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    Drug delivery systems and methods with pressure sensitive control
    11.
    发明授权
    Drug delivery systems and methods with pressure sensitive control 有权

    公开(公告)号：US11534547B2

    公开(公告)日：2022-12-27

    申请号：US16725069

    申请日：2019-12-23

    Applicant: AMGEN INC.

    Inventor： Daniel Eduardo Groszmann ,  Scott Robert Gibson

    IPC: A61M5/168 ,  A61M5/145 ,  A61M5/172 ,  A61M5/142

    Abstract: Systems and methods for drug delivery with pressure sensitive control are disclosed. A drug delivery system may include a reservoir filled or fillable with a drug, a drug delivery device coupled to the reservoir to deliver the drug from the reservoir to a patient, a pressure sensor, an output device, and a controller. The controller may be configured to determine if the drug delivery device has completed delivering a dose of the drug to the patient, and if delivery of the dose of the drug is complete, to measure tissue back pressure using the pressure sensor. Subsequently, the controller may be configured to determine if the tissue back pressure is below a first predetermined value, and if so, control the output device at least once and/or control a mechanism to retract an administration member from the patient.

    NEEDLE INSERTION MECHANISM FOR DRUG DELIVERY DEVICE
    12.
    发明申请
    NEEDLE INSERTION MECHANISM FOR DRUG DELIVERY DEVICE 有权

    公开(公告)号：US20220355025A1

    公开(公告)日：2022-11-10

    申请号：US17641458

    申请日：2020-10-05

    Applicant: AMGEN INC.

    Inventor： Tohid Pirbodaghi ,  Samin Akbari ,  Joshua Tamsky ,  Paul Daniel Faucher ,  Scott Robert Gibson ,  Sheldon B. Moberg

    IPC: A61M5/142 ,  A61M5/172

    Abstract: A drug delivery device includes a housing, a container disposed in the housing, an activation mechanism, and a needle insertion mechanism (NIM). The container has an inner volume to contain a medicament which is urged out of the container by the activation mechanism. The needle insertion mechanism (NIM) is operably coupled with the activation mechanism and includes an actuation assembly adapted to insert a needle and a cannula to deliver the medicament from the container. The actuation assembly is movable between a storage state, a first operational state, a second operational state, and a third operational state to selectively position the needle and the cannula.

    SYSTEMS AND METHODS FOR DELAYED DRUG DELIVERY
    17.
    发明公开
    SYSTEMS AND METHODS FOR DELAYED DRUG DELIVERY 审中-公开

    公开(公告)号：US20240131263A1

    公开(公告)日：2024-04-25

    申请号：US18097725

    申请日：2023-01-17

    Applicant: AMGEN INC.

    Inventor： Scott Robert Gibson ,  Adam B. McCullough

    IPC: A61M5/20 ,  A61M5/315 ,  A61M5/50

    CPC classification number: A61M5/20 ,  A61M5/2033 ,  A61M5/31515 ,  A61M5/31571 ,  A61M5/5086 ,  A61M25/06

    Abstract: Systems and methods for delayed delivery of a drug are disclosed. A drug delivery system may include a delivery member for insertion into a patient and a reservoir configured to receive a volume of a drug. An energy source may be activatable by the patient to actuate the reservoir to deliver the drug to the patient as a single bolus. A lockout system may be configured to have a locked state, wherein the lockout system prevents movement of the delivery member and/or activation of the energy source, and an unlocked state, wherein the lockout system permits movement of the delivery member and/or activation of the energy source. The lockout system may be configured to automatically change from the locked state to the unlocked state after a preselected time period has elapsed. An output element may generate a detectable output after the preselected time period has elapsed for notifying the patient.

    Needle insertion-retraction system having dual torsion spring system
    18.
    发明授权
    Needle insertion-retraction system having dual torsion spring system 有权

    公开(公告)号：US11305056B2

    公开(公告)日：2022-04-19

    申请号：US16620016

    申请日：2018-07-14

    Applicant: AMGEN INC.

    Inventor： Mehran Mojarrad ,  Scott Robert Gibson ,  Adam Livingston

    IPC: A61M5/142 ,  A61M5/145

    Abstract: An insertion/retraction mechanism for a drug delivery device is disclosed. The insertion/retraction mechanism includes a retraction hub, an insertion hub, an insertion/retraction mechanism housing, and a dual torsion spring system. The retraction hub includes a first primary rotational stop and a second primary rotational stop extending radially inwardly from an inside surface. The insertion hub is disposed inside the retraction hub and comprises a first complementary rotational stop and a second complementary rotational stop extending radially outwardly from an outside surface. The dual torsion spring system causes the first primary rotational stop and the second primary rotational stop to selectively engage the first complementary rotational stop and the secondary rotational stop, respectively, and further causes the retraction hub to rotate relative to the insertion/retraction mechanism housing as the insertion/retraction mechanism moves between an initial position, an inserted position, and a retracted position.

    DRUG DELIVERY DEVICES WITH PARTIAL DRUG DELIVERY MEMBER RETRACTION
    19.
    发明申请
    DRUG DELIVERY DEVICES WITH PARTIAL DRUG DELIVERY MEMBER RETRACTION 有权

    公开(公告)号：US20220031939A1

    公开(公告)日：2022-02-03

    申请号：US17277599

    申请日：2019-10-14

    Applicant: AMGEN INC.

    Inventor： Ali Nekouzadeh ,  Carl Conrath ,  Scott Robert Gibson ,  Basel Hasan Taha

    IPC: A61M5/145 ,  A61M5/158

    Abstract: Methods, devices, and components are provided to reduce tissue resistive pressure during a subcutaneous drug delivery operation by increasing the size of the injection cavity by partially retracting the drug delivery member after inserting the drug delivery member to a subcutaneous position. The drug delivery devices described herein include a motor operably coupled to a drug delivery member. The motor can be selectively activated by a controller to retract the drug delivery member a predetermined distance to relieve pressure in an injection cavity in a patient. A force sensor can provide the controller with a drug delivery member insertion force. The controller can then estimate a tissue resistive pressure based on the drug delivery member insertion force and determine the predetermined distance for the partial drug delivery member retraction based on the tissue resistive pressure.

    NEEDLE INSERTION-RETRACTION SYSTEM HAVING DUAL TORSION SPRING SYSTEM
    20.
    发明申请
    NEEDLE INSERTION-RETRACTION SYSTEM HAVING DUAL TORSION SPRING SYSTEM 审中-公开

    公开(公告)号：US20200230313A1

    公开(公告)日：2020-07-23

    申请号：US16620016

    申请日：2018-07-03

    Applicant: AMGEN INC.

    Inventor： Mehran Mojarrad ,  Scott Robert Gibson ,  Adam Livingston

    IPC: A61M5/142

    Abstract: An insertion/retraction mechanism for a drug delivery device is disclosed. The insertion/retraction mechanism includes a retraction hub, an insertion hub, an insertion/retraction mechanism housing, and a dual torsion spring system. The retraction hub includes a first primary rotational stop and a second primary rotational stop extending radially inwardly from an inside surface. The insertion hub is disposed inside the retraction hub and comprises a first complementary rotational stop and a second complementary rotational stop extending radially outwardly from an outside surface. The dual torsion spring system causes the first primary rotational stop and the second primary rotational stop to selectively engage the first complementary rotational stop and the secondary rotational stop, respectively, and further causes the retraction hub to rotate relative to the insertion/retraction mechanism housing as the insertion/retraction mechanism moves between an initial position, an inserted position, and a retracted position.

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