公开(公告)号：US5285788A

公开(公告)日：1994-02-15

申请号：US962145

申请日：1992-10-16

Applicant: James W. Arenson ,  Ismayil M. Guracar ,  Janna G. Clark ,  Marc D. Weinshenker

Inventor： James W. Arenson ,  Ismayil M. Guracar ,  Janna G. Clark ,  Marc D. Weinshenker

IPC: A61B8/06 ,  A61B8/14 ,  G01N29/06 ,  G01N29/44 ,  G01P5/00 ,  G01S7/52 ,  G01S15/89 ,  A61B8/00

CPC classification number: G01S15/8979 ,  A61B8/06 ,  A61B8/13 ,  G01N29/0609 ,  G01S7/5206 ,  G01S7/52071 ,  G01S7/52074 ,  A61B8/0883

Abstract: An ultrasound tissue imaging system having an acoustic transducer, B-mode imaging means to produce with said transducer an electronically scanned B-mode image of tissue under examination, Doppler imaging means that accepts and processes large amplitude, low frequency signals to produce with said transducer an electronically scanned acoustic image of moving tissue, and color display means for displaying the B-mode image as a two-dimensional image with echo intensities encoded using a first mapping function and for simultaneously displaying Doppler information from moving tissue as a two-dimensional image using a second and distinct mapping function that is spatially coordinated with and superimposed upon said B-mode image to augment the B-mode image.

Abstract translation: 一种具有声换能器的超声组织成像系统，具有所述换能器的B模式成像装置，用于检查的组织的电子扫描的B模式图像，多普勒成像装置，其接收并处理大幅度的低频信号以产生所述换能器 移动组织的电子扫描声像，以及彩色显示装置，用于将B模式图像显示为具有使用第一映射功能编码的回波强度的二维图像，并且用于同时显示来自移动组织的多普勒信息作为二维图像 使用与所述B模式图像空间协调并且叠加在所述B模式图像上的第二和不同的映射函数来增加B模式图像。

公开(公告)号：US09033885B2

公开(公告)日：2015-05-19

申请号：US12609759

申请日：2009-10-30

Applicant: Hira V. Thapliyal ,  David A. Gallup ,  James W. Arenson

Inventor： Hira V. Thapliyal ,  David A. Gallup ,  James W. Arenson

IPC: A61B8/00 ,  A61N7/00 ,  A61B8/12 ,  A61N7/02 ,  A61B17/00 ,  A61B18/00 ,  A61B19/00

CPC classification number: A61N7/00 ,  A61B8/12 ,  A61B2017/00084 ,  A61B2017/00092 ,  A61B2017/00106 ,  A61B2018/00029 ,  A61B2018/00642 ,  A61B2090/061 ,  A61N7/022 ,  A61N2007/0052 ,  A61N2007/0073 ,  A61N2007/0078

Abstract: Systems and methods for ablating tissue include an ablation device having an energy source and a sensor. The energy source provides a beam of energy directable to target tissue, and the sensor senses energy reflected back from the target tissue. The sensor collects various information from the target tissue in order to facilitate adjustment of ablation operating parameters, such as changing power or position of the energy beam. Gap distance between the energy source and target tissue, energy beam incident angle, tissue motion, tissue type, lesion depth, etc. are examples of some of the information that may be collected during the ablation process and used to help control ablation of the tissue.

公开(公告)号：US08607800B2

公开(公告)日：2013-12-17

申请号：US13630652

申请日：2012-09-28

Applicant: Hira V. Thapliyal ,  David A. Gallup ,  James W. Arenson

Inventor： Hira V. Thapliyal ,  David A. Gallup ,  James W. Arenson

IPC: A61B19/00

CPC classification number: A61B17/320068 ,  A61B17/2202 ,  A61B18/1492 ,  A61B18/24 ,  A61B2017/00106 ,  A61B2017/00243 ,  A61B2017/003 ,  A61B2017/22024 ,  A61B2018/00029 ,  A61N7/02 ,  A61N7/022 ,  A61N2007/0078

Abstract: A tissue ablation system for treating fibrillation in a patient comprises a steerable interventional catheter having an energy source that emits a beam of energy to ablate tissue thereby creating a conduction block for aberrant electrical pathways. The system also includes a handle disposed near a proximal end of the interventional catheter and has an actuation mechanism for steering the interventional catheter. A console allows the system to be controlled and provides power to the system, and a display pod is electrically coupled with the console. The display pod has a display panel to display system information to a user and allows the user to control the system. A catheter pod is releasably coupled with the handle electrically and mechanically, and also electrically coupled with the display pod.

