Methods and materials for assessing prostate cancer therapies and compounds
    11.
    发明申请
    Methods and materials for assessing prostate cancer therapies and compounds 有权
    用于评估前列腺癌疗法和化合物的方法和材料

    公开(公告)号:US20070191443A1

    公开(公告)日:2007-08-16

    申请号:US10590445

    申请日:2005-02-23

    IPC分类号: A61K31/4166 C07D233/84

    CPC分类号: A61K31/426

    摘要: A modest (2-5 fold) increase in androgen receptor (AR) mRNA is the only expression change consistently associated with developing resistance to antiandrogen therapy. Increased levels of AR confer resistance to anti-androgens by amplifying signal output from low levels of residual ligand and altering the normal response to antagonists. This invention provides cell based assays for use in the examination of new therapeutic modalities and provides for the design of novel antiandrogen compounds.

    摘要翻译: 雄激素受体(AR)mRNA的适度(2-5倍)增加是与抗雄激素治疗发展抵抗力的唯一表达变化。 增加的AR水平通过放大来自低水平的残留配体的信号输出并改变对拮抗剂的正常反应来赋予抗雄激素抗性。 本发明提供用于检查新的治疗方式的基于细胞的测定法,并提供新的抗雄激素化合物的设计。

    Generator cooling with mixing downstream of the cooler
    13.
    发明授权
    Generator cooling with mixing downstream of the cooler 失效
    发电机冷却与冷却器下游混合

    公开(公告)号:US06239522B1

    公开(公告)日:2001-05-29

    申请号:US09450725

    申请日:1999-11-30

    IPC分类号: H02K908

    CPC分类号: H02K9/10

    摘要: In a generator with a cooling system which draws in, from the generator, cooling medium heated by the heat-generating elements of the generator and which guides the hot cooling medium to at least two cooling units (23), which cooling units (23) operate in parallel and cool the cooling medium before it is led back to the heat-generating elements of the generator, operation substantially uninfluenced by failures of the cooling units (23) is made possible by means being provided which mix together the cooling medium flows (31) flowing from the different cooling units (23) after they emerge from the cooling units (23) and before they are supplied to the heat-generating elements of the generator.

    摘要翻译: 在具有冷却系统的发电机中,该冷却系统从发电机吸入由发电机的发热元件加热并将热冷却介质引导到至少两个冷却单元(23)的冷却介质,该冷却单元(23) 在冷却介质被引导回到发电机的发热元件之前并行地冷却并且冷却冷却介质,通过提供冷却单元(23)的故障基本上不受影响的操作可以通过将冷却介质流动混合在一起而实现 31)在从冷却单元(23)出来之后并且在它们被供应到发电机的发热元件之前从不同的冷却单元(23)流出。

    Apparatus and method for controlling transmission parameters of home
network stations transmitting on a telephone line medium
    14.
    发明授权
    Apparatus and method for controlling transmission parameters of home network stations transmitting on a telephone line medium 有权
    用于控制在电话线介质上发送的家庭网络站的传输参数的装置和方法

    公开(公告)号:US6094441A

    公开(公告)日:2000-07-25

    申请号:US182988

    申请日:1998-10-30

    摘要: A physical layer transceiver of a home network station connected to a telephone medium has an architecture enabling adaptation of detection circuitry based on received network signals to enable reliable recovery of data signals. The physical layer transceiver includes an input amplifier that amplifies network signals according to one of 128 gain settings set by a receiver gain control signal. A signal conditioning circuit includes an envelope detector configured for outputting an envelope of the amplified received signal, and an energy detector configured for outputting an energy signal of the amplified received signals. The envelope signal and the energy signal are supplied to slicer threshold circuits, configured for outputting noise, peak, data event and energy event signals based on noise threshold, peak threshold, data transition threshold, and energy threshold signals, respectively. A digital controller controls the input amplifier gain and the threshold values, and adjusts the gain and threshold values based on the noise event signal and the peak event signal within an access ID (AID) interval. A link controller monitors the number of errors in received data packets, and causes the media access controller and physical layer transceiver to output AID command packets that signal a transmitting station to reduce transmit data rate or increase transmit power to improve reception reliability on the telephone line medium.

    摘要翻译: 连接到电话介质的家庭网络站的物理层收发器具有能够基于接收到的网络信号来适应检测电路的架构,以实现数据信号的可靠恢复。 物理层收发器包括输入放大器,其根据由接收机增益控制信号设置的128个增益设置之一放大网络信号。 信号调理电路包括被配置为输出放大的接收信号的包络的包络检测器,以及被配置为输出放大的接收信号的能量信号的能量检测器。 包络信号和能量信号被提供给限幅器阈值电路,其被配置为分别基于噪声阈值,峰值阈值,数据转换阈值和能量阈值信号输出噪声,峰值,数据事件和能量事件信号。 数字控制器控制输入放大器增益和阈值,并且基于接入ID(AID)间隔内的噪声事件信号和峰值事件信号来调整增益和阈值。 链路控制器监视接收到的数据分组中的错误数量,并使介质访问控制器和物理层收发器输出信号发送站的AID命令分组,以降低发送数据速率或增加发送功率,以提高电话线上的接收可靠性 中。

    Organo omega-alkenyl cyclopentacarbyl silane compounds
    16.
    发明授权
    Organo omega-alkenyl cyclopentacarbyl silane compounds 失效
    有机ω-烯基环戊二烯基硅烷化合物

    公开(公告)号:US5856547A

    公开(公告)日:1999-01-05

    申请号:US963113

    申请日:1997-10-28

    摘要: An (organo) (omega-alkenyl) (cyclopentacarbyl) silane compound is provided. A process that produces an (organo) (omega-alkenyl) (cyclopentacarbyl) silane compound is provided. A process to polymerize olefins, especially ethylene, with a metallocene compound that comprises an (organo) (omega-alkenyl) (cyclopentacarbyl) silane compound is provided.

