公开(公告)号：US06214809B1

公开(公告)日：2001-04-10

申请号：US09284704

申请日：1999-04-19

Applicant: Bernard Fermini ,  Joseph J. Lynch, Jr. ,  Joseph J. Salata ,  Richard J. Swanson

Inventor： Bernard Fermini ,  Joseph J. Lynch, Jr. ,  Joseph J. Salata ,  Richard J. Swanson

IPC: A61K3166

CPC classification number: A61K31/664 ,  A61K31/00 ,  A61K31/50 ,  A61K31/66 ,  Y10S514/821

Abstract: A method of treating or preventing supraventricular tachyarrhythmias is disclosed which comprises the use of a compound which selectively blocks the ultra-rapidly-activating delayed rectifier K+ current (IKur) of the human atrium.

Abstract translation: 公开了一种治疗或预​​防室上性快速性心律失常的方法，其包括使用选择性阻断人类心房的超快速活化延迟整流K +电流（IKur）的化合物。

公开(公告)号：US5969017A

公开(公告)日：1999-10-19

申请号：US958958

申请日：1997-10-28

Applicant: Joseph J. Lynch, Jr. ,  Richard J. Swanson ,  Joseph J. Salata ,  Bernard Fermini

Inventor： Joseph J. Lynch, Jr. ,  Richard J. Swanson ,  Joseph J. Salata ,  Bernard Fermini

IPC: C07D237/24 ,  A61K31/00 ,  A61K31/50 ,  A61K31/66 ,  A61K45/00 ,  A61P9/00 ,  A61P9/06 ,  A61P43/00 ,  C07F9/53 ,  C08J5/52 ,  A01N57/18 ,  A01N57/34 ,  C08K5/51

CPC classification number: C07F9/5333 ,  A61K31/00 ,  A61K31/50 ,  A61K31/66 ,  C07D237/24 ,  C07F9/532 ,  C07F9/5325

Abstract: This application discloses a method of treating or preventing atrial arrhythmias which utilizes compounds which are blockers of the ultra-rapidly-activating delayed rectifier K.sup.+ current (I.sub.Kur) of the human atrium in a use-dependent and/or rate dependent manner, and which provide the selective block preferentially at fast heart rates so that the effect is realized or maximized when required.

Abstract translation: 本申请公开了一种治疗或预​​防心房心律失常的方法，该方法利用作为人类心房的超快速激活延迟整流K +电流（IKur）的阻断剂的化合物，其依赖于和/或速率依赖的方式，其提供 选择性阻断优先以快速心率，使得当需要时实现或最大化效果。

公开(公告)号：US5776930A

公开(公告)日：1998-07-07

申请号：US881399

申请日：1997-06-24

Applicant: Joseph J. Lynch, Jr. ,  Joseph J. Salata

Inventor： Joseph J. Lynch, Jr. ,  Joseph J. Salata

IPC: A61K31/5513 ,  C07D243/20 ,  C07D243/22 ,  C07D243/24 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D471/04 ,  C07D495/04 ,  A61K31/545 ,  A61K31/135 ,  A61K31/16 ,  A61K31/38

CPC classification number: C07D401/12 ,  A61K31/5513 ,  C07D243/20 ,  C07D243/22 ,  C07D243/24 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D471/04 ,  C07D495/04 ,  Y10S514/821

Abstract: A method of preventing, treating, terminating and protecting against cardiac arrhythmias, such as atrial, supraventricular and ventricular ectopy, tachycardia, flutter or fibrillation, including atrial, supraventricular and ventricular arrhythmias resulting from myocardial ischemic injury in a patient in need thereof, comprising administration of a selective I.sub.Ks antagonist and a beta-adrenergic receptor blocking agent, administered in combined therapy either simultaneously, separately or sequentially is presented. Additionally, a pharmaceutical preparation comprising a selective I.sub.Ks antagonist and a beta-adrenergic receptor blocking agent, wherein these compounds are administered simultaneously, separately or sequentially is presented.

Abstract translation: 一种预防，治疗，终止和保护免受心律失常的方法，例如心房，室上和室性异位，心动过速，扑动或颤动，包括由有需要的患者引起的心肌缺血性损伤引起的心房，室上性和室性心律失常的方法，包括给药 的选择性IKs拮抗剂和β-肾上腺素能受体阻断剂，以联合治疗同时，分别或顺序施用。 此外，提供了包含选择性IKs拮抗剂和β-肾上腺素能受体阻断剂的药物制剂，其中这些化合物分别或顺序同时施用。

公开(公告)号：US5020403A

公开(公告)日：1991-06-04

申请号：US368833

申请日：1989-06-20

Applicant: Joseph J. D'Angelo ,  Joseph J. D'Angelo, Jr.

Inventor： Joseph J. D'Angelo ,  Joseph J. D'Angelo, Jr.

