公开(公告)号：US20180008949A1

公开(公告)日：2018-01-11

申请号：US15546924

申请日：2016-03-10

申请人： GE Healthcare Limited

发明人： Xavier Franci ,  Philippe Dumont ,  Steve Lignon ,  Audrey Marie Lange ,  Nicolas Verbrugge

IPC分类号： B01J19/00 ,  A61K51/04 ,  B01J19/18 ,  C07H5/02

CPC分类号： B01J19/004 ,  A61K51/0491 ,  B01J19/0093 ,  B01J19/18 ,  B01J2219/00799 ,  B01J2219/00833 ,  B01J2219/00862 ,  B01J2219/00867 ,  B01J2219/00894 ,  B01J2219/00916 ,  B01J2219/00918 ,  B01J2219/00927 ,  B01J2219/00952 ,  C07B2200/05 ,  C07H5/02

摘要： The present invention provides a system for the production of a radiopharmaceutical including a radiosynthesis apparatus and a disposable cassette. The system of the invention includes a device that enables a position on the cassette to be freed for inclusion of an additional reagent vial. With the system of the invention a broader range of radiochemical syntheses can be envisaged using the cassette.

公开(公告)号：US20140050635A1

公开(公告)日：2014-02-20

申请号：US14113843

申请日：2012-04-27

申请人： Carlo Azzi ,  Claudia Castellano ,  Francesca Aversano

发明人： Carlo Azzi ,  Claudia Castellano ,  Francesca Aversano

IPC分类号： B01J19/00

CPC分类号： B01J19/00 ,  B01J19/004 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00376 ,  B01J2219/00495 ,  B01J2219/00599 ,  B01J2219/00698 ,  B01J2219/00725 ,  B01J2219/00788 ,  B01J2219/00806 ,  B01J2219/0081 ,  B01J2219/00817 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00927

摘要： Device for the synthesis of peptide-based radioactive drugs, for diagnostic and/or therapeutic use, includes: a frame; a closing case for the frame; a first disposable main module; a second disposable module, slidingly associated with the first module; a third disposable test-tube holder module, reversibly fixable to the frame (100) with fixing elements that allow the translation thereof with respect to the same. The first, second and third modules are arranged for irreversibly coupling so as to form one single disposable collector inside which the whole synthesis process of the concerned radioactive drug is performed, where at the end of the process, the collector may be removed from the device as one single contaminated mono block. The device is controlled by a remote control and drive workstation that includes a computer and devices for storing and managing data concerning the synthesis of the specific radioactive drug obtained for each treated patient.

摘要翻译： 用于合成基于肽的放射性药物用于诊断和/或治疗用途的装置包括：框架; 框架的封闭箱; 第一个一次性主模块; 第二一次性模块，与第一模块滑动相关联; 第三一次性试管保持器模块，可逆地固定到框架（100）上，固定元件允许相对于框架100的翻转。 第一，第二和第三模块被布置成不可逆地联接，以便形成一个单一的一次性收集器，在该单个的一次性收集器内执行相关放射性药物的整个合成过程，其中在处理结束时，收集器可以从装置 作为一个单一污染的单体块。 该装置由包括计算机的远程控制和驱动工作站控制，以及用于存储和管理关于为每个处理的患者获得的特定放射性药物的合成的数据的装置。

公开(公告)号：US08075851B2

公开(公告)日：2011-12-13

申请号：US11540344

申请日：2006-09-29

申请人： Arkadij M Elizarov ,  Hartmuth C. Kolb ,  R. Michael Van Dam ,  James R. Heath

发明人： Arkadij M Elizarov ,  Hartmuth C. Kolb ,  R. Michael Van Dam ,  James R. Heath

IPC分类号： B01L3/00

CPC分类号： B01F11/0042 ,  B01F11/0071 ,  B01F13/0059 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00396 ,  B01J2219/00398 ,  B01J2219/00414 ,  B01J2219/00418 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00731 ,  B01J2219/00759 ,  B01J2219/00783 ,  B01J2219/00788 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00826 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00858 ,  B01J2219/0086 ,  B01J2219/00862 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00907 ,  B01J2219/00916 ,  B01J2219/00927 ,  B01J2219/00986

摘要： Described herein are automated, integrated microfluidic device comprising a chemical reaction chip comprising for performing chemical reaction, a microscale column integrated with the chip and configured for liquid flow from the column to at least one flow channel, and wherein the fluid flow into the column is controlled by on-chip valves; and comprising at least two on-chip valves for controlling fluid flow in the microfluidic device.

