公开(公告)号：US20150257986A1

公开(公告)日：2015-09-17

申请号：US14660466

申请日：2015-03-17

Applicant: ADA Foundation

Inventor： Jirun Sun ,  Rafael Lee Bowen

IPC: A61K6/083

CPC classification number: A61K6/083 ,  A61K6/0835 ,  C08L33/08

Abstract: A composition of matter includes one or more functionalized vinylbenzyl components of the formula covalently connected to one or more R functional components; the one or more R functional groups selected from a group including one or more hydroxyl methyl (—CHOH—) moieties and/or derivatives thereof, one or more ethoxy (—CH2—CH2—O—) moieties and/or derivatives thereof, and one or more benzene (C6H6) and/or derivatives thereof; and ether links that connect the functionalized vinylbenzyl components and the R functional components.

Abstract translation: 物质组合物包括一种或多种与一种或多种R官能组分共价连接的式的官能化乙烯基苄基组分; 一个或多个选自包括一个或多个羟基甲基（-CHOH-）部分和/或其衍生物，一个或多个乙氧基（-CH 2 -CH 2 -O-）部分和/或其衍生物的基团的R官能团，以及 一种或多种苯（C 6 H 6）和/或其衍生物; 和连接官能化乙烯基苄基组分和R官能组分的醚连接。

公开(公告)号：US20200247062A1

公开(公告)日：2020-08-06

申请号：US16852974

申请日：2020-04-20

Applicant: ADA Foundation

Inventor： Jirun Sun ,  Young Jong Lee

IPC: B29C64/393 ,  B29C64/386 ,  C08J9/00 ,  B29C64/00 ,  B29C64/336 ,  A61K6/15 ,  A61K6/62 ,  A61K6/71 ,  A61K6/76 ,  A61K6/887 ,  B33Y50/02 ,  B33Y80/00 ,  B29C64/106 ,  C08K3/22 ,  C08K5/08 ,  C08K5/18 ,  G02B1/04

Abstract: A computer-controlled system for forming composition-controlled objects using 3D printing includes two or more liquid reactant reservoirs, and a mixing sub-system for mixing the two or more liquid reactant compositions, which in turn includes a flow control sub-system to control a mass ratio of the mixed two or more liquid reactant compositions. The computer-controlled system further includes a scanning sub-system that, under control of the computer, causes relative motion of a mixed liquid reactants nozzle over a substrate; thereby depositing the mixed liquid reactant compositions onto the substrate. The system still further includes an illuminations system, operated under control of the computer, to polymerize the deposited mixed liquid reactant compositions.

公开(公告)号：US10231906B2

公开(公告)日：2019-03-19

申请号：US15345733

申请日：2016-11-08

Applicant: ADA Foundation

Inventor： Jirun Sun ,  Rafael Bowen

IPC: C08L33/08 ,  A61K6/083

Abstract: A composition of matter includes one or more functionalized vinylbenzyl components of the formula wherein n is an integer equal to or greater than 1 covalently connected to one or more R functional components; the one or more R functional groups selected from a group including one or more hydroxyl methyl (—CHOH—) moieties and/or derivatives thereof, one or more ethoxy (—CH2—CH2—O—) moieties and/or derivatives thereof, and one or more benzene derivatives; and ether links that connect the functionalized vinylbenzyl components and the R functional components.

公开(公告)号：US09931281B2

公开(公告)日：2018-04-03

申请号：US14952492

申请日：2015-11-25

Applicant: ADA Foundation

Inventor： Jirun Sun

IPC: A61K6/083 ,  A61K6/00

CPC classification number: A61K6/083 ,  A61K6/0052 ,  A61K6/0091 ,  A61K6/0038 ,  C08L33/08 ,  A61K6/0835

Abstract: A multi-functional self-healing dental composite may intrinsically repair the micro-crack and prevent the crack from propagating to catastrophic failure, thus significantly extending the service life of the restorative material. The self-healing dental composite includes a dental resin matrix, fillers, healing powder, and healing liquid containing micro-capsules distributed throughout the matrix. Each of the micro-capsules have a silica she formed by the hydrolysis condensation of TEOS in the presence of an aqueous solution of a healing liquid. The healing liquid includes a homo-polymers(s) and/or copolymer(s) of carboxylic acid(s). The healing powder particles distributed throughout the resin matrix, and include alumina, silica and other elements. The self-healing may be triggered automatically as a result of micro-cracking, induced by thereto/mechanical fatigue. During the self-healing process, antibacterial agents may be released to provide protection of the composites against cariogenic bacteria. The self-healing dental composites also may improve tooth remineralization, and caries prevention though fluoride release.

