公开(公告)号：US10328118B2

公开(公告)日：2019-06-25

申请号：US15439206

申请日：2017-02-22

Applicant: The Medicines Company ,  AbbVie Inc.

Inventor： Adel Rafai Far ,  Gopal Krishna ,  Min Ding ,  Sanjay R. Chemburkar ,  Carl M. Knable ,  James P. Petzel ,  Julie J. Pruyne ,  Douglas M. Reamer

IPC: A61K9/19 ,  C07K9/00 ,  A61K38/14 ,  A61K47/26 ,  C12P21/02

Abstract: Drug substance preparations of oritavancin having high purity are disclosed, along with pharmaceutical compositions comprising such oritavancin drug substance preparations, and drug products or dosage forms comprising such pharmaceutical compositions.

公开(公告)号：US10316338B1

公开(公告)日：2019-06-11

申请号：US15010557

申请日：2016-01-29

Applicant: AbbVie Inc.

Inventor： Michael J. Abrahamson ,  Angelica B. Kielbus ,  William T. Riordan ,  David R. Hill ,  Sanjay R. Chemburkar ,  Rajarathnam E. Reddy ,  Timothy B. Towne ,  Jianzhang Mei ,  Gareth J. Brown ,  Stefan Mix

IPC: C12P7/62

Abstract: Disclosed are methods of synthesizing enantioenriched difluoroalkylcyclopropyl amino esters and their salts, such as the dicyclohexylamine salt of (1S,2R)-2-(difluoromethyl)-1-(propoxycarbonyl)cyclopropane carboxylic acid. These compounds are useful intermediates in the synthesis of viral protease inhibitors.

公开(公告)号：US20190048326A1

公开(公告)日：2019-02-14

申请号：US16172111

申请日：2018-10-26

Applicant: AbbVie Inc.

Inventor： Michael J. Abrahamson ,  Rajarathnam E. Reddy ,  William T. Riordan ,  Sanjay R. Chemburkar

IPC: C12N9/06

Abstract: Disclosed are, among other things, variant polypeptides, nucleic acids encoding the polypeptides, production of the variant polypeptides, and use of the variant polypeptides in various applications, such as screening and synthetic methods. For example, the variant polypeptides, or enzymatically-active fragments thereof, are useful for converting aliphatic keto acids to aliphatic alpha amino acids.

公开(公告)号：US10059969B1

公开(公告)日：2018-08-28

申请号：US14874001

申请日：2015-10-02

Applicant: AbbVie Inc.

Inventor： Michael J. Abrahamson ,  Julie J. Pruyne ,  Angelica B. Kielbus ,  John E. Lallaman ,  Rajarathnam E. Reddy ,  Sanjay R. Chemburkar

IPC: C12P13/04 ,  C07C51/377 ,  C07C67/343

CPC classification number: C12P13/04 ,  C12Y104/01009

Abstract: Disclosed herein is a process for preparing enantioenriched (S)-2-aminonon-8-enoic acid by amination of 2-oxonon-8-enoic acid in the presence of an enzyme and an ammonia source.

公开(公告)号：US09649352B2

公开(公告)日：2017-05-16

申请号：US14801303

申请日：2015-07-16

Applicant: The Medicines Company ,  AbbVie Inc.

Inventor： Adel Rafai Far ,  Gopal Krishna ,  Min Ding ,  Sanjay R. Chemburkar ,  Carl M. Knable ,  James P. Petzel ,  Julie J. Pruyne ,  Douglas M. Reamer

IPC: A61K38/14 ,  A61K9/19 ,  A61K47/26

CPC classification number: A61K38/14 ,  A61K9/19 ,  A61K47/26 ,  C07K9/008 ,  C12P21/02

Abstract: Drug substance preparations of oritavancin having high purity are disclosed, along with pharmaceutical compositions comprising such oritavancin drug substance preparations, and drug products or dosage forms comprising such pharmaceutical compositions.