摘要翻译： 本文描述的是包括用于进行化学反应的化学反应芯片的自动化集成微流体装置，与芯片集成的微量柱，并且构造成用于从柱流到至少一个流动通道的液体流，并且其中流入塔的流体流是 由片上阀控制; 并且包括用于控制微流体装置中的流体流动的至少两个片上阀。

公开(公告)号：US10067249B2

公开(公告)日：2018-09-04

申请号：US14653907

申请日：2013-12-20

申请人： GE Healthcare Limited

发明人： Alok M. Srivastava ,  Victor Samper ,  Stefan Riese

IPC分类号： B01J19/00 ,  B01J19/24 ,  G01T1/10 ,  G01T7/00

CPC分类号： G01T7/00 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/0086 ,  B01J2219/00927 ,  B01J2219/00954 ,  B01J2219/00968 ,  G01T1/10

摘要： Radiation-sensitive material embedded in a disposable radiochemistry device gives the device the additional capability of recording radiation dose, for readout at a later time. There is provided a device comprising means for the introduction of a precursor compound, means for the introduction of a radionuclide, a reaction vessel for reacting said precursor compound and said suitable source of a radionuclide to obtain a radiolabelled compound, and one or more pieces of radiation-sensitive material embedded into said device wherein at least one of said pieces is positioned to be exposed to radioactivity associated with said radiolabelled compound.

公开(公告)号：US09884306B2

公开(公告)日：2018-02-06

申请号：US14324180

申请日：2014-07-05

申请人： ACADEMIA SINICA

发明人： Yeu-Kuang Hwu ,  Sheng-Feng Lai ,  Cheng-Liang Wang

IPC分类号： B01J19/12 ,  B01J19/00 ,  B01J19/02 ,  B01J19/08 ,  B01J19/24 ,  B01J4/00

CPC分类号： B01J19/125 ,  B01J4/002 ,  B01J19/0093 ,  B01J19/02 ,  B01J19/082 ,  B01J19/2415 ,  B01J2219/00164 ,  B01J2219/00799 ,  B01J2219/00801 ,  B01J2219/00822 ,  B01J2219/00833 ,  B01J2219/00927 ,  B01J2219/00939 ,  B01J2219/00959 ,  B01J2219/0277 ,  B01J2219/0295 ,  B01J2219/0871 ,  B01J2219/0877

摘要： A convection-free flow-type reactor includes a reactor body. The reactor body includes a reaction chamber to house a fluid. An inlet is in communication with the reaction chamber to allow input of a reactant fluid. An outlet is in communication with the reaction chamber to allow output of a product fluid. An energy beam source device provides an energy beam to irradiate the reactant fluid in the reaction chamber. The disclosure further provides a convection-free flow-type synthesis method.

公开(公告)号：US08658112B2

公开(公告)日：2014-02-25

申请号：US13286418

申请日：2011-11-01

申请人： Arkadij M. Elizarov ,  Hartmuth C. Kolb ,  R. Michael Van Dam ,  James R. Heath

发明人： Arkadij M. Elizarov ,  Hartmuth C. Kolb ,  R. Michael Van Dam ,  James R. Heath

IPC分类号： G01N33/00

CPC分类号： B01F11/0042 ,  B01F11/0071 ,  B01F13/0059 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00396 ,  B01J2219/00398 ,  B01J2219/00414 ,  B01J2219/00418 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00731 ,  B01J2219/00759 ,  B01J2219/00783 ,  B01J2219/00788 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00826 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00858 ,  B01J2219/0086 ,  B01J2219/00862 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00907 ,  B01J2219/00916 ,  B01J2219/00927 ,  B01J2219/00986

摘要： Described herein are automated, integrated microfluidic device comprising a chemical reaction chip comprising for performing chemical reaction, a microscale column integrated with the chip and configured for liquid flow from the column to at least one flow channel, and wherein the fluid flow into the column is controlled by on-chip valves; and comprising at least two on-chip valves for controlling fluid flow in the microfluidic device.

摘要翻译： 本文描述的是包括用于进行化学反应的化学反应芯片的自动化集成微流体装置，与芯片集成的微量柱，并且构造成用于从柱流到至少一个流动通道的液体流，并且其中流入塔的流体流是 由片上阀控制; 并且包括用于控制微流体装置中的流体流动的至少两个片上阀。

公开(公告)号：US20240199962A1

公开(公告)日：2024-06-20

申请号：US18085172

申请日：2022-12-20

申请人： David Wragg ,  Jamie Kraus

发明人： David Wragg ,  Jamie Kraus

IPC分类号： C10G33/02 ,  B01D17/04 ,  B01J19/08 ,  B01J19/12

CPC分类号： C10G33/02 ,  B01D17/04 ,  B01J19/088 ,  B01J19/12 ,  B01J2219/00853 ,  B01J2219/00927 ,  B01J2219/00934 ,  C10G2300/1033

