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公开(公告)号：US20090111750A1
公开(公告)日：2009-04-30
申请号：US12262821
申请日：2008-10-31
CPC分类号： A61K38/1748 , A61K8/65 , A61K38/015 , A61Q1/02 , A61Q1/06 , A61Q1/10 , A61Q3/02 , A61Q5/02 , A61Q5/04 , A61Q5/06 , A61Q5/065 , A61Q5/12 , A61Q9/02 , A61Q19/002 , A61Q19/007 , A61Q19/08 , A61Q19/10 , C07K14/4741
摘要： Soluble keratin derivatives are disclosed. The soluble keratin derivatives may include a soluble keratin protein having at least one substituted chemical group at a lysine group, terminal amine group and/or hydroxyl amino acid group of a soluble keratin protein. Soluble keratin derivatives may be formed by succinylation or quaternisation, or by reaction with fatty acid derivatives. The soluble keratin derivatives may be used in personal care formulations, and may also comprise mixtures of several different soluble keratin derivatives.
摘要翻译： 公开了可溶性角蛋白衍生物。 可溶性角蛋白衍生物可以包括在可溶性角蛋白蛋白质的赖氨酸基团，末端胺基团和/或羟基氨基酸基团具有至少一个取代的化学基团的可溶性角蛋白蛋白质。 可溶性角蛋白衍生物可以通过琥珀酰化或季铵化形成，或通过与脂肪酸衍生物的反应形成。 可溶性角蛋白衍生物可以用于个人护理制剂中，并且还可以包含几种不同的可溶性角蛋白衍生物的混合物。
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12.发明申请PRODUCTION OF BIOPOLYMER FILM, FIBRE, FOAM AND ADHESIVE MATERIALS FROM SOLUBLE S-SULFONATED KERATIN DERIVATIVES 审中-公开生物聚合物薄膜，纤维，泡沫和粘合材料从可溶性硫酸化的克拉丁衍生物公开(公告)号：US20090069541A1
公开(公告)日：2009-03-12
申请号：US12252218
申请日：2008-10-15
申请人： Robert James Kelly , Alisa Dawn Roddick-Lanzilotta , Douglas Alexander Rankin , Warren Glenn Bryson
发明人： Robert James Kelly , Alisa Dawn Roddick-Lanzilotta , Douglas Alexander Rankin , Warren Glenn Bryson
IPC分类号： C07K14/78
CPC分类号： C08J5/18 , C08H1/06 , C08J9/28 , C08J2201/048 , C08J2389/00 , D01F4/00 , Y10T428/14 , Y10T428/28 , Y10T428/2852
摘要： Film, fibre, foam and adhesive materials are produced from soluble S-sulfonated keratins. Once formed, the films, fibres, foams or adhesives are treated to modify the properties of the materials, in particular to improve the wet strength of the materials. Treatments used include removal of the S-sulfonate group by treatment with a reducing agent, treatment with an acid or treatment with a common protein crosslinking agent or treatment with a reduced form of keratin or keratin protein. The films are made by solvent casting a solution of S-sulfonated keratin proteins, the foam made by freeze-drying a solution of S-sulfonated keratin proteins and the fibres made by extruding a solution of a S-sulfonated keratin protein.
摘要翻译： 膜，纤维，泡沫和粘合剂材料由可溶性S-磺化角蛋白产生。 一旦形成，则处理膜，纤维，泡沫或粘合剂以改变材料的性质，特别是改善材料的湿强度。 使用的处理包括通过用还原剂处理除去S-磺酸盐基团，用酸处理或用常见的蛋白质交联剂处理或用还原形式的角蛋白或角蛋白蛋白处理。 通过溶剂浇铸S-磺化角蛋白溶液，通过冷冻干燥S-磺化角蛋白蛋白溶液制成的泡沫和通过挤出S-磺化角蛋白溶液的纤维制成的薄膜。
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13.发明申请POROUS KERATIN CONSTRUCTS, WOUND HEALING ASSEMBLIES AND METHODS USING THE SAME 审中-公开多孔康宁结构，创伤治疗组合和使用它的方法公开(公告)号：US20080317826A1
公开(公告)日：2008-12-25
申请号：US12127694
申请日：2008-05-27
申请人： Robert James Kelly , Gudmunder Fertram Sigurjonsson , Clive Marsh , Robert Allen Smith , Mohammad Azam Ali
发明人： Robert James Kelly , Gudmunder Fertram Sigurjonsson , Clive Marsh , Robert Allen Smith , Mohammad Azam Ali
CPC分类号： A61F13/00068 , A61F13/00012 , A61F13/069 , A61F2013/00157 , A61F2013/00174 , A61F2013/00519 , A61F2013/00536 , A61F2013/0054 , A61F2013/0074 , A61K38/39
摘要： A porous keratin construct for use in wound healing is disclosed. The porous keratin construct may be used standing alone or in combination with a synthetic foam backing layer. Either the porous keratin construct or the porous keratin construct and synthetic foam combination may be used in a wound therapy such as negative pressure wound therapy. An assembly for use in negative pressure wound therapy may comprise a porous keratin construct or porous keratin construct and synthetic foam combination, a wound drape to encapsulate the wound and the porous keratin construct or porous keratin construct and synthetic foam combination, and a vacuum source in fluid communication with the wound drape to apply a negative pressure to the area encapsulated by the wound drape
