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11.发明公开公开(公告)号：US20230181672A1
公开(公告)日：2023-06-15
申请号：US17923394
申请日：2021-04-20
IPC分类号： A61K38/00 , C07K14/765
CPC分类号： A61K38/00 , C07K14/765 , C07K2319/43 , C12N2750/14143
摘要： This application provides the first observation of methylmalonylation/malonylation in organic acidemias (OAs), such as methylmalonic acidemia (MMA) and propionic acidemia (PA), which results in modification of enzymes in key pathways dysregulated in OAs, including sirtuin 5 (SIRT5). Hyperacylation of SIRT5 prevents it from de-acylating CPS1 (including removing methymalonyllation), which prevents activation of CPS1 and likewise, inhibits a key component of the glycine cleavage system, GCSH. Based on these observations, provided herein is a mutant form of SIRT5 containing four mutated lysines that cannot accept acyl groups, methods of its use for treating OA patients, and kits.
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公开(公告)号：US20230159653A1
公开(公告)日：2023-05-25
申请号：US17437065
申请日：2020-03-07
申请人： MEMORIAL SLOAN KETTERING CANCER CENTER , The U.S.A, as represented by the Secretary, Department of Health and Human Services
发明人： DIMITAR NIKOLOV , NAYANENDU SAHA , ZHONGYU ZHU , DIMITER STANCHEV DIMITROV , DOROTHEA ROBEV , THOMAS EDGEWORTH WHITE
CPC分类号： C07K16/2896 , A61P35/00 , A61K39/00
摘要： The present invention provides various ADAM17 binding molecules (including antibodies and fragments thereof), compositions comprising such ADAM17 binding molecules, and methods of using such ADAM17 binding molecules and compositions, for example in inhibiting binding of ADAM17 to ADAM17 substrates (such as ErbB ligands), in inhibiting the proliferation of cancer cells, and in treating cancer.
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公开(公告)号：US11639930B2
公开(公告)日：2023-05-02
申请号：US16761034
申请日：2018-11-01
申请人： The U.S.A., as represented by the Secretary, Department of Health and Human Services , Yale University
发明人： Sanjai Kumar , Nitin Verma , Ankit Puri , Peter J. Krause
IPC分类号： C07K14/44 , G01N33/543 , C12N15/10 , G01N33/569
摘要： Identification of immunodominant Babesia microti antigens using genome-wide immunoscreening is described. Candidate antigens were screened against sera from patients with clinical babesiosis. Also described are diagnostic assays with high sensitivity and specificity for detecting B. microti-specific antibodies in patient samples using the identified immunodominant antigens.
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公开(公告)号：US20230057461A1
公开(公告)日：2023-02-23
申请号：US17792507
申请日：2021-01-26
发明人： Stavroula Mili
IPC分类号： C12N15/113 , A61K45/06 , A61P35/04
摘要： Provided herein are antisense oligonucleotides (ASOs) specific for Rab13 and Net1, for example specific for a GA-rich region of the 3′-UTR. In some examples, the ASOs are modified. Methods of using these ASOs to reduce the migration of metastatic cancer cells are provided, for example as a use to treat metastatic cancer.
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公开(公告)号：US20230050416A1
公开(公告)日：2023-02-16
申请号：US17938529
申请日：2022-10-06
IPC分类号： C12N15/62 , C07K14/705 , C07K14/725 , C07K16/18 , C07K16/28
摘要： The invention provides an isolated and purified nucleic acid sequence encoding a chimeric antigen receptor (CAR) directed against B-cell Maturation Antigen (BCMA). The invention also provides host cells, such as T-cells or natural killer (NK) cells, expressing the CAR and methods for destroying multiple myeloma cells.
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公开(公告)号：US20230039456A1
公开(公告)日：2023-02-09
申请号：US17786129
申请日：2020-12-17
申请人： Gregory Matlashewski , Wen-Wei Zhang , Patrick Lypaczewski , The U.S.A., as represented by the Secretary, Department of Health and Human Services , Ohio State Innovation Foundation
发明人： Hira L. Nakhasi , Ranadhir Dey , Sreenivas Gannavaram , Subir Karmakar , Gregory Matlashewski , Abhay Satoskar , Wen-Wei Zhang , Patrick Lypaczewski
IPC分类号： A61K39/008 , C12N15/63 , C12N1/10 , A61P33/02
摘要： Disclosed herein are modified Leishmania species and compositions thereof, such as live, attenuated organisms, immunogenic compositions, vaccines, and pharmaceutical compositions. Further disclosed are methods related to the modified Leishmania species, such as methods of production and methods of use.
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17.发明授权公开(公告)号：US11529312B2
公开(公告)日：2022-12-20
申请号：US16091768
申请日：2017-04-06
IPC分类号： A61K9/127 , A61K39/02 , C12N1/20 , A61K31/6615 , A61P11/00 , A61P29/00 , A61K31/685 , A61K39/00
摘要： Embodiments of the present disclosure include anti-inflammatory compositions and methods of use thereof. The compositions include purified lipids from Francisella, for example, virulent strains of Francisella. Other features and advantages of the invention will be apparent from the detailed description, and from the claims.
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公开(公告)号：US20220362297A1
公开(公告)日：2022-11-17
申请号：US17674378
申请日：2022-02-17
申请人： Regents of the University of Minnesota , Intima Bioscience, Inc. , The U.S.A., as Represented by the Secretary, Department of Health and Human Services
发明人： Branden MORIARITY , Beau WEBBER , Modasir CHOUDHRY , Steven A. ROSENBERG , Douglas C. PALMER , Nicholas P. RESTIFO
IPC分类号： A61K35/17 , C07K14/715 , C12N15/113 , C07K14/47 , C07K14/725 , C12N5/0783 , C07K14/705 , C12N15/90 , C12N9/22 , C12N9/96
摘要： Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer.
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公开(公告)号：US11464801B2
公开(公告)日：2022-10-11
申请号：US16588357
申请日：2019-09-30
申请人： Lentigen Technology, Inc. , The U.S.A., as represented by the Secretary, Department of Health and Human Services
IPC分类号： A61K35/17 , C07K16/28 , C07K14/725 , C07K14/705 , A61P35/02 , A61K39/395 , A61K48/00 , A61K39/00
摘要： Chimeric antigen receptors containing CD33 antigen binding domains are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments, and pharmaceutical compositions, relating to the chimeric antigen receptors are also disclosed. Methods of treating or preventing cancer in a subject, and methods of making chimeric antigen receptor T cells are also disclosed.
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20.发明授权公开(公告)号：US11313867B2
公开(公告)日：2022-04-26
申请号：US16652804
申请日：2018-09-26
发明人： Byron Winslow Caughey , Bradley Richard Groveman , Christina Doriana Groveman , Lynne DePuma Raymond , Andrew Gregory Hughson
IPC分类号： G01N33/68 , G01N33/543
摘要： Methods are disclosed for determining whether a subject has a synucleinopathy. Methods are also disclosed for detecting misfolded alpha synuclein (αSyn) in a biological sample or fraction thereof. These methods include the use of an αSyn seeding assay.
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