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公开(公告)号：US07297342B2
公开(公告)日：2007-11-20
申请号：US10517378
申请日：2003-06-10
申请人： Philip Victor Peplow , Subasinghe Nisanke George Premalal Jayantha Dias , Alisa Dawn Roddick-Lanzilotta , Robert James Kelly
发明人： Philip Victor Peplow , Subasinghe Nisanke George Premalal Jayantha Dias , Alisa Dawn Roddick-Lanzilotta , Robert James Kelly
CPC分类号： C08H1/06 , A61L27/227 , A61L27/46 , A61L27/56 , A61L2430/02 , C08L89/04
摘要： The invention provides a biocompatible material derived from keratin that is useful for many aspects of medical treatment of bone. The keratin material is preferably S-sulfonated and enriched in intermediate filament proteins of high molecular weight. The keratin material may be porous for use as a bone replacement and augmentation product but also provided is the use of dense keratin materials in bone treatment for use as an internal fixation appliance in the treatment of bone fractures and bone regeneration, and a method for preparing the keratin material for use in the preservation, restoration and development of form and function of bone.
摘要翻译： 本发明提供衍生自角蛋白的生物相容性材料，其可用于治疗骨的许多方面。 角蛋白材料优选被S-磺化并富集高分子量的中间丝蛋白质。 角蛋白材料可以是多孔的，用作骨替代和增强产品，但也提供了在骨治疗中使用致密的角蛋白材料用作骨折和骨再生的治疗中的内固定用具，以及制备方法 用于保护，恢复和发展骨骼形态和功能的角蛋白材料。
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公开(公告)号：US07892572B2
公开(公告)日：2011-02-22
申请号：US11907021
申请日：2007-10-09
申请人： Philip Victor Peplow , Subasinghe Nisanke George Premalal Jayantha Dias , Alisa Dawn Roddick-Lanzilotta , Robert James Kelly
发明人： Philip Victor Peplow , Subasinghe Nisanke George Premalal Jayantha Dias , Alisa Dawn Roddick-Lanzilotta , Robert James Kelly
CPC分类号： C08H1/06 , A61L27/227 , A61L27/46 , A61L27/56 , A61L2430/02 , C08L89/04
摘要： The invention provides a biocompatible material derived from keratin that is useful for many aspects of medical treatment of bone. The keratin material is preferably S-sulfonated and enriched in intermediate filament proteins of high molecular weight. The keratin material may be porous for use as a bone replacement and augmentation product but also provided is the use of dense keratin materials in bone treatment for use as an internal fixation appliance in the treatment of bone fractures and bone regeneration, and a method for preparing the keratin material for use in the preservation, restoration and development of form and function of bone.
摘要翻译： 本发明提供衍生自角蛋白的生物相容性材料，其可用于治疗骨的许多方面。 角蛋白材料优选被S-磺化并富集高分子量的中间丝蛋白质。 角蛋白材料可以是多孔的，用作骨替代和增强产品，但也提供了在骨治疗中使用致密的角蛋白材料用作骨折和骨再生的治疗中的内固定用具，以及制备方法 用于保护，恢复和发展骨骼形态和功能的角蛋白材料。
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3.发明申请PRODUCTION OF BYPOLYMER FILM, FIBRE, FOAM AND ADHESIVE MATERIALS FROM SOLUBLE S-SULFONATED KERATIN DERIVATIVE 审中-公开来自可溶性S-SULFONATED KERATIN衍生物的副产物膜，纤维，泡沫和粘合材料的生产公开(公告)号：US20090062513A1
公开(公告)日：2009-03-05
申请号：US12252243
申请日：2008-10-15
申请人： Robert James Kelly , Alisa Dawn Roddick-Lanzilotta , Douglas Alexander Rankin , Warren Glenn Bryson
发明人： Robert James Kelly , Alisa Dawn Roddick-Lanzilotta , Douglas Alexander Rankin , Warren Glenn Bryson
CPC分类号： C08J5/18 , C08H1/06 , C08J9/28 , C08J2201/048 , C08J2389/00 , D01F4/00 , Y10T428/14 , Y10T428/28 , Y10T428/2852
摘要： Film, fibre, foam and adhesive materials are produced from soluble S-sulfonated keratins. Once formed, the films, fibres, foams or adhesives are treated to modify the properties of the materials, in particular to improve the wet strength of the materials. Treatments used include removal of the S-sulfonate group by treatment with a reducing agent, treatment with an acid or treatment with a common protein crosslinking agent or treatment with a reduced form of keratin or keratin protein. The films are made by solvent casting a solution of S-sulfonated keratin proteins, the foam made by freeze-drying a solution of S-sulfonated keratin proteins and the fibres made by extruding a solution of a S-sulfonated keratin protein.
