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    Compound containing carboxylate ester and N2S2 ligand bi-functional groups and manufacturing method thereof
    14.
    发明申请
    Compound containing carboxylate ester and N2S2 ligand bi-functional groups and manufacturing method thereof 有权
    含羧酸酯和N2S2配位体双官能团的化合物及其制备方法

    公开(公告)号：US20100056804A1

    公开(公告)日：2010-03-04

    申请号：US12203214

    申请日：2008-09-03

    Applicant: Show-Wen LIU ,  Tsyh-Lang Lin ,  Cheng-Fang Hsu ,  Cheng-Hsien Lin ,  Tsai-Yueh Luo ,  Lie-Hang Shen ,  Hwa-Jan Chen

    Inventor： Show-Wen LIU ,  Tsyh-Lang Lin ,  Cheng-Fang Hsu ,  Cheng-Hsien Lin ,  Tsai-Yueh Luo ,  Lie-Hang Shen ,  Hwa-Jan Chen

    IPC: C07D207/30

    CPC classification number: C07D207/46 ,  Y02P20/55

    Abstract: A compound containing carboxylate ester and N2S2 ligand bi-functional groups and a manufacturing method thereof are disclosed. The S in the N2S2 ligand of the compound containing carboxylate ester and N2S2 ligand bi-functional groups includes a protective group so as to avoid to be oxidized and easy storage. In a complex reaction, the protective group is automatically released As to the active carboxylate ester, it is for reacting with compounds having amino groups such as amines, amino acids, peptides, or protein etc while the N2S2 ligand is for bonding with technetium or rhenium so as to form neutral complex. The compound containing carboxylate ester and N2S2 ligand bi-functional groups is applied to radiopharmaceuticals such as contrast agents for tissues and target agents.

    Abstract translation: 公开了含有羧酸酯和N 2 S 2配位体双官能团的化合物及其制备方法。 含有羧酸酯和N2S2配位体双官能团的化合物的N2S2配体中的S包括保护基，以避免被氧化并容易储存。 在复杂的反应中，保护基被自动释放对于活性羧酸酯，它是与具有氨基的化合物如胺，氨基酸，肽或蛋白质等反应，而N2S2配体与锝或铼键合 从而形成中性复合物。 含有羧酸酯和N 2 S 2配位体双功能基团的化合物被应用于放射性药物，例如用于组织和靶标的造影剂。

    AUTOMATED SYNTHESIS SYSTEM FOR IODINE-123-IBZM NUCLEAR MEDICINE
    15.
    发明申请
    AUTOMATED SYNTHESIS SYSTEM FOR IODINE-123-IBZM NUCLEAR MEDICINE 审中-公开
    自动合成系统，用于碘-123-IBZM核医学

    公开(公告)号：US20140072482A1

    公开(公告)日：2014-03-13

    申请号：US13611710

    申请日：2012-09-12

    Applicant: Chia-Jung Chang ,  Wei-Kang Chou ,  An-Shoei Yang ,  Mei-Hsiu Liao ,  Lie-Hang Shen

    Inventor： Chia-Jung Chang ,  Wei-Kang Chou ,  An-Shoei Yang ,  Mei-Hsiu Liao ,  Lie-Hang Shen

    IPC: B01J19/24

    CPC classification number: B01J19/004 ,  B01J19/0093 ,  B01J2219/00799 ,  B01J2219/00813 ,  B01J2219/00817 ,  B01J2219/00831 ,  B01J2219/00867 ,  B01J2219/00889 ,  B01J2219/00894 ,  B01J2219/00918 ,  B01J2219/00927

    Abstract: An automated synthesis system for iodine-123-IBZM nuclear medicine includes a control/display means, a reactant supply means connecting to the control/display means; an adsorption means connecting to the control/display means and to the reactant supply means, an oxidation means connecting the control/display means, the reactant supply means and the adsorption means, a product collection means connecting to the control/display means, the reactant supply means, the adsorption means and the oxidation means; a waste liquid collection means connecting to the control/display means, the adsorption means and the product collection means, and a gas filtration means connecting the control/display means, the oxidation means and the product collection means. This system can automate the processing steps needed for marking, such as oxidation, reduction, neutralization, adsorption, washing and elution etc, and reduce hand operating time, radiation exposure dose, and mistakes and deviations, while stabilizing the product quality, increasing the product yield, and improving the purity.

