公开(公告)号：US20220280792A1

公开(公告)日：2022-09-08

申请号：US17702621

申请日：2022-03-23

申请人： The Regents of the University of California ,  U.S. Government Represented by the Department of Veterans Affairs ,  LightSide MD, LLC

发明人： Karunesh GANGULY ,  Adelyn TSU ,  Nikhilesh NATRAJ ,  Gabriel Philip HOWLES-BANERJI ,  Rajiv DOSHI ,  Kondapavulur T. VENKATESWARA-RAO

IPC分类号： A61N1/36 ,  A61B5/00 ,  A61N1/04 ,  A61B5/30 ,  A61B5/375

摘要： Methods and apparatuses for sensory electrical stimulation of the peripheral nervous system to improve human motor function and performance are described. Methods and devices may be used to enhance physical performance of athletes, professionals, and gamers or improve motor function (hand, finger and limb movement) in patients rehabilitating from neurological deficits and impairments caused by stroke, traumatic brain injury and other neurologic or non-neurologic conditions. These apparatuses and methods may be used for physical training and mental training (to improve memory and functional performance including motor coordination, limb-eye coordination, occupational and recreational skills) through periodic or sustained sensory electrical stimulation. Treatment plans may be based on biomarkers and may be used alone or in combination with other apparatuses. Learning and feedback techniques individualize treatment parameters depending on the subject's neurologic and motor function in diseased patients and healthy users.

公开(公告)号：US20220160208A1

公开(公告)日：2022-05-26

申请号：US17601377

申请日：2020-04-03

申请人： The Board of Trustees of the Leland Stanford Junior University ,  U.S. Government Represented by the Department of Veterans Affairs

发明人： Joseph C. Liao ,  Lei Xing ,  Eugene Shkolyar ,  Xiao Jia

IPC分类号： A61B1/00 ,  A61B1/307 ,  A61B1/06 ,  G06T7/10

摘要： Over 2 million cystoscopies are performed annually in the United States and Europe for detection and surveillance of bladder cancer. Adequate identification of suspicious lesions is critical to minimizing recurrence and progression rates, however standard cystoscopy misses up to 20% of bladder cancer. Access to adjunct imaging technology may be limited by cost and availability of experienced personnel. Machine learning holds the potential to enhance medical decision-making in cancer detection and imaging. Various embodiments described herein are directed to methods for identifying cancers, tumors, and/or other abnormalities present in a person's bladder. Additional embodiments are directed to machine learning systems to identify cancers, tumors, and/or other abnormalities present in a person's bladder, while additional embodiments will also identify benign or native structures or features in a person's bladder. Further embodiments incorporate such systems into cystoscopy equipment to allow for real time and/or immediate detection of cancers, tumors, and/or other abnormalities present in a person's bladder during a cystoscopy procedure.

公开(公告)号：US11285321B2

公开(公告)日：2022-03-29

申请号：US16461085

申请日：2017-11-14

申请人： The Regents of the University of California ,  U.S. Government Represented by the Department of Veterans Affairs ,  LightSide MD, LLC

发明人： Karunesh Ganguly ,  Adelyn Tsu ,  Nikhilesh Natraj ,  Gabriel Philip Howles-Banerji ,  Rajiv Doshi ,  Kondapavulur T. Venkateswara-Rao

IPC分类号： A61N1/00 ,  A61N1/36 ,  A61B5/00 ,  A61N1/04 ,  A61B5/30 ,  A61B5/375 ,  A61N1/378

摘要： Methods and apparatuses for sensory electrical stimulation of the peripheral nervous system to improve human motor function and performance are described. Methods and devices may be used to enhance physical performance of athletes, professionals, and gamers or improve motor function (hand, finger and limb movement) in patients rehabilitating from neurological deficits and impairments caused by stroke, traumatic brain injury and other neurologic or non-neurologic conditions. These apparatuses and methods may be used for physical training and mental training (to improve memory and functional performance including motor coordination, limb-eye coordination, occupational and recreational skills) through periodic or sustained sensory electrical stimulation. Treatment plans may be based on biomarkers and may be used alone or in combination with other apparatuses. Learning and feedback techniques individualize treatment parameters depending on the subject's neurologic and motor function in diseased patients and healthy users.

公开(公告)号：US20210158894A1

公开(公告)日：2021-05-27

申请号：US16961120

申请日：2019-01-09

申请人： The Board of Trustees of the Leland Stanford Junior University ,  U.S. Government represented by the Department of Veterans Affairs

发明人： Jingjing Li ,  Sai Zhang ,  Michael P. Snyder ,  Cuiping Pan ,  Philip S. Tsao

IPC分类号： G16B20/20 ,  G16B40/20 ,  G06F17/18

摘要： Processes to identify a subset of trait-related genes and classify individuals are described. Generally, systems generate classification models which are used to identify the subset of trait-related genes and classify individuals. The classification models are also used in various applications, including developing research tools, performing diagnostics, and treating individuals.

公开(公告)号：US20140100224A1

公开(公告)日：2014-04-10

申请号：US13927302

申请日：2013-06-26

申请人： The University of North Carolina at Chapel Hill ,  U.S. Government represented by the Department of Veterans Affairs ,  The Regents of the University of California

发明人： Frank M. Longo ,  Stephen M. Massa

IPC分类号： C07D265/30 ,  C07D233/61 ,  C07D473/08 ,  C07D413/06 ,  C07D413/12

CPC分类号： C07D265/30 ,  C07D207/16 ,  C07D233/61 ,  C07D233/72 ,  C07D233/76 ,  C07D241/08 ,  C07D295/13 ,  C07D295/135 ,  C07D295/185 ,  C07D295/26 ,  C07D295/32 ,  C07D413/06 ,  C07D413/12 ,  C07D473/08 ,  C07K5/06034

摘要： The present application is related to compounds which are novel neurotrophin mimetics. The application also discloses the treatment of disorders associated with p75 expression, such as degradation or dysfunction of cells expressing p75 in a mammal by administering an effective amount of such compounds.