摘要翻译： 膜，纤维，泡沫和粘合剂材料由可溶性S-磺化角蛋白产生。 一旦形成，则处理膜，纤维，泡沫或粘合剂以改变材料的性质，特别是改善材料的湿强度。 使用的处理包括通过用还原剂处理除去S-磺酸盐基团，用酸处理或用常见的蛋白质交联剂处理或用还原形式的角蛋白或角蛋白蛋白处理。 通过溶剂浇铸S-磺化角蛋白溶液，通过冷冻干燥S-磺化角蛋白蛋白溶液制成的泡沫和通过挤出S-磺化角蛋白溶液的纤维制成的薄膜。
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公开(公告)号：US20080038327A1
公开(公告)日：2008-02-14
申请号：US10583445
申请日：2004-12-16
CPC分类号： A61L15/32 , A61K38/39 , A61L26/0047 , A61L26/008
摘要： The invention relates to a would care product that provides a biochemical environment around a wound to promote wound healing. The wound care product includes a keratin protein fraction material in which the protein fraction is intact, is from the intermediate filament protein family or the high sulfur protein family and in which the protein fraction is S-sulfonated. The invention also described a method of making a wound care product.
摘要翻译： 本发明涉及一种在伤口周围提供生化环境以促进伤口愈合的护理产品。 伤口护理产品包括其中蛋白质级分完整的角蛋白蛋白级分物质，来自中间丝蛋白家族或高硫蛋白质家族，其中蛋白质级分是S-磺化的。 本发明还描述了一种制备伤口护理产品的方法。
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公开(公告)号：US20080004423A1
公开(公告)日：2008-01-03
申请号：US10572593
申请日：2004-09-13
申请人： Robert James Kelly , Mohammad Azam Ali , Alisa Dawn Roddick-Lanzilotta , Gillian Worth , Mohammad Mahbubul Hassan , John Robert McLaughlin , Alan John McKinnon
发明人： Robert James Kelly , Mohammad Azam Ali , Alisa Dawn Roddick-Lanzilotta , Gillian Worth , Mohammad Mahbubul Hassan , John Robert McLaughlin , Alan John McKinnon
CPC分类号： C08F289/00 , C08F261/04 , C08F271/02 , C08F283/06 , C08L29/04 , C08L51/003 , C08L51/08 , C08L89/04 , Y10T428/2913 , C08L2666/26 , C08L2666/02
摘要： The application describes materials derived from keratin proteins in combination with polymers, either as intimate mixtures with water soluble polymers, or as chemically bound copolymers. The keratin protein is a specific keratin protein fraction, and is preferably intact, s-sulfonated and from the intermediate filament protein family. The application also describes the process for production of these materials.
