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公开(公告)号:US20250000955A1
公开(公告)日:2025-01-02
申请号:US18614952
申请日:2024-03-25
Inventor: V. Michael Holers , Nirmal Banda , Liudmila Kulik
Abstract: The present invention provides delivery methods and constructs for treating inflammatory diseases in an individual. The targeted delivery approach utilizes an antibody that recognizes an epitope found to be present at sites of inflammation. The antibody is used to deliver a MAp44 polypeptide or fragment thereof to sites of inflammation, where it inhibits the lectin pathway of complement activation.
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公开(公告)号:US20240424673A1
公开(公告)日:2024-12-26
申请号:US18668453
申请日:2024-05-20
Inventor: Daniel Szafir , Michael E. Walker , Hooman Hedayati
Abstract: Systems and methods for human-robot communication. More particularly, some embodiments use augmented reality to facilitate communication of robot intention and teleoperation in human-robot cooperative environments. Various embodiments of the present technology provide a middleware that integrates augmented reality (AR) with novel teleoperation interfaces to increase operation effectiveness, support the user in conducting concurrent work, and decrease stress. Various embodiments provide predictive graphical interfaces such that a teleoperator controls a virtual robot surrogate, rather than directly operating the robot itself, providing the user with foresight regarding where the physical robot will end up and how it will get there. In accordance with various embodiments a user may select between two AR interfaces using such a surrogate: one focused on real-time control and one inspired by waypoint delegation.
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公开(公告)号:US12166623B2
公开(公告)日:2024-12-10
申请号:US18249580
申请日:2021-10-18
Inventor: Yang Wang , Yu T. Morton
Abstract: DLOS and reflected signal components of an RF carrier signal are received. The reflected component is reflected from a point on the surface of the earth. The DLOS and reflected components are converted to digital DLOS IF and reflected IF signals, respectively. Modeled parameters are generated using the digital DLOS IF signal and locations of one or more antennas, the transmitter, and the point. A reference signal is generated based on the modeled parameters. The reference signal is correlated with the digital reflected IF signal to produce in-phase and quadrature-phase correlation results. A C/N0 and an estimated phase (EP) are calculated for the digital reflected IF signal from the correlation results. A KF is applied to the EP to produce an estimated filter phase (EFP). The KF is adapted to filter the EP using the estimated C/N0 to reduce cycle slips and noise in the EFP.
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公开(公告)号:US20240382385A1
公开(公告)日:2024-11-21
申请号:US18765795
申请日:2024-07-08
Inventor: Adam Green , Steven Lammers , Jennifer Wagner , Ken Liechty , Jahmel Jordon
IPC: A61J15/00
Abstract: A feeding tube configured to allow intact pills to pass through an internal lumen of the feeding tube. Some embodiments of the feeding tube include a main body having a lumen extending between a proximal end and a distal end of the main body. The proximal end includes an inlet aperture leading to the lumen and the distal end includes an outlet aperture fluidically coupled to the lumen. The main body includes a thin-walled transcutaneous section configured to temporarily receive a tubular structural support member that can operate as a traditional feeding tube. The tubular structural support member can be removed to allow a pill delivery device to deliver an intact pill through the lumen and out of the outlet aperture.
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公开(公告)号:US12070216B2
公开(公告)日:2024-08-27
申请号:US17845700
申请日:2022-06-21
Inventor: Max Bannister Mitchell , Alexander Travis Brown
IPC: A61B17/11 , A61M60/148 , A61M60/178 , A61M60/863
CPC classification number: A61B17/11 , A61M60/148 , A61M60/178 , A61M60/863 , A61B2017/1107 , A61M2205/0216
Abstract: An implantable anastomotic assembly, which is configured to be attached to cardiovascular tissue, includes a connection interface, a plurality of outer plates, and a plurality of connectors configured to extend between and interconnect the connection interface and the plurality of outer plates, respectively, according to various embodiments. The connection interface is separate from and non-contiguous with the plurality of outer plates, according to various embodiments.
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公开(公告)号:US20240245049A1
公开(公告)日:2024-07-25
申请号:US18627309
申请日:2024-04-04
Inventor: Marc MATHIAS , Kang LI , Miguel FLORES BELLVER , Silvia APARICIO DOMINGO , Conan CHEN , Valeria CANTO-SOLER
CPC classification number: A01N1/0263 , A61F9/0017 , A61K35/30
Abstract: A cell transplant carrier including a carrier plate and a carrier housing. The carrier plate includes a body and one or more chambers defined in the body. Each of the one or more chambers is configured to receive a cell transplant and is shaped to cause the cell transplant to be at least partially exposed in order to permit removal of the cell transplant therefrom. The carrier housing includes a carrier plate opening leading to an inner compartment configured to removably receive the carrier plate.
