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    SORBENT CARTRIDGE CONFIGURATIONS FOR IMPROVED DIALYSATE REGENERATION
    11.
    发明申请
    SORBENT CARTRIDGE CONFIGURATIONS FOR IMPROVED DIALYSATE REGENERATION 有权
    用于改进的透析再生的SORBENT CARTRIDGE配置

    公开(公告)号：US20140217028A1

    公开(公告)日：2014-08-07

    申请号：US13836973

    申请日：2013-03-15

    申请人： Bryant J. Pudil ,  Thomas E. Meyer ,  David B. Lura ,  Martin T. Gerber

    发明人： Bryant J. Pudil ,  Thomas E. Meyer ,  David B. Lura ,  Martin T. Gerber

    IPC分类号： A61M1/16

    CPC分类号： A61M1/1656 ,  A61M1/1654 ,  A61M1/1668 ,  A61M1/167 ,  A61M1/1696 ,  A61M1/287 ,  A61M1/3486 ,  A61M2205/02 ,  B01D15/08

    摘要： A regeneration system that has a first regeneration module containing a first chosen regenerative substance; a second regeneration module containing the first chosen regenerative substance; and a first mixing chamber. A first outlet stream of a fluid sequentially exits the first mixing chamber, flows through the first regeneration module in fluid communication with the first chosen regenerative substance and returns to the first mixing chamber, and a second outlet stream of the fluid sequentially exits the first mixing chamber and flows through the second regeneration module in fluid communication with the first chosen regenerative substance.

    摘要翻译： 一种再生系统，其具有包含第一选择再生物质的第一再生模块; 包含第一选择再生物质的第二再生模块; 和第一混合室。 流体的第一出口流顺序地离开第一混合室，流过第一再生模块与第一选择的再生物质流体连通并返回到第一混合室，并且流体的第二出口流依次离开第一混合 并且与第一选择的再生物质流体连通地流过第二再生模块。

    HEMODIALYSIS SYSTEM HAVING A FLOW PATH WITH A CONTROLLED COMPLIANT VOLUME
    14.
    发明申请
    HEMODIALYSIS SYSTEM HAVING A FLOW PATH WITH A CONTROLLED COMPLIANT VOLUME 审中-公开
    具有控制合格体积的流路的血液透析系统

    公开(公告)号：US20130199998A1

    公开(公告)日：2013-08-08

    申请号：US13565733

    申请日：2012-08-02

    申请人： Thomas D. Kelly ,  SuPing Lyu ,  Bryant J. Pudil ,  Thomas E. Meyer

    发明人： Thomas D. Kelly ,  SuPing Lyu ,  Bryant J. Pudil ,  Thomas E. Meyer

    IPC分类号： A61M1/16

    CPC分类号： A61M1/3482 ,  A61M1/1696 ,  A61M2202/0021 ,  A61M2202/0413

    摘要： Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.

    摘要翻译： 公开了用于执行肾脏替代疗法的系统和方法，其具有或使用透析器，控制组件，吸附剂盒和流体储存器，其被配置为适于被需要治疗的个体穿戴或携带的重量和尺寸。 用于执行肾脏替代治疗的系统具有受控的依从性透析电路，其中控制泵控制流体穿过透析膜的双向运动。 透析电路和用于循环血液的体外循环通过透析膜流体连通。 在体外循环和透析回路之间移动的流体通量由控制泵运行的速率改变，从而可以控制超滤速率和对流间隙。 该系统提供对吸附剂盒的入口和出口导电性的监测，以提供量化或监测吸附剂盒去除尿素的设施。

    Hemodialysis system having a flow path with a controlled compliant volume
    15.
    发明授权
    Hemodialysis system having a flow path with a controlled compliant volume 有权

    公开(公告)号：US10695481B2

    公开(公告)日：2020-06-30

    申请号：US13565733

    申请日：2012-08-02

    申请人： Thomas D. Kelly ,  SuPing Lyu ,  Bryant J. Pudil ,  Thomas E. Meyer

    发明人： Thomas D. Kelly ,  SuPing Lyu ,  Bryant J. Pudil ,  Thomas E. Meyer

    IPC分类号： A61M1/34 ,  A61M1/16

    摘要： Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.