摘要翻译： 该应用描述了衍生自与聚合物组合的角蛋白蛋白质的材料，作为与水溶性聚合物的紧密混合物，或作为化学结合共聚物。 角蛋白蛋白质是特定的角蛋白级分，优选是完整的，磺化的和中间丝蛋白质家族。 该应用还描述了生产这些材料的过程。
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6.发明授权Production of biopolymer film, fibre, foam and adhesive materials from soluble S-sulfonated keratin derivatives 有权从可溶性S-磺化角蛋白衍生物生产生物聚合物膜，纤维，泡沫和粘合剂材料公开(公告)号：US07465321B2
公开(公告)日：2008-12-16
申请号：US10488188
申请日：2002-08-30
申请人： Robert James Kelly , Alisa Dawn Roddick-Lanzilotta , Douglas Alexander Rankin , Warren Glenn Bryson
发明人： Robert James Kelly , Alisa Dawn Roddick-Lanzilotta , Douglas Alexander Rankin , Warren Glenn Bryson
IPC分类号： D06M13/256 , A61K38/17 , C07K14/435 , B32B9/02
CPC分类号： C08J5/18 , C08H1/06 , C08J9/28 , C08J2201/048 , C08J2389/00 , D01F4/00 , Y10T428/14 , Y10T428/28 , Y10T428/2852
摘要： Film, fibre, foam and adhesive materials are produced from soluble S-sulfonated keratins. Once formed, the films, fibres, foams or adhesives are treated to modify the properties of the materials, in particular to improve the wet strength of the materials. Treatments used include removal of the S-sulfonate group by treatment with a reducing agent, treatment with an acid or treatment with a common protein crosslinking agent or treatment with a reduced form of keratin or keratin protein. The films are made by solvent casting a solution of S-sulfonated keratin proteins, the foam made by freeze-drying a solution of S-sulfonated keratin proteins and the fibres made by extruding a solution of a S-sulfonated keratin protein.
摘要翻译： 膜，纤维，泡沫和粘合剂材料由可溶性S-磺化角蛋白产生。 一旦形成，则处理膜，纤维，泡沫或粘合剂以改变材料的性质，特别是改善材料的湿强度。 使用的处理包括通过用还原剂处理除去S-磺酸盐基团，用酸处理或用常见的蛋白质交联剂处理或用还原形式的角蛋白或角蛋白蛋白处理。 通过溶剂浇铸S-磺化角蛋白溶液，通过冷冻干燥S-磺化角蛋白蛋白溶液制成的泡沫和通过挤出S-磺化角蛋白溶液的纤维制成的薄膜。
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公开(公告)号：US20100330019A1
公开(公告)日：2010-12-30
申请号：US12740633
申请日：2008-10-31
CPC分类号： A61K38/1748 , A61K8/65 , A61K38/015 , A61Q1/02 , A61Q1/06 , A61Q1/10 , A61Q3/02 , A61Q5/02 , A61Q5/04 , A61Q5/06 , A61Q5/065 , A61Q5/12 , A61Q9/02 , A61Q19/002 , A61Q19/007 , A61Q19/08 , A61Q19/10 , C07K14/4741
摘要： Soluble keratin derivatives are disclosed. The soluble keratin derivatives may include a soluble keratin protein having at least one substituted chemical group at a lysine group, terminal amine group and/or hydroxyl amino acid group of a soluble keratin protein. Soluble keratin derivatives may be formed by succinylation or quaternisation, or by reaction with fatty acid derivatives. The soluble keratin derivatives may be used in personal care formulations, and may also comprise mixtures of several different soluble keratin derivatives.
