公开(公告)号：US3891998A

公开(公告)日：1975-07-01

申请号：US43140374

申请日：1974-01-07

Applicant: NAT RES DEV

Inventor： LENNOX WILLIAM MURDOCH

IPC: A61F2/00 ,  A61F2/30 ,  A61F2/40 ,  A61F1/24

CPC classification number: A61F2/40 ,  A61F2/4059 ,  A61F2/4081 ,  A61F2002/3082 ,  A61F2002/30822 ,  A61F2002/30827 ,  A61F2002/4018 ,  A61F2310/00029

Abstract: An endoprosthetic scapular glenoid component is provided with a concave bearing surface of elongated part-spherical shape significantly less than hemispherical extent. The surface forms the larger end face of a generally frusto-pyramidal body of which the side faces have a relieved structure for fixation in the scapular with gap-filling cement. The pyramidal body is preferably quadrilateral with two opposed planar side faces and the other two convexly rounded. For use in a total shoulder joint device, the glenoid component can be associated with a variety of generally spherically headed, intramedullary stemmed, humeral components. Preferably the humeral component head is of minor segmental form, and the stem inclined relative to the head over a major free end portion of its length.

Abstract translation: 内侧假体肩胛关节盂部件具有比半球形程度更小的细长部分球形形状的凹形支承表面。 表面形成大致截头锥体的较大端面，侧面具有缓释结构，用于用间隙填充水泥固定在肩胛骨中。 金字塔形体优选为四边形，具有两个相对的平面侧面，另外两个凸起圆形。 为了用于全肩关节装置，关节盂部件可以与各种通常为球形的髓内梗死肱骨组件相关联。 优选地，肱骨构件头部具有小的节段形式，并且杆在其长度的主要自由端部上相对于头部倾斜。

公开(公告)号：US3887386A

公开(公告)日：1975-06-03

申请号：US38217373

申请日：1973-07-24

Applicant: NAT RES DEV

Inventor： MAJUMDAR AMALENDU JYOTI

IPC: C03C3/04 ,  C03C3/076 ,  C03C3/078 ,  C03C3/083 ,  C03C3/087 ,  C03C3/095 ,  C03C3/112 ,  C03C13/00 ,  C04B14/42 ,  C04B26/10 ,  C04B28/04 ,  C04B31/06

CPC classification number: C03C3/076 ,  C03C3/04 ,  C03C3/078 ,  C03C3/083 ,  C03C3/087 ,  C03C3/095 ,  C03C3/112 ,  C03C13/00 ,  C03C13/001 ,  C03C13/002 ,  C04B14/42 ,  C04B26/10 ,  C04B28/04

Abstract: Fibre reinforced cementitious products are described comprising glass fibrous material distributed throughout a cement matrix, in which the glass is one having per se a degree of alkali resistance such that when tested in the form of an abraded fibre of length 2 1/2 inches and diameter of from 0.4 to 1.0 X 10 3 inches said fibre has a tensile strength of at least 100,000 p.s.i. after treatment with saturated aqueous Ca(OH)2 solution at 100*C. for 4 hours followed by successive washings at ambient temperature with water, then with aqueous hydrochloric acid (1%) for 1 minute, water, acetone, following by drying, said fibre experiencing not more than 10% reduction in diameter during said test. The reinforcement of Portland cement structures by fibres of diameter 0.4 to 1.0 X 10 3 and lengths of up to 4 inches is described. Alkali resistant glasses useful for production of these products comprise the CaO-MgO-Al2O3-SiO2 glasses including those in the anorthite field, silica zirconia glasses, and silica stannic oxide glasses. The products have outstanding durability and impact resistance.