    摘要翻译: 提供了(有机)(ω-烯基)(环戊二烯基)硅烷化合物。 提供产生(有机)(ω-烯基)(环戊二甲酰基)硅烷化合物的方法。 提供了一种使烯烃(特别是乙烯)与包含(有机)(ω-烯基)(环戊二甲酰基)硅烷化合物的茂金属化合物聚合的方法。

    Apparatus for plasma treatment
    18.
    发明授权
    Apparatus for plasma treatment 失效
    等离子体处理装置

    公开(公告)号:US5399254A

    公开(公告)日:1995-03-21

    申请号:US659817

    申请日:1991-02-22

    摘要: The invention concerns an apparatus for the plasma treatment of substrates in a plasma discharge excited by a high frequency between two electrodes 3, 8 to which power is supplied by a high frequency source, where the first electrode is configured as a hollow electrode 3 and the second one as an electrode 8 holding a substrate 7 and situated upstream of the hollow chamber 10 of the first electrode which it also passes. The hollow electrode is enclosed by a dark space shield and has an edge pointing in direction of the second electrode and also has projection located between the edge. These projections are on the same potential as the second electrode. The radio frequency power is thus decoupled from the substrate bias voltage (selfbias) and the distance between the first and the second electrode can be changed.

    摘要翻译: 本发明涉及一种用于等离子体处理等离子体处理装置,该等离子体处理由两个电极3,8之间的高频激发的等离子体放电,两个电极之间由高频源供电,其中第一电极被配置为中空电极3, 第二个作为保持基板7并位于第一电极的中空室10的上游的电极8。 中空电极由暗空间屏蔽物包围,并且具有指向第二电极的方向的边缘,并且还具有位于边缘之间的突起。 这些突起与第二电极具有相同的电位。 因此,射频功率与衬底偏置电压(自耦合)分离,并且可以改变第一和第二电极之间的距离。

    Apparatus for coupling microwave power out of a first space into a
second space
    19.
    发明授权
    Apparatus for coupling microwave power out of a first space into a second space 失效
    用于将微波功率从第一空间耦合到第二空间的装置

    公开(公告)号:US5283538A

    公开(公告)日:1994-02-01

    申请号:US27921

    申请日:1993-03-08

    IPC分类号: H01P5/08 H01P5/00

    CPC分类号: H01P5/08

    摘要: The invention relates to a device for coupling microwave power out of a first chamber (21) into a second chamber (22). For this purpose a primary antenna (2) and a secondary antenna (3) are provided, the primary antenna (2) reaching into the first chamber (21), while the secondary antenna (3) reaches into the second chamber (22). Between the first chamber (21) and the second chamber (22) there is provided a dividing wall (20) through which a current-carrying means (11) is brought, which joins together the primary antenna (2) and the secondary antenna (3).

    摘要翻译: 本发明涉及一种用于将微波功率从第一腔室(21)耦合到第二腔室(22)中的装置。 为此,提供主天线(2)和辅助天线(3),主天线(2)到达第一腔室(21),而辅助天线(3)到达第二腔室(22)。 在第一室(21)和第二室(22)之间设置有分隔壁(20),通过所述分隔壁(20)连接主要天线(2)和辅助天线 3)。

    Device for mounting and transporting substrates in vacuum apparatus
    20.
    发明授权
    Device for mounting and transporting substrates in vacuum apparatus 失效
    用于在真空设备中安装和运输基板的装置

    公开(公告)号:US5259603A

    公开(公告)日:1993-11-09

    申请号:US828259

    申请日:1992-01-30

    IPC分类号: C23C14/50 B25B1/20

    摘要: Device for mounting thin, preferably flat substrates (11, 11', . . . ) and for the transport of these substrates (11, 11'. . . ) in treatment apparatus, for example vacuum coating and etching apparatus, the device being formed by a frame (1), preferably in a rectangular shape, which is of such size that in the area surrounded by the frame (1) a support, e.g., a support formed of spoke-like round rods (6, 6', . . . ). can be inserted, and on this support fastening means for mounting the substrates (11, 11', . . . ) are provided, which hold the substrates (11, 11', . . . ) such that their substantially planar lateral surfaces run approximately parallel to the plane of the frame.

    摘要翻译: 用于安装薄的,优选平坦的基板(11,11'等)并且用于将这些基板(11,11')输送到处理装置中的装置,例如真空涂覆和蚀刻装置,所形成的装置 通过框架(1),优选为矩形形状,其尺寸使得在由框架(1)包围的区域中,支撑件(例如由辐条状圆棒(6,6',...)形成的支撑件)形成。 ...)。 并且在该支撑件上提供用于安装基板(11,11'...)的紧固装置,其固定基板(11,11'...),使得其基本上平坦的侧表面大致运行 平行于框架的平面。