公开(公告)号：US20150353550A1

公开(公告)日：2015-12-10

申请号：US14715330

申请日：2015-05-18

Applicant: AbbVie Inc.

Inventor： Michael R. Schrimpf ,  Chih-Hung Lee ,  Tao Li ,  Gregory A. Gfesser ,  Kathleen H. Mortell ,  Ramin Faghih ,  Diana L. Nersesian ,  Kevin B. Sippy ,  William H. Bunnelle ,  Marc Scanio ,  Lei Shi ,  Murali Gopalakrishnan ,  Diana L. Donnelly-Roberts ,  Min Hu

IPC: C07D471/18

CPC classification number: G01N33/5058 ,  C07D471/18 ,  C07D487/10 ,  C07D487/18 ,  G01N33/6896 ,  G01N2800/28 ,  G01N2800/30

Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

Abstract translation: 本申请涉及式（I），（II），（III），（IV），（V）或（VI）的吲哚和二氢吲哚衍生物，其中a，R1，R2，R3，R4，R5， V，W，X，Y和Z如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。

公开(公告)号：US20150158867A1

公开(公告)日：2015-06-11

申请号：US14624517

申请日：2015-02-17

Applicant: AbbVie Inc.

Inventor： Michael R. Schrimpf ,  Diana L. Nersesian ,  Kevin B. Sippy ,  Jianguo Ji ,  Tao Li ,  Marc Scanio ,  Lei Shi ,  Chih-Hung Lee ,  William H. Bunnelle ,  Geoff G.Z. Zhang ,  Paul J. Brackemeyer ,  Shuang Chen ,  Rodger F. Henry

IPC: C07D471/18 ,  A61K31/439 ,  A61K31/501 ,  A61K31/444 ,  C07C309/29 ,  A61K31/095

CPC classification number: C07D471/18 ,  A61K31/095 ,  A61K31/439 ,  A61K31/444 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K45/06 ,  C07C309/29 ,  C07D451/14 ,  C07D471/08 ,  C07F5/022

Abstract: The invention relates to compounds that are azaadamantane derivatives, particularly ether- or amine-substituted azaadamantane derivatives and salts and prodrugs thereof, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.

Abstract translation: 本发明涉及作为氮杂金刚烷衍生物的化合物，特别是醚取代或胺取代的氮杂金刚烷衍生物及其盐和前体药物，包含这些化合物的组合物，使用这些化合物和组合物的方法，制备这些化合物的方法以及在此过程中获得的中间体 。

公开(公告)号：US09029361B2

公开(公告)日：2015-05-12

申请号：US14101912

申请日：2013-12-10

Applicant: AbbVie Inc.

Inventor： Pramila A. Bhatia ,  John T. Randolph ,  Michael R. Schrimpf ,  Qingwei I. Zhang

IPC: A61K31/551 ,  C07D487/04

CPC classification number: C07D487/04

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, treat pain; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

Abstract translation: 本发明涉及：（a）其特别是治疗疼痛的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。

公开(公告)号：US08987453B2

公开(公告)日：2015-03-24

申请号：US13653192

申请日：2012-10-16

Applicant: AbbVie Inc.

Inventor： Michael R. Schrimpf ,  Diana L. Nersesian ,  Kevin B. Sippy ,  Jianguo Ji ,  Tao Li ,  Marc Scanio ,  Lei Shi ,  Chih-Hung Lee ,  William H. Bunnelle ,  Geoff G. Z. Zhang ,  Paul J. Brackemeyer ,  Shuang Chen ,  Rodger F. Henry

IPC: C07D471/18 ,  A61K45/06 ,  A61K31/444 ,  C07D471/08 ,  C07F5/02 ,  A61K31/439 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506

CPC classification number: C07D471/18 ,  A61K31/095 ,  A61K31/439 ,  A61K31/444 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K45/06 ,  C07C309/29 ,  C07D451/14 ,  C07D471/08 ,  C07F5/022

Abstract: The invention relates to compounds that are azaadamantane derivatives, particularly ether- or amine-substituted azaadamantane derivatives and salts and prodrugs thereof, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.

Abstract translation: 本发明涉及作为氮杂金刚烷衍生物的化合物，特别是醚取代或胺取代的氮杂金刚烷衍生物及其盐和前体药物，包含这些化合物的组合物，使用这些化合物和组合物的方法，制备这些化合物的方法以及在此过程中获得的中间体 。

公开(公告)号：US20130096132A1

公开(公告)日：2013-04-18

申请号：US13653192

申请日：2012-10-16

Applicant: AbbVie Inc.

