公开(公告)号：US11684664B2

公开(公告)日：2023-06-27

申请号：US16850143

申请日：2020-04-16

Applicant: St. Jude Children's Research Hospital

Inventor： Elaine Tuomanen ,  Elizabeth R. Mann

IPC: A61K39/02 ,  A61K39/09 ,  C07K14/315 ,  C07K14/47 ,  A61K39/00

CPC classification number: A61K39/092 ,  C07K14/3156 ,  C07K14/47 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/55544 ,  A61K2039/55583 ,  A61K2039/575 ,  A61K2039/6068 ,  A61K2039/645 ,  C07K2319/00 ,  C07K2319/40

Abstract: Compositions nod methods are provided for the prevention and treatment of bacterial infections, including pneumococcal infections. Compositions provided herein comprise a variety immunogenic fusion proteins, wherein at least one polypeptide component of a given fusion protein comprises a CbpA polypeptide and/or a cytolysoid polypeptide, or an active variant or fragment thereof. Methods are provided for the prevention and treatment of bacterial infections, including pneumococcal infections by employing die various immunogenic fusion proteins having at least one polypeptide component comprising a CbpA polypeptide and/or acytolysoid polypeptide, or an active variant or fragment thereof.

公开(公告)号：US20230129075A1

公开(公告)日：2023-04-27

申请号：US17792284

申请日：2021-01-13

Applicant: St. Jude Children's Research Hospital

Inventor： Xiaotu Ma ,  Eric M. Davis

IPC: G16B30/00 ,  C12Q1/6869

Abstract: A method for measuring and suppressing errors within instrument (sequencer) of targeted next generation sequencing workflow are described herein.

公开(公告)号：US20230073558A1

公开(公告)日：2023-03-09

申请号：US17762441

申请日：2020-09-22

Applicant: University of Florida Research Foundation, Incorporated ,  St. Jude Children's Research Hospital, Inc. ,  University of Tennessee Research Foundation

Inventor： Jatinder Kaur Lamba ,  Stanley Pounds ,  Abdelrahman H. Elsayed ,  Xueyuan Cao

IPC: C12Q1/6886 ,  G16B25/10 ,  A61P35/02

Abstract: Aspects of the disclosure relate to compositions and methods for predicting prognosis and classifying risk of subjects having certain cancers, for example acute myeloid leukemia (AML). In some embodiments, methods described by the disclosure comprise a step of assessing the mRNA expression of certain leukemic stem cell (LSC)-enriched genes in a subject to produce a predictive score for pediatric AML. In some embodiments, methods described by the disclosure comprise a step of assessing the mRNA expression of certain genes of pharmacological relevance for standard chemotherapy consisting of Cytarabine (also known as Ara-C), daunorubicin and etoposide in a subject to produce a predictive score for pediatric AML.

公开(公告)号：US20230019849A1

公开(公告)日：2023-01-19

申请号：US17783040

申请日：2020-12-04

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Stephan GOTTSCHALK ,  Mireya VELASQUEZ ,  Abdullah FREIWAN ,  Abishek VAIDYA ,  Deanna LANGFITT

IPC: C12N5/0783 ,  C12N5/00 ,  B01D15/38

Abstract: Methods for preparing CD7-negative, CD3-positive T cells, which optionally express a chimeric antigen receptor, are provided as is a method of using such cells in a method for treating cancer, in particular a CD7+ cancer. In one aspect, the invention provides a method for preparing a population of CD7-negative, CD3-positive T cells by (a) performing a first selection by depleting, from a population of primary immune cells, cells that express CD7 thereby generating a population of CD7-negative cells; (b) performing a second selection by enriching, from the population of CD7-negative cells, T cells that express CD3 thereby generating a population of CD7-negative and CD3-positive T cells, and (c) incubating the population of CD7-negative and CD3-positive T cells in a culture vessel under stimulating conditions, thereby generating stimulated CD7-negative, CD3-positive T cells.

公开(公告)号：US20220406435A1

公开(公告)日：2022-12-22

申请号：US17820755

申请日：2022-08-18

Applicant: St. Jude Children's Research Hospital

Inventor： Ida Annunziata ,  Alessandra D'Azzo ,  Shai White-Gilbertson

IPC: G16H20/40 ,  G01N33/574 ,  G16H20/00 ,  C07B59/00 ,  C12N15/86 ,  C12N15/11 ,  C12N9/24 ,  C12N9/48 ,  C12N15/63 ,  A61K38/47 ,  A61K38/48 ,  C12Q1/34 ,  G01N33/573

Abstract: Methods are provided for the prognosis, diagnosis and treatment of various pathological states, including cancer, chemotherapy resistance and dementia associated with Alzheimer's disease. The methods provided herein are based on the discovery that various proteins with a high level of sialylation are shown herein to be associated with disease states, such as, cancer, chemotherapy resistance and dementia associated with Alzheimer's disease. Such methods provide a lysosomal exocytosis activity profile comprising one or more values representing lysosomal exocytosis activity. Also provided herein, is the discovery that low lysosomal sialidase activity is associated with various pathological states. Thus, the methods also provide a lysosomal sialidase activity profile, comprising one or more values representing lysosomal sialidase activity. A lysosomal sialidase activity profile is one example of a lysosomal exocytosis activity profile.

