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公开(公告)号：US20060024752A1
公开(公告)日：2006-02-02
申请号：US11185361
申请日：2005-07-20
IPC分类号： G01N33/53
摘要： Novel conjugates of protected aldehyde active metabolites of cyclophosphamide including reagents and immunogens thereof and monoclonal antibodies generated by these immunogens, said reagents and immunogens useful in immunoassays for the monitoring of the active metabolites of cyclophosphamide in patients being treated with cyclophosphamide.
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12.发明申请公开(公告)号：US20050014210A1
公开(公告)日：2005-01-20
申请号：US10622254
申请日：2003-07-18
IPC分类号： G01N33/53 , A61K39/00 , C07D317/58 , C07K16/44 , C12N5/10 , G01N33/94 , C07D317/44 , G01N33/537 , G01N33/543
CPC分类号： C07D317/46 , A61K39/0005 , C07K16/44 , G01N33/946 , Y02P20/55 , Y10S530/809
摘要： The present invention comprises novel analogs of ecstasy-class compounds and novel ecstasy-class immunogens leashed out of, i.e., derived from, the methylenedioxy position. The invention also comprises unique monoclonal antibodies generated using MDO-leashed MDMA immunogens as well as unique conjugates and tracers. These antibodies, conjugates, and tracers are useful in immunoassays for the detection of ecstasy-class compounds in biological fluids.
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公开(公告)号：US20060216769A1
公开(公告)日：2006-09-28
申请号：US11384848
申请日：2006-03-20
IPC分类号： G01N33/53 , C07K16/18 , C07D305/12
CPC分类号： C07D305/14 , C07K16/44 , G01N33/532 , G01N33/94 , G01N2407/02 , Y10S436/815
摘要： Novel conjugates of docetaxel and novel docetaxel immunogens derived from the 7 and 10 positions of docetaxel and monoclonal antibodies generated by these docetaxel linked immunogens are useful in immunoassays for the quantification and monitoring of docetaxel in biological fluids.
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公开(公告)号：US20060099665A1
公开(公告)日：2006-05-11
申请号：US11301101
申请日：2005-12-12
IPC分类号： G01N33/537
CPC分类号： G01N33/94 , G01N33/5308 , G01N2407/02 , Y10S436/815
摘要： Novel conjugates of taxol and novel taxol immunogens derived from the 9 and 7 positions of taxol and monoclonal antibodies generated by these taxol linked immunogens are useful in immunoassays for the quantification and monitoring of taxol in biological fluids.
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公开(公告)号：US20060024769A1
公开(公告)日：2006-02-02
申请号：US11191497
申请日：2005-07-28
IPC分类号： G01N33/53
CPC分类号： G01N33/94 , G01N33/5308 , G01N2407/02 , Y10S436/815
摘要： Novel conjugates of taxol and novel taxol immunogens derived from the 9 and 7 positions of taxol and monoclonal antibodies generated by these taxol linked immunogens are useful in immunoassays for the quantification and monitoring of taxol in biological fluids.
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公开(公告)号：US20050009076A1
公开(公告)日：2005-01-13
申请号：US10900447
申请日：2004-07-27
申请人： Mitali Ghoshal , Gerald Sigler , Raymond Hui , Ronald Hawley , Eva Hoess , Erasmus Huber , John Patterson , Salvatore Salamone , Allan Dorn
发明人： Mitali Ghoshal , Gerald Sigler , Raymond Hui , Ronald Hawley , Eva Hoess , Erasmus Huber , John Patterson , Salvatore Salamone , Allan Dorn
IPC分类号： G01N33/531 , C07D307/88 , C07D405/12 , C07D473/08 , C07J19/00 , C07J41/00 , C07J43/00 , G01N33/53 , G01N33/535 , G01N33/573 , G01N33/58 , G01N33/78 , G01N33/94 , C12Q1/68 , C07H15/24 , C07H21/04 , C07J17/00
CPC分类号： C07D405/12 , C07D307/88 , C07D473/08 , C07H15/20 , C07H15/22 , C07H15/24 , C07J17/00 , C07J19/005 , C07J41/0005 , C07J41/0055 , C07J43/003 , G01N33/53 , G01N33/535 , G01N33/5735 , G01N33/581 , G01N33/78 , G01N33/9453 , G01N2333/904
摘要： The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide. The present invention also provides novel compounds, assay reagents and packaged kits useful for performing such measurements.
