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公开(公告)号：US20100144737A1
公开(公告)日：2010-06-10
申请号：US12316028
申请日：2008-12-08
Applicant: Felice Aisha Chow , Stephen J. Klaus , Ingrid Langsetmo Parobok
Inventor： Felice Aisha Chow , Stephen J. Klaus , Ingrid Langsetmo Parobok
CPC classification number: C12N5/0636 , A61K31/00 , A61K31/19 , A61K31/44 , A61K31/50 , C12N2501/999
Abstract: The present invention relates to methods and compounds useful for inhibiting T helper cell differentiation. Methods and compounds for decreasing IL-12 signaling in T helper cells are also provided.
Abstract translation: 本发明涉及可用于抑制T辅助细胞分化的方法和化合物。 还提供了用于减少T辅助细胞中IL-12信号传导的方法和化合物。
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公开(公告)号：US20050020487A1
公开(公告)日：2005-01-27
申请号：US10861590
申请日：2004-06-03
Applicant: Stephen Klaus , Christopher Molineaux , Thomas Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd Seeley , Robert Stephenson
Inventor： Stephen Klaus , Christopher Molineaux , Thomas Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd Seeley , Robert Stephenson
IPC: A61K31/00 , A61K31/165 , A61K31/395 , A61P7/06 , A61K38/16
CPC classification number: C07D217/24 , A61K31/00 , A61K31/165 , A61K31/17 , A61K31/395 , A61K31/472 , C07C275/40
Abstract: The present invention relates to methods and compounds for regulating or enhancing erthropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
Abstract translation: 本发明涉及用于调节或增强红细胞生成和铁代谢以及用于治疗或预防慢性疾病的铁缺乏和贫血的方法和化合物。
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公开(公告)号：US09775902B2
公开(公告)日：2017-10-03
申请号：US13180262
申请日：2011-07-11
Applicant: Stephen J. Klaus , Ingrid Langsetmo Parobok , Christopher T. Jacob
Inventor： Stephen J. Klaus , Ingrid Langsetmo Parobok , Christopher T. Jacob
IPC: A61K31/121 , A61K31/194 , A61K45/06 , A61K38/49
CPC classification number: A61K45/06 , A61K31/121 , A61K31/194 , A61K38/49 , A61K2300/00
Abstract: The present invention relates to methods and agents useful for the treatment of stroke, including ischemic stroke and hemorrhagic stroke. In particular, methods and agents for treating stroke in a subject are provided, wherein the agent is administered prior to diagnosis of the stroke as an ischemic stroke or a hemorrhagic stroke.
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公开(公告)号：US08604013B2
公开(公告)日：2013-12-10
申请号：US12804042
申请日：2010-07-12
Applicant: Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
Inventor： Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
CPC classification number: C07D217/24 , A61K31/00 , A61K31/165 , A61K31/17 , A61K31/395 , A61K31/472 , C07C275/40
Abstract: The present invention relates to methods for treating anemia in a subject having a low percent transferrin saturation by administering to the subject an effective amount of a compound that inhibits hypoxia-inducible factor prolyl hydroxylase activity.