公开(公告)号：US20220288235A1

公开(公告)日：2022-09-15

申请号：US17636152

申请日：2020-08-19

Applicant: St. Jude Children's Research Hospital, Inc.

Inventor： Stanislav S. ZAKHARENKO ,  Prakash DEVARAJU

IPC: A61K48/00 ,  C07K14/47 ,  A61P25/18

Abstract: Described is a method for treating a social memory deficit in a subject with a neuropsychiatric disease is treated by administering a peptide encoded by 2510002D24Rik or Atp23 genes, a vector expressing such peptide, or an agent capable of increasing the level or activity of such peptide. The method may be used to treat schizophrenia or autism. The peptide, vector or agent can be administered directly to the hippocampus, such as by transcranial surgical injection.

公开(公告)号：US20220274948A1

公开(公告)日：2022-09-01

申请号：US17740148

申请日：2022-05-09

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Marcus FISHER ,  Fatemeh KERAMATNIA ,  Kevin MCGOWAN ,  Jaeki MIN ,  Gisele A. NISHIGUCHI ,  Jeanine PRICE ,  Zoran RANKOVIC ,  Das SOURAV ,  Charles G. MULLIGHAN ,  Yunchao CHANG

IPC: C07D401/04 ,  A61K31/45 ,  A61K45/06 ,  C07D405/14 ,  C07D413/14 ,  C07D409/14 ,  A61P35/00 ,  A61P35/02

Abstract: In one aspect, the disclosure relates to substituted N-(2-(2,6-dioxopiperidinyl-3-yl)-1,3-dioxoisoindolin-5-ypaiylsulfo namide analogs that useful as modulators of cereblon (CRBN) activity, methods of making same, pharmaceutical compositions comprising same, and methods of treating various clinical conditions and disorders using same, e.g., a disorder of uncontrolled cellular proliferation, such as a cancer, which may be associated with cereblon protein dysfunction and/or a GSPT1 dysfunction. In various further aspects, the disclosed compounds can selectively modulate the degradation of GSPT1 protein, i.e., the disclosed compounds can act as GSPT1 degraders. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US11419920B2

公开(公告)日：2022-08-23

申请号：US17010595

申请日：2020-09-02

Applicant: UCL BUSINESS LTD ,  ST. JUDE CHILDREN'S RESEARCH HOSPITAL

Inventor： Amit Nathwani ,  Jenny McIntosh ,  Edward Tuddenham ,  Andrew Davidoff

IPC: C12N15/09 ,  A61K38/37 ,  C07K14/755 ,  A01K67/027 ,  A61K48/00

Abstract: There is provided a nucleic acid molecule comprising a nucleotide sequence encoding a Factor VIII protein, wherein a B domain portion of the Factor VIII protein is encoded by a nucleotide sequence between 90 and 111 nucleotides in length and has an amino acid sequence that is at least 85% identical to SEQ ID NO: 4 which comprises six asparagine residues. Also provided is a Factor VIII protein, a vector comprising the above nucleic acid molecule, a host cell, a transgenic animal, a method of treating Haemophilia for example, Haemophilia A, and a method for the preparation of a parvoviral gene delivery vector.

公开(公告)号：US20220259670A1

公开(公告)日：2022-08-18

申请号：US17616279

申请日：2020-06-30

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

Inventor： Pradyot DASH ,  Paul THOMAS

IPC: C12Q1/6886 ,  C12Q1/6806

Abstract: A kit and method for analyzing nucleic acid molecules encoding T cell receptor (TCR) a and β from individual T cells are disclosed. In particular, a method for analyzing individual T cells using high-throughput multiplex amplification and deep sequencing of nucleic acids encoding TCRαβ is provided.

公开(公告)号：US20220251167A1

公开(公告)日：2022-08-11

申请号：US17618716

申请日：2020-06-19

Applicant: St. Jude Children's Research Hospital, Inc. ,  UNIVERSITY OF MARYLAND, BALTIMORE

Inventor： Paul THOMAS ,  Jeremy CRAWFORD ,  Allison KIRK ,  Anthony ZAMORA ,  Scott E. STROME

IPC: C07K14/725 ,  A61K39/00 ,  A61P35/00

Abstract: A vector harboring nucleic acids encoding a recombinant T cell receptor having antigenic specificity for a DnaJ heat shock protein family member B1-protein kinase cAMP-activated catalytic subunit alpha (DNAJB1-PRKACA) fusion protein is provided, as are host cells and a method for treating fibrolamellar hepatocellular carcinoma with the vector.