IPC: B26D7/02 ,  B26F3/12

CPC classification number: B26F3/12 ,  B26D7/025 ,  Y10T29/49798 ,  Y10T83/293 ,  Y10T83/4529 ,  Y10T83/4594 ,  Y10T83/4645

Abstract: A web feeding, cutting and dispensing machine includes a pneumatic cylinder for moving a hot wire to cut measured-length sheets from web stock. A pneumatic clamp cylinder moves a clamp bar for momentarily clamping the web during cutting. Upon pressing a start button, a pneumatic control valve sequentially operates the respective cutting and clamping cylinders for quickly retracting the hot wire, while more slowly retracting the clamp. Conversely, after the next measured web length has advanced, this control valve again sequentially operates these two cylinders in reverse order for quickly clamping while slower cutting. This dual control by one valve is advantageously achieved (1) by throttling air flow in retracting the clamp cylinder relative to retracting the cut cylinder, and conversely (2) by throttling air flow in advancing the cut cylinder relative to advancing the clamp cylinder. A compact machine has a hollow movable clamp bar torque member for equally driving both clamp arms by one clamp cylinder at one side of the machine. This movable clamp bar also serves as a passageway containing a torque shaft for equally driving both cutting arms by one cut cylinder at the other side. A "floating" upper feed roll accommodates different thicknesses of foam web without requiring adjustment and enables a lower feed roll to rotate continuously regardless of whether the web is clamped or not. Each cut sheet is conveniently held by a holder ready for use and is gently removable from the holder.

Abstract translation: 卷筒纸送料，切割和分配机器包括用于移动热丝以从卷材原料切割测量长度的片材的气缸。 气动夹紧缸在切割过程中移动夹紧杆以暂时夹紧纸幅。 当按下启动按钮时，气动控制阀顺序地操作相应的切割和夹紧气缸，以快速缩回热丝，同时更缓慢地缩回夹具。 相反，在下一个测量的卷筒纸长度提前后，该控制阀再次依次顺序地操作这两个气缸，以便在较慢的切割时快速夹紧。 有利的是通过一个阀的这种双重控制（1）通过在缩回夹紧缸时相对于缩回切割的圆筒而节流空气流，并且相反地（2）通过在推动切割圆柱体相对于夹紧圆柱体前进而节流气流。 紧凑型机器具有中空的可动夹杆扭矩构件，用于通过机器一侧的一个夹紧缸同样驱动两个夹紧臂。 该可动夹杆还用作通道，该通道包含用于在另一侧通过一个切割圆筒同时驱动两个切割臂的扭矩轴。 “浮动”上进料辊容纳不同厚度的泡沫纤维网，而不需要调节，并且使得较低的进料辊能够连续旋转，而不管卷材是否被夹紧。 每个切割片由保持器方便地保持准备使用，并且从保持器轻轻地移除。

公开(公告)号：US20100125320A1

公开(公告)日：2010-05-20

申请号：US12607806

申请日：2009-10-28

Applicant: Jeannette C. Polkinghorne ,  Joseph A. Cihlar ,  Mitchell L. Horn-Wyffels ,  Joseph J. Nelsen ,  Raymond Gessler ,  Erin K. Webb ,  Joseph J. Schachtner ,  Arienne P. Simon ,  Andrew De Kock

Inventor： Jeannette C. Polkinghorne ,  Joseph A. Cihlar ,  Mitchell L. Horn-Wyffels ,  Joseph J. Nelsen ,  Raymond Gessler ,  Erin K. Webb ,  Joseph J. Schachtner ,  Arienne P. Simon ,  Andrew De Kock

IPC: A61N1/05 ,  B29C45/14 ,  B44C1/22

CPC classification number: A61N1/05 ,  A61N1/375

Abstract: The various embodiments disclosed herein relate to medical electrical leads. More specifically, certain embodiments relate to leads having one or more drug-eluting components that are overmolded or otherwise positioned on the lead. Other embodiments relate to leads having one or more patterned surfaces, including some leads with one or more patterned surfaces over which one or more drug-eluting components are positioned. Further implementations relate to leads having one or more overmolded patterned surfaces, including some embodiments in which the overmolded surfaces contain at least one drug-eluting component.