摘要翻译： 公开了可溶性角蛋白衍生物。 可溶性角蛋白衍生物可以包括在可溶性角蛋白蛋白质的赖氨酸基团，末端胺基团和/或羟基氨基酸基团具有至少一个取代的化学基团的可溶性角蛋白蛋白质。 可溶性角蛋白衍生物可以通过琥珀酰化或季铵化形成，或通过与脂肪酸衍生物的反应形成。 可溶性角蛋白衍生物可以用于个人护理制剂中，并且还可以包含几种不同的可溶性角蛋白衍生物的混合物。
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公开(公告)号：US07148327B2
公开(公告)日：2006-12-12
申请号：US10483607
申请日：2002-07-17
申请人： Robert James Kelly , Gillian Helen Worth , Alisa Dawn Roddick-Lanzilotta , Douglas Alexander Rankin , Gregory David Ellis , Paul Johannes Roy Mesman , Conal Garth Summers , Diane Joyce Singleton
发明人： Robert James Kelly , Gillian Helen Worth , Alisa Dawn Roddick-Lanzilotta , Douglas Alexander Rankin , Gregory David Ellis , Paul Johannes Roy Mesman , Conal Garth Summers , Diane Joyce Singleton
CPC分类号： C07K14/4741
摘要： A process for the preparation of soluble proteins of high molecular weight with little or no damage to the structural integrity of the proteins. The process is economically and environmentally acceptable by virtue of the cost of reagents that are used, and the recycling of some of those reagents, and is suitable for the production of soluble proteins on a large scale. The process includes a first stage using oxidative sulfitolysis followed by a second stage using mild conditions to extract the soluble protein. In the case of wool as the protein source the process leads to the production of soluble keratin proteins fractionated into the classes S-sulfonated keratin intermediate filament proteins and S-sulfonated keratin high sulfur proteins.
摘要翻译： 一种制备高分子量可溶性蛋白质的方法，对蛋白质的结构完整性几乎没有或没有损害。 由于使用的试剂的成本和这些试剂中的一些的再循环，该方法在经济上和环境上都是可接受的，并且适用于大规模生产可溶性蛋白质。 该方法包括使用氧化亚磺酸溶解的第一阶段，随后使用温和条件提取可溶性蛋白质的第二阶段。 在羊毛作为蛋白质来源的情况下，该过程导致可分离成S-磺化角蛋白中间丝蛋白和S-磺化角蛋白高硫蛋白的可溶性角蛋白的产生。
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公开(公告)号：US07767756B2
公开(公告)日：2010-08-03
申请号：US10572593
申请日：2004-09-13
申请人： Robert James Kelly , Mohammad Azam Ali , Alisa Dawn Roddick-Lanzilotta , Gillian Worth , Mohammad Mahbubul Hassan , John Robert McLaughlin , Alan John McKinnon
发明人： Robert James Kelly , Mohammad Azam Ali , Alisa Dawn Roddick-Lanzilotta , Gillian Worth , Mohammad Mahbubul Hassan , John Robert McLaughlin , Alan John McKinnon
CPC分类号： C08F289/00 , C08F261/04 , C08F271/02 , C08F283/06 , C08L29/04 , C08L51/003 , C08L51/08 , C08L89/04 , Y10T428/2913 , C08L2666/26 , C08L2666/02
摘要： The application describes materials derived from keratin proteins in combination with polymers, either as intimate mixtures with water soluble polymers, or as chemically bound copolymers. The keratin protein is a specific keratin protein fraction, and is preferably intact, s-sulfonated and from the intermediate filament protein family. The application also describes the process for production of these materials.
摘要翻译： 该应用描述了衍生自与聚合物组合的角蛋白蛋白质的材料，作为与水溶性聚合物的紧密混合物，或作为化学结合共聚物。 角蛋白蛋白质是特定的角蛋白级分，优选是完整的，磺化的和中间丝蛋白质家族。 该应用还描述了生产这些材料的过程。
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公开(公告)号：US07732574B2
公开(公告)日：2010-06-08
申请号：US10583445
申请日：2004-12-16
CPC分类号： A61L15/32 , A61K38/39 , A61L26/0047 , A61L26/008
摘要： The invention relates to a would care product that provides a biochemical environment around a wound to promote wound healing. The wound care product includes a keratin protein fraction material in which the protein fraction is intact, is from the intermediate filament protein family or the high sulfur protein family and in which the protein fraction is S-sulfonated. The invention also described a method of making a wound care product.
摘要翻译： 本发明涉及一种在伤口周围提供生化环境以促进伤口愈合的护理产品。 伤口护理产品包括其中蛋白质级分完整的角蛋白蛋白级分物质，来自中间丝蛋白家族或高硫蛋白质家族，其中蛋白质级分是S-磺化的。 本发明还描述了一种制备伤口护理产品的方法。
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