摘要翻译： 公开了一种用于伤口愈合的多孔角蛋白构建体。 多孔角蛋白构建体可以单独使用或与合成泡沫背衬层组合使用。 多孔角蛋白构建体或多孔角蛋白构建体和合成泡沫组合可用于伤口治疗如负压伤口治疗。 用于负压伤口治疗的组件可以包括多孔角蛋白构建体或多孔角蛋白构建体和合成泡沫组合，用于包封伤口的伤口覆盖物和多孔角蛋白构建体或多孔角蛋白构建体和合成泡沫组合，以及真空源 与伤口悬垂液体连通以对由伤口覆盖物封装的区域施加负压
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公开(公告)号：US08142807B2
公开(公告)日：2012-03-27
申请号：US11987939
申请日：2007-12-06
IPC分类号： A61F2/00
CPC分类号： A61L27/52 , A61L27/227 , A61L27/26 , A61L27/3608 , A61L27/365 , A61L27/46 , A61L27/48 , A61L27/502 , A61L2430/02 , C08L89/00
摘要： The invention relates to a material for use as bone void filler comprising soluble keratin protein. The material may be in the form of a putty, gel or emulsion. Additional components may be added to the material to improve handling characteristics and bone enhancement capabilities. The material may be formulated to serve as a suitable carrier for demineralized bone matrix. This invention also describes methods for making the material.
摘要翻译： 本发明涉及一种用作包含可溶性角蛋白的骨空隙填料的材料。 该材料可以是油灰，凝胶或乳液的形式。 可以向材料中添加额外的组分以改善处理特征和骨增强能力。 该材料可以配制成用作软化骨基质的合适载体。 本发明还描述了制造材料的方法。
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15.发明授权Production of biopolymer film, fibre, foam and adhesive materials from soluble S-sulfonated keratin derivatives 有权从可溶性S-磺化角蛋白衍生物生产生物聚合物膜，纤维，泡沫和粘合剂材料公开(公告)号：US07465321B2
公开(公告)日：2008-12-16
申请号：US10488188
申请日：2002-08-30
申请人： Robert James Kelly , Alisa Dawn Roddick-Lanzilotta , Douglas Alexander Rankin , Warren Glenn Bryson
发明人： Robert James Kelly , Alisa Dawn Roddick-Lanzilotta , Douglas Alexander Rankin , Warren Glenn Bryson
IPC分类号： D06M13/256 , A61K38/17 , C07K14/435 , B32B9/02
CPC分类号： C08J5/18 , C08H1/06 , C08J9/28 , C08J2201/048 , C08J2389/00 , D01F4/00 , Y10T428/14 , Y10T428/28 , Y10T428/2852
摘要： Film, fibre, foam and adhesive materials are produced from soluble S-sulfonated keratins. Once formed, the films, fibres, foams or adhesives are treated to modify the properties of the materials, in particular to improve the wet strength of the materials. Treatments used include removal of the S-sulfonate group by treatment with a reducing agent, treatment with an acid or treatment with a common protein crosslinking agent or treatment with a reduced form of keratin or keratin protein. The films are made by solvent casting a solution of S-sulfonated keratin proteins, the foam made by freeze-drying a solution of S-sulfonated keratin proteins and the fibres made by extruding a solution of a S-sulfonated keratin protein.
摘要翻译： 膜，纤维，泡沫和粘合剂材料由可溶性S-磺化角蛋白产生。 一旦形成，则处理膜，纤维，泡沫或粘合剂以改变材料的性质，特别是改善材料的湿强度。 使用的处理包括通过用还原剂处理除去S-磺酸盐基团，用酸处理或用常见的蛋白质交联剂处理或用还原形式的角蛋白或角蛋白蛋白处理。 通过溶剂浇铸S-磺化角蛋白溶液，通过冷冻干燥S-磺化角蛋白蛋白溶液制成的泡沫和通过挤出S-磺化角蛋白溶液的纤维制成的薄膜。
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公开(公告)号：US20080206301A1
公开(公告)日：2008-08-28
申请号：US11987939
申请日：2007-12-06
IPC分类号： A61F2/00
CPC分类号： A61L27/52 , A61L27/227 , A61L27/26 , A61L27/3608 , A61L27/365 , A61L27/46 , A61L27/48 , A61L27/502 , A61L2430/02 , C08L89/00
摘要： The invention relates to a material for use as bone void filler comprising soluble keratin protein. The material may be in the form of a putty, gel or emulsion. Additional components may be added to the material to improve handling characteristics and bone enhancement capabilities. The material may be formulated to serve as a suitable carrier for demineralized bone matrix. This invention also describes methods for making the material.
