公开(公告)号：US20100123963A1

公开(公告)日：2010-05-20

申请号：US12570228

申请日：2009-09-30

申请人： Takeshi Shibasaki

发明人： Takeshi Shibasaki

IPC分类号： G11B27/36

CPC分类号： G11B20/182 ,  G11B5/455 ,  G11B19/048 ,  G11B20/1816 ,  G11B27/36 ,  G11B2220/2516

摘要： According to one embodiment, a magnetic storage apparatus configured to write data to and read data from a magnetic medium with a head includes a setting module, a write module, a read module, and a quality measurement module. The setting module sets a plurality of sections divided in the track direction of the magnetic medium and a predetermined reference path along the track direction, and also sets at least one offset for each of the sections such that the offset is different between adjacent sections. The offset is the position of the head with respect to the reference path. The write module writes a first data pattern to the offset set by the setting module and writes a second data pattern to the reference path a predetermined number of times. The read module reads the first data pattern written by the write module. The quality measurement module measures the quality of the first data pattern read by the read module.

摘要翻译： 根据一个实施例，被配置为向具有磁头的磁介质写数据和从磁介质读数据的磁存储装置包括设置模块，写模块，读模块和质量测量模块。 设置模块设置在磁性介质的磁道方向上划分的多个部分和沿磁道方向的预定参考路径，并且还为每个部分设置至少一个偏移，使得相邻部分之间的偏移量不同。 偏移量是头部相对于参考路径的位置。 写入模块将第一数据模式写入由设置模块设置的偏移量，并将第二数据模式写入参考路径预定次数。 读取模块读取由写入模块写入的第一个数据模式。 质量测量模块测量读取模块读取的第一个数据模式的质量。

公开(公告)号：US20090237830A1

公开(公告)日：2009-09-24

申请号：US12406284

申请日：2009-03-18

申请人： Takeshi SHIBASAKI

发明人： Takeshi SHIBASAKI

IPC分类号： G11B21/02

CPC分类号： G11B5/6005 ,  G11B5/6064

摘要： One aspect of the embodiments is related to a method of controlling a flying height of a head slider. The method includes the steps of measuring a first correlation value between an air pressure and a heating element sensitivity of the head slider, measuring a second correlation value between the air pressure and the flying height of the head slider, calculating a reference heating-element sensitivity at normal air pressure from the first correlation value, measuring a heating element sensitivity of the heating element when the head slider is lifted, calculating the difference between the heating element sensitivity and the reference heating-element sensitivity to calculate an amount of variation in air pressure from the first correlation value, and calculating an amount of variation in the flying height of the head slider from the amount of variation in air pressure and the second correlation value and controlling the heating element.

摘要翻译： 实施例的一个方面涉及一种控制磁头滑块的飞行高度的方法。 该方法包括以下步骤：测量头部滑动器的空气压力和加热元件灵敏度之间的第一相关值，测量气压和头部滑块的飞行高度之间的第二相关值，计算参考加热元件灵敏度 在来自第一相关值的正常空气压力下，测量当磁头滑块抬起时加热元件的加热元件灵敏度，计算加热元件灵敏度和参考热元件灵敏度之间的差以计算空气压力变化量 并根据空气压力的变化量和第二相关值计算磁头滑块的飞行高度的变化量，并控制加热元件。

公开(公告)号：US07112432B2

公开(公告)日：2006-09-26

申请号：US10864423

申请日：2004-06-10

申请人： Akio Ozaki ,  Hideo Mori ,  Takeshi Shibasaki ,  Katsuhiko Ando ,  Keiko Ochiai ,  Shigeru Chiba ,  Yoichi Uosaki

发明人： Akio Ozaki ,  Hideo Mori ,  Takeshi Shibasaki ,  Katsuhiko Ando ,  Keiko Ochiai ,  Shigeru Chiba ,  Yoichi Uosaki

IPC分类号： C12N1/20 ,  C12N15/75 ,  C12N15/76 ,  C07H21/04

CPC分类号： C12N9/0071 ,  C12P13/24 ,  C12Y114/11002 ,  Y10S435/832 ,  Y10S435/886

摘要： An isolated gene encodes for a L-proline-3-hydroxylase having the amino acid sequence of SEQ ID NOS: 1, 2, 15, 16 and 17, or for a protein having enzymatic activity to hydroxylate the 3-position of L-proline and to act on free L-proline in the presence of 2-ketoglutaric acid and divalent iron ions to produce cis-3-hydroxy-L-proline. The gene is inserted into a vector and the resulting recombinant DNA is used to create a transformant. L-proline-3-hydroxylase is produced by culturing the transformant in a medium.