公开(公告)号：US08475379B2

公开(公告)日：2013-07-02

申请号：US12620287

申请日：2009-11-17

Applicant: Hira V. Thapliyal ,  David A. Gallup ,  James W. Arenson ,  Paul Mohr ,  Tim Proulx ,  Robert A. Brommer

Inventor： Hira V. Thapliyal ,  David A. Gallup ,  James W. Arenson ,  Paul Mohr ,  Tim Proulx ,  Robert A. Brommer

IPC: A61B8/00

CPC classification number: A61N7/022 ,  A61B8/12 ,  A61B8/445 ,  A61B8/4488 ,  A61B8/4494 ,  A61B2018/00023 ,  A61B2090/3782 ,  G01S15/8952 ,  G01S15/899

Abstract: A transducer subassembly with combined imaging and therapeutic capabilities is disclosed. The subassembly includes heat sinks that are configured to maintain the transducer at a low operating temperature so that the transducer operates at high efficiency and also can handle a wider range of frequencies. The subassembly is also configured to allow cooling fluid to flow past the transducer element. One heat sink in the subassembly also acts as an acoustic matching layer and another heat sink acts as a backing. Alternatively, the second heat sink which acts as a backing is optional. The transducer is configured to transmit at one power level for imaging, and at a second power level for ablating. The transducer may comprise sub-elements transmitting at different power levels. The subassembly may be operated at one power level for imaging and a second power level for ablating.

Abstract translation: 公开了具有组合成像和治疗能力的传感器子组件。 子组件包括散热器，其被配置为将换能器保持在低工作温度，使得换能器以高效率运行并且还可以处理更宽的频率范围。 该子组件还构造成允许冷却流体流过换能器元件。 子组件中的一个散热器还用作声匹配层，另一散热器用作背衬。 或者，用作背衬的第二散热器是可选的。 换能器被配置为以一个功率电平进行成像传输，并且在第二功率电平下进行烧蚀。 换能器可以包括以不同功率电平发送的子元件。 子组件可以在用于成像的一个功率水平下操作和用于烧蚀的第二功率水平。

公开(公告)号：US20130096592A1

公开(公告)日：2013-04-18

申请号：US13630652

申请日：2012-09-28

Applicant: Hira V. THAPLIYAL ,  David A. GALLUP ,  James W. ARENSON

Inventor： Hira V. THAPLIYAL ,  David A. GALLUP ,  James W. ARENSON

IPC: A61N7/02

CPC classification number: A61B17/320068 ,  A61B17/2202 ,  A61B18/1492 ,  A61B18/24 ,  A61B2017/00106 ,  A61B2017/00243 ,  A61B2017/003 ,  A61B2017/22024 ,  A61B2018/00029 ,  A61N7/02 ,  A61N7/022 ,  A61N2007/0078

Abstract: A tissue ablation system for treating fibrillation in a patient comprises a steerable interventional catheter having an energy source that emits a beam of energy to ablate tissue thereby creating a conduction block for aberrant electrical pathways. The system also includes a handle disposed near a proximal end of the interventional catheter and has an actuation mechanism for steering the interventional catheter. A console allows the system to be controlled and provides power to the system, and a display pod is electrically coupled with the console. The display pod has a display panel to display system information to a user and allows the user to control the system. A catheter pod is releasably coupled with the handle electrically and mechanically, and also electrically coupled with the display pod.

