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公开(公告)号：US20180256774A9
公开(公告)日：2018-09-13
申请号：US15355397
申请日：2016-11-18
发明人： Adam Rago , John Marini , Gregory T. Zugates , Marc Helmick , Upma Sharma
CPC分类号： A61L24/0036 , A61L24/06
摘要： Systems, methods and kits for treating hemorrhages within cavities are provided. The methods utilize the application of a rapid spike of pressure to the closed cavity, followed by a steady state pressure or pressures.
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公开(公告)号：US10052107B2
公开(公告)日：2018-08-21
申请号：US14212930
申请日：2014-03-14
发明人： Rany Busold , John Marini , Upma Sharma , Adam Rago , Jennifer Mortensen , Joseph Lomakin , Gregory T. Zugates , Janet Komatsu , Jeffrey Groom, III
CPC分类号： A61B17/12118 , A61B17/12186 , A61B17/1219 , A61B17/12195 , A61B2017/1205 , A61B2217/005 , A61F2/07 , A61F2/95 , A61F2002/077 , A61M25/0067 , A61M25/007 , A61M25/0074 , A61M25/10 , A61M25/1006 , A61M2025/0004 , A61M2025/0078 , A61M2025/0175
摘要： Systems and method for treating aneurysms are provided which utilize formulations that form polymer foams in situ. The formulations generally have a buoyancy greater than or less than blood, and either float to the top of the aneurysm and foam from the top down or sink to the bottom and foam from the bottom up.
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公开(公告)号：US20180028189A1
公开(公告)日：2018-02-01
申请号：US15729993
申请日：2017-10-11
发明人： Adam Rago , John Marini , Gregory T. Zugates , Marc Helmick , Upma Sharma
CPC分类号： A61B17/12 , A61B2017/12004 , A61L24/0036 , A61L24/046 , A61L2400/04 , A61M13/003 , A61M2205/3341 , A61M2205/3344 , A61M2210/1021 , A61M2210/12 , C08L75/04
摘要： Systems, methods and kits for treating hemorrhages within cavities are provided. The methods utilize the application of a rapid spike of pressure to the closed cavity, followed by a steady state pressure or pressures.
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公开(公告)号：US09044580B2
公开(公告)日：2015-06-02
申请号：US13815910
申请日：2013-03-15
发明人： Toby Freyman , Joseph Lomakin , John Marini , Jennifer Mortensen , Adam Rago , Rany Busold , Upma Sharma , Gregory T. Zugates
IPC分类号： A61F2/02 , A61M37/00 , A61L31/06 , A61L31/12 , A61L31/14 , A61L24/00 , A61L24/04 , A61F2/07 , A61B17/12 , A61J1/20 , A61F2/06
CPC分类号： A61B17/12181 , A61B17/12113 , A61B17/12118 , A61B17/1214 , A61B2017/1205 , A61F2/07 , A61F2002/065 , A61F2002/077 , A61F2210/0085 , A61J1/2093 , A61L24/0036 , A61L24/0089 , A61L24/046 , A61L31/06 , A61L31/128 , A61L31/146 , A61L2300/60 , A61L2400/06 , A61M37/00 , C08L67/04 , C08L83/04
摘要： Systems, methods and kits relating to in-situ forming polymer foams for the treatment of aneurysms or fluid filled spaces are disclosed. The systems include an insertable medical device and an in-situ forming foam of lava like materials with a fast forming outer skin and a slower hardening interior that is formed from a one-, two- or multi-part formulation. When used to treat an aneurysm, the foam is placed into contact with at least a portion of an exterior surface of the medical device and/or the tissue surface of the aneurysm.
摘要翻译： 公开了与原位形成聚合物泡沫相关的用于治疗动脉瘤或填充液体的空间的系统，方法和试剂盒。 这些系统包括可插入的医疗装置和具有快速成形外皮的熔岩状材料的原位成形泡沫体，以及由一部分，两部分或多部分制剂形成的较慢的硬化内部。 当用于治疗动脉瘤时，将泡沫放置成与医疗装置的外表面的至少一部分和/或动脉瘤的组织表面接触。
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公开(公告)号：US20230414840A1
公开(公告)日：2023-12-28
申请号：US18465782
申请日：2023-09-12
发明人： Upma Sharma , Irina Gitlin , Gregory T. Zugates , Adam Rago , Parisa Zamiri , Rany Busold , Robert J. Caulkins , Toby Freyman , Quynh Pham , Changcheng You , Jeffrey Carbeck
IPC分类号： A61L31/06 , A61J1/20 , A61L27/18 , A61L27/56 , A61L27/58 , A61L31/14 , A61M37/00 , A61B17/12 , C08L63/00
CPC分类号： A61L31/06 , A61J1/2093 , A61L27/18 , A61L27/56 , A61L27/58 , A61L31/148 , A61L31/146 , A61M37/00 , A61B17/12031 , A61B17/12163 , A61B17/12186 , A61L31/141 , C08L63/00 , A61L2400/04 , A61L2400/06 , A61B2017/12004 , A61L2400/18
摘要： Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).
