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公开(公告)号:US06880554B1
公开(公告)日:2005-04-19
申请号:US09642982
申请日:2000-08-21
申请人: Ronald Alan Coffee
发明人: Ronald Alan Coffee
CPC分类号: B05B5/002 , A61M15/0091 , A61M15/0093 , A61M15/02 , B05B5/0255 , B05B5/043
摘要: An inhaler, comprising an electrohydrodynamic comminution means, a means for partially or fully discharging the liquid comminution and a conduit through which the liquid comminution is administered, wherein the discharging means is arranged to be activated by inhalation of the user.
摘要翻译: 一种吸入器,包括电动粉碎装置,用于部分或全部排出液体粉碎的装置和通过其施用液体粉碎物的导管,其中排放装置被布置成通过吸入使用者而被激活。
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公开(公告)号:US06386195B1
公开(公告)日:2002-05-14
申请号:US09377085
申请日:1999-08-19
申请人: Ronald Alan Coffee
发明人: Ronald Alan Coffee
IPC分类号: A61M1100
CPC分类号: B05B5/002 , A61M15/0091 , A61M15/0093 , A61M15/02 , B05B5/0255 , B05B5/043
摘要: A dispensing device has a liquid supplier having a liquid outlet; an electrical charger for generating an electrical field to cause liquid issuing from the liquid outlet to be comminuted to provide electrically charged comminuted matter; an electrical discharger for providing ions for at least partially electrically discharging the comminuted matter; and an ion attracter for attracting ions generated by the electrical discharger away from the electrical charger until a spray cloud of electrically charged comminuted matter has been established by the electrical charger.
摘要翻译: 分配装置具有液体供应器,其具有液体出口; 用于产生电场以使液体从液体出口发出的液体被粉碎以提供带电粉碎物质的电动充电器; 放电器,用于提供用于至少部分电解排出粉碎物质的离子; 以及用于将由放电器产生的离子吸引离开充电器的离子吸收剂,直到充电器已经建立了充满电的粉碎物质的喷雾。
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公开(公告)号:US06252129B1
公开(公告)日:2001-06-26
申请号:US09230171
申请日:1999-01-21
申请人: Ronald Alan Coffee
发明人: Ronald Alan Coffee
IPC分类号: A61F1300
CPC分类号: A61F13/00085 , A61F13/00995 , A61F2013/0011 , A61F2013/00157 , A61F2013/00519 , A61F2013/0091 , A61F2013/00914 , A61F2013/00927 , A61M15/02 , B05B5/1691 , Y10S977/836 , Y10S977/892 , Y10S977/90 , Y10S977/915
摘要: A dispensing device and method for forming a least partially solid or gel-like material from a liquid. At least one liquid issuing from an outlet is subjected to an electric field causing the liquid to form at least one electrically charged jet which, after formation, forms a fiber (F) or breaks up into fiber fragments (FF) or particles (D). The thus formed at least partially solid or gel-like material may be directly deposited, by virtue of the energy in the electrical field, onto a surface area, for example an area of skin enabling, for example, formation of a dressing for a wound or burn which is of high specific area and extremely absorbent. A biologically active ingredient such as a pharmaceutical ingredient or biological matter such as DNA may be incorporated into the fibers (F), fragments (FF) or particles (D). Fibrils, particles or microcapsules incorporating a biologically active ingredient may be supplied for oral or nasal administration to an animal such as a human being.
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公开(公告)号:US07977527B2
公开(公告)日:2011-07-12
申请号:US12823205
申请日:2010-06-25
申请人: Ronald Alan Coffee
发明人: Ronald Alan Coffee
IPC分类号: A61F13/00
CPC分类号: A61F13/00063 , A61F13/069 , A61F13/36 , A61F2013/0011 , A61F2013/00157 , A61F2013/00519 , A61F2013/0091 , A61F2013/00914 , A61F2013/00923 , A61F2013/00927 , A61M15/0003 , A61M15/0011 , A61M15/02 , B05B1/044 , B05B1/06 , B05B1/14 , B05B5/0255 , B05B5/1691 , B05B7/061 , B05B12/1472 , D01D5/0084 , D01F1/10
摘要: Described is a method of supplying an active ingredient to a location beneath the outer layer of skin or into soft tissue which includes the steps of providing a polymer-containing liquid comprising an active ingredient; subjecting the liquid issuing from an outlet to an electric field to cause the liquid to form at least one electrically charged jet that breaks up to provide charged fiber fragments or fibrils containing an active ingredient, the fiber fragments or fibrils being capable of sticking onto the outer layer of skin or soft tissue to supply the active ingredient beneath the outer layer of skin or soft tissue; and contacting skin with the fiber fragments or fibrils.