    Abstract translation: 碘-123-IBZM核药物的自动合成系统包括控制/显示装置，连接到控制/显示装置的反应物供应装置; 连接到控制/显示装置和反应物供应装置的吸附装置，连接控制/显示装置，反应物供应装置和吸附装置的氧化装置，连接到控制/显示装置的产品收集装置，反应物 供给装置，吸附装置和氧化装置; 连接到控制/显示装置，吸附装置和产品收集装置的废液收集装置，以及连接控制/显示装置，氧化装置和产品收集装置的气体过滤装置。 该系统可以自动化氧化，还原，中和，吸附，洗涤和洗脱等标记所需的加工步骤，减少手工操作时间，辐射暴露剂量，错误和偏差，同时稳定产品质量，增加产品 产率，提高纯度。

    Radiation Method for Fabrication of Nano-sized Compound Antibacterial Fabric Textile
    18.
    发明申请
    Radiation Method for Fabrication of Nano-sized Compound Antibacterial Fabric Textile 审中-公开
    纳米复合抗菌织物的制备辐射方法

    公开(公告)号：US20090092645A1

    公开(公告)日：2009-04-09

    申请号：US11867701

    申请日：2007-10-05

    Applicant: Te-Hsing Wu ,  Bin Lin ,  Nini-Chen Tsai ,  Chia-Chieh Chen ,  Lie-Hang Shen ,  Wuu-Jyh Lin

    Inventor： Te-Hsing Wu ,  Bin Lin ,  Nini-Chen Tsai ,  Chia-Chieh Chen ,  Lie-Hang Shen ,  Wuu-Jyh Lin

    IPC: A61K9/70 ,  A61P31/04

    CPC classification number: A61L15/14 ,  A61K9/10 ,  A61K47/02 ,  A61L15/46 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/624 ,  D06M10/008 ,  D06M10/06 ,  D06M11/65 ,  D06M11/79 ,  D06M11/83 ,  D06M16/00 ,  D06M23/08 ,  D06M2101/32 ,  D06M2101/34

    Abstract: The invention discloses an innovative process to produce highly antibacterial nano-composite fabric textile containing silver metal compound. The process mainly uses high-energy D-ray radiation to modify silver type of bactericides and graft or crosslink them onto Nylon or PET fiber surface to produce excellent antibacterial textile products. The mechanism uses silver nano-compound as performance additive and through Co-60 irradiation technique reduces and firmly fastens silver particles onto Nylon or PET (Polyethylene Terephthalate) fiber material. Because the inorganic silver type bactericides actively interact with enzymes in bacteria or destroy cell walls to achieve good bactericidal effect, the radiation process does not need initiators or other additives. So the process is simple and effective. The test results prove excellent bactericidal power and potential value in household or medical textile products.

    Abstract translation: 本发明公开了一种生产含有银金属化合物的高抗菌纳米复合织物织物的创新方法。 该方法主要采用高能D射线辐射法改性银类杀菌剂，并将其接枝或交联到尼龙或PET纤维表面，生产出优良的抗菌纺织品。 该机理采用银纳米复合材料作为性能添加剂，通过Co-60辐照技术可将银粒子还原并牢固地固定在尼龙或PET（聚对苯二甲酸乙二醇酯）纤维材料上。 由于无机银型杀菌剂与细菌中的酶积极相互作用或破坏细胞壁以达到良好的杀菌效果，所以辐射过程不需要引发剂或其他添加剂。 所以这个过程很简单有效。 测试结果证明了家用或医用纺织品的优良杀菌力和潜在价值。

    Automatic Apparatus for Feeding and Measuring Radioactive Medicine
    19.
    发明申请
    Automatic Apparatus for Feeding and Measuring Radioactive Medicine 审中-公开
    放射性医学饲料自动化装置

    公开(公告)号：US20120207570A1

    公开(公告)日：2012-08-16

    申请号：US13028085

    申请日：2011-02-15

    Applicant: Chia-Jung Chang ,  Chung-Li Chen ,  Mei-Hsiu Liao ,  Lie-Hang Shen

    Inventor： Chia-Jung Chang ,  Chung-Li Chen ,  Mei-Hsiu Liao ,  Lie-Hang Shen

    IPC: B65G1/00

    CPC classification number: G21H5/00 ,  A61B6/037 ,  G21F5/14

    Abstract: Disclosed is an automatic apparatus for feeding and measuring radioactive medicine. The automatic apparatus includes a base, two elevators, two clamping units, a translation unit, a limiting unit, and a holder. The first elevator is movably supported on the base. The first clamping unit includes a sliding block movably supported on the first elevator, a shaft rotationally connected to the sliding block, and a quick-release clamp connected to the shaft. The translation unit is located on the base. The second elevator is movably supported on the translation unit. The second clamping unit includes a sliding block movably supported on the second elevator, a shaft connected to the sliding block thereof, and a pneumatic clamp connected to the shaft thereof. The limiting unit is connected to the second elevator and operable for limiting downward movement of the second elevator. The holder is located on the base.

    Abstract translation: 本发明公开了一种放射性药物供给和测量自动装置。 自动装置包括基座，两个电梯，两个夹紧单元，平移单元，限制单元和保持器。 第一个电梯可移动地支撑在基座上。 第一夹紧单元包括可移动地支撑在第一升降机上的滑动块，与滑动块旋转地连接的轴以及连接到轴的快速释放夹。 翻译单位位于基地。 第二电梯可移动地支撑在翻译单元上。 第二夹紧单元包括可移动地支撑在第二升降机上的滑动块，连接到其滑动块的轴和连接到其轴的气动夹具。 限制单元连接到第二电梯并且可操作以限制第二电梯的向下运动。 持有人位于基地。

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