    FLUID CIRCUIT FOR DELIVERY OF RENAL REPLACEMENT THERAPIES
    16.
    发明申请
    FLUID CIRCUIT FOR DELIVERY OF RENAL REPLACEMENT THERAPIES 有权
    用于输送肾脏替代治疗的流体回路

    公开(公告)号：US20140217029A1

    公开(公告)日：2014-08-07

    申请号：US13757693

    申请日：2013-02-01

    申请人： Thomas E. Meyer ,  David B. Lura ,  Bryant J. Pudil ,  Martin T. Gerber

    发明人： Thomas E. Meyer ,  David B. Lura ,  Bryant J. Pudil ,  Martin T. Gerber

    IPC分类号： A61M1/16

    CPC分类号： A61M1/1621 ,  A61M1/1601 ,  A61M1/1652 ,  A61M1/1656 ,  A61M1/1658 ,  A61M1/1664 ,  A61M1/1668 ,  A61M1/3465 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3646 ,  A61M1/3649

    摘要： A flow loop for hemodialysis, hemodiafiltration and hemofiltration for the treatment of pathological conditions such as End Stage Renal Disease (ESRD) that has a controlled compliant flow path for preparing fluids required for a hemodialysis therapy session from water. The controlled compliant flow path modifies water into any one of a solution for priming a hemodialysis system, a physiologically compatible solution for contacting blood, a physiologically compatible solution for infusion to a subject, and a solution for blood rinse back to a subject. The controlled compliant flow path has a means for selectively metering in and metering out fluid from the flow path.

    摘要翻译： 用于血液透析，血液透析滤过和血液滤过用于治疗诸如终末期肾脏疾病（ESRD）的病理状况的流动回路，其具有用于制备用于从水进行血液透析治疗所需的液体的受控顺应流动路径。 受控的顺应性流动路径将水改变成用于引发血液透析系统的溶液中的任何一种，用于接触血液的生理学相容溶液，用于输注给受试者的生理学相容溶液，以及用于血液冲洗回到受试者的溶液。 受控制的柔性流动路径具有用于选择性地计量流出并流出流体的流体的装置。

    MULTIMODAL DIALYSIS SYSTEM
    20.
    发明申请
    MULTIMODAL DIALYSIS SYSTEM 有权
    多模式DIALYSIS系统

    公开(公告)号：US20120273354A1

    公开(公告)日：2012-11-01

    申请号：US13451395

    申请日：2012-04-19

    申请人： Soykan Orhan ,  Bryant J. Pudil ,  Thomas E. Meyer

    发明人： Soykan Orhan ,  Bryant J. Pudil ,  Thomas E. Meyer

    IPC分类号： A61M1/28 ,  B01D61/46 ,  B01D61/54 ,  A61M1/14

    CPC分类号： A61M1/1696 ,  A61M1/14 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1605 ,  A61M1/1609 ,  A61M1/1613 ,  A61M1/1654 ,  A61M1/28 ,  A61M1/284 ,  A61M1/287 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3334 ,  B01D61/02 ,  B01D61/422 ,  B01D61/445 ,  B01D61/46 ,  G06F19/00

    摘要： A dialysis device for operation in multiple modes and for maintaining a known gradient of potassium ion or other electrolyte between the blood of a patient and a dialysate fluid is described. The dialysis device is capable of being used for hemodialysis or peritoneal dialysis, and the dialysis device is capable of operation with a dialysate purification unit outside of a clinical setting or with a supply of water that can be supplied in a clinical setting. The dialysis device has a composition sensor containing a potassium-sensitive electrode for measuring a potassium ion concentration in one or more of the patient's blood and the dialysate fluid and an infusate pump operated to adjust a potassium ion concentration in the dialysate fluid based at least in part on data from the composition sensor.

    摘要翻译： 描述了用于在多种模式中操作并用于在患者血液和透析液之间维持已知梯度的钾离子或其他电解质的透析装置。 透析装置能够用于血液透析或腹膜透析，并且透析装置能够在临床环境之外的透析液净化单元或能够在临床环境中供应的水的供给下进行操作。 该透析装置具有含有用于测量患者血液和透析液中的一种或多种中的钾离子浓度的钾敏感电极的成分传感器，以及至少在以下方式调节透析液中的钾离子浓度的输液泵 部分来自组合传感器的数据。