公开(公告)号：US06767726B2

公开(公告)日：2004-07-27

申请号：US10138632

申请日：2002-05-06

申请人： Akio Ozaki ,  Hideo Mori ,  Takeshi Shibasaki ,  Katsuhiko Ando ,  Keiko Ochiai ,  Shigeru Chiba ,  Yoichi Uosaki

发明人： Akio Ozaki ,  Hideo Mori ,  Takeshi Shibasaki ,  Katsuhiko Ando ,  Keiko Ochiai ,  Shigeru Chiba ,  Yoichi Uosaki

IPC分类号： C12N902

CPC分类号： C12N9/0071 ,  C12P13/24 ,  C12Y114/11002 ,  Y10S435/814

摘要： An isolated gene encodes for a L-proline-3-hydroxylase having the amino acid sequence of SEQ ID NOS: 1, 2, 15, 16 and 17, or for a protein having enzymatic activity to hydroxylate the 3-position of L-proline and to act on free L-proline in the presence of 2-ketoglutaric acid and divalent iron ions to produce cis-3-hydroxy-L-proline. The gene is inserted into a vector and the resulting recombinant DNA is used to create a transformant. L-proline-3-hydroxylase is produced by culturing the transformant in a medium.

摘要翻译： 分离的基因编码具有SEQ ID NO：1,2,15,16和17的氨基酸序列的L-脯氨酸-3-羟化酶，或编码具有酶活性的蛋白质，以使L-脯氨酸的3-位羟基化 并在2-酮戊二酸和二价铁离子存在下作用于游离的L-脯氨酸以产生顺式-3-羟基-L-脯氨酸。 将该基因插入载体中，并将​​所得的重组DNA用于产生转化体。 通过在培养基中培养转化体产生L-脯氨酸-3-羟化酶。

公开(公告)号：US6010891A

公开(公告)日：2000-01-04

申请号：US287375

申请日：1999-04-07

申请人： Akio Ozaki ,  Hideo Mori ,  Takeshi Shibasaki ,  Katsuhiko Ando ,  Keiko Ochiai ,  Shigeru Chiba ,  Yoichi Uosaki

发明人： Akio Ozaki ,  Hideo Mori ,  Takeshi Shibasaki ,  Katsuhiko Ando ,  Keiko Ochiai ,  Shigeru Chiba ,  Yoichi Uosaki

IPC分类号： C12N9/02 ,  C12P13/24 ,  C07H21/04 ,  C07K1/00 ,  C12N1/20 ,  C12N15/00

CPC分类号： C12N9/0071 ,  C12P13/24 ,  C12Y114/11002 ,  Y10S435/814

摘要： An industrially applicable process for producing cis-3-hydroxy-L-proline, which is useful as a raw material for medicines or as an additive to foods. In the process, L-proline is converted into cis-3-hydroxy-L-proline in the presence of an enzyme source which is derived from a microorganism belonging to the genus Streptomyces or Bacillus and which catalyzes hydroxylation of L-proline into cis-3-hydroxy-L-proline, a divalent iron ion and 2-ketoglutaric acid, in an aqueous medium, and the produced cis-3-hydroxy-L-proline is collected from the aqueous medium. A novel enzyme L-proline-3-hydroxylase, a gene of L-proline-3-hydroxylase which is useful for the process, a transformant containing the gene, and a process for producing L-proline-3-hydroxylase using the transformant, is also provided.

