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公开(公告)号：US6001067A
公开(公告)日：1999-12-14
申请号：US811473
申请日：1997-03-04
IPC分类号： G01N27/30 , A61B5/00 , A61B5/145 , A61B5/1473 , A61B5/1495 , C12Q1/00 , G01N27/327
CPC分类号： A61B5/14865 , A61B5/0004 , A61B5/14532 , A61B5/1495 , C12Q1/006
摘要： Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.
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公开(公告)号：US20120179014A1
公开(公告)日：2012-07-12
申请号：US13411414
申请日：2012-03-02
IPC分类号： A61B5/05
CPC分类号： A61B5/14532 , A61B5/0031 , A61B5/1455 , A61B5/14558 , A61B5/1459 , A61B5/1486 , A61B5/14865 , A61B2562/17 , C12Q1/006
摘要： Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.
摘要翻译： 描述了用于确定分析物水平的装置和方法。 装置和方法允许植入分析物监测装置，例如葡萄糖监测装置，其导致输送可靠的血液流以将样品输送到植入装置。 这些设备在传感器区域中包括独特的架构布置，可以在长时间内获得准确的数据。
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公开(公告)号：US07974672B2
公开(公告)日：2011-07-05
申请号：US12763013
申请日：2010-04-19
IPC分类号： A61B5/05
CPC分类号： A61B5/14865 , A61B5/0004 , A61B5/14532 , A61B5/1495 , C12Q1/006
摘要： Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.
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公开(公告)号：US07835777B2
公开(公告)日：2010-11-16
申请号：US12645270
申请日：2009-12-22
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/0004 , A61B5/14532 , A61B5/1495 , C12Q1/006
摘要： Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.
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公开(公告)号：US20100099970A1
公开(公告)日：2010-04-22
申请号：US12645097
申请日：2009-12-22
IPC分类号： A61B5/1473 , A61B5/1468
CPC分类号： A61B5/14865 , A61B5/0004 , A61B5/14532 , A61B5/1495 , C12Q1/006
摘要： Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.
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公开(公告)号：US20080228054A1
公开(公告)日：2008-09-18
申请号：US12037830
申请日：2008-02-26
申请人： Mark C. Shults , James H. Brauker , Victoria Carr-Brendel , Mark A. Tapsak , Dubravka Markovic , Stuart J. Updike , Rathbun K. Rhodes
发明人： Mark C. Shults , James H. Brauker , Victoria Carr-Brendel , Mark A. Tapsak , Dubravka Markovic , Stuart J. Updike , Rathbun K. Rhodes
IPC分类号： A61B5/05
CPC分类号： A61L31/10 , A61B5/14532 , A61B5/14865 , A61B5/1495 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/00 , B33Y80/00 , C12Q1/006
摘要： An implantable analyte-measuring device including a membrane adapted to promote vascularization and/or interfere with barrier cell layer formation. The membrane includes any combination of materials, architecture, and bioactive agents that facilitate analyte transport to provide long-term in vivo performance of the implantable analyte-measuring device.
摘要翻译： 一种可植入分析物测量装置，其包括适于促进血管形成和/或干扰屏障细胞层形成的膜。 膜包括材料，结构和生物活性剂的任何组合，其促进分析物传输以提供可植入分析物测量装置的长期体内性能。
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公开(公告)号：US06741877B1
公开(公告)日：2004-05-25
申请号：US09489588
申请日：2000-01-21
IPC分类号： A61B500
CPC分类号： A61B5/14865 , A61B5/14532 , C12Q1/006
摘要： Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.
摘要翻译： 描述了用于确定分析物水平的装置和方法。 装置和方法允许植入分析物监测装置，例如葡萄糖监测装置，其导致输送可靠的血液流以将样品递送到植入的装置。 这些设备包括传感器区域中的独特的微架构布置，允许在长时间段内获得准确的数据。
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公开(公告)号：US4994167A
公开(公告)日：1991-02-19
申请号：US216683
申请日：1988-07-07
IPC分类号： C12Q1/00 , G01N27/30 , G01N27/40 , G01N33/487
CPC分类号： G01N27/3271 , C12Q1/002 , C12Q1/005
摘要： A biological fluid measuring device for determining the presence and the amounts of substances in a biological fluid without the need for dilution of the fluid comprises a main housing including electronic circuit means and at least one electrode, and a cartridge having a membrane. The cartridge is removably mounted on the housing and the membrane is maintained operably associated by osmotic pressure with the electrode. The cartridge also includes means for protecting the membrane when the device is not in use. An enzyme electrode is also disclosed comprising a multilayered homogeneous monolithic membrane and an intermediate water-swellable coating.
摘要翻译： 用于确定生物流体中物质的存在和数量而不需要稀释流体的生物流体测量装置包括包括电子电路装置和至少一个电极的主壳体和具有膜的盒体。 墨盒可拆卸地安装在外壳上，并且膜通过与电极的渗透压可操作地相关联。 该盒还包括当该装置不使用时保护膜的装置。 还公开了一种酶电极，其包括多层均匀整体膜和中间水溶胀性涂层。
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公开(公告)号：US4757022A
公开(公告)日：1988-07-12
申请号：US122395
申请日：1987-11-19
IPC分类号： A61B5/00 , G01N27/30 , G01N27/40 , G01N33/487 , C12M1/34
CPC分类号： G01N27/3271 , A61B5/1486 , Y10S435/817
摘要： A biological fluid measuring device for determining the presence and the amounts of substances in a biological fluid without the need for dilution of the fluid comprises a main housing including electronic circuit means and at least one elecrode, and a cartridge having a membrane. The cartridge is removably mounted on the housing and the membrane is operably associated with the electrode. The cartridge also includes means for protecting the membrane when the device is not in use.
摘要翻译： 用于确定生物流体中物质的存在和数量而不需要稀释流体的生物流体测量装置包括包括电子电路装置和至少一个电极的主壳体和具有膜的盒体。 盒可移除地安装在壳体上，并且膜可操作地与电极相关联。 该盒还包括当该装置不使用时保护膜的装置。
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公开(公告)号：US4240438A
公开(公告)日：1980-12-23
申请号：US947949
申请日：1978-10-02
申请人： Stuart J. Updike , Mark C. Shults
发明人： Stuart J. Updike , Mark C. Shults
IPC分类号： A61B5/00 , C12Q1/00 , G01N27/416 , G01N33/487 , G01N27/26
CPC分类号： A61B5/14865 , C12Q1/006 , G01N27/3271
摘要： A method for monitoring blood glucose levels at frequent intervals, which includes a method for equalizing the temperature and oxygen level in the blood and sensing the rate of oxygen consumption by the glucose contained in the blood in the presence of glucose oxidase enzyme immobilized on a hydrophobic membrane covering a measurement electrode and elements employed therein including the equalizing method and the electrode and method for preparing same.
摘要翻译： 一种用于频繁地监测血糖水平的方法，其包括在固定在疏水性的葡萄糖氧化酶的存在下，使血液中含有的葡萄糖中的葡萄糖的血液中的温度和氧水平均衡，并检测血糖中的氧消耗速率的方法 膜覆盖其中使用的测量电极和元件，包括均化方法和电极及其制备方法。
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