Abstract translation: 用于治疗患者原纤维化的组织消融系统包括具有能量源的可引导介入​​导管，所述能量源发射能量束以消融组织，从而为异常电通路形成传导阻滞。 该系统还包括设置在介入导管的近端附近的手柄，并具有用于转导介入导管的致动机构。 控制台允许系统被控制并为系统提供电力，并且显示盒与控制台电耦合。 显示盒具有显示面板，用于向用户显示系统信息，并允许用户控制系统。 导管盒与手柄电气和机械可释放地联接，并且还与显示盒电耦合。

公开(公告)号：US08414508B2

公开(公告)日：2013-04-09

申请号：US12609274

申请日：2009-10-30

Applicant: Hira V. Thapliyal ,  David A. Gallup ,  James W. Arenson

Inventor： Hira V. Thapliyal ,  David A. Gallup ,  James W. Arenson

IPC: A61B17/00

CPC classification number: A61N7/022 ,  A61B5/0008 ,  A61B5/4893 ,  A61B8/08 ,  A61B90/98 ,  A61B2017/00106 ,  A61B2017/00243 ,  A61B2018/00005 ,  A61N2007/0026 ,  A61N2007/0078

Abstract: A tissue ablation method for treating atrial fibrillation in a patient comprises locating an ostium of a pulmonary vein and positioning an interventional catheter adjacent the ostium. The interventional catheter has an energy source. Collateral tissue adjacent the ostium is located and tissue around the ostium is ablated with energy from the energy source so as to form a contiguous lesion circumscribing the ostium. The lesion blocks aberrant electrical pathways in the tissue so as to reduce or eliminate the atrial fibrillation. The ablating is modified so as to avoid ablating or otherwise damaging the collateral tissue.

Abstract translation: 用于治疗患者心房颤动的组织消融方法包括定位肺静脉的口，并将介入导管定位在邻近口处。 介入导管具有能量源。 定位邻近口的附近组织，并且能量来自能量的能量消除口周围的组织，以形成围绕口的连续病变。 病变阻止组织中的异常电通路，以减少或消除心房颤动。 烧蚀被修改以避免消融或以其他方式损伤侧支组织。

公开(公告)号：US20110257563A1

公开(公告)日：2011-10-20

申请号：US12909642

申请日：2010-10-21

Applicant: Hira V. Thapliyal ,  David A. Gallup ,  James W. Arenson ,  Robert Brommer

Inventor： Hira V. Thapliyal ,  David A. Gallup ,  James W. Arenson ,  Robert Brommer

IPC: A61N7/02

CPC classification number: A61N7/022 ,  A61B2017/00053 ,  A61B2017/00092 ,  A61B2017/00106 ,  A61B2017/320069 ,  A61B2018/00029 ,  A61M25/0147 ,  A61M25/0152 ,  A61N2007/0091

Abstract: A tissue ablation system for treating fibrillation in a patient comprises a steerable interventional catheter having an energy source that emits a beam of energy to ablate tissue thereby creating a conduction block for aberrant electrical pathways. The system also includes a handle disposed near a proximal end of the interventional catheter and has an actuation mechanism for steering the interventional catheter. A console allows the system to be controlled and provides power to the system, and a display pod is electrically coupled with the console. The display pod has a display panel to display system information to a user and allows the user to control the system. A catheter pod is releasably coupled with the handle electrically and mechanically, and also electrically coupled with the display pod.

Abstract translation: 用于治疗患者原纤维化的组织消融系统包括具有能量源的可引导介入​​导管，该能量源发射能量束以消融组织，从而为异常电通路形成传导阻滞。 该系统还包括设置在介入导管的近端附近的手柄，并具有用于转导介入导管的致动机构。 控制台允许系统被控制并为系统提供电力，并且显示盒与控制台电耦合。 显示盒具有用于向用户显示系统信息的显示面板，并允许用户控制系统。 导管盒与手柄电气和机械可释放地联接，并且还与显示盒电耦合。

公开(公告)号：US07773074B2

公开(公告)日：2010-08-10

申请号：US11170323

申请日：2005-06-28

Applicant: James W. Arenson ,  John I. Jackson

Inventor： James W. Arenson ,  John I. Jackson

IPC: G06F3/041

CPC classification number: A61B8/00 ,  A61B8/4254 ,  A61B8/461 ,  A61B8/466 ,  A61B8/467 ,  A61B8/483 ,  G06F3/017 ,  G06F3/0346 ,  G06F3/04815 ,  G06F2203/04806

Abstract: A physical 3D volume object is manipulated to navigate through a volume image. The orientation of the volume object, such as a cube or other shaped device, is sensed. As the volume object is rotated, the viewing direction associated with three dimensional rendering rotates. The volume object may represent a viewer's eye or the object for determining the viewing direction from the volume object orientation. The volume object may be untethered and/or generally flat, allowing ease of use. The volume object may be associated with a shape of an organ or tissue to provide further frame of reference.