摘要翻译： 用于生产顺式-3-羟基-L-脯氨酸的工业上适用的方法，其可用作药物的原料或作为食品添加剂。 在此过程中，L-脯氨酸在衍生自属于链霉菌属或芽孢杆菌属的微生物的酶源存在下转化为顺式-3-羟基-L-脯氨酸，其催化L-脯氨酸的羟基化为顺式 - 3-羟基-L-脯氨酸，二价铁离子和2-酮戊二酸，在水性介质中收集生成的顺式-3-羟基-L-脯氨酸。 一种新型的L-脯氨酸-3-羟化酶，可用于该方法的L-脯氨酸-3-羟化酶的基因，含该基因的转化体，以及使用该转化体产生L-脯氨酸-3-羟化酶的方法， 也提供。

公开(公告)号：US20130335842A1

公开(公告)日：2013-12-19

申请号：US13604484

申请日：2012-09-05

申请人： Takeshi SHIBASAKI

发明人： Takeshi SHIBASAKI

IPC分类号： G11B27/36 ,  G11B20/18

CPC分类号： G11B20/18 ,  G11B27/36

摘要： According to one embodiment, there is provided a method for determining whether a defect on a disk in an apparatus includes head is a recess or a protrusion. The method detects a first defect on the disk using a read element provided in the head. The method detects a second defect on the disk using a head disk interference sensor provided in the head. The method further determines whether a third defect is a recessed defect or a protruding defect based on a ratio between a first width of the first defect in a radial direction on the disk and a second width of the second defect in the radial direction of the disk. The third defect is identified based on the first defect and the second defect.

摘要翻译： 根据一个实施例，提供了一种用于确定包括头部的设备中的盘上的缺陷是凹陷还是突起的方法。 该方法使用设置在头部中的读取元件来检测盘上的第一缺陷。 该方法使用设置在头部中的头盘干涉传感器来检测盘上的第二缺陷。 该方法还基于盘的径向上的第一缺陷的第一宽度与盘的径向方向上的第二缺陷的第二宽度之间的比率进一步确定第三缺陷是凹陷缺陷还是突出缺陷 。 基于第一缺陷和第二缺陷来识别第三缺陷。

公开(公告)号：US07238501B2

公开(公告)日：2007-07-03

申请号：US10610561

申请日：2003-07-02

申请人： Akio Ozaki ,  Hideo Mori ,  Takeshi Shibasaki ,  Katsuhiko Ando ,  Shigeru Chiba

发明人： Akio Ozaki ,  Hideo Mori ,  Takeshi Shibasaki ,  Katsuhiko Ando ,  Shigeru Chiba

IPC分类号： C12P13/24

CPC分类号： C12N9/0071 ,  C12P13/24 ,  C12Y114/11002

摘要： The present invention is directed to a process for producing trans-4-hydroxy-L-proline, which is useful as a raw material for medicines or as an additive to foods. In the process, L-proline is converted into trans-4-hydroxy-L-proline in the presence of an enzyme source which is derived from a microorganism belonging to the genus Dactylosporangium, Amycolatopsis or Streptomyces and which catalyzes the hydroxylation of L-proline into trans-4-hydroxy-L-proline, a divalent iron ion and 2-ketoglutaric acid, in an aqueous medium, and the produced trans-4-hydroxy-L-proline is collected from the aqueous medium. In addition, the present invention is directed to a process for producing trans-4-hydroxy-L-proline, wherein the L-proline biosynthesis activity of the host cell of the transformant is reinforced.

摘要翻译： 本发明涉及一种生产反式-4-羟基-L-脯氨酸的方法，其可用作药物的原料或作为食品添加剂。 在此过程中，L-脯氨酸在衍生自属于Dactylosporangium，Amycolatopsis或Streptomyces属的微生物的酶源的存在下转化成反式-4-羟基-L-脯氨酸，其催化L-脯氨酸的羟基化 在水性介质中转化成反式-4-羟基-L-脯氨酸，二价铁离子和2-酮戊二酸，从水性介质中收集生成的反式-4-羟基-L-脯氨酸。 此外，本发明涉及一种生产反式-4-羟基-L-脯氨酸的方法，其中转化体宿主细胞的L-脯氨酸生物合成活性得到增强。

公开(公告)号：US20060258746A1

公开(公告)日：2006-11-16

申请号：US11272107

申请日：2005-11-08

申请人： Toshikazu Kamiya ,  Takeshi Shibasaki ,  Asuka Otofuji ,  Yasushi Sakai ,  Akemi Ogawa ,  Miho Komatsu

