公开(公告)号：US09408888B2

公开(公告)日：2016-08-09

申请号：US13980701

申请日：2012-01-30

Applicant: Amlanjyoti Dhar ,  Shampa Mallick ,  Israr Ahmed ,  Aditya Konar ,  Santu Bandyopadhyay ,  Siddhartha Roy

Inventor： Amlanjyoti Dhar ,  Shampa Mallick ,  Israr Ahmed ,  Aditya Konar ,  Santu Bandyopadhyay ,  Siddhartha Roy

IPC: A61K38/16 ,  A61K38/10 ,  A61K9/00 ,  C07K14/47 ,  A61K45/06 ,  C07K14/00

CPC classification number: A61K38/16 ,  A61K9/0019 ,  A61K38/10 ,  A61K45/06 ,  C07K14/00 ,  C07K14/47 ,  A61K2300/00

Abstract: The present invention describes a novel bivalent helically constrained peptide targeted against S100B that is an effective anti-cancer drug against cancers that over-express S100B. This helix mimetic targeted against S100B induces rapid apoptosis in cancer cells that over-express a calcium binding protein S100B through simultaneous inhibition of key growth pathways including activation of p53.

Abstract translation: 本发明描述了针对S100B的新型二价螺旋约束肽，其是针对过表达S100B的癌症的有效抗癌药物。 靶向S100B的这种螺旋模拟物通过同时抑制关键生长途径（包括p53的激活）诱导过度表达钙结合蛋白S100B的癌细胞中的快速凋亡。

公开(公告)号：US20140155331A1

公开(公告)日：2014-06-05

申请号：US13980701

申请日：2012-01-30

Applicant: Amlanjyoti Dhar ,  Shampa Mallick ,  Israr Ahmed ,  Aditya Konar ,  Santu Bandyopadhyay ,  Siddhartha Roy

Inventor： Amlanjyoti Dhar ,  Shampa Mallick ,  Israr Ahmed ,  Aditya Konar ,  Santu Bandyopadhyay ,  Siddhartha Roy

IPC: A61K38/16 ,  C07K14/00

CPC classification number: A61K38/16 ,  A61K9/0019 ,  A61K38/10 ,  A61K45/06 ,  C07K14/00 ,  C07K14/47 ,  A61K2300/00

Abstract: The present invention describes a novel bivalent helically constrained peptide targeted against S100B that is an effective anti-cancer drug against cancers that over-express S100B. This helix mimetic targeted against S100B induces rapid apoptosis in cancer cells that over-express a calcium binding protein S100B through simultaneous inhibition of key growth pathways including activation of p53.

Abstract translation: 本发明描述了针对S100B的新型二价螺旋约束肽，其是针对过表达S100B的癌症的有效抗癌药物。 靶向S100B的这种螺旋模拟物通过同时抑制关键生长途径（包括p53的激活）诱导过度表达钙结合蛋白S100B的癌细胞中的快速凋亡。

公开(公告)号：US20120283263A1

公开(公告)日：2012-11-08

申请号：US13321445

申请日：2010-12-31

Applicant: Vasanta Madhava Sharma Gangavaram ,  Jhillu Singh Yadav ,  Radha Krishna Palakodety ,  Arun Bandyopadhyay ,  Siddhartha Roy ,  Santu Bandyopadhyay ,  Rakesh Kamal Johri ,  Subhash Chander Sharma ,  Balaram Ghosh ,  Mabalirajan Ulaganathan ,  Sakshi Balwani ,  Bholanath Paul ,  Ashok Kumar Saxena

Inventor： Vasanta Madhava Sharma Gangavaram ,  Jhillu Singh Yadav ,  Radha Krishna Palakodety ,  Arun Bandyopadhyay ,  Siddhartha Roy ,  Santu Bandyopadhyay ,  Rakesh Kamal Johri ,  Subhash Chander Sharma ,  Balaram Ghosh ,  Mabalirajan Ulaganathan ,  Sakshi Balwani ,  Bholanath Paul ,  Ashok Kumar Saxena

