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11.发明公开公开(公告)号：US20240148614A1
公开(公告)日：2024-05-09
申请号：US18384188
申请日：2023-10-26
Inventor： Sin Young KIM
IPC: A61K6/56
CPC classification number: A61K6/56
Abstract: Proposed are a method of preparing new biomaterials for dental pulp regeneration and a composition of new biomaterials prepared accordingly. The composition of new biomaterials prepared according to the method of preparing new biomaterials for dental pulp regeneration by mixing a first precursor containing calcium silicate-based cement (CSC) at an appropriate concentration and a second precursor containing a secretome of dental pulp-derived mesenchymal stem cells in an appropriate ratio and then drying the resulting mixture under appropriate drying conditions is characterized by further improving the osteogenic differentiation ability of dental pulp stem cells compared to existing materials while maintaining the microhardness of the composition to an appropriate standard. In addition, the composition is advantageous in that an aesthetic effect is excellent by not causing tooth discoloration.
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公开(公告)号：US20240115660A1
公开(公告)日：2024-04-11
申请号：US18297805
申请日：2023-04-10
Inventor： Yeun-Jun CHUNG , Kiyuk CHANG , Seung-Hyun JUNG , Eunhye PARK
CPC classification number: A61K38/177 , A61P9/10
Abstract: The present invention relates to a composition for preventing or treating heart failure including TREM2 protein or a fragment thereof as an active ingredient. The TREM2 protein or fragment thereof according to the present invention can be prepared as a soluble form and used as an injection, and when injected into the body, it promotes functional and structural improvement of the infarcted heart, and is effective for preventing or treating heart failure, and more specifically, it can be advantageously used for preventing or treating heart failure that appears as a sequela of myocardial infarction.
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公开(公告)号：US20240050106A1
公开(公告)日：2024-02-15
申请号：US18265819
申请日：2021-12-01
Inventor： Hong Jae LEE
CPC classification number: A61B17/1671 , A61F2/4611 , A61F2002/30622
Abstract: A cervical spine endplate preparation apparatus is provided. To this end, the present invention comprises: a handle part having a handle to be held by hand and a leading rod extending from the handle in the length direction and for guiding to a space inside the spine of a part to be operated on; a rotating shaft part having an adjustment grip, which generates a driving force by means of rotation by hand, and a rotating shaft passing through the inside of the handle and leading rod; and a shaver part which has a case, provided on the leading rod and inserted into the space of the spine, and a shaver installed inside the case and mating with the rotating shaft to rotate by means of the driving force of the adjustment grip, and having a part of a blade exposed to the top of the case and rotating.
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公开(公告)号：US20240029882A1
公开(公告)日：2024-01-25
申请号：US18039566
申请日：2021-12-21
Inventor： Jae Woong LEE , Myungshin KIM , Yong Gu KIM , Sung Min CHO
Abstract: The present disclosure relates to a diagnostic classification device and method and, in particular, can provide a diagnostic classification device and method, which can provide an accurate diagnosis with only existing gene expression level measurement technology by extracting an expressed gene specifically expressed from gene expression level information about a patient and classifying a diagnosis name by using the expression level of the extracted expressed gene and artificial intelligence.
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公开(公告)号：US11865007B2
公开(公告)日：2024-01-09
申请号：US17419446
申请日：2019-12-20
Inventor： Sang Hwa Lee , Joo Yup Lee
IPC: A61F2/30
CPC classification number: A61F2/3099 , A61F2002/30242 , A61F2002/30331 , A61F2002/30383 , A61F2002/30604 , A61F2002/30991 , A61F2002/30993
Abstract: A customized artificial temporomandibular joint unit according to an embodiment of the present disclosure includes a first plate provided along a lower line of a lower jawbone forming a temporomandibular joint and having an insertion groove that is outwardly open, a second plate provided at a temporal bone forming the temporomandibular joint together with the lower jawbone, and a main prothesis detachably combined to the first plate without a separate fastening device by being forcibly fit into the insertion groove while approaching the first plate, and arranged in a customized manner at a facing surface location facing the second plate.