发明人： Toshikazu Kamiya ,  Takeshi Shibasaki ,  Asuka Otofuji ,  Yasushi Sakai ,  Akemi Ogawa ,  Miho Komatsu

IPC分类号： A61K31/198

CPC分类号： A61K31/198

摘要： A person, who has symptoms including difficulty in going to sleep, feeling languid after waked up or having a hard time awaking, is desirous of a medicament and a nutritional food that can alleviate the symptoms and improve his or her health. Specifically, one object of the present invention is to provide an orally administered agent, a food and drink, or a food additive which can be used for improving the process of going to sleep and waking. An orally administered agent, a food and drink, or a food additive for improving the process of going to sleep and waking, containing ornithine or a salt thereof as an active ingredient can be provided according to the present invention.

摘要翻译： 患有睡眠困难，睡眠觉醒或醒来困难等症状的人，希望能够减轻症状，改善身体健康的药物和营养食品。 具体地说，本发明的一个目的是提供可用于改善睡眠和醒来过程的口服制剂，食品和饮料或食品添加剂。 根据本发明，可以提供含有鸟氨酸或其盐作为活性成分的口服给药剂，食品饮料或用于改善睡眠和醒来过程的食品添加剂。

公开(公告)号：US20060035957A1

公开(公告)日：2006-02-16

申请号：US10529721

申请日：2003-09-30

申请人： Toshiaki Takeda ,  Kenjiro Shimada ,  Hideo Kawabe ,  Takeshi Shibasaki ,  Tomoya Takahashi

发明人： Toshiaki Takeda ,  Kenjiro Shimada ,  Hideo Kawabe ,  Takeshi Shibasaki ,  Tomoya Takahashi

IPC分类号： A61K31/4015

CPC分类号： A61K31/401

摘要： In accordance with the present invention, there are provided a preventive or of preventing or therapeutic agent for decubitus comprising an N-acylated derivative of hydroxyproline or a salt thereof; the above preventive or therapeutic agent wherein the N-acylated derivative of hydroxyproline or a salt thereof is contained in an amount of 0.1 to 15% by weight to the total weight; and the preventive or therapeutic agent for decubitus wherein the N-acylated group of the N-acylated derivative of hydroxyproline is an N-acylated group having 1 to 24 carbon atoms.

摘要翻译： 根据本发明，提供了包含羟脯氨酸的N-酰化衍生物或其盐的预防或预防或治疗褥疮的治疗剂; 上述预防或治疗剂，其中羟基脯氨酸的N-酰化衍生物或其盐的含量为总重量的0.1至15重量％; 以及N-脯氨酸N-酰化衍生物的N-酰化基为碳原子数为1〜24的N-酰化基的褥疮预防或治疗剂。

公开(公告)号：US06617140B2

公开(公告)日：2003-09-09

申请号：US09833555

申请日：2001-04-13

申请人： Akio Ozaki ,  Hideo Mori ,  Takeshi Shibasaki ,  Katsuhiko Ando ,  Shigeru Chiba

发明人： Akio Ozaki ,  Hideo Mori ,  Takeshi Shibasaki ,  Katsuhiko Ando ,  Shigeru Chiba

IPC分类号： C12P1324

CPC分类号： C12N9/0071 ,  C12P13/24 ,  C12Y114/11002

摘要： Provided is an industrially applicable process for producing trans-4-hydroxy-L-proline, which is useful as a raw material for medicines or as an additive to foods. In the process, L-proline is converted into trans-4-hydroxy-L-proline in the presence of an enzyme source which is derived from a microorganism belonging to the genus Dactylosporangium, Amycolatopsis or Streptomyces and which catalyzes the hydroxylation of L-proline into trans-4-hydroxy-L-proline, a divalent iron ion and 2-ketoglutaric acid, in an aqueous medium, and the produced trans-4-hydroxy-L-proline is collected from the aqueous medium. Also provided is a novel enzyme L-proline-4-hydroxylase which is useful for the process, a gene of L-proline-4-hydroxylase which is useful for the process, a transformant containing the gene, and a process for producing L-proline-4-hydroxylase using the transformant. In addition, provided is a process for producing L-proline-4-hydroxylase using the transformant which contains the gene and has a reinforced proline biosynthesis activity.