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11.发明授权Portable ion trap mass spectrometer with metal hydride container as source of hydrogen buffer gas 有权便携式离子阱质谱仪，金属氢化物容器作为氢气缓冲气体源公开(公告)号：US08476586B2
公开(公告)日：2013-07-02
申请号：US13168690
申请日：2011-06-24
CPC分类号： H01J49/424 , H01J49/0013 , H01J49/0081 , H01J49/0481 , H01J49/422
摘要： A mass spectrometry (MS) method which includes generating in a vicinity of the quadrupole ion trap hydrogen molecules, directing at least part of the hydrogen molecules into the quadrupole ion trap cell, applying AC and DC voltages to quadrupole ion trap cell electrodes to create a combined AC/DC trapping field, placing sample ions inside the quadrupole ion trap cell, cooling at least part of said ions using said hydrogen molecules as a buffer gas, changing the combined AC/DC trapping field to eject the ions from the quadrupole ion trap cell, and detecting the ejected ions.
摘要翻译： 一种质谱（MS）方法，其包括在四极离子阱附近产生氢分子，将至少部分氢分子引入四极离子阱电池中，向四极离子阱电池电极施加AC和DC电压，以产生 组合的AC / DC捕获场，将样品离子放置在四极离子阱单元内，使用所述氢分子作为缓冲气体冷却至少部分所述离子，改变组合的AC / DC捕获场以从四极离子阱中排出离子 电池，并检测被排出的离子。
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公开(公告)号：US08471199B1
公开(公告)日：2013-06-25
申请号：US13441532
申请日：2012-04-06
CPC分类号： H01J49/0013
摘要： A portable mass spectrometer having an atmospheric pressure interface for introducing ions generated at ambient pressure gas conditions into a vacuum of the mass spectrometer. The mass spectrometer has a vacuum chamber having at least one vacuum section and at least one gas inlet for directing the ambient pressure gas including the ions into the at least one vacuum section. The at least one gas inlet has a gas passage channel of a length L and a limiting cross section S with a ratio of L/S being less than 20,000 cm−1. The mass spectrometer has a radio frequency (RF) ion guide in the at least one vacuum section positioned for collecting the ions from the at least one gas inlet and transmitting the ions further to a mass analyzer for analyzing the ions transmitted from the ion guide.
摘要翻译： 一种便携式质谱仪，具有用于将在环境压力气体条件下产生的离子引入质谱仪真空的大气压界面。 质谱仪具有至少一个真空部分的真空室和至少一个气体入口，用于将包括离子的环境压力气体引导到至少一个真空部分中。 至少一个气体入口具有长度为L的气体通道通道和L / S的比例小于20,000cm -1的限制横截面S. 所述质谱仪在所述至少一个真空部分中具有射频（RF）离子引导件，定位成用于从所述至少一个气体入口收集离子，并将所述离子进一步传输到质量分析器，以分析从所述离子导向器传输的离子。
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公开(公告)号：US20110224104A1
公开(公告)日：2011-09-15
申请号：US11757020
申请日：2007-06-01
申请人： Evgenia Razumovski , Berk Oktem , Appavu K. Sundaram , Vsevolod S. Rakov , Sudeepta Shanbhag , Sergey Kurnosenko , Vladimir M. Doroshenko
发明人： Evgenia Razumovski , Berk Oktem , Appavu K. Sundaram , Vsevolod S. Rakov , Sudeepta Shanbhag , Sergey Kurnosenko , Vladimir M. Doroshenko
CPC分类号： C12Q1/04 , C40B20/08 , G01N33/6851 , G16B40/00
摘要： A method and system for identification of microorganisms in a sample. The method includes processing the sample to produce at least one group of biomarker molecules from at least one microorganism in the sample, tandem mass-analyzing biomarker fragment ions from the at least one group of biomarker molecules to obtain a sample biomarker tandem mass spectrum of the biomarker, and identifying the microorganism in the sample based on a comparison of the sample biomarker tandem mass spectrum to an experimentally-derived reference tandem mass spectrum (stored in the reference library) from a known microorganism. The system includes a sample processing unit configured to process the sample and produce at least one group of biomarker molecules from at least one microorganism in the sample. The system includes a mass-analyzer for tandem mass analysis biomarker fragment ions. The system includes a processor configured to identify the microorganism in the sample based on a comparison of a sample biomarker tandem mass spectrum to an experimentally-derived reference tandem mass spectrum from a known microorganism.
