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    MOLECULAR DIAGNOSIS CARTRIDGE
    11.
    发明申请
    MOLECULAR DIAGNOSIS CARTRIDGE 有权

    公开(公告)号：US20250091053A1

    公开(公告)日：2025-03-20

    申请号：US18580994

    申请日：2022-06-24

    Applicant: OPTOLANE TECHNOLOGIES INC.

    Inventor： Seung Sun CHO ,  Won Yong CHOI ,  Sang Hoon LEE

    IPC: B01L9/00

    Abstract: Disclosed is a molecular diagnosis cartridge which is formed so that a molecular diagnosis chip can be easily inserted therein. The molecular diagnosis cartridge accommodating the molecular diagnosis chip comprises: a cartridge bottom member arranged on the lower portion; a hinge sub-ring arranged along the outer circumference of the cartridge bottom member; a cartridge outline member which is accommodated in a space defined by the hinge sub-ring fastened with the cartridge bottom member; a chip sliding member which has a shape surrounding the molecular diagnosis chip, is arranged on the cartridge outline member, and accommodates the molecular diagnosis chip that is inserted in an inclined direction; and a torsion spring-like member which is fastened with a kind of a seesaw axle protruding from the inner wall of the cartridge outline member, supports the chip sliding member to be inclined with respect to the cartridge bottom member in an open mode operation, and supports the chip sliding member to be parallel to the cartridge bottom member in a close mode operation. According to the present invention, the molecular diagnosis chip is inclinedly inserted in the chip sliding member, and easiness in insertion of the molecular diagnosis chip can be achieved. Also, as the cartridge cover is pressed, the chip sliding member accommodating the molecular diagnosis chip makes a seesaw movement on the basis of the seesaw axle and is moved to the cartridge bottom member, and thus, the molecular diagnosis chip arranged in the chip sliding member can be seated in the molecular diagnosis cartridge.

    Cartridge for digital real-time PCR
    12.
    发明授权
    Cartridge for digital real-time PCR 有权

    公开(公告)号：US11426731B2

    公开(公告)日：2022-08-30

    申请号：US16390380

    申请日：2019-04-22

    Applicant: OPTOLANE Technologies Inc.

    Inventor： Sergiy Oleksandrov ,  Do Young Lee ,  Min Sik Song ,  Kyung Hak Choi

    IPC: B01L3/00 ,  C12Q1/6806 ,  C12Q1/686

    Abstract: A cartridge for digital real-time Polymerase chain reaction (PCR) includes a microfluidic chamber, a well array, a CMOS photo sensor array and a PCB. The microfluidic chamber includes an inlet formed for injection of a liquid sample, the microfluidic chamber being capable of injection molding. The well array includes a plurality of microwells through which upper and lower portions are perforated and being attached to a lower surface of the microfluidic chamber. The CMOS photo sensor array is disposed below the well array to capture a response image of a sample filled in microwells of the well array. The PCB has a vent formed for vacuum processing of micro flow path formed in the microfluidic chamber, a space formed between the well array and the microfluidic chamber, and a microwell formed in the well array as the liquid sample is injected through the inlet.

    PCR MODULE, PCR SYSTEM HAVING THE SAME, AND METHOD OF INSPECTING USING THE SAME
    14.
    发明申请
    PCR MODULE, PCR SYSTEM HAVING THE SAME, AND METHOD OF INSPECTING USING THE SAME 审中-公开

    公开(公告)号：US20190217303A1

    公开(公告)日：2019-07-18

    申请号：US16361594

    申请日：2019-03-22

    Applicant: OPTOLANE Technologies Inc.

    Inventor： DoYoung LEE ,  In Gyun JEON ,  An Shik CHOI ,  Kyung Hak CHOI

    IPC: B01L7/00 ,  B01L3/00 ,  G01N21/64 ,  C12Q1/686

    Abstract: A polymerase chain reaction (PCR) module is detachably combined with a reader system. The reader system includes a central processing unit (CPU) receiving a photo sensing signal to calculate gene amplification amount in real time and generating a temperature control signal based on a temperature signal and a temperature control information. The PCR module includes a photo sensor assembly, a partition wall, and an interface module. The photo sensor assembly includes a plurality of photo sensors and a temperature sensor. The photo sensors are arranged in an array shape to sense emission light generated from a specimen to generate the photo sensing signal. The partition wall is protruded from the photo sensor assembly to define a reaction space in which the specimen is received. The interface module is electrically connected to the photo sensor assembly to transmit the photo sensing signal and the temperature signal to the reader system.