摘要翻译： 本申请涉及新型神经营养因子模拟物的化合物。 本申请还公开了通过施用有效量的这些化合物治疗与p75表达相关的紊乱，例如哺乳动物表达p75的细胞的降解或功能障碍。

公开(公告)号：US20210244659A1

公开(公告)日：2021-08-12

申请号：US17251605

申请日：2019-06-27

申请人： The Board of Trustees of the Leland Stanford Junior University ,  U.S. Government Represented by the Department of Veterans Affairs

发明人： David Myung ,  Sarah Hull ,  Sarah Heilshorn ,  Christopher Lindsay ,  Christopher Madl ,  Hyun Jong Lee

IPC分类号： A61K9/00 ,  A61F2/14 ,  A61K9/06 ,  A61K47/36 ,  A61K47/10 ,  A61K47/42

摘要： Compositions and methods are provided for lamellar and defect reconstruction of corneal stromal tissue using biomaterials that form a defined gel structure in situ. Such gels can serve as cellular or acellular lamellar substitutes to reconstruct corneal stroma, facilitate matrix remodeling, and support multilayered re-epithelialization of wounded corneal stromal tissue, as well delivery vehicles for cells, biomolecules, and/or pharmaceutical agents to wound sites throughout the body.

公开(公告)号：US20210180136A1

公开(公告)日：2021-06-17

申请号：US17248798

申请日：2021-02-08

申请人： Marco Tulio Medina-Hernandez ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  RIKEN ,  INSTITUTO NACIONAL DE NEUROLOGIA Y NEUROCIRUGIA MANUEL VELASCO SUAREZ ,  U.S. GOVERNMENT REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS

发明人： Antonio V. Delgado-Escueta ,  Kazuhiro Yamakawa ,  Toshimitsu Suzuki ,  Marco Tulio Medina-Hernandez ,  Maria Elisa Alonso Vilatela

IPC分类号： C12Q1/6883

摘要： Compositions and methods for diagnosis or treatment of epilepsy disease with EFHC1, EFHC1 agonists, or EFHC1 analogs are provided. Compositions and methods for diagnosis or treatment of epilepsy disease with EFHC1a, EFHC1a agonists, or EFHC1a analogs are provided.

公开(公告)号：US20160222069A1

公开(公告)日：2016-08-04

申请号：US15134168

申请日：2016-04-20

申请人： U.S. Government represented by the Department of Veterans Affairs ,  The Regents of the University of California ,  Cornell Research Foundation, Inc. ,  Fundação Oswaldo Cruz - FIOCRUZ

发明人： Albert I. Ko ,  Mitermayer Galvão Reis ,  Julio Henrique Rosa Croda ,  Isadora Cristina Siqueira ,  David A. Haake ,  James Matsunaga ,  Lee W. Riley ,  Michele Barocchi ,  Tracy Ann Young

IPC分类号： C07K14/20

CPC分类号： C07K16/1207 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/20 ,  C12Q1/68 ,  C12Q1/689 ,  G01N33/56911 ,  G01N2469/20 ,  Y02A50/56

摘要： The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.

公开(公告)号：US20160106331A1

公开(公告)日：2016-04-21

申请号：US14919702

申请日：2015-10-21

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  THE U.S. GOVERNMENT REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS

发明人： Todd S. Zorick ,  Mark Mandelkern

IPC分类号： A61B5/04 ,  A61B5/16 ,  A61B5/00 ,  A61B5/0476

CPC分类号： A61B5/04012 ,  A61B5/0476 ,  A61B5/048 ,  A61B5/16 ,  A61B5/4076 ,  A61B5/4809 ,  A61B5/4812 ,  A61B5/7264 ,  G06F17/14

摘要： A system and method for Multifractal-Detrended Fluctuation Analysis (MF-DFA) on digitized Human EEG signals is presented. A list of Hurst exponents, or Hurst exponent spectrum (“h” values) are generated, and multifractal singularity spectrum indices (“D(h)” values) produce a graph that approximates an inverted parabola. The output multifractal DFA spectrum is able to represent key features of the internal neuronal dynamics for the cortical neurons underlying the scalp-placed electrode which records the signals.

摘要翻译： 提出了一种用于数字化人脑电信号的多分形 - 偏移波动分析（MF-DFA）的系统和方法。 产生Hurst指数列表或Hurst指数谱（“h”值），多重分形奇异频谱索引（“D（h）”值）产生近似反转抛物线的图形。 输出多分形DFA频谱能够表示记录信号的头皮放置电极下面的皮质神经元的内部神经元动力学的关键特征。

公开(公告)号：US10913980B2

公开(公告)日：2021-02-09

申请号：US16181093

申请日：2018-11-05

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  RIKEN ,  INSTITUTO NACIONAL DE NEUROLOGIA Y NEUROCIRUGIA MANUEL VELASCO SUAREZ ,  U.S. GOVERNMENT REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS

发明人： Antonio V. Delgado-Escueta ,  Kazuhiro Yamakawa ,  Toshimitsu Suzuki ,  Marco Tulio Medina-Hernandez ,  Maria Elisa Alonso Vilatela

IPC分类号： C07H21/04 ,  C12Q1/68 ,  C12Q1/6883

摘要： Compositions and methods for diagnosis or treatment of epilepsy disease with EFHC1, EFHC1 agonists, or EFHC1 analogs are provided. Compositions and methods for diagnosis or treatment of epilepsy disease with EFHC1a, EFHC1a agonists, or EFHC1a analogs are provided.