Abstract translation: 本文公开的各种实施例涉及医疗电引线。 更具体地，某些实施方案涉及具有一种或多种药物洗脱组分的引线，所述药物洗脱组分被包覆成型或以其他方式定位在引线上。 其它实施方案涉及具有一个或多个图案化表面的引线，包括具有一个或多个图案化表面的一些引线，一个或多个药物洗脱组分位于该图案表面上。 进一步的实施方式涉及具有一个或多个包覆成型的图案化表面的引线，包括其中包覆成型的表面含有至少一种药物洗脱组分的一些实施方案。

公开(公告)号：US12214325B1

公开(公告)日：2025-02-04

申请号：US17743324

申请日：2022-05-12

Applicant: Joseph J Calvo

Inventor： Joseph J Calvo

IPC: B01F31/00 ,  B01F33/84 ,  B01F101/21

Abstract: A processor-applicator system configured for the processing of at least one, and in some instance a plurality of compounds into a formulation for the subsequent expulsion therefrom. Such a system may comprise an applicator system and an intermediate section, the latter of which may house at least one cartridge having at least one compound disposed therein. Such cartridge may be disposed in mechanical relation to a vibratory component and a projectile chamber, each of which may effectuate a transfer of kinetic energy onto the at least one cartridge, thereby effectuating various changes to the compound therein, and resulting in the withdrawal of at least a portion of such compound into a reservoir of the applicator system for the subsequent expulsion therefrom. Such a system may be configured for use in a variety of fields, such as cosmetics, pharmaceuticals, beverages, and foodstuffs, and thus may operate with a plurality of compounds.

公开(公告)号：US12157100B1

公开(公告)日：2024-12-03

申请号：US17318230

申请日：2021-05-12

Applicant: Joseph J. Wrubel

Inventor： Joseph J. Wrubel

IPC: B01F35/00 ,  B01F31/24 ,  B01F35/42

Abstract: The adapter connects an aerosol or similarly shaped can to a power tool for the purpose of mixing the contents within the can. The adapter preferably connects a reciprocating power tool, such as a reciprocating saw, to a spray paint can that is necessarily shaken before use. To secure the can to the power tool, the adapter has multiple fingers that grasp the end of an aerosol can with respective tabs. The tabs catch on a ring on the topside of the spray paint can to prevent it from breaking away from the reciprocating tool during operation. To secure the adapter to the can, the fingers and tabs have a diameter that is smaller than the diameter of the can rim but deform into an oblong arrangement to receive the can before returning to the circular arrangement and locking the can in place. To deform the adapter, an actuator is connected to the side of the cylindrical body and the can is held in place until the actuator is actuated and the tabbed fingers can be pulled away from the can.

公开(公告)号：US20230151450A1

公开(公告)日：2023-05-18

申请号：US17987484

申请日：2022-11-15

Applicant: Daniel S. Codd ,  Joseph J. McCrink

Inventor： Daniel S. Codd ,  Joseph J. McCrink

IPC: C21D9/08 ,  B23K31/02 ,  C22C38/22 ,  C22C38/26 ,  C22C38/24 ,  C21D1/42 ,  C21D6/00 ,  C22C38/00 ,  C22C38/04

CPC classification number: C21D9/08 ,  B23K31/027 ,  C21D1/42 ,  C21D6/002 ,  C21D6/005 ,  C22C38/001 ,  C22C38/04 ,  C22C38/22 ,  C22C38/24 ,  C22C38/26 ,  C21D2211/008

Abstract: An integrated welding and thermal processing method includes heating adjoining surfaces, at least one of which is a creep strength enhanced ferritic (CSEF) steel alloy, to a sufficiently high temperature above their melting points to form a weld. The weld is allowed cool below the martensitic start temperature of one or both CSEF alloys. Thereafter, a supplemental heat source tempers the CSEF alloys by reheating the weld area at a rate of 10° C. per second or greater to above the CSEF alloys’ martensitic start temperatures, but not above the austenitization temperature of the CSEF alloys. After the weld’s heat affected zone is maintained at a temperature between the CSEF alloys’ martensitic finish temperature and martensitic start temperature, the weld is allowed to cool at a rate of 15° C. per minute or greater.

公开(公告)号：US20230000192A1

公开(公告)日：2023-01-05

申请号：US17663258

申请日：2022-05-13

Applicant: Joseph J. Sugameli

Inventor： Joseph J. Sugameli

IPC: A42B1/22

Abstract: Foam piece attached to a clip that slides onto the inside of the hat to keep head cool. is disclosed.

公开(公告)号：US11300484B1

公开(公告)日：2022-04-12

申请号：US15732259

申请日：2017-10-16

Applicant: Joseph J. Bango

Inventor： Joseph J. Bango

IPC: G01N1/22 ,  G01N1/26 ,  G01N1/24 ,  G01N1/02

Abstract: The disclosed invention is a new concept for a network of specialized continuous ambient air sampling systems, which employ a novel non-destructive ionization and separation method, coupled to a near real-time genomic sequencer. The network of preferably pathogen samplers, would constitute a plurality of distributed nodes throughout the world, with bacterial & viral concentration, identification, and mutation data uploaded to the cloud for epidemic/pandemic predictive modeling. The proposed system offers the ability to migrate from outbreak surveillance, to outbreak forecast. In addition, the capability for continuous data of genomic sequencing offers an enhanced capability to help track antigenic drift and antigenic shift. While optimized for viral capture and analysis, any airborne pathogen or spore can be accepted using the technology. Applications include world health monitoring, pandemic prediction, and detection of real-time bioterror pathogen deployment.