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公开(公告)号:US20240417441A1
公开(公告)日:2024-12-19
申请号:US18800744
申请日:2024-08-12
Applicant: Regents of the University of Minnesota
Inventor: Bruce Kenneth Walcheck , Dan Samuel Kaufman , Jianming Wu , Yawu Jing , Zhenya Ni
IPC: C07K14/735 , A61K38/17 , A61K39/00 , A61K39/395 , C07K16/32 , C12N5/0783 , C12N5/0786 , C12N5/0787
Abstract: This disclosure describes, generally, a modified form of CD16, genetically-modified cells that express the modified CD16, and methods that involve the genetically-modified cells. The modified form of CD16 can exhibit increased anti-tumor and/or anti-viral activity due, at least in part, to reduced susceptibility to ADAM17-mediated shedding upon NK cell stimulation.
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公开(公告)号:US20240416117A1
公开(公告)日:2024-12-19
申请号:US18659672
申请日:2024-05-09
Applicant: Mayo Foundation for Medical Education and Research , Regents of the University of Minnesota
Inventor: Hai-Long Wang , Gregory A. Worrell , Vanda A. Lennon , Haidong Dong , Lynne T. Bemis , Richard G. Melvin
IPC: A61N1/36 , A61K9/00 , A61K31/7105 , A61K31/713 , A61N2/00
Abstract: Methods for modulating the release and content of extracellular vesicles from target cells using electrical stimulation are provided. Compositions comprising extracellular vesicles or extracts of extracellular vesicles and methods of administering the compositions to a subject are also provided.
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公开(公告)号:US20240408105A1
公开(公告)日:2024-12-12
申请号:US18412006
申请日:2024-01-12
Inventor: Marc D. Basson , Vadim J. Gurvich
IPC: A61K31/5377 , A61K31/40 , A61P1/04 , A61P17/02
Abstract: Methods to activate or enhance phosphorylation of focal adhesion kinase (FAK) are provided herein. Methods to treat epithelial disorders in mammals. namely diseases of the gut. comprising the administration of one or more small molecules having FAK activation properties are also provided.
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公开(公告)号:US20240407764A1
公开(公告)日:2024-12-12
申请号:US18689179
申请日:2022-09-09
Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor: Emad S. Ebbini , Nayef Abdulrahman Alshamlan , Abhishek Sahoo
Abstract: Embodiments are directed to a method for use in ultrasound imaging of matter in a region comprising providing wave energy into the region and transducing wave energy returned from the region to form a set of receive signals defining received signal data. The method comprises separating linear and nonlinear components of the received signal data based on a second order Volterra model. The method also comprises computing an estimate of a tissue acoustic nonlinearity parameter, B/A, using a ratio of the nonlinear component to the linear component, and identifying tissue characteristics of the matter in the region using the B/A.
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公开(公告)号:US20240402400A1
公开(公告)日:2024-12-05
申请号:US18733569
申请日:2024-06-04
Inventor: Seungjun Lee , Dongjea Seo , Sang Hyun Park , Tony Low , Steven J. Koester , Rehan Younas , Christopher Hinkle
IPC: G02B5/00
Abstract: Approaches to stack monolayer transition metal dichalcogenides (TMD) materials to develop near-perfect light absorbers (NPLAs) with only two atomic layers of TMD. Stacking TMDs may result in interlayer coupling with undesirable light absorbing behavior. The NPLAs of this disclosure stacks monolayer TMDs in such a way as to minimize TMD interlayer coupling, thus preserving TMD strong band nesting properties. Examples of approaches in this disclosure control the interlayer coupling by, for example, (a) twisted TMD bi-layers and (b) adding a buffer layer, e.g., a TMD/buffer layer/TMD tri-layer heterostructure. The NPLAs of this disclosure use the band nesting effect in TMDs, combined with a Salisbury screen geometry, to demonstrate NPLAs using only two or three uniform atomic layers of TMDs.