Abstract translation: 操纵物理3D卷对象以在卷映像中导航。 感测卷对象（诸如立方体或其它成形装置）的取向。 当卷对象旋转时，与三维渲染相关联的观看方向旋转。 卷对象可以表示观看者的眼睛或用于从卷对象方向确定观看方向的对象。 体积对象可以是无约束的和/或大致平坦的，允许易于使用。 体积对象可以与器官或组织的形状相关联，以提供进一步的参考框架。

公开(公告)号：US20100152582A1

公开(公告)日：2010-06-17

申请号：US12483174

申请日：2009-06-11

Applicant: Hira V. Thapliyal ,  David A. Gallup ,  James W. Arenson

Inventor： Hira V. Thapliyal ,  David A. Gallup ,  James W. Arenson

IPC: A61N7/02 ,  A61B18/18 ,  A61B18/02 ,  A61B18/04 ,  A61B8/00

CPC classification number: A61B18/02 ,  A61B18/1492 ,  A61B18/18 ,  A61B2017/00106 ,  A61B2017/00243 ,  A61B2018/00029 ,  A61B2018/00375 ,  A61B2018/0262 ,  A61B2018/1807 ,  A61N7/022

Abstract: A system for ablating tissue comprises an ergonomically shaped handpiece having a proximal end and a distal end. An energy source is near the distal end of the handpiece and is adapted to deliver energy to the tissue and create a zone of ablation that blocks abnormal electrical activity in the tissue. The system also includes a barrier near a front face of the energy source. The barrier is adapted to prevent direct contact between blood and the energy source so that the blood does not coagulate on the front face.

Abstract translation: 用于消融组织的系统包括具有近端和远端的符合人体工程学的手柄。 能量源靠近手持件的远端，并且适于将能量传递到组织并产生阻挡组织中异常电活动的消融区域。 该系统还包括靠近能源前表面的障碍物。 阻挡层适于防止血液和能量源之间的直接接触，使得血液在前表面上不凝结。

公开(公告)号：US20100114094A1

公开(公告)日：2010-05-06

申请号：US12609705

申请日：2009-10-30

Applicant: Hira V. Thapliyal ,  David A. Gallup ,  James W. Arenson

Inventor： Hira V. Thapliyal ,  David A. Gallup ,  James W. Arenson

IPC: A61B18/14 ,  A61B8/14

CPC classification number: A61N7/022 ,  A61B8/0883 ,  A61B8/0891 ,  A61B8/12 ,  A61B8/14 ,  A61B34/10 ,  A61B2017/00039 ,  A61B2090/3782 ,  A61N2007/0052 ,  G06F19/00 ,  G06F19/321 ,  G16H15/00 ,  G16H20/40

Abstract: Methods for ablating tissue in a patient having atrial fibrillation comprise advancing an elongate flexible shaft through a patient's vasculature into a chamber of a heart. The elongate flexible shaft has an energy source and a sensor. Tissue in the heart is scanned with the sensor and data about the tissue is captured. The captured data is grouped into one of a plurality of tissue classifications and an anatomical map of the tissue showing the grouped data is displayed. At least a portion of the tissue is ablated so as to form a conduction block that blocks aberrant electrical pathways in the heart. The ablated tissue is grouped into one or more predefined tissue classifications during or prior to the ablation.

Abstract translation: 具有心房颤动的患者中的消融组织的方法包括将细长的柔性轴穿过患者的脉管系统进入心脏的腔室。 细长的柔性轴具有能量源和传感器。 用传感器扫描心脏中的组织，并捕获关于组织的数据。 捕获的数据被分组为多个组织分类中的一个，并且显示组织数据的组织的解剖图。 组织的至少一部分被消融以形成阻挡心脏中的异常电通路的传导阻滞。 消融的组织在消融期间或之前被分组为一个或多个预定义的组织分类。