摘要翻译: 描述了将活性成分供应到皮肤外层下方的位置或软组织中的方法,其包括提供含有活性成分的含聚合物的液体的步骤; 将从出口发出的液体经受电场使液体形成至少一个带电的射流,其分解以提供含有活性成分的带电纤维碎片或原纤维,所述纤维碎片或原纤维能够粘附到外部 皮肤或软组织层,以将活性成分提供在皮肤或软组织的外层下方; 并使皮肤与纤维碎片或原纤维接触。
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公开(公告)号:US06684879B1
公开(公告)日:2004-02-03
申请号:US09868266
申请日:2001-08-09
IPC分类号: A61M1100
CPC分类号: B05B12/004 , A61M15/0066 , A61M15/008 , A61M15/025 , A61M2205/8206 , B05B5/0255 , B05B5/053 , B05B5/1691 , B05B12/00
摘要: An inhaler has a housing containing a chamber (1a) providing a reservoir (8) for liquid providing an active ingredient to be supplied to a liquid outlet (10a). First and second electrodes are spaced apart (11 and 12) with the first electrode being spaced apart (11 and 12) with the first electrode being provided at or adjacent the liquid outlet (10a). A voltage supply (5, 7) is activated in response to air flowing through an air inlet (30) of the housing to provide a potential difference between the first and second electrodes (11 and 12) to create an electric field for causing comminution of liquid issuing from the liquid supply outlet (10a) to produce a stream of electrically charged comminuted matter for supply to the nasal passages of a user via an outlet (4) of the housing.
摘要翻译: 吸入器具有容纳室(1a)的壳体,所述室(1a)提供用于液体的储存器(8),所述储存器提供要供应到液体出口(10a)的活性成分。 第一和第二电极间隔开(11和12),其中第一电极间隔开(11和12),第一电极设置在液体出口(10a)处或邻近液体出口(10a)。 响应于流过壳体的空气入口(30)的空气来激活电压源(5,7),以在第一和第二电极(11和12)之间提供电位差,以产生用于引起粉末的电场 液体从液体供应出口(10a)排出,以产生一个带电的粉碎物质流,用于经由壳体的出口(4)供给用户的鼻通道。
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公开(公告)号:US06318640B1
公开(公告)日:2001-11-20
申请号:US09535518
申请日:2000-03-24
申请人: Ronald Alan Coffee
发明人: Ronald Alan Coffee
IPC分类号: B05B5025
CPC分类号: B05B5/003 , A61M15/02 , B05B5/0255 , B05B5/0531 , B05B5/16
摘要: A comminuting liquid device, a medicament delivery device, an inhaler, a method of providing droplets for delivery to the respiratory tract, a pocket-sized dispenser, and a method of mixing liquids by droplet coalescence. Liquids are subjected to electrical potentials to produce electrically charged droplets for delivery to the upper respiratory tract.
摘要翻译: 粉碎液体装置,药物输送装置,吸入器,提供用于输送到呼吸道的液滴的方法,口袋式分配器以及通过液滴聚结混合液体的方法。 液体经受电位以产生带电液滴以输送到上呼吸道。
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公开(公告)号:US6105877A
公开(公告)日:2000-08-22
申请号:US835676
申请日:1997-04-10
申请人: Ronald Alan Coffee
发明人: Ronald Alan Coffee
IPC分类号: A61M13/00 , A61M15/02 , B01D61/42 , B05B5/00 , B05B5/025 , B05B5/053 , B05B5/16 , F04B9/00 , F04B19/00 , F04B37/00
CPC分类号: B05B5/003 , A61M15/02 , B05B5/0255 , B05B5/0531 , B05B5/16
摘要: A device for comminuting liquid has a liquid supply with first and second outlets, a first electrohydrodynamic comminuter for subjecting liquid issuing from the first outlet to an electrical potential to cause the liquid to be commrinuted to form a comminution of one polarity and a second electrohydrodynamic comminuter for subjecting liquid issuing from the second outlet to an electrical potential to cause liquid to be commninuted to form a comminution of the opposite polarity. The first and second electrohydrodynamic comminuters are arranged so as to cause substantial admixing of two opposite polarity comminutions.
