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公开(公告)号：US20140038968A1
公开(公告)日：2014-02-06
申请号：US13653452
申请日：2012-10-17
Applicant: Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara A. Miskowski , Janet L. Ralbovsky , Mark J. Schulz
Inventor： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara A. Miskowski , Janet L. Ralbovsky , Mark J. Schulz
IPC: C07D251/38 , C07D403/12
CPC classification number: C07D251/38 , C07D401/12 , C07D403/12 , C07D405/14
Abstract: The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.
Abstract translation: 本发明涉及某些新的式（I）化合物：以及制备这些化合物，组合物，中间体及其衍生物以及用于治疗促动蛋白原1或原激素1受体介导的病症的方法。
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公开(公告)号：US08609627B2
公开(公告)日：2013-12-17
申请号：US13144718
申请日：2010-02-09
Applicant: Jong Hyun Cho , Steven J. Coats , Raymond F. Schinazi , Hongwang Zhang , Longhu Zhou
Inventor： Jong Hyun Cho , Steven J. Coats , Raymond F. Schinazi , Hongwang Zhang , Longhu Zhou
CPC classification number: A61K31/7076 , A61K31/675 , A61K31/7028 , A61K31/7042 , A61K31/7052 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/708 , A61K45/06 , C07D473/16 , C07H19/173 , C07H19/20 , Y02A50/385 , Y02A50/387 , Y02A50/393 , A61K2300/00
Abstract: The present invention is directed to compounds, compositions and methods for treating or preventing cancer and viral infections, in particular, HIV, HCV, Norovirus, Saporovirus, HSV-1, HSV-2, Dengue virus, Yellow fever, and HBV in human patients or other animal hosts. The compounds are certain 6-substituted purine monophosphates, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HIV-1, HIV-2, HCV, Norovirus, Saporovirus, HSV-1, HSV-2, Dengue virus, Yellow fever, and HBV.
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公开(公告)号：US20130210774A1
公开(公告)日：2013-08-15
申请号：US13817522
申请日：2011-08-26
Applicant: Steven J. Coats , Franck Amblard , Hongwang Zhang , Longhu Zhou , Richard Anthony Whitaker , Tamara Rosario McBrayer , Raymond F. Schinazi , Junxing Shi
Inventor： Steven J. Coats , Franck Amblard , Hongwang Zhang , Longhu Zhou , Richard Anthony Whitaker , Tamara Rosario McBrayer , Raymond F. Schinazi , Junxing Shi
IPC: A61K31/4178 , C07D403/14 , A61K31/4192 , A61K45/06 , A61K31/5377 , C07D401/14 , A61K31/444 , A61K31/506 , C07D403/04 , A61K31/655
CPC classification number: C07D403/14 , A61K31/4178 , A61K31/4192 , A61K31/444 , A61K31/506 , A61K31/5377 , A61K31/655 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D407/14 , C07D413/14
Abstract: The present invention is directed to compounds, compositions and methods for treating or preventing hepatitis C virus (HCV) infection in human subjects or other animal hosts. The compounds are as also pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof as pharmaceutical compositions and methods for treatment or prevention of HCV infection.
Abstract translation: 本发明涉及用于治疗或预防人受试者或其他动物宿主中丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 作为用于治疗或预防HCV感染的药物组合物和方法，化合物也是其药学上可接受的盐，前药和其它衍生物。
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公开(公告)号：US08362247B2
公开(公告)日：2013-01-29
申请号：US13113751
申请日：2011-05-23
Applicant: Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara A. Miskowski , Janet L. Ralbovsky , Mark J. Schulz
Inventor： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara A. Miskowski , Janet L. Ralbovsky , Mark J. Schulz
IPC: C07D403/06 , C07D403/12 , C07D403/14 , C07D401/06 , C07D401/12 , C07D401/14 , A61K31/506 , A61P1/00 , A61P1/06
CPC classification number: C07D239/545 , C07D251/20 , C07D251/34 , C07D251/38 , C07D251/46 , C07D403/12
Abstract: The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.