摘要： The invention is directed to systems, apparatus and methods for demulsifying an emulsion, and generating plasma enhanced treatment fluids, with at least one plasma reactor to produce plasma in reaction with the emulsion to cause flocculation and coalescence in the emulsion for phase separation of the constituents and chemical reaction with reactor fluids. After separation, the separated constituents in the emulsion are removed from the reaction chamber for processing of further emulsion. Plasma enhanced treatment fluids are removed from the reaction chamber and used in further processes. According to an example, the emulsion may be a crude oil emulsion with the separated crude oil produced for further processing or sale. The systems, apparatus and methods also produce plasma enhanced treatment fluids that may be reused in other oil recovery processes for example.

公开(公告)号：US20240076656A1

公开(公告)日：2024-03-07

申请号：US18215296

申请日：2023-06-28

申请人： 10x Genomics, Inc.

发明人： David Michael PATTERSON ,  Steven William SHORT ,  Dieter WILK ,  Pingwei ZHUANG ,  Solongo Batjargal ZIRALDO

IPC分类号： C12N15/10 ,  B01J19/00 ,  B41M5/24 ,  C12N9/12 ,  C12N9/22 ,  G03F7/11

CPC分类号： C12N15/1093 ,  B01J19/0046 ,  B41M5/24 ,  C12N9/1264 ,  C12N9/22 ,  C12Y207/07031 ,  C12Y301/11001 ,  G03F7/11 ,  B01J2219/00855 ,  B01J2219/00927 ,  B01J2219/00993 ,  B01J2219/0894 ,  B01J2540/68

摘要： Provided in some aspects are methods for light-controlled in situ surface patterning of a substrate comprising a step of blocking or ablating oligonucleotide molecules in a boundary region separating a plurality of spot regions, and attaching oligonucleotides to oligonucleotide molecules in a first one or more of the spot regions.

公开(公告)号：US20180021750A1

公开(公告)日：2018-01-25

申请号：US15547011

申请日：2016-03-16

申请人： GE Healthcare Limited

发明人： Philippe Dumont

IPC分类号： B01J19/00 ,  C07B59/00

CPC分类号： B01J19/0093 ,  B01J19/004 ,  B01J2219/00799 ,  B01J2219/00813 ,  B01J2219/00822 ,  B01J2219/00833 ,  B01J2219/00867 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/00894 ,  B01J2219/00918 ,  B01J2219/00927 ,  B01J2219/00952 ,  B01J2219/00961 ,  B01J2219/00986 ,  C07B59/00 ,  C07B2200/05

摘要： The present invention relates to an automated radiosynthesis device adapted for enhanced automatic disconnection of a disposable kit once a radiosynthesis has been carried out. The automated radiosynthesis device of the invention therefore reduces the time to remove the disposable kit from the radiosynthesis device and reduces radiation exposure to the operator.

公开(公告)号：US20130144052A1

公开(公告)日：2013-06-06

申请号：US13809506

申请日：2011-07-05

申请人： Marco Mueller

发明人： Marco Mueller

IPC分类号： C07B59/00 ,  C07H5/02

CPC分类号： C07B59/005 ,  B01J19/0093 ,  B01J2219/00788 ,  B01J2219/0081 ,  B01J2219/00813 ,  B01J2219/00817 ,  B01J2219/00891 ,  B01J2219/00898 ,  B01J2219/00916 ,  B01J2219/00927 ,  C07B59/00 ,  C07B2200/05 ,  C07H5/02 ,  Y02P20/55

摘要： The invention relates to a device for the synthesis of radio-labeled compounds, which comprisesa reaction vessel for reacting a precursor compound having protective groups with a radioactive isotope to obtain a first reaction product; a first cartridge for hydrolyzing the protective groups of the first reaction product to obtain a second reaction product; and a second cartridge for purifying the second reaction product, wherein the reaction vessel, the first cartridge, and the second cartridge are connected to each other via pipelines. Here it is provided that the first cartridge contains 801 to 1200 mg of a solid carrier and/or the reaction vessel is a reaction vessel made of a temperature-resistant plastic with the plastic having a temperature resistance of at least 120° C.

摘要翻译： 本发明涉及一种用于合成放射性标记化合物的装置，其包括用于使具有保护基团的前体化合物与放射性同位素反应以获得第一反应产物的反应容器; 用于水解第一反应产物的保护基团以获得第二反应产物的第一筒; 以及用于净化所述第二反应产物的第二筒，其中所述反应容器，所述第一盒和所述第二盒通过管道相互连接。 这里规定，第一筒包含801至1200mg的固体载体和/或反应容器是由具有至少120℃的耐温性的塑料制成的耐温塑料的反应容器。