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公开(公告)号：US11246964B2
公开(公告)日：2022-02-15
申请号：US16376087
申请日：2019-04-05
发明人： Upma Sharma , Irina Gitlin , Gregory T. Zugates , Adam Rago , Parisa Zamiri , Rany Busold , Robert J. Caulkins , Toby Freyman , Quynh Pham , Changcheng You , Jeffrey Carbeck
IPC分类号： A61L27/56 , A61L31/06 , A61J1/20 , A61L27/18 , A61L27/58 , A61L31/14 , A61M37/00 , A61B17/12 , C08L63/00
摘要： Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).
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公开(公告)号：US10687795B2
公开(公告)日：2020-06-23
申请号：US15411505
申请日：2017-01-20
发明人： Upma Sharma , Rany Busold , Adam Rago , Gregory T. Zugates , Toby Freyman , Lisette Manrique Miller
IPC分类号： A61F2/02 , A61B17/00 , B05B7/24 , B01F5/06 , B01F7/00 , B01F13/00 , B01F15/00 , B01F15/02 , B05C17/005 , B01F3/04 , A61C9/00 , A61M5/14 , A61M5/145 , A61M5/168 , B05B7/00 , A61M13/00 , A61M5/19 , B65D81/32 , A61B17/88
摘要： Delivery systems for in situ forming foam formulations are provided. The devices may include various actuation mechanisms and may entrain air into fluid formulation components in a variety of ways, including mixing with air and the addition of compressed gas.
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公开(公告)号：US10293076B2
公开(公告)日：2019-05-21
申请号：US15355397
申请日：2016-11-18
发明人： Adam Rago , John Marini , Gregory T. Zugates , Marc Helmick , Upma Sharma
摘要： Systems, methods and kits for treating hemorrhages within cavities are provided. The methods utilize the application of a rapid spike of pressure to the closed cavity, followed by a steady state pressure or pressures.
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公开(公告)号：US20180177507A9
公开(公告)日：2018-06-28
申请号：US14212930
申请日：2014-03-14
发明人： Rany Busold , John Marini , Upma Sharma , Adam Rago , Jennifer Mortensen , Joseph Lomakin , Gregory T. Zugates , Janet Komatsu , Jeffrey Groom, III
CPC分类号： A61B17/12118 , A61B17/12186 , A61B17/1219 , A61B17/12195 , A61B2017/1205 , A61B2217/005 , A61F2/07 , A61F2/95 , A61F2002/077 , A61M25/0067 , A61M25/007 , A61M25/0074 , A61M25/10 , A61M25/1006 , A61M2025/0004 , A61M2025/0078 , A61M2025/0175
摘要： Systems and method for treating aneurysms are provided which utilize formulations that form polymer foams in situ. The formulations generally have a buoyancy greater than or less than blood, and either float to the top of the aneurysm and foam from the top down or sink to the bottom and foam from the bottom up.
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公开(公告)号：US20170325796A1
公开(公告)日：2017-11-16
申请号：US15411505
申请日：2017-01-20
发明人： Upma Sharma , Rany Busold , Adam Rago , Gregory T. Zugates , Toby Freyman , Lisette Manrique Miller
IPC分类号： A61B17/00 , B05B7/24 , A61M5/14 , A61M5/145 , A61M5/168 , B05B7/00 , B01F15/02 , B01F15/00 , B01F13/00 , B01F7/00 , B01F5/06 , B01F3/04 , B05C17/005
摘要： Delivery systems for in situ forming foam formulations are provided. The devices may include various actuation mechanisms and may entrain air into fluid formulation components in a variety of ways, including mixing with air and the addition of compressed gas.
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