Abstract translation: 描述了纤维增强水泥质产品，其包括分布在整个水泥基质中的玻璃纤维材料，其中玻璃是本身具有一定程度的耐碱性的玻璃纤维材料，使得当以21/2英寸的磨损纤维的形式和直径为 从0.4至1.0×10 -3英寸，所述纤维的拉伸强度至少为100,000psi 在饱和Ca（OH）2水溶液中于100℃处理4小时，然后在环境温度下用水，然后用盐酸水溶液（1％）连续洗涤1分钟，然后用水，丙酮干燥， 所述纤维在所述测试期间经历直径减少不超过10％。

公开(公告)号：US3875927A

公开(公告)日：1975-04-08

申请号：US37719573

申请日：1973-07-09

Applicant: NAT RES DEV

Inventor： TREXLER PHILIP CHARLES

IPC: B01L1/04 ,  B25J21/02 ,  A61B19/00

CPC classification number: B01L1/04 ,  B25J21/02 ,  Y10S55/29

Abstract: An isolator comprises an enclosure member adapted to provide a controlled microbiological environment and having a transfer port for passage of objects into and out of the enclosure member. The transfer port comprises a conduit communicating at one end with the interior of the enclosure member, and having its other end external to the enclosure member, and air supply means communicating with the conduit to direct a flow of sterilised air over the inner surface of the conduit. Preferably the conduit has an inner wall and an outer wall spaced apart over at least part of the conduit, and there is provided an array of openings distributed over the inner surface of the conduit.

公开(公告)号：US3871954A

公开(公告)日：1975-03-18

申请号：US43091874

申请日：1974-01-04

Applicant: NAT RES DEV

Inventor： ZUCKERMAN ARIE JEREMY

IPC: C12N5/071 ,  C12N7/08 ,  C12K9/00

CPC classification number: C12N7/00 ,  C12N5/067 ,  C12N2770/32364

Abstract: A method for producing a human embryo liver cell line which comprises disaggregating human embryo liver, suspending the cells in a growth medium, replacing this with fresh medium if it becomes acid, and allowing a confluent sheet of spindle-shaped cells of the cell line to form. The cells of the cell line, which are designated by A.T.C.C. No. CL99, may be sub-cultured and may be used as the basis of a cell-culture system for the culturing of mammalian cells in tissue culture. Viruses may be cultivated in a culture system based on cells of the cell line to provide antigenic material for the preparation of vaccines.

Abstract translation: 一种生产人胚胎肝细胞系的方法，其包括将人胚肝分解，将细胞悬浮于生长培养基中，如果其变为酸，则用新鲜培养基代替该胚细胞，并将细胞系的纺锤形细胞的汇合片 形成。 细胞系的细胞，由A.T.C.C. 编号CL99可以被亚培养，并且可以用作组织培养中哺乳动物细胞培养的细胞培养系统的基础。 可以在基于细胞系的细胞的培养系统中培养病毒，以提供用于疫苗制备的抗原材料。

公开(公告)号：US3870051A

公开(公告)日：1975-03-11

申请号：US35491073

申请日：1973-04-26

Applicant: NAT RES DEV

Inventor： BRINDLEY GILES SKEY

IPC: A61N1/36

CPC classification number: A61N1/36007 ,  Y10S128/25

Abstract: Urinary control by electrical stimulation of the sphincter and bladder muscles is effected by way of the sacral ventral roots, selection in the resultant muscle action being effected by use of discriminating signal forms. Sphincter closure action is effected by use of a low intensity pulse train whereby the sphincter is stimulated but not the bladder and so incontinence is avoided. Bladder muscle action to cause micturation is effected by use of a higher intensity pulse train whereby both muscles are stimulated during each pulse train, but during each interruption the sphincter relaxes while the bladder remains contracted.

Abstract translation: 括约肌和膀胱肌肉通过电刺激进行泌尿控制是通过骶腹根进行的，通过使用鉴别信号形式来选择所产生的肌肉作用。 括约肌闭合作用是通过使用低强度的脉冲串来实现的，其中括约肌被刺激而不是膀胱，因此避免了尿失禁。 通过使用较高强度的脉冲串来实现膀胱肌肉作用，从而在每个脉冲串期间刺激肌肉，但是在每次中断期间，当膀胱保持收缩时，括约肌松弛。