IPC: A61K31/53 ,  A61P11/06 ,  C12Q1/18 ,  C07D403/14

CPC classification number: C07D403/14 ,  A61K31/53 ,  C07D251/50 ,  C07D251/52

Abstract: A novel heterocyclic compound belonging to ‘triazine-aryl-bis-indoles’, useful for the treatment of asthma. The pathway by which this compound inhibits asthma is also demonstrated. The present invention also provides a process for the preparation of above compounds and their derivatives are presented.

Abstract translation: 属于三嗪 - 芳基 - 双 - 吲哚的新型杂环化合物，可用于治疗哮喘。 还证明了该化合物抑制哮喘的途径。 本发明还提供了制备上述化合物的方法及其衍生物。

公开(公告)号：US20120190738A1

公开(公告)日：2012-07-26

申请号：US13144263

申请日：2010-01-12

Applicant: Santu Bandyopadhyay ,  Bikas Chandra Pal ,  Jaisankar Parasuraman ,  Siddhartha Roy ,  Jayashree Bagchi Chakrabotry ,  Indrani Choudhury Mukherjee ,  Sanjit Kumar Mahato ,  Aditya Konar ,  Srabanti Rakshit ,  Labanya Mandal ,  Dipyaman Ganguly ,  Kausik Paul ,  Anirban Manna ,  Jayaraman Vinayagam ,  Churala Pal

Inventor： Santu Bandyopadhyay ,  Bikas Chandra Pal ,  Jaisankar Parasuraman ,  Siddhartha Roy ,  Jayashree Bagchi Chakrabotry ,  Indrani Choudhury Mukherjee ,  Sanjit Kumar Mahato ,  Aditya Konar ,  Srabanti Rakshit ,  Labanya Mandal ,  Dipyaman Ganguly ,  Kausik Paul ,  Anirban Manna ,  Jayaraman Vinayagam ,  Churala Pal

IPC: A61K31/36 ,  A61K31/225 ,  C07C215/54 ,  A61K31/138 ,  C07C255/33 ,  A61P35/02 ,  A61K31/15 ,  C07D317/50 ,  C07C39/10 ,  A61K31/05 ,  A61P35/00 ,  C07C69/353 ,  A61K31/277

CPC classification number: C07D317/06 ,  C07C251/40 ,  C07C251/66 ,  C07C255/36 ,  C07C255/38

Abstract: The present invention relates to compounds of general formula I for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention also relates to the use of compound of general formula I for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention further relates to a method of treating malignancy by inhibition of PI3-Akt pathway and or induction of NO by administration of compound or said composition to a mammal in need thereof.

Abstract translation: 本发明涉及通过抑制PI3-Akt途径或诱导NO而治疗恶性肿瘤的通式I化合物。 本发明还涉及通式I的化合物用于通过抑制PI3-Akt途径和或诱导NO而治疗恶性肿瘤的用途。 本发明还涉及通过向有需要的哺乳动物施用化合物或所述组合物来抑制PI3-Akt通路和/或诱导NO治疗恶性肿瘤的方法。

公开(公告)号：US07615574B2

公开(公告)日：2009-11-10

申请号：US10613122

申请日：2003-07-07

Applicant: Santu Bandyopadhyay ,  Bikash Chandra Pal ,  Samir Bhattacharya ,  Keshab Chandra Roy ,  Gautam Bandyopadhyay

Inventor： Santu Bandyopadhyay ,  Bikash Chandra Pal ,  Samir Bhattacharya ,  Keshab Chandra Roy ,  Gautam Bandyopadhyay