摘要翻译: 用于粉碎液体的装置具有第一和第二出口的液体供应,第一电动流动粉碎机,用于使从第一出口排出的液体发挥电势,使液体进行粉碎以形成一种极性的粉碎物,以及第二电动流动粉碎机 用于使从第二出口排出的液体达到电势,使液体被分配以形成相反极性的粉碎。 第一和第二电动流动粉碎机布置成使得两个相反极性粉碎的实质混合。
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公开(公告)号:US08074640B2
公开(公告)日:2011-12-13
申请号:US10539487
申请日:2003-12-18
CPC分类号: A01M1/2044 , A61L9/145 , A61L9/22 , A61L2209/22
摘要: A housing has a dispensing outlet (400) and contains: a liquid supplier (7) for supplying liquid containing at least one volatile component to a liquid outlet (7a); an electric field provider (41, 42, 7) for causing liquid issuing from the liquid outlet to provide electrically charged droplets from which at least a part of the at least one volatile component evaporates to produce vapour; a collection receptacle (92) for collecting electrically charged droplets to inhibit the electrically charged droplets from passing through the dispensing outlet; an attraction electrode (91) for attracting electrically charged droplets into the collection receptacle (90); and a flow director (95) for directing vapour away from the collection receptacle (92) and towards the dispensing outlet (400).
摘要翻译: 壳体具有分配出口(400)并且包含:用于将含有至少一种挥发性组分的液体供应到液体出口(7a)的液体供应器(7); 用于使液体从液体出口发出的液体提供带电液滴的电场提供器(41,42,7),所述至少一个挥发性组分的至少一部分从该液滴蒸发以产生蒸气; 收集容器(92),用于收集带电液滴以阻止带电液滴通过分配出口; 用于将带电液滴吸引到收集容器(90)中的吸引电极(91); 以及用于将蒸气引导从收集容器(92)并朝向分配出口(400)的导流器(95)。
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公开(公告)号:US07972622B1
公开(公告)日:2011-07-05
申请号:US10018160
申请日:2000-05-05
CPC分类号: D01D5/0007 , A61J3/00 , A61J3/06 , A61K9/0056 , A61K9/2095
摘要: Consumable or dissolvable tablets are manufactured by supplying a liquid containing a biodissolvable carrier to an outlet; establishing an electric field between the outlet and a support surface to cause liquid issuing from the outlet to form at least one fiber or fibrils of the biodissolvable carrier which fiber or fibrils deposit(s) onto the surface to form a fiber web or mat; separating the web or mat into a plurality of individual tablets; and incorporating at least one active ingredient on or in the tablets.
摘要翻译: 通过将含有生物可溶性载体的液体供给到出口来制造消耗或可溶性片剂; 在所述出口和支撑表面之间建立电场以使得从所述出口发出的液体形成所述生物可溶性载体的至少一种纤维或原纤维,所述纤维或原纤维将所述纤维或原纤维沉积在所述表面上以形成纤维网或垫; 将网或垫分离成多个单独的片剂; 并将至少一种活性成分掺入片剂上或片剂中。
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公开(公告)号:US20100266668A1
公开(公告)日:2010-10-21
申请号:US12788602
申请日:2010-05-27
申请人: Ronald Alan Coffee , David Neville Davies , Johnathan Essex-Lopresti , Margaret Sin Ka Wan , Anna Busby
发明人: Ronald Alan Coffee , David Neville Davies , Johnathan Essex-Lopresti , Margaret Sin Ka Wan , Anna Busby
IPC分类号: A61K9/70 , A61K38/02 , A61K31/711 , A61K31/616 , A61K31/192 , A61K39/00 , A61K39/42 , A61P31/14 , A61P35/00 , A61P37/08 , A61P11/00 , B01J19/08
摘要: A method of manufacturing a dosage form is described wherein a liquid solution of a biologically compatible polymer containing a suspension of particulate material that is insoluble in the polymer is supplied to a liquid supply tube (2) having an outlet (2a) and an electrical field is established between the outlet (2a) and a surface (19) spaced from the outlet (2a) to cause liquid issuing from the outlet to form a jet which dries to form a polymer fibre containing particles of the particulate material and which deposits onto the surface (19) to form a dosage which consists of said particulate containing fibre which fibre dissolves or disintegrates in a wet environment such as the mouth.
摘要翻译: 描述了制备剂型的方法,其中将含有不溶于聚合物的颗粒材料的悬浮液的生物相容性聚合物的液体溶液供应到具有出口(2a)和电场的液体供应管(2) 在出口(2a)和与出口(2a)间隔开的表面(19)之间建立,以使得从出口排出的液体形成干燥的射流,以形成含有颗粒材料颗粒的聚合物纤维,并且沉积在 表面(19)以形成由所述含纤维颗粒组成的剂量,所述纤维在纤维在诸如口腔的湿润环境中溶解或分解。
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