公开(公告)号：US20230408436A1

公开(公告)日：2023-12-21

申请号：US18335818

申请日：2023-06-15

Applicant: Board of Regents, The University of Texas System ,  Arizona Board of Regents on Behalf of Arizona State University ,  William Marsh Rice University

Inventor： Dino Villagran ,  Paul Westerhoff ,  Jonathan Josue Calvillo Solis ,  Michael Wong

IPC: G01N27/30 ,  G01N27/42 ,  C25D3/48

CPC classification number: G01N27/308 ,  G01N27/42 ,  C25D3/48

Abstract: A method of electrochemical sensing includes providing an electrochemical sensor comprising a glassy carbon substrate and gold nanoparticles located on a surface of the glassy carbon substrate; and sensing electrochemically a compound selected from the group consisting of polyfluoroalkyl compounds or perfluoroalkyl compounds using the electrochemical sensor. PFOA quantification was performed by Square Wave Adsorptive Cathodic Stripping Voltammetry (SW-AdCSV) in test solutions with a 100-5,000 ppt concentration. The concentration has a linear relationship with the stripping current within this range. Analysis of tap and groundwater samples performed by additions method demonstrated precision and accuracy above 95%. These electrodes show stability throughout 200 cycles, and reproducibility across similarly prepared but different electrodes above 97.5%. Providing the electrochemical sensor can include providing at least one member selected from the group consisting of perfluoro-1-octanethiol (PFTO), 2,2,2-trifluoroethanethiol (TFET) or perfluorodecanethiol (PFDT) on the surface of the glassy carbon substrate.

公开(公告)号：US11767303B2

公开(公告)日：2023-09-26

申请号：US17384051

申请日：2021-07-23

Applicant: Health Research, Inc. ,  Arizona Board of Regents on Behalf of the University of Arizona ,  Board of Regents, The University of Texas System

Inventor： Hongmin Li ,  Zhong Li ,  Jia Zhou ,  Jimin Xu ,  Qing-Yu Zhang

IPC: A61K31/5375 ,  C07D265/30 ,  C07C233/75 ,  C07D211/46 ,  A61P31/14 ,  C07D409/12 ,  C07D213/75 ,  C07D333/54

CPC classification number: C07D265/30 ,  A61P31/14 ,  C07C233/75 ,  C07D211/46 ,  C07D213/75 ,  C07D333/54 ,  C07D409/12

Abstract: The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof. The present disclosure further relates to methods of inhibiting viral replication including contacting one or more cells that have been infected with a virus with an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the virus comprises a flavivirus. Also disclosed is a method of treating and/or preventing a flavivirus infection and/or a condition resulting from a flavivirus infection including administering an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof under conditions effective to treat and/or prevent a flavivirus infection and/or a condition resulting from a flavivirus infection.

公开(公告)号：US11746049B2

公开(公告)日：2023-09-05

申请号：US17565025

申请日：2021-12-29

Applicant: The Regents of the University of California ,  Arizona Board of Regents on Behalf of Arizona State University

Inventor： Gaurav Sant ,  Laurent G. Pilon ,  Bu Wang ,  Narayanan Neithalath ,  Zhenhua Wei ,  Benjamin Young ,  Gabriel D. Falzone ,  Dante Simonetti

IPC: C04B7/19 ,  C04B7/46 ,  C04B7/38 ,  C04B9/20 ,  C04B40/02 ,  C04B7/36 ,  C04B28/04 ,  C04B111/00 ,  B01J19/24 ,  B01J19/08

CPC classification number: C04B7/19 ,  C04B7/367 ,  C04B7/38 ,  C04B7/46 ,  C04B9/20 ,  C04B28/04 ,  C04B40/0231 ,  B01J19/087 ,  B01J19/245 ,  B01J2219/24 ,  C04B2111/00017 ,  C04B2111/00129 ,  C04B28/04 ,  C04B18/067

Abstract: A manufacturing process of a concrete product includes: (1) extracting calcium from solids as portlandite; (2) forming a cementitious slurry including the portlandite; (3) shaping the cementitious slurry into a structural component; and (4) exposing the structural component to carbon dioxide sourced from a flue gas stream, thereby forming the concrete product.

公开(公告)号：US11692226B2

公开(公告)日：2023-07-04

申请号：US16635233

申请日：2018-07-31

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA ,  ARIZONA BOARD OF REGENTS ON BEHALF OF THE NORTHERN ARIZONA UNIVERSITY

Inventor： Ronald L. Heimark ,  Kelsey Guest ,  Jason Wilder ,  Virginia Ware ,  Christina Laukaitis

IPC: C12Q1/6883

CPC classification number: C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/178

Abstract: The invention disclosed herein generally relates to genotyping one or more single nucleotide polymorphisms (SNPs) to stratify cancer risk and/or prognosis.

公开(公告)号：US11634699B2

公开(公告)日：2023-04-25

申请号：US17052116

申请日：2019-05-01

Applicant: The Regents of the University of California ,  The Board of Regents of The University of Texas System

Inventor： Robert T. Clubb ,  Brendan Rayhan Amer ,  Janine Y. Fu ,  Scott McConnell ,  Hung Ton-That ,  Chungyu Chang

IPC: C12N9/52 ,  C07K1/13 ,  C12P21/00

Abstract: Covalently cross-linked pilus polymers displayed on the cell surface of Gram-positive bacteria are assembled by class C sortase enzymes. These pilus-specific transpeptidases located on the bacterial membrane catalyze a two-step protein ligation reaction—first, cleaving the LPXTG motif of one pilin protomer to form an acyl-enzyme intermediate, and second, joining the terminal threonine to the nucleophilic lysine residue residing within the pilin motif of another pilin protomer. Informed by the high-resolution crystal structures of corynebacterial pilus-specific sortase (SrtA) and by developing structural variants of the sortase enzyme whose catalytic pocket has been unmasked by activating mutations, we have developed new reagents capable of forming isopeptide bonds in vitro. The reagents disclosed herein can catalyze ligation of isolated SpaA domains in vitro provide a facile and versatile new platform for protein engineering and bio-conjugation that has major implications for biotechnology.

