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公开(公告)号:US20070298036A1
公开(公告)日:2007-12-27
申请号:US11843587
申请日:2007-08-22
申请人: Henry Chiu , Hilary Clark , Kathryn Dennis , Sherman Fong , Jill Schoenfeld , William Wood , Thomas Wu
发明人: Henry Chiu , Hilary Clark , Kathryn Dennis , Sherman Fong , Jill Schoenfeld , William Wood , Thomas Wu
IPC分类号: A61K39/395 , A61K38/00 , C07K16/18 , C12N1/00 , C12N1/20 , C12N15/00 , C12N15/11 , C12N5/06 , C12P21/06 , C12Q1/68 , G01N33/53
CPC分类号: C07K14/47 , A61K38/00 , C07K14/4713 , G01N33/564
摘要: The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
摘要翻译: 本发明涉及含有新蛋白质的组合物和使用这些组合物来诊断和治疗免疫相关疾病的方法。
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公开(公告)号:US20070268929A1
公开(公告)日:2007-11-22
申请号:US11821073
申请日:2007-06-21
申请人: Michael Moretti , David Geddes , Thomas Wu , Salil Suri , Scott Furey
发明人: Michael Moretti , David Geddes , Thomas Wu , Salil Suri , Scott Furey
CPC分类号: H04J3/1617 , H04J2203/0067 , H04J2203/0082 , H04L29/06 , H04L69/08
摘要: Methods and apparatus for bridging network protocols are disclosed. A protocol bridge may be used to function as a target for a network processor while performing a target mode operation, while functioning as an initiator on behalf of the network processor while performing an initiator mode operation. In one embodiment, the protocol bridge determines the mode of operation based on information in a received frame's header. In another embodiment, the protocol bridge couples a Fibre Channel device to a storage processor on a packet-over-SONET network.
摘要翻译: 公开了桥接网络协议的方法和装置。 当执行目标模式操作时,可以使用协议桥作为网络处理器的目标,同时在执行启动器模式操作时用作代表网络处理器的启动器。 在一个实施例中,协议桥基于接收帧的头部中的信息来确定操作模式。 在另一实施例中,协议桥将光纤通道设备耦合到SONET网络上的存储处理器。
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公开(公告)号:US20070212735A1
公开(公告)日:2007-09-13
申请号:US11534850
申请日:2006-09-25
申请人: Avi Ashkenazi , Belinda Caims , Patrick Dowd , Gretchen Frantz , Dorothy French , Lino Gonzalez , Paul Polakis , Victoria Smith , Beni Wolf , Thomas Wu , Zemin Zhang
发明人: Avi Ashkenazi , Belinda Caims , Patrick Dowd , Gretchen Frantz , Dorothy French , Lino Gonzalez , Paul Polakis , Victoria Smith , Beni Wolf , Thomas Wu , Zemin Zhang
IPC分类号: G01N33/574 , C07K16/30 , C07K14/82
CPC分类号: C07K16/30 , A61K47/6803 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K2039/505
摘要: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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14.
公开(公告)号:US20070184444A1
公开(公告)日:2007-08-09
申请号:US10567939
申请日:2004-08-11
申请人: Alexander Abbas , Hilary Clark , Wenjun Ouyang , P. Mickey Williams , William Wood , Thomas Wu
发明人: Alexander Abbas , Hilary Clark , Wenjun Ouyang , P. Mickey Williams , William Wood , Thomas Wu
IPC分类号: C12Q1/68 , G01N33/567 , C07K14/74 , C07K16/28 , C07H21/04
CPC分类号: C12Q1/6837 , C07K14/47 , C12N9/2417 , C12Y302/01001 , G01N33/53 , G01N33/564 , G01N33/6893 , G01N2800/24
摘要: The present invention relates to composition containing novel proteins and method of using those compositions for the dignosis and treatment of immune related diseases.
摘要翻译: 本发明涉及含有新蛋白质的组合物和使用这些组合物进行免疫相关疾病的治疗和治疗的方法。
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公开(公告)号:US20070141066A1
公开(公告)日:2007-06-21
申请号:US11609071
申请日:2006-12-11
申请人: Heidi Phillips , William Forrest , Samir Kharbanda , Thomas Wu
发明人: Heidi Phillips , William Forrest , Samir Kharbanda , Thomas Wu
IPC分类号: C12Q1/68 , G01N33/574 , G06F19/00 , A61K39/395 , A61K33/24
CPC分类号: C12Q1/6886 , A61K45/06 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/57407 , G01N2500/00
摘要: The invention provides generally a method of monitoring, diagnosing, prognosing and treating glioma. Specifically, the invention provides for three (3) prognostic subclasses of glioma, which are differentially associated with activation of the akt and notch signaling pathways. Tumor displaying neural or proneural PN lineage markers (including notch pathway elements) show longer median patient survival, while the two remaining tumor markers Prolif and Mes are associated with shortened survival. Tumors classified in this manner may also be treated with the appropriate PN- Prolif- or Mes-therapeutic corresponding to the subclassification in combination with anti-mitotic agents, anti-angiogenic agents, Akt antagonists, and neural differentiation agents. Alternatively, the invention also provides for method of prognosing and diagnosing glioma with a two-gene model based on the expression levels of PTEN and DLL3.
