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    Products and Methods
    5.
    发明申请
    Products and Methods 审中-公开
    产品与方法

    公开(公告)号：US20130039856A1

    公开(公告)日：2013-02-14

    申请号：US13581190

    申请日：2011-02-25

    申请人： David Weinkove

    发明人： David Weinkove

    IPC分类号： A61K31/42 ,  A61K31/505 ,  A61K38/02 ,  A61K39/395 ,  A61K31/655 ,  A61K31/519 ,  A61K31/26 ,  A61K31/438 ,  A61K31/436 ,  C07D261/16 ,  C12Q1/02 ,  A61K49/00 ,  C40B30/06 ,  G01N27/62 ,  A61P43/00 ,  A61K31/606

    CPC分类号： A61K31/606 ,  A23L33/15 ,  A23V2002/00 ,  A61K31/42 ,  A61K31/505 ,  A23V2200/302 ,  A23V2250/7058

    摘要： The present invention concerns medicaments for slowing ageing. The medicaments can include an inhibitor of microbial folate biosynthesis as well as agents capable of reducing folate uptake by an animal. Examples of such medicaments include inhibitors that reduce the activity of an enzyme in the folate biosynthesis pathway, such as sulfonamides including sulfamethoxazole. The invention also concerns a food supplement, additive, functional food, or nutraceutial comprising the inhibitor or agent or composition as discussed above, as well as methods for screening for an agent for use as a medicament for slowing ageing comprising determining whether a test agent inhibits microbial folate biosynthesis, or whether the test agent reduces folate uptake by a non-human animal.

    摘要翻译： 本发明涉及减缓老化的药物。 药物可以包括微生物叶酸生物合成的抑制剂以及能够降低动物叶酸摄取的药剂。 这些药物的实例包括降低叶酸生物合成途径中酶的活性的抑制剂，例如包括磺胺甲恶唑的磺酰胺。 本发明还涉及包含上述抑制剂或试剂或组合物的食品补充剂，添加剂，功能性食品或营养品，以及用于筛选用作减缓老化的药物的试剂的方法，包括测定试验剂是否抑制 微生物叶酸生物合成，或测试剂是否降低非人类动物的叶酸摄取。

    Compositions Comprising Edible Oils and Vitamins and/or Minerals and Methods for Making the Compositions
    7.
    发明申请
    Compositions Comprising Edible Oils and Vitamins and/or Minerals and Methods for Making the Compositions 有权
    包含食用油和维生素和/或矿物质的组合物和制备组合物的方法

    公开(公告)号：US20080274175A1

    公开(公告)日：2008-11-06

    申请号：US11579527

    申请日：2005-05-18

    申请人： Jack H. Schramm ,  James W. McGrath

    发明人： Jack H. Schramm ,  James W. McGrath

    IPC分类号： A61K9/48 ,  A61K31/20 ,  A61K31/59 ,  A61K31/355 ,  A61K31/714 ,  A61K31/44 ,  A61K31/4985 ,  A61P43/00

    CPC分类号： A23D9/007 ,  A23D7/005 ,  A23L33/11 ,  A23L33/115 ,  A23L33/12 ,  A23L33/15 ,  A23V2002/00 ,  A61K9/02 ,  A61K9/4858 ,  A23V2250/7058 ,  A23V2250/706 ,  A23V2250/1868 ,  A23V2250/7052 ,  A23V2250/187

    摘要： The invention provides compositions for an administration to a mammal orally or in a suppository that include one or more edible oils (preferably including one or more omega-3 fatty acids), one or more plant stanols, phytosterols, or esters thereof, and admixed in the one or more edible oils one or more water-soluble vitamins and/or minerals, for example, vitamins B6, B9 and/or B12. The invention also provides a method of making the compositions comprising mixing the foregoing components to form a suspension or emulsion of the vitamins and/or minerals in the edible oils. The mixture can be inserted into hollow soft or hard capsules, gelcaps or caplets. The edible oils can coat particles of the water-soluble vitamins and/or minerals, which may provide them with an improved absorption in the body due to an increased resistance to degradation in the acidic environment of the stomach.

    摘要翻译： 本发明提供了口服或栓剂给予哺乳动物的组合物，其包括一种或多种食用油（优选包括一种或多种ω-3脂肪酸），一种或多种植物甾烷醇，植物甾醇或其酯，并混合在 一种或多种食用油一种或多种水溶性维生素和/或矿物质，例如维生素B6，B9和/或B12。 本发明还提供一种制备组合物的方法，包括混合前述组分以形成食用油中的维生素和/或矿物质的悬浮液或乳液。 混合物可以插入中空的软或硬胶囊，胶囊或胶囊。 食用油可以涂覆水溶性维生素和/或矿物质的颗粒，这可能由于在胃的酸性环境中的降解性的增加而使其在体内具有改善的吸收。

    Methods of producing edible fungi containing activated folates and nutritional supplements containing activated folates
    10.
    发明申请
    Methods of producing edible fungi containing activated folates and nutritional supplements containing activated folates 有权
    生产含活性叶酸的食用真菌和含活性叶酸的营养补充剂的方法

    公开(公告)号：US20040258711A1

    公开(公告)日：2004-12-23

    申请号：US10821609

    申请日：2004-04-09

    发明人： Siddharth Shastri ,  Peilin Guo ,  Jarrow L. Rogovin

    IPC分类号： A61K035/84 ,  A01G001/04 ,  A61K031/525

    CPC分类号： C12N1/14 ,  A23L7/00 ,  A23L31/00 ,  A23L33/125 ,  A23L33/15 ,  A23V2002/00 ,  A61K36/07 ,  A61K36/074 ,  A23V2250/7058

    摘要： Methods are described for producing reduced, methylated, biologically active forms of folate, including 5-methyltetrahydrofolate (i.e. 5-methyltetrahydropteroylglutamic acid), 5-formyltetrahydrofolate, 10-formyltetrahydrofolate and tetrahydrofolate. Edible mushroom-producing fungi are cultivated to enhance the uptake of pteroylmonoglutamate (synthetic folate) into edible portions of the plants. The mushroom-producing fungi reduce and methylate the pteroylmonoglutamates into activated folates. The cultivated mycelia or mushrooms of the mushroom-producing fungi are harvested, and may be consumed directly or processed into oral dosage formats (capsules, tablets, softgels, powders, gel packets, liquids, nutritional bars, beverages) for use as functional foods or nutritional supplements.

    摘要翻译： 描述了用于生产还原的，甲基化的，生物活性形式的叶酸的方法，包括5-甲基四氢叶酸（即5-甲基四氢丙酰基谷氨酸），5-甲酰四氢叶酸，10-甲酰四氢叶酸和四氢叶酸。 栽培可食用的蘑菇生产真菌以增强叶酸甲羟丁酸（合成叶酸）摄入植物的可食用部分。 生产蘑菇的真菌减少并甲基化蝶呤单谷氨酸成为活化的叶酸。 收获产生蘑菇的真菌的培养的菌丝体或蘑菇，并且可以直接消毒或加工成用作功能性食品的口服剂型（胶囊，片剂，软胶囊，粉末，凝胶包，液体，营养棒，饮料）或 营养补充剂。