    BIOCHIP INCLUDING SIDE EMITTING-TYPE LIGHT-EMITTING DEVICE AND FABRICATION METHOD THEREOF
    15.
    发明申请
    BIOCHIP INCLUDING SIDE EMITTING-TYPE LIGHT-EMITTING DEVICE AND FABRICATION METHOD THEREOF 审中-公开

    公开(公告)号：US20180284024A1

    公开(公告)日：2018-10-04

    申请号：US16001056

    申请日：2018-06-06

    Applicant: OPTOLANE TECHNOLOGIES INC.

    Inventor： Do Young LEE ,  In Gyun JEON

    IPC: G01N21/64 ,  H01L31/18 ,  H01L31/12

    Abstract: The present disclosure a biochip including a side emitting-type light-emitting device, in which the bio-chip includes: a light-emitting device for emitting light from a fluorescent material; reflective layers provided over and under the light-emitting device so as to emit light from the sides of the light-emitting device; and reaction regions formed by etching of flanking regions of the light-emitting device. In the biochip, light emitted from the sides of the light-emitting device causes a biochemical reaction in the reaction regions. According to the present disclosure, light emitted from the light-emitting device moves only laterally without being transferred to the top or bottom of the bio-layer, and is transferred to the reaction regions formed by etching of flanking regions of the light-emitting device, so that a biochemical reaction in the reaction regions can be more efficiently performed.

    IN VITRO DIAGNOSTIC CHIP HAVING MULTIPLE LEVELS OF HYDROPHILICITY
    17.
    发明公开
    IN VITRO DIAGNOSTIC CHIP HAVING MULTIPLE LEVELS OF HYDROPHILICITY 审中-公开

    公开(公告)号：US20240286126A1

    公开(公告)日：2024-08-29

    申请号：US18573475

    申请日：2022-06-10

    Applicant: OPTOLANE TECHNOLOGIES INC.

    Inventor： Seung Sun CHO ,  An Shik CHOI ,  Byoung Joo KWAK ,  Sergiy OLEKSANDROV ,  Jae Hun KIM

    IPC: B01L3/00

    CPC classification number: B01L3/502 ,  B01L2200/0684 ,  B01L2200/14 ,  B01L2300/042 ,  B01L2300/0829 ,  B01L2300/161 ,  B01L2400/088

    Abstract: Disclosed is an in vitro diagnostic chip having multiple levels of hydrophilicity, which differentially controls the flow rates of a liquid sample and thus enables the liquid sample to be evenly distributed all the way to corner or edge regions of a reaction space. The in vitro diagnostic chip having multiple levels of hydrophilicity comprises: a well array comprising a plurality of wells; and a multi-hydrophilic coating layer coated on the well array and controlling the flow rates of a sample so as to be mutually different. The hydrophilic coating layer is formed on the well array so as to have high hydrophilicity in accordance with the center region of the well array, and to have low hydrophilicity in accordance with the peripheral region of the well array, and thus the formation of an air pocket in the reaction space may be blocked. Accordingly, the occurrence of an error caused by the air pocket in a PCR test result may be prevented.

    Immunoassay cartridge
    20.
    发明授权
    Immunoassay cartridge 有权

    公开(公告)号：US11162941B2

    公开(公告)日：2021-11-02

    申请号：US15881986

    申请日：2018-01-29

    Applicant: OPTOLANE Technologies Inc.

    Inventor： Do Young Lee ,  Kyung Hak Choi

    IPC: G01N33/543 ,  B01L3/00 ,  G01N21/64 ,  G02B5/22 ,  G01N21/76 ,  G01N21/03

    Abstract: An immunoassay cartridge is disclosed that can enhance the reliability of an antigen-antibody reaction while increasing a speed of an antigen-antibody reaction. An immunoassay cartridge includes a reaction chamber and a fluorescence sensor assembly. A plurality of antibodies or antigens is attached to an inner surface including a bottom surface of the reaction chamber closest to the sensor. The fluorescence sensor assembly is disposed on a bottom surface of the reaction chamber. Since the bottom surface of the reaction chamber and the upper surface of the fluorescence sensor assembly are arranged to coincide with each other, even if fluid is repeatedly moved in a first direction after the fluid moves in a second direction in the reaction chamber and then moved in the first direction, there is no obstacle in the movement of the fluid. Thus, it is possible to increase the probability of antigen-antibody reaction in the reaction chamber.

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