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Patent Agency Ranking
公开(公告)号：US11859207B2
公开(公告)日：2024-01-02
申请号：US16465933
申请日：2017-12-01
Inventor： Tai Gyu Kim , Hyun Jung Sohn , Cheol Hwa Hong
CPC classification number: C12N5/0634 , A61K35/17 , C07K14/70539 , C12N5/0638 , C12N9/22 , C12N15/11 , C12N15/63 , C12N15/85 , C12N2310/20 , C12N2502/99 , C12N2800/80
Abstract: The present invention relates to an artificial antigen-presenting cell prepared from an HLA-null cell line by using a multiplex CRISPR-Cas9 system and the use thereof and, more particularly, to a novel artificial antigen-presenting cell which includes the ability to present antigens of HLA class I and a co-stimulatory molecule group transferred from an HLA-A, -B, -C null cell line generated using a multiplex CRISPR-Cas9 system and to stimulate T cells, an immunotherapeutic agent using the same, and the use thereof for treating tumors, pathogenic infections, and autoimmune diseases.
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公开(公告)号：US20230416687A1
公开(公告)日：2023-12-28
申请号：US18342930
申请日：2023-06-28
Inventor： Sung Won KIM , Ayoung JO , Min Jae LIM , Jung Eun LEE , Seung Ho YANG
IPC: C12N5/071
CPC classification number: C12N5/0688 , C12N2502/30 , C12N2503/02
Abstract: The present invention relates to a lung cancer model based on a normal lung organoid, prepared by fusing cancer cells to the normal lung organoid. By using the lung cancer model according to the present invention, it is possible not only to observe the progression or metastasis pattern of lung cancer from the early stage of proliferating lung cancer cells to the stage of forming a tumor but also to compare the effect of an anticancer agent at each stage, and thus the information on an appropriate therapeutic agent may be provided according to the stage of cancer development.
In addition, since the lung cancer model according to the present invention includes a normal lung organoid and cancer cells, which are fused, it can be effectively used to confirm the effect of an anticancer agent on normal tissue and the effect of cancer cell-specific apoptosis. In addition, since a conventional method of injecting human lung cancer cells into a mouse has a problem in that unpredictable reactions are caused by immune responses or the like, the present invention is expected to be effectively used as a human lung cancer model.-
公开(公告)号：US20230293627A1
公开(公告)日：2023-09-21
申请号：US18008773
申请日：2021-09-14
Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION , POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION
Inventor： Ji Chang YOU , Kyung Lee YU , Joo-Yeon YOO , Nari KIM
Abstract: The present invention relates to an anti-HIV-1 composition including SCOTIN protein and a nucleotide encoding the same; use of preventing and treating HIV-1 infection, including the composition; or a method for inhibiting the generation and proliferation of the virus, and the SCOTIN protein has effects on the expression and action of important structural proteins of HIV-1, thereby effectively inhibiting the generation and proliferation of HIV-1.
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19.发明公开公开(公告)号：US20230284900A1
公开(公告)日：2023-09-14
申请号：US18014026
申请日：2021-06-23
Inventor： Yong Chan KIM , Dong Jin CHANG , So Jin PARK
IPC: A61B3/12 , A61B3/00 , G06F18/2411 , A61B3/10 , G16H50/20
CPC classification number: A61B3/12 , A61B3/0025 , G06F18/2411 , A61B3/102 , G16H50/20
Abstract: A method of determining pathologic myopia by using the geometric structure of a posterior sclera of a fundus includes obtaining geometric location data about a fovea, an optic disc, and a deepest point of the eye (DPE) in the posterior sclera of the fundus; obtaining an elevation difference TEPSfovea−DPE between the fovea and the DPE, an elevation difference TEPSdisc−DPE between the optic disc and the DPE, and an elevation difference TEPSfovea−disc between the fovea and the optic disc by using location information about the fovea, the optic disc, and the DPE in the posterior sclera; and determining pathologic myopia by using at least two elevation differences selected from among the elevation difference TEPSfovea−DPE between the fovea and the DPE, the elevation difference TEPSdisc−DPE between the optic disc and the DPE, and the elevation difference TEPSfovea−disc between the fovea and the optic disc.
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公开(公告)号：US20230186474A1
公开(公告)日：2023-06-15
申请号：US17625911
申请日：2020-03-18
Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION , KONKUK UNIVERSITY GLOCAL INDUSTRY-ACADEMIC COLLABORATION FOUNDATION
Inventor： Hyun Jeong KIM , Hong Gee ROH
CPC classification number: G06T7/0016 , A61B5/055 , G06T19/20 , G06T2207/20224 , G06T2207/10088 , G06T2200/04 , G06T2207/10076 , G06T2207/30101 , G06T2207/20132 , G06T2207/20092 , G06T2207/30096 , G06T2219/2012
Abstract: Provided are a simultaneous implementation method of 3D subtraction arteriography, 3D subtraction venography, and 4D color angiography through post-processing of image information of 4D magnetic resonance (MR) angiography, and a medical imaging system.
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