公开(公告)号：US3869729A

公开(公告)日：1975-03-11

申请号：US31948072

申请日：1972-12-29

Applicant: NAT RES DEV

Inventor： ATTENBOROUGH CHRISTOPHER GEORG

IPC: A61F2/00 ,  A61F2/38 ,  A61F2/42 ,  A61F1/24

CPC classification number: A61F2/4241 ,  A61F2/3854 ,  A61F2002/30354 ,  A61F2220/0033

Abstract: An endoprosthetic bone joint device, suitable for the knee or other joints, is provided by way of two components of which one is slotted to receive in captive rotatable engagement therein a linkage member projecting from the other. In the direction of the slot, the slotted component has a generally convex bearing surface which engages a similarly directed concave bearing surface on the other component, but in an orthogonal direction the former surface can present two raised portions to engage respective depressions in the latter surface and resulting in a rib and groove along each side of the slot. This double rib groove formation is appropriate to a knee joint device, but can be simplified to singular curvature for another joint such as a finger. Also, the lateral dimension of the slot can progressively vary to allow a progressively varying lateral rocking capability with rotation of the components.

Abstract translation: 适于膝盖或其他关节的假体内骨关节装置通过两个部件提供，其中一个部件被开槽以在其中可自由转动地接合在另一个中的连接部件。 在狭槽的方向上，开槽部件具有大致凸起的支承表面，该表面接合另一部件上的相似方向的凹形支承表面，但是在正交方向上，前者表面可以呈现两个凸起部分以与后面的相应的凹陷 并且沿着槽的每一侧产生肋和凹槽。 这种双肋槽形成适合于膝关节装置，但是可以简化为另一关节（例如手指）的单一曲率。 此外，槽的横向尺寸可以逐渐变化，以允许随着部件旋转而逐渐变化的横向摆动能力。

公开(公告)号：US3869437A

公开(公告)日：1975-03-04

申请号：US39021673

申请日：1973-08-21

Applicant: NAT RES DEV

Inventor： LINDSAY DAVID GORDON ,  SHALL SYDNEY

IPC: A61K38/00 ,  C07K14/62 ,  C07C103/52 ,  A61K17/02 ,  C07G7/00

CPC classification number: C07K14/62 ,  A61K38/00

Abstract: A physiologically acceptable insulin derivative has the terminal amino group of the B chain (B1, phenylalanine) protected by an acyl group or other blocking group containing up to seven carbon atoms and the amino group of the A chain (A1, glycine) is either free or protected by means of an acyl or other blocking group containing no more than four carbon atoms and preferably no more than three atoms other than hydrogen. Pharmaceutical preparations may be prepared containing an effective amount of such an insulin derivative together with a physiologically acceptable diluent. An insulin derivative of reduced antigenicity is obtainable from porcine or bovine insulin by reacting the insulin with an acylating agent or other blocking reagent to acylate or otherwise block the amino group of the B1 amino acid and optionally block the A1 and/or B29 amino acid, followed by purification of the derivative by various methods.

Abstract translation: 生理上可接受的胰岛素衍生物具有由酰基或其它含有至多7个碳原子的封闭基保护的B链（B1，苯丙氨酸）的末端氨基，A链（A1，甘氨酸）的氨基是游离的 或通过含有不超过四个碳原子，优选不超过三个除了氢原子的酰基或其它封闭基团来保护。 可以制备含有有效量的这种胰岛素衍生物和生理上可接受的稀释剂的药物制剂。 降低抗原性的胰岛素衍生物可通过使胰岛素与酰化剂或其它阻断试剂反应来从猪或牛胰岛素获得，以酰化或以其它方式阻断B1氨基酸的氨基并任选地阻断A1和/或B29氨基酸， 然后用各种方法纯化衍生物。

公开(公告)号：US3868357A

公开(公告)日：1975-02-25

申请号：US22106072

申请日：1972-01-26

Applicant: NAT RES DEV

Inventor： SMYTH DEREK GEORGE ,  KO ARTHUR SAI CHUN

IPC: A61K38/00 ,  C07K14/62 ,  C07K14/625 ,  C07C103/52 ,  A61K17/02 ,  C07G7/00

CPC classification number: C07K14/62 ,  A61K38/00 ,  C07K14/625

Abstract: Insulin derivatives which are water soluble, readily isolated, immunologically acceptable and which retain hypoglycaemic activity are those in which at least one of the A1, B1 and B29 aminoacid amino groups is converted into a blocked amino group having a substituent capable of forming an anion, e.g., by substitution with dicarboxylic acid radicals.