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公开(公告)号:US20240238421A1
公开(公告)日:2024-07-18
申请号:US18392543
申请日:2023-12-21
Inventor: Karin A. PAYNE , Melissa D. KREBS
IPC: A61K47/36 , A61K9/00 , A61K9/06 , A61K47/22 , A61L27/20 , A61L27/52 , A61L27/54 , A61P19/00 , C07K16/22 , C08J3/075 , A61B17/16
CPC classification number: A61K47/36 , A61K9/0019 , A61K9/06 , A61K47/22 , A61L27/20 , A61L27/52 , A61L27/54 , A61P19/00 , C07K16/22 , C08J3/075 , A61B17/16 , A61L2300/256 , A61L2300/412 , A61L2300/414 , A61L2300/416 , A61L2300/62 , A61L2430/06 , C08J2305/04 , C08J2305/08
Abstract: The present invention relates to the unexpected discovery of compositions and methods for the treatment of growth plate defects. In certain embodiments, the methods prevent the growth of “bony bars” at the site of growth plate injury, thereby preventing growth arrest and/or deformity. In certain embodiments, the compositions comprise hydrogels comprising at least one biological factor capable of preventing bony bar formation.
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公开(公告)号:US20240238301A1
公开(公告)日:2024-07-18
申请号:US18622525
申请日:2024-03-29
Inventor: Michael R. VERNERIS , Laura Michelle MCLAUGHLIN
IPC: A61K31/519 , A61K35/28 , A61P37/06
CPC classification number: A61K31/519 , A61K35/28 , A61P37/06
Abstract: Embodiments of the instant disclosure generally relate to compositions and methods for improving engraftment, reducing the risk of cellular implantation or transplantation rejection, reducing toxicities due to radiation and chemotherapy treatments and/or treating a malignant or non-malignant condition or a subject having a solid organ transplantation using stem cell implantation in combination with compositions disclosed herein. In certain embodiments, compositions and methods disclosed herein concern administering a composition including, but not limited to, at least one Janus kinase (JAK) inhibitor. In some embodiments, compositions and methods disclosed herein can be administered in combination with and/or before, during and/or after hematopoietic cell transplantation (HCT) to treat a health condition in a subject.
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公开(公告)号:US20240229072A9
公开(公告)日:2024-07-11
申请号:US18547348
申请日:2022-02-22
Inventor: Ram H. NAGARAJ , Rooban B. NAHOMI
CPC classification number: C12N15/86 , A61K9/0048 , A61K48/0075 , A61P27/06 , C07K14/47 , C12N2750/14143
Abstract: Gene therapy for a retinal disease, injury, or condition in a subject involves administering to the subject a pharmaceutical composition containing a recombinant adeno-associated viral vector encoding at least one heat shock protein, such as Hsp27. A recombinant adeno-associated viral vector can include a promoter sequence that induces production of a heat shock protein specifically in retinal ganglion cells. The loss of such cells causes retinal damage and loss of eyesight in patients afflicted with an ocular condition. The disclosed viral vector may be included in pharmaceutical compositions that may be administered intravitreally using an administration device. A single injection 10 may be therapeutically sufficient for treating various ocular conditions.
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公开(公告)号:US12029732B2
公开(公告)日:2024-07-09
申请号:US17604858
申请日:2020-04-20
Inventor: Tamara Terzian , Neil Box
IPC: A61K31/428 , A61K31/429 , A61P7/10
CPC classification number: A61K31/428 , A61K31/429 , A61P7/10
Abstract: Disclosed herein are compositions, methods, and systems useful in the prevention, management, or treatment of various conditions associated the lymphatic vasculature, including, but not limited to lymphedema. The disclosed methods and compositions are useful in reducing the activity of p53 in a subject at risk for or suffering from a disease or condition associated with lymphatic vasculature, including adults, children, infants, and embryos. Reduction in p53 activity may be achieve through reduction in one or more of p53 gene expression, p53 transcriptional activity, p53 DNA-binding affinity, etc. In many embodiments, the disease or condition is lymphedema, for example lymphedema associated with Milroy's disease, Klippel-Trenaunay and Cloves Syndromes. In many embodiments, treatment may involve administering a compound or pharmaceutically acceptable salt thereof to a subject in need thereof, exemplary compounds include, anti-p53 compounds, PFT, and PFT-β.
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