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    DENSITY-ADJUSTED LIQUIDS AND METHODS USING SAME
    14.
    发明公开
    DENSITY-ADJUSTED LIQUIDS AND METHODS USING SAME 审中-公开

    公开(公告)号：US20240002782A1

    公开(公告)日：2024-01-04

    申请号：US18038088

    申请日：2021-11-25

    Applicant: STEMCELL TECHNOLOGIES CANADA INC.

    Inventor： Eric JERVIS ,  Kyle HUKEZALIE ,  Kylan WALSH ,  Tia SOJONKY ,  Karen MARKWICK ,  Michael HIATT

    IPC: C12N5/00 ,  C12N5/074 ,  C12N5/0735

    CPC classification number: C12N5/0018 ,  C12N5/0696 ,  C12N5/0606 ,  C12N2525/00

    Abstract: Disclosed are liquids and methods for manipulating the localization and/or buoyancy of a population of particles, or one or more subpopulation thereof, within a volume of a liquid. The specific density of the liquids may be adjusted using specific gravity-modifying means depending on the application and/or on the average density of a population of particles, or one or more subpopulations thereof, within the liquid. For example, density-adjusted liquids may be used to bias a population of particles, or one or more subpopulations of particles, upward or downward within a volume of the liquid. As another example, density-adjusted liquids may be used to maintain the distribution of a population of neutrally buoyant particles, or one or more subpopulation thereof, within a volume of such liquid.

    KITS, COMPOSITIONS AND METHODS FOR CELL ENRICHMENT
    15.
    发明申请
    KITS, COMPOSITIONS AND METHODS FOR CELL ENRICHMENT 有权

    公开(公告)号：US20210230542A1

    公开(公告)日：2021-07-29

    申请号：US15734791

    申请日：2019-06-06

    Applicant: STEMCELL Technologies Canada Inc.

    Inventor： Frann Antignano

    IPC: C12N5/078 ,  C07K16/28

    Abstract: Kits, compositions and methods for enriching myeloid-derived suppressor cells (MDSCs) are provided. In one embodiment, the kit comprises (a) one or more antibodies or fragments thereof that bind one or more non-MDSC target cells; and (b) a plurality of particles, wherein the plurality of particles are linked or linkable to at least one of the one or more antibodies.

    COMPOSITIONS AND METHODS FOR RAPID AND REVERSIBLE BIOMOLECULAR LABELING
    20.
    发明申请
    COMPOSITIONS AND METHODS FOR RAPID AND REVERSIBLE BIOMOLECULAR LABELING 有权

    公开(公告)号：US20240426816A1

    公开(公告)日：2024-12-26

    申请号：US18750208

    申请日：2024-06-21

    Applicant: StemCell Technologies Canada Inc.

    Inventor： Samuel Jon Clarke ,  Adil Kassam

    IPC: G01N33/533 ,  G01N33/532 ,  G01N33/569 ,  G01N33/58

    Abstract: This disclosure provides compositions and methods for a low-avidity, high-affinity and high-specificity biomolecular interaction that is rapidly reversible under physiological conditions. The methods comprise linking biological targets (such as molecules, proteins, DNA, cells, extracellular vesicles, etc.) with polymers and anti-polymer ligands and a way to reverse their binding using physiologically compatible polymeric compounds. The methods also comprise a way to combine different polymer/anti-polymer systems for orthogonal labeling. The compositions comprise labels including particles (fluorescent, magnetic, dense, etc.) conjugated to polymers or labels conjugated to anti-polymer antibodies. The compositions also comprise biomolecules (proteins, antibodies, DNA, etc.) conjugated to the polymers. These methods and compositions represent a major improvement to the state-of-the-art. They are particularly useful for separation and isolation of biological targets using particles, but have important application to other fields including fluorescent imaging.

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