公开(公告)号：US20170088656A1

公开(公告)日：2017-03-30

申请号：US15276821

申请日：2016-09-27

Applicant: ADA Foundation

Inventor： Jirun Sun

IPC: C08F220/68 ,  C08K3/36 ,  C09D11/107 ,  C09D133/14 ,  B33Y70/00 ,  C09J133/14 ,  C09J129/10 ,  A61K6/00 ,  A61K6/083 ,  C08F216/12 ,  C09D129/10

CPC classification number: C08F220/68 ,  A61K6/0023 ,  A61K6/0052 ,  A61K6/083 ,  B33Y70/00 ,  C08F216/125 ,  C08F222/1006 ,  C08K3/36 ,  C09D11/101 ,  C09D11/107 ,  C09D129/10 ,  C09D133/14 ,  C09J129/10 ,  C09J133/14

Abstract: A composition of matter includes a mixture of styrene derivative monomers and methacrylate/acrylate derivative monomers, which have one or more urethane, carbamate, amide, and/or amine functional groups, and initiators, and the compositions are used to achieve composition control of the forming polymer, with the mole fraction of acrylate/methacrylate and styrene moieties in the forming polymer determined preferably by the chemistry and composition of the feeding monomers rather than the viscosity of the monomers.

公开(公告)号：US20160193119A1

公开(公告)日：2016-07-07

申请号：US14952492

申请日：2015-11-25

Applicant: ADA Foundation

Inventor： Jirun Sun

IPC: A61K6/083 ,  A61K6/00

CPC classification number: A61K6/083 ,  A61K6/0052 ,  A61K6/0091 ,  A61K6/0038 ,  C08L33/08 ,  A61K6/0835

Abstract: A multi-functional self-healing dental composite may intrinsically repair the micro-crack and prevent the crack from propagating to catastrophic failure, thus significantly extending the service life of the restorative material. The self-healing dental composite includes a dental resin matrix, fillers, healing powder, and healing liquid containing micro-capsules distributed throughout the matrix. Each of the micro-capsules have a silica she formed by the hydrolysis condensation of TEOS in the presence of an aqueous solution of a healing liquid. The healing liquid includes a homo-polymers(s) and/or copolymer(s) of carboxylic acid(s). The healing powder particles distributed throughout the resin matrix, and include alumina, silica and other elements. The self-healing may be triggered automatically as a result of micro-cracking, induced by thereto/mechanical fatigue. During the self-healing process, antibacterial agents may be released to provide protection of the composites against cariogenic bacteria. The self-healing dental composites also may improve tooth remineralization, and caries prevention though fluoride release.

Abstract translation: 多功能自愈牙科复合材料可以固有地修复微裂纹，防止裂纹传播到灾难性故障，从而显着延长修复材料的使用寿命。 自愈牙科复合材料包括牙科树脂基质，填充剂，愈合粉末和包含分布在整个基质中的微胶囊的愈合液。 每个微胶囊都具有通过TEOS在愈合液体的水溶液存在下水解缩合形成的二氧化硅。 愈合液体包括一种或多种羧酸的均聚物和/或共聚物。 愈合粉末颗粒分布在整个树脂基体上，包括氧化铝，二氧化硅等元素。 由于由其引起的微裂纹或机械疲劳，自愈可自动触发。 在自愈过程中，可以释放抗菌剂以提供复合材料对致龋细菌的保护。 自愈牙科复合材料还可以改善牙齿再矿化，并且通过氟化物释放来预防龋齿。

公开(公告)号：US10675224B2

公开(公告)日：2020-06-09

申请号：US16356959

申请日：2019-03-18

Applicant: ADA Foundation

Inventor： Jirun Sun ,  Rafael Lee Bowen

IPC: A61K6/887 ,  A61K6/889

Abstract: A composition of matter includes one or more functionalized vinylbenzyl components of the formula wherein n is an integer equal to or greater than 1 covalently connected to one or more R functional components; the one or more R functional groups selected from a group including one or more hydroxyl methyl (—CHOH—) moieties and/or derivatives thereof, one or more ethoxy (—CH2—CH2—O—) moieties and/or derivatives thereof, and one or more benzene derivatives; and ether links that connect the functionalized vinylbenzyl components and the R functional components.