Inventor： Michael R. Schrimpf ,  Diana L. Nersesian ,  Kevin B. Sippy ,  Jianguo Ji ,  Tao Li ,  Marc Scanio ,  Lei Shi ,  Chih-Hung Lee ,  William H. Bunnelle ,  Geoff G.Z. Zhang ,  Paul J. Brackemeyer ,  Shuang Chen ,  Rodger F. Henry

IPC: C07D471/18 ,  A61K45/06 ,  A61K31/501 ,  A61K31/496 ,  A61K31/506 ,  A61K31/497 ,  A61K31/439 ,  A61K31/444

CPC classification number: C07D471/18 ,  A61K31/095 ,  A61K31/439 ,  A61K31/444 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K45/06 ,  C07C309/29 ,  C07D451/14 ,  C07D471/08 ,  C07F5/022

Abstract: The invention relates to compounds that are azaadamantane derivatives, particularly ether- or amine-substituted azaadamantane derivatives and salts and prodrugs thereof, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.

公开(公告)号：US20200255423A1

公开(公告)日：2020-08-13

申请号：US16654219

申请日：2019-10-16

Applicant: AbbVie Inc.

Inventor： Maria A. Argiriadi ,  Eric C. Breinlinger ,  Ellen Yulin Tsai Chien ,  Marlon D. Cowart ,  Kristine E. Frank ,  Michael M. Friedman ,  David J. Hardee ,  J. Martin Herold ,  Huaqing Liu ,  Wei Qiu ,  Marc J. Scanio ,  Michael R. Schrimpf ,  Thomas R. Vargo ,  Stacy A. Van Epps ,  Matthew P. Webster ,  Andrew J. Little ,  Matthew H. Katcher ,  Theresa A. Dunstan ,  David A. Schiedler

IPC: C07D471/04 ,  C07D487/04

Abstract: Disclosed herein are compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4a, R4b, X1, X2, X3, X4, X5, and n are as defined herein, pharmaceutical compositions comprising same, and methods of preparation and use.

公开(公告)号：US20190276450A1

公开(公告)日：2019-09-12

申请号：US16299485

申请日：2019-03-12

Applicant: AbbVie Inc.

Inventor： Maria A. Argiriadi ,  Eric C. Breinlinger ,  Ellen Yulin Tsai Chien ,  Marlon D. Cowart ,  Kristine E. Frank ,  Michael M. Friedman ,  David J. Hardee ,  J. Martin Herold ,  Huaqing Liu ,  Wei Qiu ,  Marc J. Scanio ,  Michael R. Schrimpf ,  Thomas R. Vargo ,  Stacy A. Van Epps ,  Matthew P. Webster ,  Andrew J. Little ,  Matthew H. Katcher

IPC: C07D471/04

Abstract: Disclosed herein are compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4a, R4b, X1, X2, X3, X4, X5, and n are as defined herein, pharmaceutical compositions comprising same, and methods of preparation and use.

公开(公告)号：US20180024144A1

公开(公告)日：2018-01-25

申请号：US15454313

申请日：2017-03-09

Applicant: AbbVie Inc.

Inventor： Michael R. Schrimpf ,  Chih-hung Lee ,  Tao Li ,  Gregory Gfesser ,  Kathleen Mortell ,  Ramin Faghih ,  Diana L. Schmidt ,  Kevin Sippy ,  William H. Bunnelle ,  Marc Scanio ,  Lei Shi ,  Murali Gopalakrishnan ,  Diana L. Donnelly-Roberts ,  Min Hu

IPC: G01N33/68 ,  G01N33/50 ,  C07D471/18 ,  C07D487/10

CPC classification number: G01N33/6896 ,  C07D471/18 ,  C07D487/10 ,  G01N33/5058 ,  G01N2800/2814 ,  G01N2800/30

Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

公开(公告)号：US20150225409A1

公开(公告)日：2015-08-13

申请号：US14693419

申请日：2015-04-22

Applicant: AbbVie Inc.

Inventor： Pramila A. Bhatia ,  John T. Randolph ,  Michael R. Schrimpf ,  Qingwei I. Zhang

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, treat pain; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

Abstract translation: 本发明涉及：（a）其特别是治疗疼痛的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。