Abstract translation: 本发明涉及通过向受试者施用有效量的抑制缺氧诱导因子脯氨酰羟化酶活性的化合物来治疗具有低转铁蛋白饱和度的受试者的贫血的方法。
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公开(公告)号：US20110038950A1
公开(公告)日：2011-02-17
申请号：US12804042
申请日：2010-07-12
Applicant: Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
Inventor： Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
IPC: A61K31/33 , A61K33/26 , A61K31/51 , A61K31/525 , A61K31/714 , A61K31/4415 , A61P7/06
CPC classification number: C07D217/24 , A61K31/00 , A61K31/165 , A61K31/17 , A61K31/395 , A61K31/472 , C07C275/40
Abstract: The present invention relates to methods and compounds for regulating or enhancing erythropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
Abstract translation: 本发明涉及用于调节或增强红细胞生成和铁代谢以及治疗或预防慢性疾病的铁缺乏和贫血的方法和化合物。
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Patent Agency Ranking
公开(公告)号：US20100280044A1
公开(公告)日：2010-11-04
申请号：US12804029
申请日：2010-07-12
Applicant: Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
Inventor： Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
IPC: A61K31/496 , A61K31/44 , A61K31/472 , A61P7/06 , A61P7/00
CPC classification number: C07D217/24 , A61K31/00 , A61K31/165 , A61K31/17 , A61K31/395 , A61K31/472 , C07C275/40
Abstract: The present invention relates to methods and compounds for regulating or enhancing erthropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
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公开(公告)号：US20070259960A1
公开(公告)日：2007-11-08
申请号：US11704535
申请日：2007-02-08
Applicant: Stephen Klaus , Ingrid Langsetmo Parobok , Christopher Jacob
Inventor： Stephen Klaus , Ingrid Langsetmo Parobok , Christopher Jacob
IPC: A61K31/194 , A61P9/10
CPC classification number: A61K45/06 , A61K31/121 , A61K31/194 , A61K38/49 , A61K2300/00
Abstract: The present invention relates to methods and agents useful for the treatment of stroke, including ischemic stroke and hemorrhagic stroke. In particular, methods and agents for treating stroke in a subject are provided, wherein the agent is administered prior to diagnosis of the stroke as an ischemic stroke or a hemorrhagic stroke.
Abstract translation: 本发明涉及可用于治疗中风的方法和药剂，包括缺血性卒中和出血性中风。 特别地，提供了用于治疗受试者中风的方法和药剂，其中所述药物在诊断为中风之前作为缺血性中风或出血性中风进行施用。
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公开(公告)号：US08629131B2
公开(公告)日：2014-01-14
申请号：US12804066
申请日：2010-07-12
Applicant: Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
Inventor： Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
CPC classification number: C07D217/24 , A61K31/00 , A61K31/165 , A61K31/17 , A61K31/395 , A61K31/472 , C07C275/40
Abstract: The present invention relates to methods for increasing iron absorption in a subject by administering to the subject an effective amount of a compound that inhibits hypoxia-inducible factor prolyl hydroxylase activity.
Abstract translation: 本发明涉及通过向受试者施用有效量的抑制缺氧诱导因子脯氨酰羟化酶活性的化合物来增加受试者的铁吸收的方法。
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公开(公告)号：US08604012B2
公开(公告)日：2013-12-10
申请号：US12804033
申请日：2010-07-12
Applicant: Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
Inventor： Stephen J. Klaus , Christopher J. Molineaux , Thomas B. Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd W. Seeley , Robert C. Stephenson
CPC classification number: C07D217/24 , A61K31/00 , A61K31/165 , A61K31/17 , A61K31/395 , A61K31/472 , C07C275/40
Abstract: The present invention relates to methods and compounds for increasing serum iron in a subject.
Abstract translation: 本发明涉及用于增加受试者血清铁的方法和化合物。
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公开(公告)号：US08124582B2
公开(公告)日：2012-02-28
申请号：US10729704
申请日：2003-12-04
Applicant: Volkmar Guenzler-Pukall , Stephen J. Klaus , Ingrid Langsetmo Parobok , Todd W. Seeley
IPC: A61K38/17
CPC classification number: A61K38/1709 , A61K31/00 , A61K31/437 , A61K31/44 , A61K31/4425 , A61K31/47 , A61K31/472 , A61K31/4745 , A61K31/502
Abstract: The present invention relates to methods and compounds for regulating glucose metabolism, achieving glucose homeostasis, and decreasing blood glucose levels. Methods and compounds for treating or preventing diabetes, hyperglycemia, and disorders and conditions associated with altered or impaired glucose metabolism are also provided.
Abstract translation: 本发明涉及用于调节葡萄糖代谢，实现葡萄糖体内平衡和降低血糖水平的方法和化合物。 还提供了用于治疗或预防糖尿病，高血糖症和与葡萄糖代谢改变或受损的疾病和病症相关的方法和化合物。
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