公开(公告)号：US20190382343A1

公开(公告)日：2019-12-19

申请号：US16545110

申请日：2019-08-20

Applicant: ADA Foundation

Inventor： Jirun Sun ,  Nicole Ritzert ,  Xiaohong Wang

IPC: C07D213/76

Abstract: A multi-functional, stimuli-responsive material includes a substrate functionalized with a pH-sensitive Azo-QPS compound or co-assemblies containing Azo-QPS compounds. The Azo-QPS compound includes a positively-charged phenyl-azo-pyridinium core, an anion affiliated with the core, a head group, a tail group, a surface bonding group coupling the pH-sensitive Azo-QPS compound to the substrate, and a spacer connecting the pH-sensitive Azo-QPS compound to the surface bonding group.

公开(公告)号：US20180105495A1

公开(公告)日：2018-04-19

申请号：US15723763

申请日：2017-10-03

Applicant: ADA Foundation

Inventor： Jirun Sun

IPC: C07D213/76 ,  G01N33/543 ,  G01N33/68 ,  C08F220/34

CPC classification number: C07D213/76 ,  C08F220/34 ,  G01N33/5438 ,  G01N33/6887 ,  G01N2333/78

Abstract: A new azo-type quaternary pyridinium salt (Azo-QPS) shows enhanced activity at acidic conditions (e.g., pH=5); in neutral or basic conditions, this new Azo-QPS shows a much lower level (2-50 times less) anti-bacterial activity. The use of such a “stimulus-enhance” antibiotic can response to the proliferation of bacteria directly. It helps reduce or prevent the build-up of potent antibacterial agents in the oral environment. The antibacterial properties of Azo-QPS are “activated” when the environmental pH becomes acidic; this acidic pH may be indicative of the accumulation of Streptococcus mutans, or the initiation of tooth decay.

公开(公告)号：US20180086002A1

公开(公告)日：2018-03-29

申请号：US15702779

申请日：2017-09-13

Applicant: ADA Foundation

Inventor： Jirun Sun ,  Young Lee

IPC: B29C64/393 ,  B33Y70/00 ,  B33Y10/00 ,  B33Y80/00 ,  G02B1/04 ,  A61K6/083 ,  A61K6/00 ,  C08K5/08 ,  C08K5/18 ,  C08K3/36 ,  C08K3/22 ,  C08J9/26 ,  B33Y50/02

CPC classification number: B29C64/393 ,  A61K6/0002 ,  A61K6/0052 ,  A61K6/0073 ,  A61K6/0088 ,  A61K6/083 ,  B29C64/00 ,  B29C64/106 ,  B29C64/336 ,  B29C64/386 ,  B29K2067/04 ,  B29K2071/00 ,  B29K2105/0002 ,  B29K2105/0005 ,  B29K2105/0085 ,  B29K2105/04 ,  B29K2309/02 ,  B29L2011/0016 ,  B29L2031/7532 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y50/00 ,  B33Y50/02 ,  B33Y70/00 ,  B33Y80/00 ,  C08J9/0061 ,  C08J9/26 ,  C08J2201/026 ,  C08J2201/0422 ,  C08J2201/0446 ,  C08J2201/0462 ,  C08J2207/10 ,  C08J2329/10 ,  C08J2335/02 ,  C08J2425/06 ,  C08K3/22 ,  C08K3/36 ,  C08K5/08 ,  C08K5/18 ,  C08K2003/2227 ,  C08K2003/2241 ,  G02B1/04 ,  G02B1/041

Abstract: A computer-controlled method for forming a composition-controlled product using 3D printing includes disposing two or more liquid reactant compositions in respective two or more reservoirs; and mixing the two or more liquid reactant compositions, which in turn includes controlling by the computer a mass ratio of the mixed two or more liquid reactant compositions. The computer-controlled method further includes scanning, under control of the computer, a mixed liquid reactants nozzle over a substrate; depositing the mixed liquid reactant compositions onto the substrate; and operating, under control of the computer, a light source to polymerize the deposited mixed liquid reactant compositions.