Abstract translation: 水溶性，易分离，免疫学可接受且保持低血糖活性的胰岛素衍生物是其中A1，B1和B29氨基酸氨基中的至少一个转化为具有能够形成阴离子的取代基的封闭氨基的那些， 例如，用二羧酸基取代。

公开(公告)号：US3863276A

公开(公告)日：1975-02-04

申请号：US22752872

申请日：1972-02-17

Applicant: NAT RES DEV

Inventor： AGNEW KENNETH MALCOLM ,  COWARD TIMOTHY ,  TOMKIN DOUGLAS FRAZER

IPC: A47K13/00 ,  G03D9/00 ,  A47K11/02 ,  G03D11/00

CPC classification number: A47K13/00

Abstract: A seat for sanitary equipment such as water closets and commodes, has an elongated aperture extending between the front and rear, two non-planar profiled areas bordering the sides of the aperture towards its front, and a relieved area bordering the aperture behind the two areas. The profiled areas are trough formations to receive and support the thighs, and the relieved area is U-shaped and dished around the aperture to clear the buttocks. In a commode, such a seat conveniently forms part of a platform including at least one supplementary seating area extending laterally from the seat, there preferably being two such areas to form wings in an overall configuration which is curved or angled in plan view. Other features associated with such a commode comprise a user support arrangement upstanding from the platform rear and including a back rest and hand rail/arm rests, and also legs with rollers which can be rendered effective or not, the legs and support arrangement being adjustable in height and, in the latter case, angular disposition.

Abstract translation: 用于卫生设备（例如水厕和垃圾）的座椅具有在前后之间延伸的细长孔，两个非平面轮廓区域邻近孔的侧面朝向其前部，以及与两个区域后面的孔对接的缓解区域 。 形状区域是接收和支撑大腿的槽形结构，缓解区域是U形的，并围绕孔径抛出以清除臀部。 在通风口中，这样的座位可方便地形成平台的一部分，该平台包括至少一个从座椅横向延伸的辅助座位区域，优选地具有两个这样的区域以形成在俯视图中弯曲或成角度的整体构造的翼。 与这种接头相关联的其他特征包括从平台后部竖立的用户支撑装置，并且包括靠背和手扶轨/扶手，以及具有可以有效或无效的滚轮的腿，腿和支撑装置可调节 高度，在后一种情况下，角度配置。

公开(公告)号：US3862425A

公开(公告)日：1975-01-21

申请号：US33826273

申请日：1973-03-05

Applicant: NAT RES DEV

Inventor： MYERS MELVYN JOHN

IPC: G01T1/164 ,  G01T1/29 ,  G21K1/02 ,  G01T1/20

CPC classification number: G01T1/2985 ,  A61B6/4258 ,  G01T1/1642 ,  G21K1/025

Abstract: A radiation position detector is described particularly for detecting the source of gamma radiation over which a gamma camera is scanned. Electrical signals are generated representing the coordinates of the focal point of the gamma camera and of the received radiation. The received radiation signals are multiplied by a compensating factor to correct for a particular depth of radiation so that radiation starting at that depth is in focus. The corrected signals and the camera co-ordinate signals are combined so that a picture can be obtained in focus for the particular depth. Multiplexing may be used to provide correction for a plurality of depths.

Abstract translation: 特别地描述了一种辐射位置检测器，用于检测伽马照相机被扫描的伽马辐射源。 产生电信号，表示γ照相机的焦点和所接收的辐射的坐标。 所接收的辐射信号乘以补偿因子以校正特定的辐射深度，使得从该深度开始的辐射是焦点。 校正的信号和相机坐标信号被组合，使得可以获得针对特定深度的图像。 多路复用可用于为多个深度提供校正。