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17 条记录 (耗时 0.02 秒)

    Punctal cannula
    16.
    发明授权
    Punctal cannula 失效
    穿刺套管

    公开(公告)号：US06428502B1

    公开(公告)日：2002-08-06

    申请号：US09567175

    申请日：2000-05-08

    申请人： John C. Lang

    发明人： John C. Lang

    IPC分类号： A61M2500

    CPC分类号： A61F9/00772 ,  A61B17/3417 ,  A61B2017/3419 ,  A61M2025/1052 ,  A61M2210/0612

    摘要： A lacrimal cannula, which is used for the removal of plugs or obstructions from mammalian lacrimal canaliculi having a punctum, includes a body having a distal portion, a proximal portion, an external annulus disposed proximate the distal portion, and a hollow bore for fluid delivery from the distal portion. The external annulus has an outer diameter greater than the outer diameter of the distal portion. The distal portion is inserted into the mammalian punctum without dilating the punctum and the external annulus has a generally spherical geometry which forms a seal with the external surface of the punctum without dilating the punctum and without the necessity of forcefully pressing the cannula against the punctal tissue to create a seal. The distal portion also has a relatively short length so that the distal portion is easily inserted into the canaliculus without contacting the plug or obstruction and thus interfering with the formation of the punctal seal. The proximal portion is coupled to a hub for removably coupling the proximal portion to a conventional syringe. Once the external surface of the punctum is sealed, the cannula is then used to inject an ophthalmic fluid, which may or may not be heated, into the punctum so as to pressurize a portion of the canaliculus between the plug or obstruction and the punctum to dislodge the plug or obstruction.

    摘要翻译： 用于从具有泪点的哺乳动物泪小管切除塞子或障碍物的泪管包括具有远侧部分，近端部分，靠近远侧部分设置的外部环形物的主体和用于流体输送的中空孔 从远端部分。 外环具有大于远端部外径的外径。 远端部分插入到哺乳动物的泪点中而不扩张泪点，并且外环具有大致球形的几何形状，与泪点的外表面形成密封而不会扩大泪点，并且不需要强力地将插管压在泪点组织上 创造印章。 远端部分还具有相对较短的长度，使得远侧部分容易地插入小管中，而不会接触塞子或阻塞物，从而干扰形成泪点密封。 近端部分联接到轮毂，用于将近端部分可移除地联接到常规注射器。 一旦泪点的外表面被密封，然后将套管用于将可能被加热或不加热的眼液注射到泪点中，以便将插塞或阻塞物与泪点之间的小管的一部分加压到 排除堵塞或堵塞。

    Thermally-gelling drug delivery vehicles containing cellulose ethers
    17.
    发明授权
    Thermally-gelling drug delivery vehicles containing cellulose ethers 失效
    含有纤维素醚的胶凝药物输送载体

    公开(公告)号：US5618800A

    公开(公告)日：1997-04-08

    申请号：US518289

    申请日：1995-08-23

    申请人： Bhagwati P. Kabra ,  John C. Lang

    发明人： Bhagwati P. Kabra ,  John C. Lang

    IPC分类号： A61K9/06 ,  A61K9/00 ,  A61K47/38 ,  A61K31/715 ,  C08B11/02 ,  C08B11/08

    CPC分类号： A61K9/0048 ,  A61K47/38 ,  Y10S514/912 ,  Y10S514/913 ,  Y10S514/914

    摘要： Drug delivery vehicles which reversibly increase in either loss modulus or storage modulus, or both, upon contact with the eye, skin, mucous membrane or body cavity are disclosed. The vehicles contain one or more nonionic substituted cellulose ethers and do not require a charged surfactant or a pH-sensitive polymer for such increase in loss modulus or storage modulus, or both, upon administration. In one embodiment, the vehicles gel upon instillation in the eye.

    摘要翻译： 公开了与眼睛，皮肤，粘膜或体腔接触时可逆地增加损失模量或储能模量或两者的药物递送载体。 载体含有一种或多种非离子取代的纤维素醚，并且在施用时不需要带电荷的表面活性剂或pH敏感性聚合物来增加损耗模量或储能模量，或两者。 在一个实施方案中，车辆在滴眼时凝胶化。