摘要翻译： 用于鉴定样品中的微生物的方法和系统。 该方法包括处理样品以从样品中的至少一个微生物产生至少一组生物标记分子，来自至少一组生物标志物分子的串联质量分析生物标记片段离子，以获得样品生物标志物串联质谱 基于样品生物标志物串联质谱与来自已知微生物的实验来源的参考串联质谱（存储在参考文库中）的比较来鉴定样品中的微生物。 该系统包括样品处理单元，其被配置为处理样品并从样品中的至少一种微生物产生至少一组生物标记分子。 该系统包括用于串联质量分析生物标志物碎片离子的质量分析器。 该系统包括处理器，其被配置为基于样品生物标志物串联质谱与来自已知微生物的实验来源的参考串联质谱的比较来鉴定样品中的微生物。
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公开(公告)号：US07723676B2
公开(公告)日：2010-05-25
申请号：US11959006
申请日：2007-12-18
CPC分类号： H01J49/0045
摘要： A method for fragmentation of analyte ions for mass spectroscopy and a system for mass spectroscopy. The method produces gas-phase analyte ions, produces gas-phase radical species separately from the analyte ions, and mixes the gas-phase analyte ions and the radical species at substantially atmospheric pressure conditions to produce fragment ions prior to introduction into a mass spectrometer. The system includes a gas-phase analyte ion source, a gas-phase radical species source separate from the gas-phase analyte ion source, a mixing region where the gas-phase analyte ions and the radical species are mixed at substantially atmospheric pressure to produce fragment ions of the analyte ions, a mass spectrometer having an entrance where at least a portion of the fragment ions are introduced into a vacuum of the mass spectrometer, and a detector in the mass spectrometer which determines a mass to charge ratio analysis of the fragment ions.
摘要翻译： 用于质谱分析的分析物离子的碎裂方法和用于质谱的系统。 该方法产生气相分析物离子，与分析物离子分开产生气相自由基物质，并在基本上大气压条件下将气相分析物离子和自由基物质混合，以便在引入质谱仪之前产生碎片离子。 该系统包括气相分析物离子源，与气相分析物离子源分离的气相自由基物质源，气相分析物离子和自由基物质在大气压下混合以产生 分析物离子的碎片离子，具有入口的质谱仪，其中至少一部分碎片离子被引入质谱仪的真空中;以及质谱仪中的检测器，其确定片段的质荷比分析 离子。
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公开(公告)号：US07485855B2
公开(公告)日：2009-02-03
申请号：US11441175
申请日：2006-05-26
CPC分类号： G01N1/34 , G01N1/2813 , G01N1/4022 , G01N1/405 , H01J49/0418 , Y10S977/881 , Y10S977/891 , Y10S977/892 , Y10T436/25125 , Y10T436/255
摘要： A system and method for cleanup of biological samples from contaminants prior to spectroscopy analysis. The system includes a support configured to hold a sample including a liquid having at least one group of biological molecules with a surface of the support binding the molecules at a surface tension angle to the liquid of less than 180 degrees. The system includes an evaporator configured to evaporate liquid from the support, a solvent applicator configured to apply a solvent for dissolution of the contaminants in the sample, and a solvent removal device configured to remove applied solvent from the sample and thereby at least partially remove the contaminants.