Abstract translation: 本发明涉及某些新的式（I）化合物：以及制备这些化合物，组合物，中间体及其衍生物以及用于治疗促动蛋白原1或原激素1受体介导的病症的方法。
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15.发明申请3'-AZIDO PURINE NUCLEOTIDE PRODRUGS FOR TREATMENT OF VIRAL INFECTIONS 有权用于治疗病毒感染的3'-AZIDO PURINE NUCLEOTIDE PRODRUGS公开(公告)号：US20120135951A1
公开(公告)日：2012-05-31
申请号：US13132920
申请日：2009-12-09
Applicant: Raymond F. Schinazi, Ph.D. , John W. Mellors , Nicolas Paul Sluis-Cremer , Steven J. Coats, Ph.D. , Richard Anthony Whitaker , Brian David Herman , Jong Hyun Cho , Longhu Zhou , Hongwang Zhang
Inventor： Raymond F. Schinazi, Ph.D. , John W. Mellors , Nicolas Paul Sluis-Cremer , Steven J. Coats, Ph.D. , Richard Anthony Whitaker , Brian David Herman , Jong Hyun Cho , Longhu Zhou , Hongwang Zhang
IPC: A61K31/7076 , A61P31/18 , A61P31/20 , C07H19/207
CPC classification number: C07D473/34 , A61K31/437 , C07D473/16 , C07D473/18 , C07H19/173 , C07H19/20 , C07H19/207
Abstract: The present invention is directed to compounds, compositions and methods for treating or preventing viral infections, in particular, HIV, and HBV, in human patients or other animal hosts. The compounds are 3′-azido-2′,3′-dideoxy purine monophosphates, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HIV-1 and HBV.
Abstract translation: 本发明涉及在人类患者或其他动物宿主中用于治疗或预防病毒感染，特别是HIV和HBV的化合物，组合物和方法。 化合物是3'-叠氮基-2'，3'-二脱氧嘌呤单磷酸酯及其药学上可接受的盐，前药和其它衍生物。 特别地，这些化合物对HIV-1和HBV显示出有效的抗病毒活性。
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Patent Agency Ranking
公开(公告)号：US20110269759A1
公开(公告)日：2011-11-03
申请号：US12913986
申请日：2010-10-28
Applicant: Steven J. COATS , Haiyan BIAN , Chaozhong CAI , Bart L. DECORTE , Li LIU , Mark J. MACIELAG , Scott L. DAX , Philip M. PITIS , Peter J. CONNOLLY , Wei HE
Inventor： Steven J. COATS , Haiyan BIAN , Chaozhong CAI , Bart L. DECORTE , Li LIU , Mark J. MACIELAG , Scott L. DAX , Philip M. PITIS , Peter J. CONNOLLY , Wei HE
IPC: A61K31/5377 , A61K31/506 , C07D413/14 , C07D403/14 , A61K31/496 , A61P19/02 , A61P25/06 , A61P25/04 , A61P13/10 , A61P17/00 , A61P1/00 , A61P35/00 , A61P29/00 , A61P25/16 , A61P25/24 , A61P25/32 , A61P9/00 , C07D401/14
CPC classification number: C07D239/47 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
Abstract: Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, Ra, and Y are defined herein.
Abstract translation: 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R1，R2，R3，Ra和Y如本文所定义。
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公开(公告)号：US07968710B2
公开(公告)日：2011-06-28
申请号：US11375407
申请日：2006-03-14
Applicant: Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara A. Miskowski , Janet L. Ralbovsky , Mark J. Schulz
Inventor： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara A. Miskowski , Janet L. Ralbovsky , Mark J. Schulz
IPC: C07D251/30 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D401/12 , C07D403/12 , A61K31/53 , A61P1/12 , A61P1/06 , A61P1/00
CPC classification number: C07D239/545 , C07D251/20 , C07D251/34 , C07D251/38 , C07D251/46 , C07D403/12
Abstract: The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.
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18.发明申请STEREOSELECTIVE PROCESS FOR PREPARING PURINE DIOXOLANE NUCLEOSIDE DERIVATIVES 审中-公开制备嘌呤二氧杂环己烷衍生物的立体选择性方法公开(公告)号：US20100210840A1
公开(公告)日：2010-08-19
申请号：US12670386
申请日：2008-07-24
Applicant: Steven J. Coats
Inventor： Steven J. Coats
IPC: C07D473/16
CPC classification number: C07D473/16
Abstract: A cost-effective process scale method for preparing purine dioxolane nucleoside derivatives in racemic or optically pure form is disclosed, as are nucleoside derivatives prepared by the method. The method involves reacting a purine or a mono- or polysilylated purine derivative with an activated dioxolane analog to produce the dioxolane nucleoside analog in commercially useful yields. Direct reaction of purine or a mono- or polysilylated purine with dioxolanes takes place with highest reported chemical yields and excellent stereoselectivity when an additive in the form of an alpha cyano carbonyl compound or silylated alpha cyano carbonyl compounds is present in the reaction mixture during the glycosylation reaction.
