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    OUTER NEEDLE ASSEMBLY
    11.
    发明公开
    OUTER NEEDLE ASSEMBLY 审中-公开

    公开(公告)号：US20230256206A1

    公开(公告)日：2023-08-17

    申请号：US18011975

    申请日：2021-06-22

    Applicant: NIPRO CORPORATION

    Inventor： Kaname SADAHIRO ,  Hiroyuki NAKAGAMI ,  Tatsuya KUDO ,  Naoya KATAOKA

    IPC: A61M25/06 ,  A61M39/06

    CPC classification number: A61M25/0606 ,  A61M39/06 ,  A61M2039/062

    Abstract: An outer needle assembly 10 comprises an outer needle 48 wherethrough an inner needle 16 passes, and a passage forming member 50 connected to the outer needle 48 and including a valve body 64 inside such that a first internal space 78 on a distal side of the valve body 64 is longer than a second internal space 79 on a proximal side thereof. A ventilation path 80 for discharging air to an outside communicates with the first internal space 78 near the valve body 64. The first internal space 78 comprises: a puncture part 56 formed in a puncturing portion of the outer needle 48; a tapered part 57 formed on the proximal side of the puncture part 56 with an inner diameter increasing toward the proximal side; and a small-diameter part 89 formed on the proximal side of the tapered part 57 with an inner diameter smaller than or equal to that of a proximal end of the tapered part 57.

    Mutant glycine oxidase derived from thermophilic bacterium belonging to family bacillus, and method for producing same
    14.
    发明授权
    Mutant glycine oxidase derived from thermophilic bacterium belonging to family bacillus, and method for producing same 有权

    公开(公告)号：US11542480B2

    公开(公告)日：2023-01-03

    申请号：US16645120

    申请日：2018-09-10

    Applicant: NIPRO CORPORATION

    Inventor： Takashi Kimura ,  Yasushi Tani

    IPC: C12N9/02 ,  C12N9/06

    Abstract: A mutant glycine oxidase is obtained by substituting at least one wild-type amino acid sequence derived from thermophilic bacteria belonging to the family Bacillus with another amino acid, and has the following enzyme properties. Molecular weight: 40,000±2,000 daltons by SDS-PAGE. Optimum temperature: 45° C. under the condition of pH 8.5 in presence of pyrophosphate. Optimum pH: pH 8.0 under the condition of 37° C. in presence of pyrophosphate. Thermal stability: Stable up to 70° C. under the condition of pH 8.5 while retaining for 1 hour in presence of pyrophosphate. pH Stability: Stable in the range of pH 5.5 to 10.0 under the condition of 4° C. while retaining for 24 hours in presence of pyrophosphate. Specific activity: 1.2 units/mg or more. Kinetic constant Km: 0.2 mM or less.

    Catheter
    15.
    发明授权
    Catheter 有权

    公开(公告)号：US11529165B2

    公开(公告)日：2022-12-20

    申请号：US16530615

    申请日：2019-08-02

    Applicant: Nipro Corporation

    Inventor： Katsuya Miyagawa ,  Misa Matsumoto ,  Tomonori Nakamura

    IPC: A61B17/3207 ,  A61B8/12 ,  A61B8/00 ,  A61B17/22 ,  A61B90/00

    Abstract: To provide a catheter having a simple structure capable of excising an atheroma in a blood vessel and capable of obtaining ultrasonic images of a blood vessel.
    [Solution] A catheter 10 has a shaft 11 having an opening 20 in a part of the side wall on the distal end side, a cutter 12 which is located in the vicinity of the opening 20 in the internal space of the shaft 11 and which can move in the axial direction 101 of the shaft 11, a balloon 23 which is disposed on the side opposite to the opening 20 with respect to the axis of the shaft 11 and which outwardly expands from the side wall of the shaft 11, and a phased array ultrasound probe 17 disposed along the circumferential direction 102 of the outer peripheral surface of the side wall in the vicinity of the opening 20 at least on the same side as the side where the opening 20 is provided with respect to the axis of the shaft 11.

    SYRINGE-SHAPED SPRAYING DEVICE
    16.
    发明申请
    SYRINGE-SHAPED SPRAYING DEVICE 有权

    公开(公告)号：US20220370294A1

    公开(公告)日：2022-11-24

    申请号：US17774190

    申请日：2020-11-05

    Applicant: NIPRO CORPORATION

    Inventor： Yukihiro YABE

    IPC: A61J1/20

    Abstract: A syringe-shaped spraying device includes: a syringe-shaped spraying device main body including a barrel that stores a liquid medicine, a plunger having a front end inserted in the barrel with a gasket being attached to the front end, and a nozzle that is provided with a spraying hole for spraying the liquid medicine and that is connected to a front end of the barrel; a vial adapter having a transfer needle to pierce a vial that stores a liquid medicine so as to suction the liquid medicine; and a connection adapter that is attached to the syringe-shaped spraying device main body and that connects the vial adapter to the syringe-shaped spraying device main body.

    Needle tip protector for indwelling needle and indwelling needle assembly
    18.
    发明授权
    Needle tip protector for indwelling needle and indwelling needle assembly 有权

    公开(公告)号：US11331454B2

    公开(公告)日：2022-05-17

    申请号：US16306624

    申请日：2017-06-02

    Applicant: NIPRO CORPORATION

    Inventor： Yoshiei Ono ,  Kohzo Ishikura ,  Tatsuya Kudo ,  Takeshi Yamaguchi

    IPC: A61M25/06 ,  A61M5/158 ,  A61M5/32

    Abstract: The present invention provides a needle tip protector of a novel structure for an indwelling needle, which enables improvements in safety, etc. as compared with conventional needle tip protectors. A needle tip protector 10 for an indwelling needle includes a tubular peripheral wall 58, and is externally attached over a needle hub 22 of an indwelling needle 16 and moved toward a needle tip 14 side so as to cover the needle tip 14. Detents 74, 74, which are to be detained with the needle hub 22 at a position in a movement of the protector toward the needle tip 14 side of the indwelling needle 16 so as to inhibit backward movement of the protector to the proximal end side of the indwelling needle 16 and to prevent the needle tip 14 from being reexposed, are formed within an inside enclosed by the peripheral wall 58, and are integrally molded with the peripheral wall 58.

    Frozen storage container and frozen storage container system
    20.
    发明授权
    Frozen storage container and frozen storage container system 有权

    公开(公告)号：US11123264B2

    公开(公告)日：2021-09-21

    申请号：US16313410

    申请日：2017-06-27

    Applicant: NIPRO CORPORATION ,  KYOTO UNIVERSITY

    Inventor： Norio Nakatsuji ,  Hirofumi Suemori ,  Tsuneo Takahashi ,  Eihachiro Kawase ,  Atsushi Taguchi ,  Ryo Tomii

    IPC: A61J1/14 ,  B65B7/02 ,  A01N1/02 ,  A61J3/00 ,  B65B51/22 ,  A61J1/20 ,  B65D51/00

    Abstract: A biological sample or drug stored inside a frozen storage container is not susceptible to contamination. The frozen storage container includes a container body with an internal space, and a partition wall which divides the internal space at least into a first space and a second space. In the container body, the first space is liquid-tightly sealed, the second space has an opening which is in communication with the outside, and the second space is liquid-tightly sealable by welding the container body. A frozen storage container system includes the frozen storage container; and a needle member which includes a needle tip portion capable of being inserted into the internal space of the container body and capable of piercing the partition wall, and has a flow path which is opened at the needle tip portion and is opened at a base end portion opposite to the needle tip portion.

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