摘要翻译： 本发明涉及一种用作包含可溶性角蛋白的骨空隙填料的材料。 该材料可以是油灰，凝胶或乳液的形式。 可以向材料中添加额外的组分以改善处理特征和骨增强能力。 该材料可以配制成用作软化骨基质的合适载体。 本发明还描述了制造材料的方法。
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公开(公告)号：US07297342B2
公开(公告)日：2007-11-20
申请号：US10517378
申请日：2003-06-10
申请人： Philip Victor Peplow , Subasinghe Nisanke George Premalal Jayantha Dias , Alisa Dawn Roddick-Lanzilotta , Robert James Kelly
发明人： Philip Victor Peplow , Subasinghe Nisanke George Premalal Jayantha Dias , Alisa Dawn Roddick-Lanzilotta , Robert James Kelly
CPC分类号： C08H1/06 , A61L27/227 , A61L27/46 , A61L27/56 , A61L2430/02 , C08L89/04
摘要： The invention provides a biocompatible material derived from keratin that is useful for many aspects of medical treatment of bone. The keratin material is preferably S-sulfonated and enriched in intermediate filament proteins of high molecular weight. The keratin material may be porous for use as a bone replacement and augmentation product but also provided is the use of dense keratin materials in bone treatment for use as an internal fixation appliance in the treatment of bone fractures and bone regeneration, and a method for preparing the keratin material for use in the preservation, restoration and development of form and function of bone.
摘要翻译： 本发明提供衍生自角蛋白的生物相容性材料，其可用于治疗骨的许多方面。 角蛋白材料优选被S-磺化并富集高分子量的中间丝蛋白质。 角蛋白材料可以是多孔的，用作骨替代和增强产品，但也提供了在骨治疗中使用致密的角蛋白材料用作骨折和骨再生的治疗中的内固定用具，以及制备方法 用于保护，恢复和发展骨骼形态和功能的角蛋白材料。
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公开(公告)号：US20090105456A1
公开(公告)日：2009-04-23
申请号：US12000222
申请日：2007-12-11
IPC分类号： C07K14/78
CPC分类号： A61L15/425 , A61L15/32 , A61L15/64 , C08H1/00 , C08L89/00
摘要： The invention relates to a porous keratin construct material comprising keratin protein for use in wound healing applications. The porous keratin construct is capable of bio-absorbing into a wound to promote wound healing. The rate at which the construct bio-absorbs into the wound may be controlled altered by controlling the degree of disulfide cross-linking between the keratin proteins in the porous keratin construct. The invention is also related to a method of making the porous keratin construct.
摘要翻译： 本发明涉及包含用于伤口愈合应用的角蛋白蛋白的多孔角蛋白构建体材料。 多孔角蛋白构建体能够生物吸收到伤口中以促进伤口愈合。 可以通过控制多孔角蛋白构建体中的角蛋白质之间的二硫键交联程度来改变构建物生物吸收到伤口中的速率。 本发明还涉及制造多孔角蛋白构建体的方法。
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公开(公告)号：US20080004423A1
公开(公告)日：2008-01-03
申请号：US10572593
申请日：2004-09-13
申请人： Robert James Kelly , Mohammad Azam Ali , Alisa Dawn Roddick-Lanzilotta , Gillian Worth , Mohammad Mahbubul Hassan , John Robert McLaughlin , Alan John McKinnon
发明人： Robert James Kelly , Mohammad Azam Ali , Alisa Dawn Roddick-Lanzilotta , Gillian Worth , Mohammad Mahbubul Hassan , John Robert McLaughlin , Alan John McKinnon
CPC分类号： C08F289/00 , C08F261/04 , C08F271/02 , C08F283/06 , C08L29/04 , C08L51/003 , C08L51/08 , C08L89/04 , Y10T428/2913 , C08L2666/26 , C08L2666/02
摘要： The application describes materials derived from keratin proteins in combination with polymers, either as intimate mixtures with water soluble polymers, or as chemically bound copolymers. The keratin protein is a specific keratin protein fraction, and is preferably intact, s-sulfonated and from the intermediate filament protein family. The application also describes the process for production of these materials.
摘要翻译： 该应用描述了衍生自与聚合物组合的角蛋白蛋白质的材料，作为与水溶性聚合物的紧密混合物，或作为化学结合共聚物。 角蛋白蛋白质是特定的角蛋白级分，优选是完整的，磺化的和中间丝蛋白质家族。 该应用还描述了生产这些材料的过程。
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