公开(公告)号：US10436785B2

公开(公告)日：2019-10-08

申请号：US15363832

申请日：2016-11-29

Applicant: Spring BioScience Corporation

Inventor： Fernando Jose Rebelo do Couto ,  Zhiming Liao ,  Yifei Zhu

IPC: G01N33/573 ,  C07K16/40 ,  C12N9/02 ,  C12N9/96 ,  G01N33/574

Abstract: The invention provides antibodies that bind specifically to human indoleamine 2,3-dioxygenase 1 (IDO1), and methods of using the same. The antibodies are capable of binding to a sequence comprising SEQ ID NO: 1 and specifically bind to human IDO1 in formalin fixed paraffin embedded tissues. The antibodies are useful in a number of different analytical techniques, including immunohistochemistry (IHC) and immunocytochemistry (ICC).

公开(公告)号：US20180208666A1

公开(公告)日：2018-07-26

申请号：US15921254

申请日：2018-03-14

Applicant: Spring BioScience Corporation

Inventor： Yifei Zhu ,  Zhiming Liao ,  Robert Pytela

IPC: C07K16/28 ,  G01N33/574

CPC classification number: C07K16/2878 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/626 ,  G01N33/574 ,  G01N2333/70578

Abstract: The invention provides antibodies immunoreactive with human OX40 and methods of using the same. The antibodies are reactive with a portion of the C-terminus of the human OX40 protein that includes amino acids 266-277. The antibodies are useful for detecting OX40 protein expression in human tissue samples, including by immunohistochemistry, immunofluorescence, or immunoblot.

公开(公告)号：US20180022809A1

公开(公告)日：2018-01-25

申请号：US15727388

申请日：2017-10-06

Applicant: Genentech, Inc. ,  Spring BioScience Corporation ,  Ventana Medical Systems, Inc.

Inventor： Marcin KOWANETZ ,  Hartmut KOEPPEN ,  Zachary BOYD ,  Zhiming LIAO ,  Yifei ZHU ,  Bharathi VENNAPUSA ,  Patrick C. ROCHE

IPC: C07K16/28 ,  G01N33/574 ,  A61K39/395 ,  G01N33/53 ,  A61K45/06 ,  C07K14/705 ,  A61N5/10

Abstract: The invention provides programmed death-ligand 1 (PD-L1) antibodies and methods of using the same.

公开(公告)号：US20150346208A1

公开(公告)日：2015-12-03

申请号：US14725953

申请日：2015-05-29

Applicant: SPRING BIOSCIENCE CORPORATION

Inventor： Fernando Jose Rebelo do Couto ,  Zhiming Liao ,  Yifei Zhu

IPC: G01N33/574 ,  C07K16/28

CPC classification number: G01N33/57492 ,  C07K16/2827 ,  C07K16/2896 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/92 ,  G01N2333/70596

Abstract: Provided herein are novel PD-L1 antibodies and methods for using the same for diagnosing a medical condition associated with elevated PD-L1 levels (e.g., cancer) in subjects in need thereof and antigen binding fragments thereof. The PD-L1 antibodies and antigen binding fragments are also useful in evaluating the efficacy of a particular therapeutic regime in a subject diagnosed as having a PD-L1-related medical condition.

Abstract translation: 本文提供了新的PD-L1抗体及其用于诊断与有需要的受试者中的升高的PD-L1水平（例如癌症）和其抗原结合片段相关的医学病症的方法。 PD-L1抗体和抗原结合片段也可用于评估诊断为患有PD-L1相关医学病症的受试者中特定治疗方案的功效。

公开(公告)号：US20180208655A1

公开(公告)日：2018-07-26

申请号：US15920367

申请日：2018-03-13

Applicant: Spring BioScience Corporation

Inventor： Yifei Zhu ,  Zhiming Liao ,  Fernando Jose Rebelo do Couto

IPC: C07K16/28 ,  C07K16/30 ,  G01N33/68 ,  G01N33/574

CPC classification number: C07K16/28 ,  C07K16/30 ,  C07K2317/20 ,  G01N33/57411 ,  G01N33/57423 ,  G01N33/6893 ,  G01N2333/705

Abstract: The present application discloses anti-GPNMB antibodies and methods of using the same. The antibodies are selected to bind to an epitope located in a C-terminal fragment of the protein and are selected for specificity in immunohistochemical assays. The antibodies are useful in, for example, immunohistochemical methods of detecting GPNMB-positive cells in tumors.

公开(公告)号：US20170146535A1

公开(公告)日：2017-05-25

申请号：US15363832

申请日：2016-11-29

Applicant: Spring BioScience Corporation

Inventor： Fernando Jose Rebelo do Couto ,  Zhiming Liao ,  Yifei Zhu

IPC: G01N33/573 ,  G01N33/574 ,  C12N9/96 ,  C07K16/40 ,  C12N9/02

CPC classification number: G01N33/573 ,  C07K16/40 ,  C07K2317/14 ,  C07K2317/20 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/567 ,  C12N9/0069 ,  C12N9/96 ,  C12Y113/11052 ,  G01N33/57496 ,  G01N2333/90241

Abstract: The invention provides antibodies that bind specifically to human indoleamine 2,3-dioxygenase 1 (IDO1), and methods of using the same. The antibodies are capable of binding to a sequence comprising SEQ ID NO: 1 and specifically bind to human IDO1 in formalin fixed paraffin embedded tissues. The antibodies are useful in a number of different analytical techniques, including immunohistochemistry (IHC) and immunocytochemistry (ICC).

公开(公告)号：US20160009805A1

公开(公告)日：2016-01-14

申请号：US14726329

申请日：2015-05-29

Applicant: GENENTECH, INC. ,  SPRING BIOSCIENCE CORPORATION ,  VENTANA MEDICAL SYSTEMS, INC.

Inventor： Marcin KOWANETZ ,  Hartmut KOEPPEN ,  Zachary BOYD ,  Zhiming LIAO ,  Yifei ZHU ,  Bharathi VENNAPUSA ,  Patrick C. ROCHE

IPC: C07K16/28 ,  G01N33/574 ,  A61K39/395 ,  C07K14/705 ,  A61K45/06

CPC classification number: C07K16/2827 ,  A61K39/3955 ,  A61K45/06 ,  A61N2005/1021 ,  C07K14/70532 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2319/30 ,  G01N33/53 ,  G01N33/57484 ,  G01N2500/10 ,  G01N2800/52

Abstract: The invention provides programmed death-ligand 1 (PD-L1) antibodies and methods of using the same.

Abstract translation: 本发明提供程序性死亡 - 配体1（PD-L1）抗体及其使用方法。