摘要翻译： 本发明提供了一种用于测量生物样品中分析物的方法，由此使非竞争性抑制剂与配体偶联并用于均匀测定。 分析物可以是药物或药物衍生物，激素，多肽或寡核苷酸。 本发明还提供了可用于进行这种测量的新型化合物，测定试剂和包装的试剂盒。
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公开(公告)号：US20110034488A1
公开(公告)日：2011-02-10
申请号：US12839336
申请日：2010-07-19
IPC分类号： A61K31/513 , C12Q1/32 , G01N33/53
CPC分类号： G01N33/94 , A61B5/15003 , A61B5/150236 , A61B5/150244 , A61B5/150351 , A61B5/150389 , A61B5/150503 , A61B5/150717 , A61B5/150755 , A61B5/153 , A61B5/154 , A61K31/505 , A61K31/513 , C12Q1/32
摘要： The present invention provides methods, compositions, devices and kits for assaying 5-FU.
摘要翻译： 本发明提供了用于测定5-FU的方法，组合物，装置和试剂盒。
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18.发明申请SITE-SPECIFIC AMINOGLYCOSIDE DERIVATIVES FOR USE IN IMMUNODIAGNOSTIC ASSAYS 有权用于免疫组织化学测定的特异性氨基磺酰胺衍生物公开(公告)号：US20070148700A1
公开(公告)日：2007-06-28
申请号：US11675216
申请日：2007-02-15
申请人： Mitali Ghoshal , Salvatore Salamone
发明人： Mitali Ghoshal , Salvatore Salamone
CPC分类号： C07H5/06 , A61K31/7008 , C07H3/06 , C07K16/44 , G01N33/9446 , Y02P20/55 , Y10S435/81 , Y10S435/968 , Y10S436/815 , Y10S530/807 , Y10T436/13
摘要： A method of making a derivatized aminoglycoside includes reacting an aminoglycoside with at least 2 equivalents of a divalent metal ion in an aprotic solvent to complex two neighboring amino group and hydroxyl group pairs; reacting the non-complexed amino groups with a protecting reagent to provide protecting groups; removing the divalent metal ion to provide two unprotected amino groups; reacting one of the unprotected amino groups with a reactive substance containing an linker, a carrier, or a label; and removing the protecting groups. This method can be used to produce novel compounds and regents.
摘要翻译： 制备衍生化的氨基糖苷的方法包括将氨基糖苷与至少2当量的二价金属离子在非质子溶剂中反应以使两个相邻的氨基和羟基对复合; 使非络合氨基与保护试剂反应以提供保护基团; 除去二价金属离子以提供两个未保护的氨基; 使一个未保护的氨基与含有接头，载体或标记的反应性物质反应; 并除去保护基。 该方法可用于生产新型化合物和试剂。
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公开(公告)号：US20070148684A1
公开(公告)日：2007-06-28
申请号：US11673031
申请日：2007-02-09
CPC分类号： G01N33/94 , C12Q1/34 , G01N33/56988 , G01N2333/16 , G01N2333/81 , G01N2333/8142
摘要： A non-isotopic immunoassay for an HIV protease inhibitor comprising incubating a sample containing the inhibitor with a receptor specific for the inhibitor or for a metabolite of said inhibitor and further with a conjugate comprising an analog of the inhibitor and a non-isotopic signal generating moiety. Signal generated as a result of binding of the inhibitor by the receptor is measured and correlated with the present or amount of protease inhibitor in the original sample
摘要翻译： 用于HIV蛋白酶抑制剂的非同位素免疫测定法包括将含有抑制剂的样品与抑制剂或所述抑制剂的代谢物特异性受体进一步与包含抑制剂类似物和非同位素信号产生部分的缀合物 。 测量由抑制剂与受体结合而产生的信号，并与原始样品中蛋白酶抑制剂的存在或量相关
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公开(公告)号：US20070092922A1
公开(公告)日：2007-04-26
申请号：US11606721
申请日：2006-11-30
CPC分类号： G01N33/94 , G01N33/5308 , G01N2407/02 , Y10S436/815
摘要： Novel conjugates of taxol and novel taxol immunogens derived from the 9 and 7 positions of taxol and monoclonal antibodies generated by these taxol linked immunogens are useful in immunoassays for the quantification and monitoring of taxol in biological fluids.
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