动器和数据驱动器提供电源的接通时间之后施加的异常复位信号，并且应用 当检测到的复位信号被确定为异常复位信号时的正常复位信号。
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Patent Agency Ranking
公开(公告)号：US09623121B2
公开(公告)日：2017-04-18
申请号：US13885126
申请日：2011-11-18
Applicant: Moon-Hee Sung , Yong Taik Lim , Young-Woock Noh , Il Han Lee
Inventor： Moon-Hee Sung , Yong Taik Lim , Young-Woock Noh , Il Han Lee
CPC classification number: A61K49/0054 , A61K49/0034 , A61K49/0056 , G01N21/6428 , G01N21/6456
Abstract: The present invention relates to an optical imaging probe for detecting a sentinel lymph node, which contains a complex of poly-gamma-glutamic acid and an optical imaging dye, and more particularly to an optical imaging probe for detecting a sentinel lymph node, which contains a poly-gamma-glutamic acid/optical imaging dye complex that, when injected subcutaneously in vivo, remains in the sentinel lymph node for a relatively long period of time and has a low tendency to migrate to other lymph nodes. The present invention provides a poly-gamma-glutamic acid/fluorescent dye complex, which contains no radiopharmaceutical and is harmless to the human body. The use of the poly-gamma-glutamic acid/fluorescent dye complex makes it possible to accurately detect the position of a sentinel lymph node in real time without concerns about radioactive contamination.
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17.发明申请HIGH-SENSITIVITY MAGNETIC RESONANCE IMAGING NANO-CONTRAST AGENT BASED ON AN ANIONIC POLYMER AND CATIONIC POLYMER ION COMPLEX, AND A PRODUCTION METHOD THEREFOR 有权基于阴离子聚合物和阳离子聚合物复合物的高灵敏度磁共振成像纳米对比剂及其制备方法公开(公告)号：US20140170077A1
公开(公告)日：2014-06-19
申请号：US14110138
申请日：2011-04-07
Applicant: Moon-Hee Sung , Yong Taik Lim , Young-Woock Noh , Il Han Lee , Hyun Min Kim
Inventor： Moon-Hee Sung , Yong Taik Lim , Young-Woock Noh , Il Han Lee , Hyun Min Kim
IPC: A61K49/12
CPC classification number: A61K49/126 , A61K49/1863 , A61K49/1872
Abstract: The present invention relates to a nano-composite containing anionic and cationic polymers and a method for preparing thereof, and more particularly to a poly-gamma-glutamic acid (γ-PGA)/chitosan/manganese iron oxide nanoparticle composite prepared by encapsulating iron oxide-based nanoparticles in a γ-PGA/chitosan polymer composite using the ionic self-assembly properties of poly-gamma-glutamic acid (γ-PGA) and chitosan, which are biocompatible polymer materials, and to a method for preparing thereof.The present invention provides a magnetic resonance imaging nano-contrast agent based on a nanoparticle composite including iron oxide-based nanoparticles encapsulated in a self-assembled composite of anionic poly-gamma-glutamic acid (γPGA) and cationic chitosan. The iron oxide-based nanoparticles encapsulated in the composite interact with each other to produce a synergistic effect on the amplification of magnetic resonance signals, and thus have an relatively excellent contrast effect compared to when they exist as single particles.
Abstract translation: 本发明涉及含有阴离子和阳离子聚合物的纳米复合物及其制备方法，更具体地涉及通过包封氧化铁制备的聚-γ-谷氨酸（γ-PGA）/壳聚糖/锰铁氧体纳米颗粒复合材料 基于聚-γ-谷氨酸（γ-PGA）和壳聚糖的离子自组装性质的γ-PGA /壳聚糖复合材料的生物相容性聚合物材料的制备方法。 本发明提供一种基于纳米颗粒复合材料的磁共振成像纳米造影剂，其包括封装在阴离子聚-γ-谷氨酸（γPGA）和阳离子壳聚糖的自组装复合物中的基于氧化铁的纳米颗粒。 封装在复合材料中的基于氧化铁的纳米颗粒彼此相互作用以对磁共振信号的扩增产生协同效应，因此与作为单个颗粒存在时相比具有相对优异的对比效果。
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18.发明授权Stable constitutively high expression vector for preparing HPV vaccine and recombinant lactic acid bacteria transformed thereby 有权用于制备HPV疫苗和由此转化的重组乳酸菌的稳定的组成型高表达载体公开(公告)号：US08685721B2
公开(公告)日：2014-04-01
申请号：US13143700
申请日：2010-01-08
Applicant: Moon-Hee Sung , Haryoung Poo , Il Han Lee
Inventor： Moon-Hee Sung , Haryoung Poo , Il Han Lee
CPC classification number: C12N15/746 , A61K39/12 , A61K2039/523 , A61K2039/542 , C12N2710/20034 , C12N2710/20045 , C12N2810/55
Abstract: A surface expression vector for preparing HPV immunogenic compositions, in which the surface expression vector contains a gene encoding a repE mutant protein having an amino acid sequence of SEQ ID NO: 1, a promoter, a poly-gamma-glutamate synthetase complex gene, and a gene which is linked with the poly-gamma-glutamate synthetase complex gene and encodes a tumor induction-associated antigen protein of human papillomavirus.An expression vector constitutively expressing a high level of the human papillomavirus (HPV) antigen protein is provided. Also, a recombinant lactic acid bacteria, transformed with the expression vector and expressing the HPV antigen protein on the surface thereof, and a composition comprising the recombinant lactic acid bacteria are provided. The recombinant lactic acid bacteria and the composition are very effective as a immunogenic composition for the treatment of cervical cancer, because they can be applied orally or directly to the vagina.