摘要翻译： 在光谱分析前从污染物中清除生物样品的系统和方法。 该系统包括支撑件，其构造成将包含具有至少一组生物分子的液体的样品保持在支架的表面，该表面以小于180度的液体的表面张力角度将分子结合。 该系统包括构造成从支撑体蒸发液体的蒸发器，配置成施加溶剂以溶解污染物到样品中的溶剂施加器，以及溶剂去除装置，其被配置为从样品中除去施加的溶剂，从而至少部分地除去 污染物
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16.发明申请Method and apparatus for processing of biological samples for mass spectrometry analysis 有权用于质谱分析的生物样品的处理方法和装置公开(公告)号：US20070275478A1
公开(公告)日：2007-11-29
申请号：US11441176
申请日：2006-05-26
IPC分类号： G01N1/00
CPC分类号： G01N1/40 , G01N1/4044 , Y10T436/11 , Y10T436/25 , Y10T436/25125
摘要： A system and corresponding method for processing of biological samples prior to spectroscopy analysis. The system includes a support for an organic sample, a solution applicator configured to apply a solution for extraction of at least one biomarker protein from the organic sample. The system includes a digester-medium applicator configured to apply to the organic sample a digesting medium capable of at least partial digestion of the biomarker proteins into peptides. The system includes a heating device configured to heat at least one of the organic sample, the solution, the digesting medium, and the biomarker proteins to a temperature above room temperature.
摘要翻译： 在光谱分析前对生物样品进行处理的系统和相应方法。 该系统包括对有机样品的支持物，溶液施用器，被配置为施加用于从有机样品中提取至少一种生物标志物蛋白质的溶液。 该系统包括消化器介质施用器，其被配置为向有机样品施加能够将生物标记蛋白至少部分消化成肽的消化介质。 该系统包括被配置为将有机样品，溶液，消化介质和生物标记蛋白中的至少一种加热至高于室温的加热装置。
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公开(公告)号：US08825413B2
公开(公告)日：2014-09-02
申请号：US12755977
申请日：2010-04-07
CPC分类号： H01J49/0036 , H01J49/38
摘要： A method and system for deconvolution of a frequency spectrum obtained in an ICR mass spectrometer based on a detection of ion oscillation overtones of the M-th order (where the integer M>1). A plurality of frequency peaks is collected within the frequency spectrum corresponding respectively to oscillations of different groups of ions, and associates at least one of the frequency peaks having a frequency f and a measured amplitude A with a particular group of the ions. The method and system identify whether the frequency peak is related to one of an overtone frequency, a subharmonic frequency, a higher harmonic frequency, or a side-shifted frequency of the oscillations of the different group of ions. The method and system derive calculated amplitudes of the overtone frequency peaks associated with the groups of ions by incorporating measured amplitudes of the frequency peaks related to the subharmonic frequency, the higher harmonic frequency, or the side-shifted frequency associated with the groups of ions into the calculated amplitudes of the overtone frequency peaks. The method and system generate a deconvoluted frequency spectrum including the overtone frequency peaks associated with the different groups of ions.
摘要翻译： 基于对M阶离子振荡泛音（其中整数M> 1）的检测，在ICR质谱仪中获得的频谱的去卷积方法和系统。 在分别对应于不同离子组的振荡的频谱内收集多个频率峰值，并且将具有频率f和测量幅度A的频率峰值中的至少一个与特定的一组离子相关联。 该方法和系统识别频率峰值是否与不同离子组的振荡的泛音频率，次谐波频率，高次谐波频率或侧移频率之一相关。 该方法和系统通过将与次谐波频率，高次谐波频率或与离子组相关联的侧移频率相关的频率峰值的测量幅度并入到离子组相关的泛音频率峰值中来计算振幅 计算的泛音频率峰值的幅度。 该方法和系统产生包括与不同离子组相关的泛音频率峰值的解卷积频谱。
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18.发明申请PORTABLE ION TRAP MASS SPECTROMETER WITH METAL HYDRIDE CONTAINER AS SOURCE OF HYDROGEN BUFFER GAS 有权具有金属氢化物容器的便携式离子质谱仪作为氢气缓冲气体源公开(公告)号：US20120326026A1
公开(公告)日：2012-12-27
申请号：US13168690
申请日：2011-06-24
CPC分类号： H01J49/424 , H01J49/0013 , H01J49/0081 , H01J49/0481 , H01J49/422