公开(公告)号：US20230101768A1

公开(公告)日：2023-03-30

申请号：US17819620

申请日：2022-08-13

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Somshuvra Mukhopadhyay ,  Chunyi Liu ,  Donald Smith

IPC: A61K31/472 ,  A61K31/513 ,  A61K31/4704 ,  A61K31/437 ,  A61K31/5377 ,  A61K31/4418 ,  A61P3/12

Abstract: Disclosed is a method for treating manganese (manganese) toxicity in a subject. The method includes administering to the subject an effective amount of a hypoxia inducible factor (HIF) prolyl hydroxylase inhibitor or a pharmaceutically acceptable salt or solvate thereof.

公开(公告)号：US11431470B2

公开(公告)日：2022-08-30

申请号：US16996061

申请日：2020-08-18

Applicant: The Board of Regents of The University of Texas System ,  The Regents of the University of California ,  Microsoft Technology Licensing, LLC

Inventor： Xiaoqian Jiang ,  Miran Kim ,  Yongsoo Song ,  Kristin Lauter

IPC: H04L9/00 ,  G06F21/60 ,  G06F17/16 ,  G06F21/62 ,  H04L9/06

Abstract: A method, system and computer program product for performing computations on sensitive data while guaranteeing privacy. A service provider receives a first and a second ciphertext from a medical provider that homomorphically encrypts matrices A and B, respectively, using an encryption key, where the matrices A and B include medical data encoded as vectors. The service provider performs a homomorphic matrix multiplication on the first and second ciphertexts without decrypting the first and second ciphertexts. An encrypted result from the performed homomorphic matrix multiplication on the first and second ciphertexts is generated and transmitted to the medical provider to decrypt which matches a result of performing a matrix multiplication on unencrypted matrices A and B thereby enabling computations to be performed on the medical data in a secure manner.

公开(公告)号：US20220233702A1

公开(公告)日：2022-07-28

申请号：US17615569

申请日：2020-06-03

Applicant: Regents of the University of Minnesota ,  Regents of the University of California

Inventor： Daniel A. Harki ,  Jian Tang ,  Ramkumar Moorthy ,  Rommie E. Amaro ,  Ozlem Demir

IPC: A61K47/55 ,  A61K47/54 ,  A61P35/00

Abstract: The disclosure is directed to compounds of the Formula (I) or (II): A—L1—B, A′—L1—B, or a pharmaceutically acceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein A is an Aurora A ligand, A′ is a CDK4/6 ligand; B is an E3 ligase ligand; and L1 is a linker, as well as pharmaceutical compositions comprising such compounds, and methods for treating cancer using such compounds.

公开(公告)号：US20220024884A1

公开(公告)日：2022-01-27

申请号：US17384051

申请日：2021-07-23

Applicant: Health Research, Inc. ,  Arizona Board of Regents on Behalf of the University of Arizona ,  Board of Regents, The University of Texas System

Inventor： Hongmin LI ,  Zhong LI ,  Jia ZHOU ,  Jimin XU ,  Qing-Yu ZHANG

IPC: C07D265/30 ,  C07C233/75 ,  C07D211/46 ,  C07D333/54 ,  C07D409/12 ,  C07D213/75 ,  A61P31/14

Abstract: The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof. The present disclosure further relates to methods of inhibiting viral replication including contacting one or more cells that have been infected with a virus with an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the virus comprises a flavivirus. Also disclosed is a method of treating and/or preventing a flavivirus infection and/or a condition resulting from a flavivirus infection including administering an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof under conditions effective to treat and/or prevent a flavivirus infection and/or a condition resulting from a flavivirus infection.

公开(公告)号：US20220000790A1

公开(公告)日：2022-01-06

申请号：US17479395

申请日：2021-09-20

Applicant: The University of North Carolina at Chapel Hill ,  The Arizona Board of Regents on behalf of the University of Arizona ,  The Regents of the University of Colorado, a body corporate

Inventor： Paul A. Dayton ,  Paul S. Sheeran ,  Terry O. Matsunaga ,  Mark A. Borden

IPC: A61K9/51 ,  A61K41/00 ,  A61K49/22 ,  B01J13/02 ,  A61K49/00 ,  A61K47/06

Abstract: Acoustically activatable particles having low vaporization energy and methods for making and using same are disclosed. A particle of material includes a first substance that includes at least one component that is a gas 25° C. and atmospheric pressure. A second substance, different from the first substance, encapsulates the first substance to create a droplet or emulsion that is stable at room temperature and atmospheric pressure. At least some of the first substance exists in a gaseous phase at the time of encapsulation of the first substance within the second substance to form a bubble. After formation of the bubble, the bubble is condensed into a liquid phase, which causes the bubble to transform into the droplet or emulsion having a core consisting of a liquid. The droplet or emulsion is an activatable phase change agent that remains a droplet having a core consisting of a liquid at 25° C. and atmospheric pressure. The first substance has a boiling point below 25° C. at atmospheric pressure.