Abstract translation: 公开了一种用于制备外消旋或光学纯的形式的嘌呤二氧戊环核苷衍生物的成本有效的工艺规模方法，以及通过该方法制备的核苷衍生物。 该方法包括使嘌呤或单或聚硅酸化嘌呤衍生物与活化的二氧杂环戊烷类似物反应，以商业上有效的收率产生二氧戊环核苷类似物。 在糖基化过程中当反应混合物中存在α氰基羰基化合物或甲硅烷基化α氰基羰基化合物形式的添加剂时，嘌呤或单或多聚化嘌呤与二氧戊环的直接反应发生，报道最高的化学产率和优异的立体选择性 反应。
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公开(公告)号：US08859595B2
公开(公告)日：2014-10-14
申请号：US13817522
申请日：2011-08-26
Applicant: Steven J. Coats , Franck Amblard , Hongwang Zhang , Longhu Zhou , Richard Anthony Whitaker , Tamara Rosario McBrayer , Raymond F. Schinazi , Junxing Shi
Inventor： Steven J. Coats , Franck Amblard , Hongwang Zhang , Longhu Zhou , Richard Anthony Whitaker , Tamara Rosario McBrayer , Raymond F. Schinazi , Junxing Shi
IPC: A61K31/4192 , A61K31/4178 , C07D249/04 , C07D403/02 , C07D403/14 , A61K31/444 , A61K31/655 , C07D413/14 , C07D401/14 , A61K45/06 , C07D405/14 , C07D403/04 , A61K31/506 , A61K31/5377
CPC classification number: C07D403/14 , A61K31/4178 , A61K31/4192 , A61K31/444 , A61K31/506 , A61K31/5377 , A61K31/655 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D407/14 , C07D413/14
Abstract: The present invention is directed to compounds, compositions and methods for treating or preventing hepatitis C virus (HCV) infection in human subjects or other animal hosts. The compounds are as also pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof as pharmaceutical compositions and methods for treatment or prevention of HCV infection.
Abstract translation: 本发明涉及用于治疗或预防人受试者或其他动物宿主中丙型肝炎病毒（HCV）感染的化合物，组合物和方法。 作为用于治疗或预防HCV感染的药物组合物和方法，化合物也是其药学上可接受的盐，前药和其它衍生物。
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20.发明授权公开(公告)号：US08815829B2
公开(公告)日：2014-08-26
申请号：US13132920
申请日：2009-12-09
Applicant: Raymond F. Schinazi , John W. Mellors , Nicolas Paul Sluis-Cremer , Steven J. Coats , Richard Anthony Whitaker , Brian David Herman , Jong Hyun Cho , Longhu Zhou , Hongwang Zhang
Inventor： Raymond F. Schinazi , John W. Mellors , Nicolas Paul Sluis-Cremer , Steven J. Coats , Richard Anthony Whitaker , Brian David Herman , Jong Hyun Cho , Longhu Zhou , Hongwang Zhang
IPC: C07H19/04 , A61K31/70 , C07H19/20 , C07D473/16 , C07H19/173 , C07D473/18 , C07H19/207 , A61K31/437
CPC classification number: C07D473/34 , A61K31/437 , C07D473/16 , C07D473/18 , C07H19/173 , C07H19/20 , C07H19/207
Abstract: The present invention is directed to compounds, compositions and methods for treating or preventing viral infections, in particular, HIV, and HBV, in human patients or other animal hosts. The compounds are 3′-azido-2′,3′-dideoxy purine monophosphates, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HIV-1 and HBV.
Abstract translation: 本发明涉及在人类患者或其他动物宿主中用于治疗或预防病毒感染，特别是HIV和HBV的化合物，组合物和方法。 化合物是3'-叠氮基-2'，3'-二脱氧嘌呤单磷酸酯及其药学上可接受的盐，前药和其它衍生物。 特别地，这些化合物对HIV-1和HBV显示出有效的抗病毒活性。
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