Abstract translation: 用于制备HPV免疫原性组合物的表面表达载体，其中所述表面表达载体含有编码具有SEQ ID NO：1的氨基酸序列的repE突变蛋白的基因，启动子，聚-γ-谷氨酸合成酶复合物基因和 与聚-γ-谷氨酸合成酶复合物基因连接并编码人乳头瘤病毒的肿瘤诱导相关抗原蛋白的基因。 提供了组成型表达高水平人乳头瘤病毒（HPV）抗原蛋白的表达载体。 此外，提供了用表达载体转化并在其表面上表达HPV抗原蛋白的重组乳酸菌和包含重组乳酸菌的组合物。 重组乳酸菌和组合物作为用于治疗子宫颈癌的免疫原性组合物是非常有效的，因为它们可以口服或直接施用于阴道。
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19.发明申请COMPOSITION FOR IMPROVING TLR-MEDIATED CELLULAR IMMUNITY COMPRISING POLY-GAMMA-GLUTAMIC ACID 审中-公开用于改善包含多糖 - 谷氨酸的TLR介导的细胞免疫的组合物公开(公告)号：US20100255040A1
公开(公告)日：2010-10-07
申请号：US12682662
申请日：2007-10-15
Applicant: Moon-Hee Sung , Chul Joong Kim , Haryoung Poo , Il Han Lee , Yang-Hyun Kim
Inventor： Moon-Hee Sung , Chul Joong Kim , Haryoung Poo , Il Han Lee , Yang-Hyun Kim
CPC classification number: A61K31/765
Abstract: The present invention relates to a composition for improving cellular immunity, which comprises an effective dose of poly-gamma-glutamic acid, and more particularly, to a composition for improving cellular immunity comprising poly-gamma-glutamic acid, which has effects of inducing enhancement of TLR-mediated Th1 cellular immunity and improving antigen presenting activity to maintain the improved activity. The inventive composition comprising an effective dose of poly-gamma-glutamic acid has very little toxicity and side effects, and can be added to a vaccine composition for preventing and treating animal viral or bacterial infections and cancer, or a vaccine composition for preventing and treating human viral or bacterial infections and cancer to show cellular immunity-enhancing effects.
Abstract translation: 本发明涉及一种用于改善细胞免疫的组合物，其包含有效剂量的聚-γ-谷氨酸，更具体地，涉及包含多聚γ-谷氨酸的组合物，所述组合物具有诱导增强的作用 的TLR介导的Th1细胞免疫并改善抗原呈递活性以维持改善的活性。 包含有效剂量的聚-γ-谷氨酸的本发明组合物具有非常少的毒性和副作用，并且可以加入用于预防和治疗动物病毒或细菌感染和癌症的疫苗组合物或用于预防和治疗的疫苗组合物 人类病毒或细菌感染和癌症显示细胞免疫增强作用。
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公开(公告)号：US20100196956A1
公开(公告)日：2010-08-05
申请号：US12532605
申请日：2008-03-21
Applicant: Moon Hee Sung , Chul Joong Kim , Seung-Pyo Hong , Haryoung Poo , Il Han Lee , Ji Yeon Kim , Kwang Kim
Inventor： Moon Hee Sung , Chul Joong Kim , Seung-Pyo Hong , Haryoung Poo , Il Han Lee , Ji Yeon Kim , Kwang Kim
CPC classification number: C12N15/746 , C12N9/1276
Abstract: Disclosed herein are an aldolase gene promoter and the use thereof, more particularly, disclosed are a promoter of aldolase gene derived from Lactobacillus casei, having a base sequence of SEQ ID NO: 1, an expression vector containing said promoter, and a recombinant microorganism transformed with said expression vector. The recombinant microorganism transformed with the expression vector containing the disclosed promoter can effectively express a target protein on the surface thereof, and thus will be useful as vaccine vehicles and the like.
Abstract translation: 本文公开了醛缩酶基因启动子及其用途，更具体地，公开了源自干酪乳杆菌的醛缩酶基因的启动子，其具有SEQ ID NO：1的碱基序列，含有所述启动子的表达载体和转化的重组微生物 与所述表达载体。 用含有公开的启动子的表达载体转化的重组微生物可以在其表面上有效地表达靶蛋白质，因此可用作疫苗载体等。
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