摘要翻译: 本发明提供一种监测,诊断,预后和治疗胶质瘤的方法。 具体而言,本发明提供了三(3)个胶质瘤的预后亚类,其与akt和缺口信号传导途径的激活差异相关。 显示神经或倾向性PN谱系标志物(包括切口通路元件)的肿瘤显示较长的患者中位数,而剩余的两个肿瘤标志物Prolif和Mes与生存期缩短相关。 以这种方式分类的肿瘤也可以用与抗有丝分裂剂,抗血管生成剂,Akt拮抗剂和神经分化剂组合的对应于分类的适当的PN- Prolif-或Mes-治疗来治疗。 或者,本发明还提供了基于PTEN和DLL3的表达水平用双基因模型预测和诊断胶质瘤的方法。
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16.
公开(公告)号:US20070117124A1
公开(公告)日:2007-05-24
申请号:US11537516
申请日:2006-09-29
申请人: Daryl Baldwin , Hilary Clark , Adrian Jubb , Hartmut Koeppen , Clifford Quan , Thomas Wu , Zemin Zhang
发明人: Daryl Baldwin , Hilary Clark , Adrian Jubb , Hartmut Koeppen , Clifford Quan , Thomas Wu , Zemin Zhang
CPC分类号: C07K14/4748 , C07K14/47 , C07K14/82
摘要: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
摘要翻译: 本发明涉及用于哺乳动物肿瘤诊断和治疗的物质组合物,以及使用这些物质组合物的方法。
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公开(公告)号:US20070048326A1
公开(公告)日:2007-03-01
申请号:US11538552
申请日:2006-10-04
申请人: Belinda Cairns , Ruihuan Chen , Gretchen Frantz , Kenneth Hillan , Hartmut Koeppen , Heidi Phillips , Paul Polakis , Susan Spencer , Victoria Smith , P. Williams , Thomas Wu , Zemin Zhang
发明人: Belinda Cairns , Ruihuan Chen , Gretchen Frantz , Kenneth Hillan , Hartmut Koeppen , Heidi Phillips , Paul Polakis , Susan Spencer , Victoria Smith , P. Williams , Thomas Wu , Zemin Zhang
IPC分类号: A61K39/395 , G01N33/574 , C07K16/30
CPC分类号: C07K16/18 , A61K47/6803 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K2039/505 , C07K16/30 , C07K16/3023 , C07K16/40 , C07K2317/73 , G01N33/57407
摘要: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号:US20070042945A1
公开(公告)日:2007-02-22
申请号:US10529348
申请日:2003-09-25
申请人: Sarah Bodary , Hilary Clark , Janet Jackman , Jill Schoenfeld , P Williams , William Wood , Thomas Wu
发明人: Sarah Bodary , Hilary Clark , Janet Jackman , Jill Schoenfeld , P Williams , William Wood , Thomas Wu
CPC分类号: C07K14/47 , A61K38/00 , C12Q1/6883 , C12Q2600/158 , G01N33/5008 , G01N33/6881 , G01N2800/205
摘要: The present invention relates to compositions and methods useful for the diagnosis and treatment of psoriasis.
摘要翻译: 本发明涉及可用于诊断和治疗牛皮癣的组合物和方法。
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公开(公告)号:US20060263774A1
公开(公告)日:2006-11-23
申请号:US10533519
申请日:2003-10-30
申请人: Hilary Clark , Jill Schoenfeld , Menno VanLookeren , P Williams , William Wood , Thomas Wu
发明人: Hilary Clark , Jill Schoenfeld , Menno VanLookeren , P Williams , William Wood , Thomas Wu
IPC分类号: C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/705 , C07K16/28
CPC分类号: C07K14/47 , C07K14/705 , C12N9/6424 , C12Q1/6883 , C12Q2600/158
摘要: The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
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公开(公告)号:US20050272120A1
公开(公告)日:2005-12-08
申请号:US11102501
申请日:2005-04-08
申请人: Patrick Dowd , Gretchen Frantz , Paul Polakis , Victoria Smith , Susan Spencer , Thomas Wu , Zemin Zhang
发明人: Patrick Dowd , Gretchen Frantz , Paul Polakis , Victoria Smith , Susan Spencer , Thomas Wu , Zemin Zhang
IPC分类号: A61K39/395 , C07H21/04 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/30 , C12N1/18 , C12N5/06 , C12P21/06
CPC分类号: C07K16/30 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K16/18 , C07K2317/73
摘要: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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