摘要： A mass spectrometry (MS) method which includes generating in a vicinity of the quadrupole ion trap hydrogen molecules, directing at least part of the hydrogen molecules into the quadrupole ion trap cell, applying AC and DC voltages to quadrupole ion trap cell electrodes to create a combined AC/DC trapping field, placing sample ions inside the quadrupole ion trap cell, cooling at least part of said ions using said hydrogen molecules as a buffer gas, changing the combined AC/DC trapping field to eject the ions from the quadrupole ion trap cell, and detecting the ejected ions
摘要翻译： 一种质谱（MS）方法，其包括在四极离子阱附近产生氢分子，将至少部分氢分子引入四极离子阱电池中，向四极离子阱电池电极施加AC和DC电压，以产生 组合的AC / DC捕获场，将样品离子放置在四极离子阱单元内，使用所述氢分子作为缓冲气体冷却至少部分所述离子，改变组合的AC / DC捕获场以从四极离子阱中排出离子 电池，并检测被排出的离子
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公开(公告)号：US08188423B2
公开(公告)日：2012-05-29
申请号：US12784532
申请日：2010-05-21
CPC分类号： H01J49/0045
摘要： A method for fragmentation of analyte ions for mass spectroscopy and a system for mass spectroscopy. The method produces gas-phase analyte ions, produces gas-phase odd-electron containing species separately from the analyte ions, and mixes the gas-phase analyte ions and the odd-electron containing species at substantially atmospheric pressure conditions to produce fragment ions prior to introduction into a mass spectrometer. The system includes a gas-phase analyte ion source, a gas-phase odd-electron containing species source separate from the gas-phase analyte ion source, a mixing region where the gas-phase analyte ions and the odd-electron containing species are mixed at substantially atmospheric pressure to produce fragment ions of the analyte ions, a mass spectrometer having an entrance where at least a portion of the fragment ions are introduced into a vacuum of the mass spectrometer, and a detector in the mass spectrometer which determines a mass to charge ratio analysis of the fragment ions.
摘要翻译： 用于质谱分析的分析物离子的碎裂方法和用于质谱的系统。 该方法产生气相分析物离子，与分析物离子分开产生含气相奇异电子物质，并在基本大气压条件下将气相分析离子和含奇异电子的物质混合，以在 引入质谱仪。 该系统包括气相分析物离子源，与气相分析物离子源分离的气相奇电子物质源，气相分析物离子和含奇异电子的物质混合的混合区域 在基本上大气压下产生分析物离子的碎片离子，质谱仪具有入口，其中至少一部分碎片离子被引入质谱仪的真空中，以及质谱仪中的检测器， 电荷比分析碎片离子。
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公开(公告)号：US20100288920A1
公开(公告)日：2010-11-18
申请号：US12784532
申请日：2010-05-21
CPC分类号： H01J49/0045
摘要： A method for fragmentation of analyte ions for mass spectroscopy and a system for mass spectroscopy. The method produces gas-phase analyte ions, produces gas-phase odd-electron containing species separately from the analyte ions, and mixes the gas-phase analyte ions and the odd-electron containing species at substantially atmospheric pressure conditions to produce fragment ions prior to introduction into a mass spectrometer. The system includes a gas-phase analyte ion source, a gas-phase odd-electron containing species source separate from the gas-phase analyte ion source, a mixing region where the gas-phase analyte ions and the odd-electron containing species are mixed at substantially atmospheric pressure to produce fragment ions of the analyte ions, a mass spectrometer having an entrance where at least a portion of the fragment ions are introduced into a vacuum of the mass spectrometer, and a detector in the mass spectrometer which determines a mass to charge ratio analysis of the fragment ions.
摘要翻译： 用于质谱分析的分析物离子的碎裂方法和用于质谱的系统。 该方法产生气相分析物离子，与分析物离子分开产生含气相奇异电子物质，并在基本大气压条件下将气相分析离子和含奇异电子的物质混合，以在 引入质谱仪。 该系统包括气相分析物离子源，与气相分析物离子源分离的气相奇电子物质源，气相分析物离子和含奇异电子的物质混合的混合区域 在基本上大气压下产生分析物离子的碎片离子，质谱仪具有入口，其中至少一部分碎片离子被引入质谱仪的真空中，以及质谱仪中的检测器， 电荷比分析碎片离子。
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