IPC: A01N37/10 ,  A61K31/235

CPC classification number: A61K45/06 ,  A61K31/192 ,  A61K31/215 ,  A61K31/216 ,  A61K31/225 ,  A61K31/235 ,  A61K31/366 ,  A61K31/70 ,  A61K31/716 ,  A61K36/67 ,  Y10S514/908 ,  A61K2300/00

Abstract: The present invention provides a method of treating acute and chronic myeloid leukemia (AML & CML) and lymphoid leukemia, said method comprising administering a pharmaceutical composition comprising pharmaceutically effective amount of chlorogenic acid (CA) and 3-o-p-Coumaryl quinic acid (PCQ) isolated from any plant parts of Piper betel or any other source, both individually or in a synergistic combination optionally along with pharmaceutically acceptable additives.

Abstract translation: 本发明提供一种治疗急性和慢性骨髓性白血病（AML和CML）和淋巴样白血病的方法，所述方法包括给药药物组合物，其包含药用有效量的绿原酸（CA）和3-对 - 香豆素奎尼酸（PCQ） 从Piper槟榔或任何其他来源的任何植物部分分离或独立地或以协同组合任选地与药学上可接受的添加剂分离。

公开(公告)号：US20110142969A1

公开(公告)日：2011-06-16

申请号：US12808964

申请日：2008-12-02

Applicant: Santu Bandyopadhyay ,  Bikas Chandra Pal ,  Jayashree Bagchi Chakraborty ,  Srabanti Rakshit ,  Labanya Mandal ,  Kausik Paul ,  Nabendu Biswas ,  Anirban Manna

Inventor： Santu Bandyopadhyay ,  Bikas Chandra Pal ,  Jayashree Bagchi Chakraborty ,  Srabanti Rakshit ,  Labanya Mandal ,  Kausik Paul ,  Nabendu Biswas ,  Anirban Manna

IPC: A61K36/67 ,  A61P35/00

CPC classification number: A61K36/67

Abstract: This invention relates to method of treating human malignancies of different origin that are sensitive to oxidative stress by administering effective amount of extract of Piper betel leaves along with a pharmaceutically acceptable additives

Abstract translation: 本发明涉及治疗对氧化应激敏感的不同来源的恶性肿瘤的方法，其中通过施用有效量的Pi叶提取物以及药学上可接受的添加剂

公开(公告)号：US20100068314A1

公开(公告)日：2010-03-18

申请号：US12623476

申请日：2009-11-23

Applicant: Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

Inventor： Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

IPC: A61K36/67 ,  A61P35/02

CPC classification number: A61K31/215 ,  A61K31/366 ,  A61K36/67 ,  Y10S514/908 ,  A61K2300/00

Abstract: A method of treating CD33+ acute and chronic myeloid leukemia in animals including humans, using fraction nos. 1 and 9 obtained from water:methanol fraction by column chromatography, with ratio of water and methanol ranging between 1:5 to 5:1, wherein said water:methanol fraction is obtained from the polar extract of Piper betel by HPLC, with retention time of 3.6 and 24.0 minutes respectively, with said fractions used both individually, and in combination.

Abstract translation: 一种在包括人类的动物中治疗CD33 +急性和慢性骨髓性白血病的方法，使用分数。 1和9从水中获得：甲醇级分，通过柱色谱法，水和甲醇的比例在1:5至5:1之间，其中所述水：甲醇部分通过HPLC从Pi the极性提取物获得，保留时间 分别为3.6和24.0分钟，所述级分分别和组合使用。

公开(公告)号：US07045157B2

公开(公告)日：2006-05-16

申请号：US10319618

申请日：2002-12-16

Applicant: Santu Bandyopadhyay ,  Bikash Pal ,  Samir Bhattacharya ,  Mitali Ray ,  Keshab Chandra Roy

Inventor： Santu Bandyopadhyay ,  Bikash Pal ,  Samir Bhattacharya ,  Mitali Ray ,  Keshab Chandra Roy