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公开(公告)号:US20240378437A1
公开(公告)日:2024-11-14
申请号:US18563316
申请日:2022-05-23
Applicant: Mayo Foundation for Medical Education and Research , Regents of the University of Minnesota
Inventor: Paul A. Friedman , Itzhak Zachi Attia , Gilad Lerman
Abstract: In some aspects, values of features obtained from training first and second machine-learning models are analyzed to correlate at least a subset of features from the first machine-learning model with at least a subset of features from the second machine-learning model. The correlated features are then applied to update the first or second machine-learning model, or to train a third machine-learning model. In other aspects, a generator machine-learning model processes a seed and a target characteristic indicator to generate a synthetic ECG signal. The synthetic ECG signal is biased according to a target physiological characteristic represented by the target characteristic indicator. The generator machine-learning model can be trained using an expert machine-learning model and in an adversarial process with a discriminator machine-learning model.
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公开(公告)号:US12142805B2
公开(公告)日:2024-11-12
申请号:US17339267
申请日:2021-06-04
Applicant: Regents of the University of Minnesota
Inventor: Rhonda Franklin , Yali Zhang , Joseph Um , Bethanie Joyce Hills Stadler , Rashaunda Henderson
Abstract: A complementary metal-oxide-semiconductor (CMOS) device includes a metal oxide layer comprising anodic aluminum oxide (AAO) and one or more nanowires (NW) of an electrically conducting material each formed within a corresponding pore extending through the AAO from a first side of the layer to a second side of the layer opposite the first side, a first electrically conducting layer disposed on the first side of the metal oxide layer, and a second electrically conducting layer disposed on the second side of the metal oxide layer. The nanowires form a via electrically connecting first electrically conducting layer and the second electrically conducting layer.
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公开(公告)号:US12138456B2
公开(公告)日:2024-11-12
申请号:US17174045
申请日:2021-02-11
Applicant: Regents of the University of Minnesota
Inventor: Hubert H. Lim , Craig D. Markovitz , Sarah J. Offutt
IPC: A61N1/36 , A61F7/00 , A61F11/00 , A61H23/02 , A61M21/00 , A61N2/00 , A61N2/02 , A61N5/06 , A61N7/00
Abstract: The invention provides methods for treating a neurological disorder or deficit, such as tinnitus and phantom limb pain.
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公开(公告)号:US20240358040A1
公开(公告)日:2024-10-31
申请号:US18649533
申请日:2024-04-29
Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor: Sonali Raghunath , Kumar P. Mallikarjunan , Tonya Schoenfuss
Abstract: A system for modifying dairy protein functionality can include a milk protein input, a treatment process, and a milk protein output. A controller can be in communication with the treatment process and can be configured to receive one or more input parameters. The controller can generate one or more treatment parameters based on the one or more input parameters. The controller can then initiate the treatment process based on one or more of the treatment parameters. The modified dairy protein functionality can be selected or optimized based on a target functionality of the milk protein output.
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公开(公告)号:US20240355227A1
公开(公告)日:2024-10-24
申请号:US18643653
申请日:2024-04-23
Applicant: Regents of the University of Minnesota
Inventor: Alex Siu Lun Fok , Anqi Zhang , Ruoqiong Chen , Tamer Abdelrehim , Bruno Pierre Lima , Stephanie Porter , Hooi Pin Chew , Dina Elsherbini , Saba Tohidkhah
IPC: G09B23/28
CPC classification number: G09B23/283
Abstract: Example artificial dental calculus models are described. In one example, an in vitro artificial dental calculus includes a dental substrate and a mineralized biofilm comprising an extracellular support material and at least one bacterial species. In one example, a method for creating an in vitro dental calculus model includes applying saliva to a dental substrate in a production environment, applying a mixture of an extracellular support material and at least one bacterial species to the dental substrate, applying a solution comprising calcium and phosphate to the mixture on the dental substrate, and removing the dental substrate from the production environment after a period of time during which a mineralized biofilm comprising the extracellular support material and the at least one bacterial species forms on the dental substrate.
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