IPC: A61K35/78 ,  C12Q1/68

CPC classification number: A61K36/67 ,  Y10S514/885

Abstract: This invention relates to use of betel leaf extract to induce IFNγ from human peripheral blood mononuclear cells and as a Th1 type immuno modulator, wherein the said method comprises the steps of, preparing water extract of betel leaf, preparation of human peripheral blood mononuclear cells, incubation of hPBMC with betel leaf extract for a period of 18–48 hours, extraction of RNA for cytokine specific RT-PCR or for flow cytometry for the detection of intracellular cytokine protein, subjecting RNA for RT-PCR to obtain PCR products using IFNγ specific known primers, and enhancement of IFNγ as reflected by IFNγ specific band.

公开(公告)号：US20060013900A1

公开(公告)日：2006-01-19

申请号：US11222815

申请日：2005-09-12

Applicant: Santu Bandyopadhyay ,  Bikash Pal ,  Samir Bhattacharya ,  Mitali Ray ,  Keshab Roy

Inventor： Santu Bandyopadhyay ,  Bikash Pal ,  Samir Bhattacharya ,  Mitali Ray ,  Keshab Roy

IPC: A61K36/67

CPC classification number: A61K36/67 ,  Y10S514/885

Abstract: This invention relates to use of betel leaf extract to induce IFNγ from human peripheral blood mononuclear cells and as a Th1 type immuno modulator, wherein the said method comprises the steps of, preparing water extract of betel leaf, preparation of human peripheral blood mononuclear cells, incubation of hPBMC with betel leaf extract for a period of 18-48 hours, extraction of RNA for cytokine specific RT-PCR or for flow cytometry for the detection of intracellular cytokine protein, subjecting RNA for RT-PCR to obtain PCR products using IFNγ specific known primers, and enhancement of IFNγ as reflected by IFNγ specific band.

Abstract translation: 本发明涉及槟榔叶提取物从人外周血单核细胞和Th1型免疫调节剂诱导IFNγ的用途，其中所述方法包括以下步骤：制备桦叶叶片的水提取物， 人外周血单核细胞的制备，hPBMC与槟榔叶提取物孵育18-48小时，提取细胞因子特异性RT-PCR的RNA或流式细胞术检测细胞内细胞因子蛋白，使RNA进行RT- PCR使用IFNgamma特异性已知引物获得PCR产物，并且由IFNgamma特异性带反映的IFNγ增强。

公开(公告)号：US06852344B2

公开(公告)日：2005-02-08

申请号：US10207039

申请日：2002-07-30

Applicant: Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

Inventor： Santu Bandyopadhyay ,  Keshab Chandra Roy ,  Mitali Ray ,  Goutam Banerjee ,  Bikash Chandra Pal ,  Tanusree Biswas ,  Samir Bhattacharya

IPC: A61K31/215 ,  A61K31/366 ,  A61K36/00 ,  A61K36/67 ,  A61K35/78

CPC classification number: A61K31/215 ,  A61K31/366 ,  A61K36/67 ,  Y10S514/908 ,  A61K2300/00

Abstract: A method of treating CD33+ acute and chronic myeloid leukemia in animals including humans, using fraction nos. 1 and 9 obtained from water:methanol fraction by column chromatography, with ratio of water and methanol ranging between 1:5 to 5:1, wherein said water:methanol fraction is obtained from the polar extract of Piper betel by HPLC, with retention time of 3.6 and 24.0 minutes respectively, with the fractions used both individually, and in combination, and a composition including the fraction nos. 1 and 9.

Abstract translation: 一种在包括人类的动物中治疗CD33 +急性和慢性骨髓性白血病的方法，使用分数。 1和9从水中获得：甲醇级分，通过柱色谱法，水和甲醇的比例在1:5至5:1之间，其中所述水：甲醇部分通过HPLC从Pi the极性提取物获得，保留时间 分别为3.6和24.0分钟，分别使用和组合使用，组合物包括分数nos。 1和9。